Fever with Rash - Indian Academy of Pediatrics · Peripheral rash with fever Erythema multiforme...

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Fever with Rash

Transcript of Fever with Rash - Indian Academy of Pediatrics · Peripheral rash with fever Erythema multiforme...

Page 1: Fever with Rash - Indian Academy of Pediatrics · Peripheral rash with fever Erythema multiforme Secondary syphilis Hand foot and mouth disease Dengue – Both central and peripheral

Fever with Rash

Page 2: Fever with Rash - Indian Academy of Pediatrics · Peripheral rash with fever Erythema multiforme Secondary syphilis Hand foot and mouth disease Dengue – Both central and peripheral

Urticaria Purpura

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Eschar near medial canthus

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History

1. Prodromal Symptoms

2. Evolution of rash

3. Associated Symptoms

4. Exposure to Infections – Persons, insects, animals

5. Travel, time of year, drug exposure

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Examinations

1. Nature of rash

2. Rash distribution – Exanthem and enanthem

3. Mucosal conjunctival lesion

4. Lymph node – Liver and spleen

5. Genital lesion and CNS involvement

6. Timing in relation to fever

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Broadly they are classified as

• Centrally distributed maculopapular

• Peripheral

• Confluent desquamative erythema

• Vesiculobullous

• Urticaria

• Purpuric

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Centrally distributed maculopapular rashes

Common viral exanthem

Drug rash

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Measles

Maculopapular rash over face Enanthem: mucus membrane

Maculopapular rash over trunk Maculopapular rash over palm

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Rubella

Page 10: Fever with Rash - Indian Academy of Pediatrics · Peripheral rash with fever Erythema multiforme Secondary syphilis Hand foot and mouth disease Dengue – Both central and peripheral

Rubella Fever : Not high grade

Rash scattered

Fever disappears when rash appears

Occipital, epitrochlear lymph node appears

No significant coryza

Short duration

Relatively benign diseases

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Roseola

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Roseola infantum (HSV 6)

• Rash appears on 4th or 5th day• Fever resolves by crisis or subsides by lysis • Caused by HSV 6 • Called as “sixth disease”• May cause febrile seizures, encephalitis, aseptic meningitis

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Erythema infectiousum (Fifth disease)Parvo virus• Fever for 3-5 days • Rash on face

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Lacy reticular rash

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Drug rash

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Features Drug rash

Rhinnorhea /conjunctivitis

Uncommon

Itching Present

Enanthem Absent

Eosinophilia and raised IgE

Usually present

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Features of drug rash

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Peripheral rash with feverErythema multiforme

Secondary syphilis

Hand foot and mouth disease

Dengue – Both central and peripheral

Hand foot and mouth disease

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Morbiliform rash

Dengue rash

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Dengue rash

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Spotted Fever and Typhusbelongs to Rickettsial group

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Eschar near medial canthus and chest

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Spotted fever and typhus belongs to rickettsial group – they are not uncommon in our country as numerous reports are there

References

1. Mahajan SK. Scrub Typhus. J Assoc Physic India 2005;53:954-82. Singh P. Scrub Typhus, a case report: Military and regionalsignificance.

MJAFI 2004; 60: 89-90.3. Soman DW. Tsutsugamushi disease (scrub typhus) inBombay City

and suburbs J Indiana State Med Assoc1954;23:389-94.4. Menon RD, Padbidri VS, Gupta NP. Sero-epidemiologicalsurvey of

scrub typhus. J Hyg Epidemiol Microbiol Immunol.1978;22:306-11.5. Saxena VK. Chigger mite infestation of small mammals in aferal

biotope of a public park area of south Delhi. J CommunDis. 1989;21:360-4.

6. Sharma A, Mahajan S, Gupta ML, et al. Investigation of an Outbreak of Scrub Typhus in Himalayan Region of India. Jpn J Infect Dis 2005;58:208-10.

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Herpes Simplex Virus 2 closely related types – HSV1 and HSV2

• Type of infection :ü Primary infection – HSV seronegative, no preexisting

immunityü Non primary 1st infection – Already infected with one type

but first time infected with other type.ü Recurrent infection – virus from latent infection periodically

reactivate• Spread by direct contact between skin and mucous membrane

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Herpes labialis/cold sore (Primary)

Herpes labialis/cold sore (Recurrent)

Herpetic Gingivostomatitis

Herpangina

Genital herpes Whitlow

Herpes Simplex Infection

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Fever with diffuse erythema and desquamation

1. Scarlet fever

2. Kawasaki disease

3. Streptococcal toxic shock syndrome

4. Staphylococcal toxic shock syndrome

5. Staphylococcal scalded skin syndrome

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Scarlet fever

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Skin and mucous membrane manifestation of Kawasaki diseases

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Skin and mucous membrane manifestation of Kawasaki diseases

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Purpuric eruption with fever

Meningococcemia

Viral infection – Coxsackie A9, echo virus, EB virus

Atypical measles

Dengue hemorrhagic fever

Bacteremia

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Acute Meningococcemia

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Fever with Inflammation ofSubcutaneous tissue

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Erythema nodosum

Idiopathic

Infections

Beta hemolytic streptococciMycobacterium speciesHepatitis B and CFungal Infection

Medicines

Sulfonamides, Oral contraceptives

SLE

Sarcoidosis

Inflammatory bowel disease

Malignancy – lymphoma and leukemia

Causes of Erythema nodosum