U, 5, DEPARTMENT OF

HEALTH. EDUCATION, AND W ELFARE

Eugene Braunwald One of 10 to Win Flemming Award

Dr. E ugene Braunwald, Chief of the Cardiology Branch of the Na­tional Heart Institute, recently re­ceived a 1965 Arthur S. Flemming Award as an outstanding young

man in the Federal Government.

The 1965 Flem­ming Awards were presented to 10 Government em­ployees, all under 40, at , a luncheon February 11 at the Statler Hilton in

Dr. Brounwold Washington. John W. Macy Jr.,

Chairman of the Civil Service Com­mission, was the principal speaker at the awards ceremony.

Five of the men, ineluding Dr. Braunwald, were honored for ach icvement in scientific or tech­nical fields, and five for achieve­ment in administrative or executive fields. Goldberg Heads Panel

The winners, selected principally for their work during Piseal Year 1964, were chosen by a panel headed by Associate Justice Arthur J. Goldberg of the Supreme Court.

Dr. Braunwald has made signifi­cant contributions to the under­standing of factors regulating the output of the heart, with particular emphasis on the importance of venous tone as a deten11inant in cardiac performance.

(S,r DR. BR/\UNWA/,T}, f'ogr -~)

NHI Film on Heart Research Scheduled for Tomorrow

All NIH employees are in­vited to attend a showing of the new National Heart Insti­tute film " Heartbeat,'' tomor­row (Thursday, Feb. 25), at 12 noon in the Clinical Center auditorium.

The international heart re­search motion picture tells it.'I story in five sequences based on research programs support­ed by NHL It was filmed in Peru, Lebanon, Uganda, Japan, East Pakistan and NIH.

ecor February 24, 1965 Vol. XVII, No. 4

ATCC Is World Focal Point For Microbiological Materials

By Beverly Warran Not everything that comes in small packages is necessarily good. This

can be readily verified by employees of the American Type Culture Col­lection which in the course of carrying out its many services for the scil'ntific community, handles a variety of "small packages" that often include virulent bacteria and dan-gerous viruses.

Established in 1!126 as a private, non-profit institution to provide a repository and distribution center for bacterial cultures, "The Col­lection" is today a world-renowned repository and distributing agency for microbiological materials.

It maintains in its Rockville,

Ca refully g loved and masked aga inst freezing temperature, a tochnician extracts ampoules containing ce ll cul­tures from liquid nitrogen tank.

Md., headquarters one of the larg­est collections of diverse microor­ganisms in the United States and perhaps the wol'ld.

I ts microbiological mater ials in­clude not only more than 4,000 strains of bacteria and some plant rusts, but fungi, algae, and pro­tozoa.

Recently, in response to the needs of researchers in virology, cancer and other medical areas, it has added viruses and tissue cul­tures.

Provides 12,0 00 Cultures

The Collection has also expandeo its other services to meet the grow­ing needs of researchers and to ur­compl ish its stated purposes of "service, research, and education."

Each year the Collection provides some 12,000 cultures to researchers all over the world. NIH scientists and investigators also use the ATCC's resources extensively. Bra­zil, F ra11ce, Thailand, Czechoslo­vakia and-under an exchange pro­gram-the Soviet Union are among

(See FOCAL POINT, Page 5)

New NIMH Statistical Technique Aids in Predicting Readmissions of Mentally Ill

Among the most important questions facing organizers of comprehen­sive community mental health services is that of patient movement, one of the complex problems in the area of care for the mentally ill.

To help provide an answer to this question, a National Institute of Mental Health statistician has de\'cloped a life table technique for determining the probability of hos­pital readmission of new psychiat­ric patients. Ta ble Describes Probability

A life table is a statistical table describing the cumulative proba­bility of an event over successh c periods of time.

By using a standard computer program and standard cohort cards, it is now possible to predict recurrence rat es which affect bed

turnover, length of stay in the community following hospitaliza­tion, and f uture· bed needs.

