Figure 1. Figure 2 ab p=0.0009 p=0.0014 *** Figure 3 a *** b cFos TP53 Beta actin cFos TP53 Beta...
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Transcript of Figure 1. Figure 2 ab p=0.0009 p=0.0014 *** Figure 3 a *** b cFos TP53 Beta actin cFos TP53 Beta...
Figure 1
Figure 2
a b
MCF10
a
UACC
ZR75.1
MCF7
MB23
1
SKBR30
20
40
60
HX
R9
IC50
(u
M)
p=
0.0
00
9
p=
0.0
01
4
TP53
Unt
CXR9
HXR90.000
0.005
0.010
0.015
0.020
Rel
ativ
e ex
pre
ssio
n
cFos
Unt
CXR9
HXR90.00
0.05
0.10
0.15
0.20
0.25
Rel
ativ
e ex
pre
ssio
n
***
Figure 3
Unt
CXR9
HXR90.00
0.02
0.04
0.06R
elat
ive
exp
ress
ion
a
Unt
CXR9
HXR90.0
0.2
0.4
0.6
0.8
1.0
Rel
ativ
e ex
pre
ssio
n
***b
cFos TP53
Beta actin
cFos TP53
Beta actin
Untreated CXR9 HXR9
Figure 4
b
a
c
**
Untreat
ed
CXR9
HXR9
0
20
40
60
80
100V
N
EA
LA
% c
ells
**
**
**
Figure 5
IC50 (M)Decreasing sensitivity
All HOX genes
SKBR3
MB23
1
MCF7
ZR75.1
UACC
MCF10
aNBT
0
2000
4000
6000M
ean
exp
ress
ion
16 23 33 42 48 51
p=
0.0
02
4
p<
0.0
00
1
p<
0.0
00
1
p<
0.0
00
1
p<
0.0
00
1* * * **
Decreasing sensitivity
HOXB1 to HOXB9
SKBR3
MB23
1
MCF7
ZR75.1
UACC
MCF10
aNBT
0
500
1000
1500
2000
2500
Mea
n e
xpre
ssio
n
16 23 33 42 48 51
p=
0.0
24
3
p=
0.0
00
8
p<
0.0
00
1
p=
0.0
01
2* * *
a b
HOXB1 to HOXB9
20 40 60
-500
0
500
1000
1500
IC50 (uM)
Mea
n e
xpre
ssio
n
r2 = 0.9778p=0.0002
SKBR3
MB231
MCF7
ZR75.1UACC MCF10a
NBT (predicted)
c
HOXB1 to HOXB9
0 20 40 600
2000
4000
6000
8000
10000
IC50 (uM)
Mea
n e
xpre
ssio
n
d
Figure 6
ab
c
0 2 7 9 12 13 19 22 27 30 34 37 40 44 48 500
500
1000
1500
2000CXR9HXR9
Days
Ave
rag
e tu
mo
ur
volu
me
mm
3
0 20 40 60 800
20
40
60
80
100CXR9HXR9
days
Per
cen
t su
rviv
al
p=0.004
p<0.001
CXR9
HXR90.0
0.2
0.4
0.6
cFo
s ex
pre
ssio
n
p=0.0027
CXR9 HXR9
S
T
d
Online resource 1
CXCL1 5.13
FOSB 4.04ATF3 3.61AREG 3.61TNFAIP3 3.70NR4A21 3.32NR4A3 3.08ZFP36 3.07CD83 2.73UPP1 2.53
PPP1R15A 2.82
CD86 2.73CCL20 2.37EGR1 2.65ARL14 2.24TNF 3.21KLF2 2.07DUSP5 2.26IL1RL1 1.86NCOA7 2.46
4 5 6 7 8 9
0250500750100012501500
*
TGATTAAT(G/T)(G/A)
Online resource 2
Log fold increase in transcription by
HXR9
Base pairs 5’ from transcription start site
Muco
id
Lobular
Ductal
0
100
200
300
400
500M
ean
exp
HO
XB
1to
B9
<5ye
ars
>5ye
ars
0
200
400
600
800
1000
Mea
n e
xp H
OX
B1t
oB
9
ER-ER+
0
200
400
600
800
Mea
n e
xp H
OX
B1t
oB
9
G2 G30
200
400
600
Mea
n e
xp H
OX
B1t
oB
9
No nodes
Nodes0
500
1000
1500
Mea
n e
xp H
OX
B1t
oB
9
Left
Right
0
200
400
600
800
1000
Mea
n e
xp H
OX
B1t
oB
9
a
b
c
d
e
f
Online resource 3
p=
0.0
12
6
p=
0.0
17
0
p=0.3488
p=0.8836 p=0.9754
p=0.2378 p=0.0688
HER2-
HER2+0
200
400
600
800
1000
Mea
n e
xp H
OX
B1t
oB
9
PR-PR+
0
200
400
600
800
Mea
n e
xp H
OX
B1t
oB
9
h
g
p=0.7544
p=0.8344