Figure 7.1 The Biology of Cancer (© Garland Science 2007) What’s dominant? Cell Fusion Allows...
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Transcript of Figure 7.1 The Biology of Cancer (© Garland Science 2007) What’s dominant? Cell Fusion Allows...
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Figure 7.1 The Biology of Cancer (© Garland Science 2007)
What’s dominant?
Cell Fusion Allows Interaction Of Disparate Genomes
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Retinoblastoma strikes in childhood and is easily diagnosed.
RETINOBLASTOMA
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Figure 7.5a The Biology of Cancer (© Garland Science 2007)
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Figure 7.5b The Biology of Cancer (© Garland Science 2007)
Familial vs sporadic Retinoblastoma Retinoblastoma Pedigree
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Figure 7.8 The Biology of Cancer (© Garland Science 2007)
Heterozygosity – 2 ways of Losing it
Mitotic
Recombination
Gene
Conversion
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Figure 7.13 The Biology of Cancer (© Garland Science 2007)
Testing For Loss of Heterozygosity
By Southern Blot By PCR
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Figure 7.14 The Biology of Cancer (© Garland Science 2007)
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Figure 7.16 The Biology of Cancer (© Garland Science 2007)
Losing Heterozygosity – A Third Way
Methylation
An example
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Figure 7.19 The Biology of Cancer (© Garland Science 2007)
Many Tumor Suppressors are Silenced by Hypermethylation
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Figure 7.21 The Biology of Cancer (© Garland Science 2007)
NF-1 – Neurofibromatotosis -1 is a GTPase Activating Protein
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Figure 7.24a The Biology of Cancer (© Garland Science 2007)
APC-/-APC+/- or +/+
APC, β-Catenin & Intestinal Crypts
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Figure 7.25a The Biology of Cancer (© Garland Science 2007)
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Figure 7.28a The Biology of Cancer (© Garland Science 2007)
The Von Hippel Landau tumor Suppressor and HIF-1
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Figure 7.29b The Biology of Cancer (© Garland Science 2007)