Data on first admissions of psy­chotic patients to 98 State mental hospitals, from July 1, 1958 to June 30, 1960, were obtained from se!ect;cd States by the N I.MR Hos­pital Studies Section. Also included, to illustrate the method, were data from the psychiatric unit of a gl'n­eral hospital, provided by the Mon­roe County, N. Y., Psychiatric Cusl" Register.

The method consists of dctcrmin­(Sce RE.4DJJISSIONS, l'aoc ~)

NATIONAL INSTITUTES OF HEALTH

PUBLIC HEALTH SERVICE

ICNND to Survey Nutritional Health In Eight Countries

Nineteen scientists from the In­terdepartmental Commit tee on Nu­trition for National Defense left for Nigeria in mid-January to con­duct a broad scope nutritional health survey in cooperation with 24 Nigerian scientists.

The ICNND team, directed by Dr. William J. Darby of the Van­derbilt University School of Medi­cine, is composed of members from eight universities and five research

Dr, William J. Dorby (left) is shown presenting the ICNND report of the nutrition survey conducted in the Hashemite Kingdom of Jordon to King Hussein. Dr. Darby received the Star of Jordon, the highe st honor bestowed by that country. - Phata by A lbert Flouty, photographer to King Hussein.

institutions. Dr. Albert L. Russell, Chief of

the Epidemiology and Biometry Branch, National Institute of Den­tal Resea1·ch, is a member of the team.

The comprehensive study, offi­cially requested by Nigeria, is ex• pected to be completed in mid-April of this year, Dr. Arnold E. Schaefer, Executive Directol' o! ICNND, stated.

A similar study will be conducted in Paraguay from mid-April to mid-June.

An a greement also was reached with the Pan-American Health Or­ganization to assist the Institute of Nutrition for Central America and

(See SURl' F. l' , f'aac 4/

Page 2 February 24, 1965 THE NIH RECORD

ecord Published bi-weekly at Bethesda, Md., by t he Public Information Section, Office of Research Information, for the infor ma tion of employees of the National Ins titutes of Health, principal research center of the Public Health Ser vice, U. S. Department of Health, Education, and Welfare, and cir culated by r equest to interest ed members of t he public.

NIH Record Office .............................. Bldg. 31, Rm. 4Bl3. Phone: 49-62125

Editor ............. .................... ................. .................................... E. Kenneth Stabler Associote Editor ...................................... ....... ......................... George J. Mannina

Stoff Correspondents

Georgiana Brimijoin, NCI; Tony Anastasi, NHI; Bryson Fleer, NIAID; Mary Anne Gates, NIAMD; Bob Callahan, NIDR; Bill Kleven, NIMH; Frances Dearman, NINDB; Frank Smith, CC; Faye Peterson, DBS; Mike Canning, NIGMS; Beverly Warran, DRFR; Dick Turlington, DRG; Bob Walters, DRS; Helene Devay, OAM; Dan Rogers, NICHD.

The NIH Record reserves the r ight to make corrections, changes or deletions in s ubmitted copy in conformity with the policy of the paper and the Department of Health, Education, and Welfar e.

NEWS from PERSONNEL

DESIGNATION OF BENEFICIARY A Department Bulletin posted

on all NIH bulletin boards until the end of February notes that if you do not name a beneficiary for Civil Service Retirement, Federal Employees' Group Life Insurance, and any unpaid compensation, pay­ment will be made in the following order of precedence: to the first of the following who at·e alive on the date that title to payment arises:

1. To the widow or widower. (In insurance claims, the courts have r uled that widow means lawful widow. Accordingly a woman who married a man who had a living undjvorced wife is not entitled up­on his death to the insurance as his widow.)

2. If neither of the above, to the child or children in equal shares, with the share of any deceased child distributed among the de­scendants of that child.

3. If none of the above, to the parents in ,equal shares or the en­tire amount to the surviving par­ent.

4. If none of the above, to the executor or administrator of the estate.

5. If none of the above, to the next of kin as determined under the laws of the State in which the employee was domiciled.

Instructions are included in the bulletin about the forms to use and where to send them if you wish to name persons not included above, or prefer them in a different order, or wish to change a previous desig­nation.

