Fever with Rash - Indian Academy of Pediatrics · Peripheral rash with fever Erythema multiforme...
Transcript of Fever with Rash - Indian Academy of Pediatrics · Peripheral rash with fever Erythema multiforme...
Fever with Rash
Urticaria Purpura
Eschar near medial canthus
History
1. Prodromal Symptoms
2. Evolution of rash
3. Associated Symptoms
4. Exposure to Infections – Persons, insects, animals
5. Travel, time of year, drug exposure
Examinations
1. Nature of rash
2. Rash distribution – Exanthem and enanthem
3. Mucosal conjunctival lesion
4. Lymph node – Liver and spleen
5. Genital lesion and CNS involvement
6. Timing in relation to fever
Broadly they are classified as
• Centrally distributed maculopapular
• Peripheral
• Confluent desquamative erythema
• Vesiculobullous
• Urticaria
• Purpuric
Centrally distributed maculopapular rashes
Common viral exanthem
Drug rash
Measles
Maculopapular rash over face Enanthem: mucus membrane
Maculopapular rash over trunk Maculopapular rash over palm
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Rubella
Rubella Fever : Not high grade
Rash scattered
Fever disappears when rash appears
Occipital, epitrochlear lymph node appears
No significant coryza
Short duration
Relatively benign diseases
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Roseola
Roseola infantum (HSV 6)
• Rash appears on 4th or 5th day• Fever resolves by crisis or subsides by lysis • Caused by HSV 6 • Called as “sixth disease”• May cause febrile seizures, encephalitis, aseptic meningitis
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Erythema infectiousum (Fifth disease)Parvo virus• Fever for 3-5 days • Rash on face
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Lacy reticular rash
Drug rash
Features Drug rash
Rhinnorhea /conjunctivitis
Uncommon
Itching Present
Enanthem Absent
Eosinophilia and raised IgE
Usually present
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Features of drug rash
Peripheral rash with feverErythema multiforme
Secondary syphilis
Hand foot and mouth disease
Dengue – Both central and peripheral
Hand foot and mouth disease
Morbiliform rash
Dengue rash
Dengue rash
Spotted Fever and Typhusbelongs to Rickettsial group
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Eschar near medial canthus and chest
Spotted fever and typhus belongs to rickettsial group – they are not uncommon in our country as numerous reports are there
References
1. Mahajan SK. Scrub Typhus. J Assoc Physic India 2005;53:954-82. Singh P. Scrub Typhus, a case report: Military and regionalsignificance.
MJAFI 2004; 60: 89-90.3. Soman DW. Tsutsugamushi disease (scrub typhus) inBombay City
and suburbs J Indiana State Med Assoc1954;23:389-94.4. Menon RD, Padbidri VS, Gupta NP. Sero-epidemiologicalsurvey of
scrub typhus. J Hyg Epidemiol Microbiol Immunol.1978;22:306-11.5. Saxena VK. Chigger mite infestation of small mammals in aferal
biotope of a public park area of south Delhi. J CommunDis. 1989;21:360-4.
6. Sharma A, Mahajan S, Gupta ML, et al. Investigation of an Outbreak of Scrub Typhus in Himalayan Region of India. Jpn J Infect Dis 2005;58:208-10.
Herpes Simplex Virus 2 closely related types – HSV1 and HSV2
• Type of infection :ü Primary infection – HSV seronegative, no preexisting
immunityü Non primary 1st infection – Already infected with one type
but first time infected with other type.ü Recurrent infection – virus from latent infection periodically
reactivate• Spread by direct contact between skin and mucous membrane
Herpes labialis/cold sore (Primary)
Herpes labialis/cold sore (Recurrent)
Herpetic Gingivostomatitis
Herpangina
Genital herpes Whitlow
Herpes Simplex Infection
Fever with diffuse erythema and desquamation
1. Scarlet fever
2. Kawasaki disease
3. Streptococcal toxic shock syndrome
4. Staphylococcal toxic shock syndrome
5. Staphylococcal scalded skin syndrome
Scarlet fever
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Skin and mucous membrane manifestation of Kawasaki diseases
Skin and mucous membrane manifestation of Kawasaki diseases
Purpuric eruption with fever
Meningococcemia
Viral infection – Coxsackie A9, echo virus, EB virus
Atypical measles
Dengue hemorrhagic fever
Bacteremia
Acute Meningococcemia
Fever with Inflammation ofSubcutaneous tissue
Erythema nodosum
Idiopathic
Infections
Beta hemolytic streptococciMycobacterium speciesHepatitis B and CFungal Infection
Medicines
Sulfonamides, Oral contraceptives
SLE
Sarcoidosis
Inflammatory bowel disease
Malignancy – lymphoma and leukemia
Causes of Erythema nodosum