Fig. 1-29. Pg. 25 Inherited Disorders “Sporadic” Cancers Aging Lysosomal Storage diseases I-Cell...
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Transcript of Fig. 1-29. Pg. 25 Inherited Disorders “Sporadic” Cancers Aging Lysosomal Storage diseases I-Cell...
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Fig. 1-29
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Pg. 25
Inherited Disorders“Sporadic” CancersAging
Lysosomal Storage diseasesI-Cell Disease
Cystic FibrosisCholera
“Sporadic” CancersAging
Alzheimer’sDisease
Cystic Fibrosis
MuscularDystrophy
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Drug Targets
Microtubules
Membrane receptors
Translation componentstRNA synthetases
Ribosomes
Ion channels
Protein kinases
G proteins
Bcl-2 Family proteins
Telomerase
Transport vesicles
Protein “pumps”
Topoisomerases
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Pg. 10
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100 µM
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Microscopy
Light Microscopy
Electron Microscopy
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Pg. 10
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Light Microscopy
Bright Field
Fluorescence
Phase-Contrast
Differential Interference Contrast (DIC)
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Electron Microscopy (EM)
Scanning EM
Transmission EM
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Chemical Composition of Cells
Pg. 58
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Pg. 79
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Chemical Bond Energies
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Gene Expression
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Monomer/Polymer
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Nitrogenous Bases of DNA and RNA
Pg. 76
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Pg. 175
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3’
3’
5’
5’
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0.34 nm
Pg. 171
Major Groove
Minor Groove
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Topoisomerase Treated DNA
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Topoisomerase Relieves Stress of OverwindingDuring DNA Replication
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Camptothecin
Topoisomerase is an Anti-Cancer Drug Target
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Werner Syndrome
15 yrs. 48 yrs.
Mutation in gene encoding RecQ helicase
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Human Karyotype
Pg. 179
247 M bp
47 M bp
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Nucleus
~ 2 meters of DNA fits in the nucleus!
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Nitrogenous Bases of DNA and RNA
Pg. 76
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RNA Molecules
5’ 5’
3’3’
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Types of RNA Molecules
mRNA (gene expression)
Transfer RNA (Translation)
Ribosomal RNA (Translation)
Small nuclear RNA (exon splicing)
Micro RNA (Gene regulation)
Small cytoplasmic RNA (protein transport)
Ribozymes (numerous biochemical functions)
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Protein FunctionsEnzymesMembrane transportIntercellular transportHormonesReceptorsNanomachinesAntibodiesToxinsFibersBioluminescence/Fluorescence
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Pg. 74
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(Pgs. 74-75)
Amino Acid Side Chains
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Extra carbon atom!
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ß-Sheet
alpha-helix
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Hydrophobic Interactions in Tertiary Structure
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Hydrogen Bonding in Tertiary Structure
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Representations of Protein Tertiary Structure
Backbone
Ribbon
Wire Frame
Space Filling
Pg. 132
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Quaternary Structure
Pg. 141
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Protein Domains
(Src protein)
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Chloride Ion Channel Protein
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Comparison of Protein Primary Structure
Cyclin-dependent Kinase Proteins
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(cytosol or ER membrane)
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Complexity of Human Gene Expression
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Pg. 202 (Modified for RNA synthesis)
RNASynthesis
OH
OH
OH
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Pg. 233
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1 µm
Pg. 233
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Exon/Intron Organization of Eukaryotic Genes
Pg. 238
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Sequence Structure of Introns
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Pg. 239
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Pg. 241
Alternative Splicing
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Pg. 237
5’ Guanine Cap Structure