MILITARY RETIRED PAY

If you are a retired regular offi­cer of one of the uniformed serv­ices, commissioned or warrant, be

DRS Obtains Equipment To Produce Inexpensive 2x2" Projection Slides

With the development of im­proved techniques and installation of modern equipment, the Photog­raphy Section of the Division of Research Services is now able t o produce 2x2" projection slides at a cost that is much Jess t han that of the 3¼x4" slide.

Not only is the 2x2" slide less expensive, but it also is unbreak­able, lighter in weight, and repre­sents no storage problem when traveling to meetings.

Slide Projects W e ll

The · modern 2x2" projector is available almost universally, and when projected, the quality of the 2x2" slide is comparable to that of the larger slide.

The 2x2" system is compatible with existing black and white nega­t ives and color transparencies, and the Photography Section provides copying and duplicating services for both.

Anyone not familiar with the 2x2" system or who would like fur­ther information may call Vernon Taylor, Chief of the Photography Section, Ext. 62251.

sure to see the Personnel Bulletin Board notice about the necessity for you to make a decision by March 1 of this year concerning the limitation on the amount of re­tirement pay you ma)' receive.

LENGTH OF SERVICE AWARDS

A compilation of names of per­sons eligible to receive 10, 20, 30, and 40-year length of service awards is now being prepared by the Employee Relations and Serv­ices Section. In order to qualify for a length of service award an employee must have completed the i,ervice prior to the cut-off date of

Dr. Robert M. Forrier, Assistont Director of the Clinicol Cente r (left), exploins the opcrotions of the Doto Processing Unit of the CC Clinicol Pothology De­portme nt to 14 graduotc students of Hospitol Administration from Cornell University, who recently toured CC focilit ies. The group wos greeted by Dr. Jack Masur, Clinicol Cente r Director, and afte, viewing the MIH movie, heard Dr. Forrier discuss the unique arrongeme nts for reseorch o nd clinicol stud ies ot NIH. The stude nts the n visite d the librory, potient core and recreo­tion oreos, Clinicol Pothology Deportment and Su,gicol Wing of the Clinicol Ccnter.- Photo by Jerry Hecht.

List of Latest Arrivals I Of Visiting Scientists 1/26-Dr. Robert T. Parfitt,

Australia. Research in the Labora­tory of Chemistry, Section on Me­dicinal Chemistry. Sponsor: Dr. E. L. May, NIAMD, Bldg. 4, Rm. llO.

1/27-Dr. Toshikatsu Yokota, Japan, Research in the Laboratory of Neurophysiology, Section on Limbic Integration and Behavior. Sponsor: Dr. Paul D. MacLean, NIMH, Bldg. 10, Rm. 3N310.

2/3- Dr. Edward Frank Evans, England, Research in the Labora­tory of Neurophysiology, Section on Spinal Cord. Sponsor: Dr. Phil­lip G. Nelson, NINDB, Bldg. 10, Rm. 3D47.

Dr. Overman to Serve On University Faculty

Dr. J ohn R. Overman, Associate Director for Collaborative Research of the National Institute of Allei·gy and Infectious Dis,eases and for­merly Professor of Microbiology and Assistant Professor of Medi­cine at Duke University Medical Centel', has been appointed to serve also as Associate Clinical Profes­sor of Medicine at the George Washington University School of Medicine.

The "modern" era in computa­tion and data processing at NIH began in 1958 with the acquisition of an IBM digital computer.

December 31, 1964. All periods of militar y and civilian service are in­cluded in the computation.

Employees who are uncertain of their eligibility fo1· one of these awards or may have been over­looked in the past may call Ext. 64851 for verification of service computation date.

Area Single fund Drive Is Outstanding Success

F ederal employees in the Wash­ington, D.C. area increased their contributions by $931,492 to a total of $5,687,693 in the combined char­ity drive conducted experimentally last fall. This is a 20 percent in­crease over the amounts previously pledged in separate campaigns.

The test campaign for the first time consolidated into a single drive the collection of voluntary contributions for the United Funds, National Health Agencies, and In­ternational Service Agencies.

Al.so for the first time, pledge payments by voluntary payroll al­lotment were authorized.

All Drives Successful

Combined drives in the six cities chosen for the experimental drives all scored outstanding successes, Civil Service Commission Chair­man John W. Macy Jr. reported.

Not all drives were completed at the time of the CSC 1·eport but latest figures showed Bremerton, Wash., up 37 percent to a total of $116,492; Chicago, Ill., up 30 per­cent to a total of $326,000; Dover, N.J., up 125 percent to a total of $96,129; Macon, Ga., up 64 percent, to a total of $342,012; and San Antonio, Tex., up 61 percent, to a total of $899,700.

Also Soves Money

The experimental drives not only have substantially increased con­tributions, but are expected to save the Government money through a single, less-expensive campaign.

Appraisal of the experimental program will be made by the Civil Service Commission in consultation w ith Federal and employee organi­zation officials and the voluntary agencies involved.

THE NIH RECORD

Dr. Newton Is Appointed Program Administrator Of NIGMS Branch

The appointment of Dr. Walter L. Newton as Program Adminis­ti·atot in the Research Training Grants Branch, National Institute of General Medical Sciences, was announced recently by Dr. Frederick L. Stone, Institute Director.

In this position Dr. Newton will be responsible for initial review of applications, ad­ministration, and overall coordina­tion of the Pathol­ Dr. Newton

ogy Training Program.

Expenditures for t his program during the current fiscal year ex­ceed $4 million, distributed among more than 85 programs at universi­ties and research institutions throughout the country.

Dr. Newton succeeds Dr. John E. Boyd, Acting Program Adminis­trator, who will return to the Uni­versity of Rochester Medical Cen­ter on July 1 to begin 'a residency in medicine.

Serves With DRS Befo1·e his appointment, Dr.

Newton was Scientific Dit-ector and Associate Chief for Laboratory Re­sources in the Division of Research Services.

He served from 1959 to 1963 as Chief of the Laboratory of Germ­free Animal Research, National Institute of Allergy and Infectious Diseases. The latter two years there, he also served as Special Assistant to the Director of Intra­mural Research.

During his earlier !Service with NIAID, he helped develop germ­free animal research and in 1957 established the Section on Germ­free Animal Studies, now the Lab­oratory of Gerrnfree Animal Re­search.

Dr. Newton joined the Commis­sioned Corps of the Public Health Service in 1943 and holds the rank of Scientist Director in the Regu­lar Corps. Until 1957 he was en­gaged in research projects in para­sitology, including assignments at NIH, various field stations in the U.S., and Puerto Rico.

Me mbe rships Listed D1·. Newton received his M.A. in

zoology in 1948 and Ph.D. in para­sitology in 1952 from George Washington University.

He is a member of Sigma Xi, the American Association for the Ad­vancement of Science, the Ameri­can Society of Tropical Medicine and Hygiene and the American Society of Parasitology.

F ebr uary 24, 1965 Page 3

Data Retrieval System Developed for Health Research Facilities

A data retrieval system to quickly provide statistical data on the health research facilities con­struction program is currently being implemented by the Program Analysis Office, Division of Re­search Facilities and Resources, under the direction of Dr. Deward Waggoner.

The retrieval system when com­pleted will make possible a compre­hensive statistical analysis of the Health Research Facilities con­struction program from its incep­tion in 1956.

Data Aids Evaluation This system will provide data

which will permit evaluation of such facets of the Health Research Facilities program as construction costs by categories, square foot­age constructed, types of institu­tions supported, comparative data on geographic locations, and areas of heal th research.

In addition, it will furnish the base for more sophisticated pro­gram evaluation on grantee accom­plishments to be developed in the future by survey techniques.

The retrieval system will be the third to be developed by the Pro­gram Analysis Office. The other two data systems cover t he general research support and general clin­ical research center programs.

NINDB Lecturer From England Reports New Trends in Cerebrovascular Disease

By Ste"e Beasley One of the world's outstanding neuropathologists in the field of stroke

recently revealed striking new trends in cerebrovascular disease to an NIH audience.

Enroute to Geneva after participating in a survey of the incidence of cerebral hemorrhage in Japan,-------------­Dr. Peter Yates of the University of Manchester, England, reported

Dr. Peter Yotes of Mancheste r Uni­versity, England, reviews his manu­script prior to his lecture here on new trends in cerebrovascular disease.­Photo by Je rry Hecht.

his findings in an NINDB-sponsored lecture in Conference Room 3, Building 31. .

In extensive comparisons between the kinds of stroke occurring in Manchester hospitals between 1940 and 1960, Dr. Yates found that distinct b ·ends occurred in the dec­ade 1950-1960.

Incidence of strokes caused by blood seepage into brain t issue (cerebral hemorrhage) declined during that period, while the oc­cunence of strokes due to block­age of brain vessels ( cerebral in­farction) increased noticeably.

The World Health Organization consultant noted that these trends occurred with pronounced uniform­ity among the general B1itish pop­ulation, as verified by examining national mor tality data. Further­more. Dr. Yates explained, the trends were similar in both men and women, and at all ages.

Effect of Drugs Cited

New NIAMD Publication Distusses Osteoporosis

Dr. Jan Cammermeyer, Chief of NI NDB's Laboratory of Neuro­pathology, called attention to the fact that drugs for lower ing blood pressure became widely available during the 1950-1960 period, which favored a lowered incidence of cerebral hemonhage.

A new pamphlet, "Facts About Osteoporosis," recently published by the National Institute of Arthri­tis and Metabolic Diseases, pre­sents general background informa­tion on this "bone-thinning" dis­order which affects middle a ged

Dr. Howord L. Andrews, NIH Radia­t ion Safe ty Officer ond Chief of the C linicol Center's Department of Radi­ation Sofety (cente r), receives the Public Health Se rvice Medal and Ce r• tificate for Meritorious Service from Dr. Jack Masur, CC Director (right), ond C. K. Himmelsbach, CC Associate Director. Dr. Andrews was cited for "his belie f in, and untiring efforts toward the odvancement of the mis­sion of the Public Health Service." -Photo by Jerry Hecht.

and elderly persons. The disease causes a gradual de­

crease in both the amount and st1·ength of bone tissue, and the affected bones become weak and porous, often in severe cases break­ing under even minor stress.

"This disease is one of the major causes of physical disability in old age," states the pamphlet. It is responsible for many of the frac­tures which victimize elderly per­sons.

Normal Bones Regene rate In the normal adult, the skele­

ton constantly and systematically rebuilds itself. In older persons, however, this regeneration of bone is sometimes interfered with due to a decrease in the body's production of hormones.

This factor, coupled with an in­sufficient intake of dietary calcium over a period of many years, and marked physical inactivity, can lead to osteoporosis.

Single copies of the pamphlet, P HS P ublication No. 1217, may be obtained from the P ublic Health Service, Washington, D.C. 20201. It is also for sale by the Superin­tendent of Documents, U.S. Gov­ernment Printing Office, Washing­ton, D.C. 20402, at five cents each.

Another interpretive comment widely suported by other physi­cians present was tl1at nutlitional factors in ce1tain populations Jed to the increase in cerebral infarc­tions during the fiftic~.

Dr. Yates found that blockage of veins due to blood clots in the brain (cerebral thrombosis) great­ly increased in Britain during the past 20 years, but not in Japan.

Both Dr. Cammermeyer and Dt'. Yates provided the observation that during Woi-ld War II in Brit­ain and Norway, the food shortage led to severely diminish.ed rates of cerebral thrombosis. Dr. Ya!P-s con­finned that the same relationship took place in Britain during the first World War.

CC Blood Bank Reports Du1·ing January, the Clinical

Center Blood Bank reports, 263 pints of blood were received from NIH donors. In t he same period CC patients received a total of 1,780 units of blood, including packed red cells, single donor plasma, and platelet product transfusions.

The first NIH Lectui-e was given by Dr. Severo Ochoa of New York University College of Medicine on January 21, 1953.

Page 4

SURVEY (Conti,u,cd f rom Pape J)

Panama in conducting an overall nutritional health survey in six Central American countries. The studies will be made over a two­and-a-half-year period.

When surveys of individual coun­t1·ies are completed, pilot studies will be developed to demonstrate procedures and programs for im­proving the nutritional status in Central American countries.

In thls project, ICNND will send five to seven specialists to work with members of the staff of INCAP and scientists from the countries concerned.

The primary objective of the studies will be to assist collaborat­ing countries in defining and solv­ing majo1· food and nutrition prob­lems and to aid local scientists and technicians in developing practical recommendations for maximum utilization of the countries' re­sources.

Collaborates With MARU The survey teams in Cent1·al

America will collaborate with the Middle America Reserach Unit lab­oratory in Panama. This labora­tory, with NIH sponsorship, studies infectious diseases in Central America.

Special research will be directed to biochemical methods of deter­mining early stages of prot ein mal­nutrition in the infant population.

In the past 10 years, ICNND has initiated programs in nutrition in 24 countries throughout the world, at the oflicial request of each coun­try.

An appraisal of the accomplish­ments in these countries was made recently at the request of AID. The survey revealed that in every country an active program for nu­trition has been implemented and incorporated in the country's nu­tritional planning program. It s howed, too, that these programs are being supported in large meas­ure by the countries themselves.

Recommendations Heeded In numerous instances another

assisting country has followed up on some of ICNND's recommenda­tions and has initiated nutrition programs.

For example, in Ethiopia the Swedish Government has estab­lished a nutritional pediatric re­search and applied program, invest­ing a quarter of a million dollars a year. This represents four times the investment of the initial ICNND survey.

At the request of the Swedish Government, ICNND has sent con­sultants to Ethiopia to aid in out­lining and developing this program.

ICNNDrs research work has re­ceived high recognition from the countries assisted.

Two former team members, Dr. Darby (now Dh·ector of t he sur•

F ebruary 24, 19(;5

During o recent tour of research installations in Southe rn France, Dr. Charles P. Huttre r, Chief of the European Office, Office of Inte rnational Research, visited the Laboratoire d'Optique Electronique in Toulouse in which is located the large electron microscope developed by Prof. Gaston Dupouy, Dire ctor of the labora­tory. The lotte r permits study of specimens having 20 t imes the thickness of objects examined by traditional e le ctron microscopes. It has thus for been used primarily for examination of metal structures, with some studies on staphylococci, plant leaves, and organs of onthropodcs' heads. The huge gen• e rator for the instrument is housed in the bubble-shaped shell (background) which Prof. Perrier, Associate Director of the laboratory (left), Dr. Huttrer (center), and on unidentified researcher ore lea ving.

Dr. Huttre r peers through the electron microscope in the laboratory at Tou­louse, where o more intensive biology program is planned. In oddition to the electron· microscope, the laboratory hos two instrument$ which permit X-ray microscopy. Some six new in­strume nts o re in process of being built, a ll for research.

vey in Nigeria) and Dr. James Din­ning, formerly of the University of Arkansas and now with the Rocke­feller Foundation in Thailand, re­ceived t he Star of Jordan, the high­est honor bestowed by that coun­try.

They were hono,·ed for their par­ticipation and contr ibutions to the discovery of the role of vitamin E in alleviating megaloblastic micro­cytic anemia occurring in infants suffering from protein malnutrition.

Another award was presented by the Chilean Government to Dr. Wil­liam Ashe of Ohio State Univer­sity as a result of ICNND assist­ance to Chile during the 1960 earth­quak e.

ICNND was established in 1955 by a memorandum of agreement by the Departments of State, Defense, Agriculture; Health, Education, and Welfare; and the I nternational Cooperation Administration (now Agency for International Develop-

READMISSIONS (Cc:mtimied f rom PagG 1)

ing the probability of release for patients admitted, classifying re­leased patients by length of stay, and determining for each length­of-stay group t he probability of 1·eturn or death in the community.

These probabilities are then link­ed to provide a compound table which can be used to answer ques­tions relating to the fate of t he original cohort of admissions.

Thus the probability of move­ment out of or back into t he hos­pital within a specified interval can be predicted for any patient whose characteristics and previous hos­pitalization experience are known.

Program Uses Compute r For example, the lifo tabli! 1n·o­

gram, carried out by computer methods, can now answer: \~' hat is the probability (1) that a patient coming into the hospital will be r e­leased within one or more months, and then return within a given pe­riod, (2) that a patient who has been in the hospital for three months will be discharged within the next month and then stay in the community for six months or more, (3) that a n ew patient will be readmitted within 10 months?

The life table method was re­ported by Dr. Anita K. Bahn, Of­fice of Biometry, NIMH, in the Journal of Chronic Diseases.

ment). Later, the Atomic Energy Commission and the Department of the Interior became participants.

Close l iaison is maintained with Food for Peace, United Nations agencies and the National Research Council.

The committee was organized to supply assistance in identifying and solving nutrition pr oblems of t echnical, military and economic

THE NIH RECORD

Dr. Specht Leaves 01 R Tokyo Office in May; Successor To Be Named

The NIH Office of International Research has announced that the Chief of its Pacific Area Office, Dr . Hejnz Specht, will return to this count ry in May, following comple­t ion of his tour of duty at the Tokyo headquarters.

The a rea of re­sponsibility of the OIR Pacific Area includes J apan, the Ph ilippines, Tai­wan, Oceana, Aus­tralia, New Zea­land, I ndonesia, Burma, India, Pak- Dr. Specht istan and the other Southeast Asian cou ntries.

Dr . Charles L. Williams, Chief of OIR, and Robert H. Grant, As­sistant Chief, are now actively seeking a replacement for Dr. Specht prior to the time of his departure from Tokyo.

Whoever is chosen to succeed Dr. Specht will supervise a professional assistant there and one in New Delhi, India. An administrative offi­cer is a lso assigned to the Tokyo office.

Qualif ications Described

The individual to be chosen for this important post, Mr. Grant said, should be an experienced investiga­tor with a doctorate (medical or scientific), who is familiar with t he problem, mechanisms and goals of medical research.

He should a lso, Mr. Grant said, have a high degree of professional standing in order to deal effectively with foreign scientists, deans and other medical school officials, and with representatives of foreign governments.

The successful applicant will be classified at the GS-14 or 15 level or equivalent Commissioned rnnk. In addition to salary compensation he will be entitled to quarters al­lowance, post allowance, and edu­cationa l allowance for children un­der 18.

importance in developing countries throughout the world, through maximum utilization of the coun­tries' own resources.

It is advised and guided by a group of consultants from colleges, universities, government and pri­vate agencies, who are recognized throughout the world as specialists in nutrition, medicine, agriculture, food technology, and biochemistry.

The services of I CNND, whlch is administered by a Secretariat at NI H within the Office of Interna­tional Research, are available to a ny interested country upon official request of t hat country to t he United States Department of State.

THE N il::t RECORfi

FOCAL POINT (Continued frow Pogo 1)

the many foreign nations ·whose scientists look to the Collection for the microbiological cultures they need for their research.

In serving as a repository for the strains of material which it maintains, the Collection frequently conducts its own research to fur­ther document the data provided by the depositor. It prepares and pe­riodically issues the "Amei-ican Type Culture Collection Catalogue of Cultures," a reference highly valued by investigators throughout the world, as well as a "Viral and Rickettsial Registry Catalogue" and a "Catalogue of Cell Lines."

Since presei-vation techniques are vitally important to its service, the Collection continually conducts research to improve methods of maintaining cultures. The majority of cultures are lyophilized-a type of freeze-drying which preservi,s them without impail·ing their via­bility.

Via ls Easily Stared In this condition cells are readily

stored in small, double vials. It ia estimated that each vial contains about 50 mi Ilion cells. The vials are labeled and placecj in cartons, ready to be shipped on request.

Lyophilized cultures need a min­imum of maintenance and pose no special handJing or shipping prob­lems.

However, not all cultures lend themselves to lyophilization, and other preservation techniques must be used. Some of these require spe­cially designed equipment, ingeni­ous packaging, and very exacting maintenance.

One Collection researcher is cur­rently investigating the use of liq­uid nitrogen temperature (- 196° C) for preserving selected organ­isms.

Whatever the method, eve·ry pre­caution is taken both to prevent the exposure of the culture to con­tamination or the staff to any haz­ards in handling the more virulenl materials.

Daily Information Provided The Collection provides technical

and occasionally non-technical in­formation for use in response to the 60 to 100 letters and varied requests it receiv,es daily.

The request may be a call for help with a problem in "isolation for identification of hemolytic streptococci in the heavy growth of Bacillus subtilis," or an urgent plea for assistance in securing a rare vaccine. If not available in the Collection, every effort will be made to find the material requeswtl by the investigator.

The day's mail may bring a re­quest for "a catalogue on Neuro­spora nutant stocks," requiring the reproduction of long lists of mate­rial, or an inquiry for procedures in preparing a culture for an al-

l~ebr uar y 24, 19G5

"Feeding t ime" at the ATCC. Cell cultures are carefully fed three times a wee k in the ste rile culture roam by technicians using fluid renewal appa ratus. - Photos by Ed Hubbard.

lergy study. Now and then a request comes

in for an "all-purpose wine yeast." This too is provided. Nor is the staff ever too busy to furnish aspir­ing young microbiologists with se­lected strains of bacteria and fungi for their science fair projects.

Because of its unique and impor­tant service to the biomedical sci­ence community and because it 1s a centralized resource, the Collec­tion meets the criteria of a special J'esearch resource and receives sup­port from the NIH Division of Re­sea1·ch Facilities and Resources.

Rece ives DRFR Support Since March 1964, when the first

special research resources g1·ant was awarded, the Collection has received over $430,000 from DRFR. It had also been awarded over $90,-000 toward the construction and equipment of its building from the Division's Health Research Facili­ties Branch. But the National Sci­ence Foundation has provided the greatest proportion of construction funds, as well as a continuing share of the annual operating costs.

The Collection also receives grant support from the National Cancer Institute, the National Institute of Allergy and Infectious Diseases and from other government and private sources.

Facility Dedicated In the lobby of its attractive,

specially planned building, dedi­cated May 1964, is a plaque ac­knowledging the support provideu by the National Science Founda­tion, the Public Health Service and other organizations which ha, e provided grants for facilities and programs so that the American Type Culture Collection may con­tinue to achieve its objectives of "service, research, and education."

The first National Conference on Cardiovascular Diseases, sponsored by the National Heart Institute and the American Heart Associa­tion, was held in Washington, D. C., J anuary 18-20, 1950.

I Technician participates in process af free ze-drying bacteria and fungi at controlled rates.

Rhinovirus Serotypes Will Be Catalogued Under Ohio Contract

Rhinoviruses, the major cause of respiratory illness in adults, ,viii be catalogued at Children's Hos­p ital, Columbus, Ohio, and dis­tributed to other collaborators un­der a National Institute of Allergy and Infectious Diseases program.

A contract has been awarded to the Children's Hospital Research Foundation, Columbus, Ohio, to es­tablish a rhinovirus typing labora­tory for the Vaccine Development Program, one of NIAID's collabor­ative research efforts.

Under the direction of Drs. Vin­cent Hamparian and Henry G. Cramblett, the center will compare by serological means rhinovirus strains from all sources, define the number of prevalent serotypes, and maintain large pools of seed virus for distribution to collaborators in the program.

Wit hin the last decade over 80 different 1·hinovirus serotypes have been isolated from human respira­tory infections. The great diversity of antigenic types among the iso-

Pa ge 5

Viral Etiology of Canine Leukemia to Be Studied Under Cancer Contract

A major facility for investiga­tion of the viral natu1·e of canine leukemia will be established by the National Cancer Institute at the Michigan State University College of Veterinary Medicine, East Lan­sing, with a Public Health Service contract totaling $596,300.

The project will be an impo1·tant part of NCI's intensified virus­cancer-leukemia research prog1·am supported by a special $10 million appropriation by Congress.

NCI and Michigan State scien­tists will explore the viral etiology of canine leukemia, the possible relationship to human leukemia, and the transmissibility of leu­kemia from one animal species to another.

The facility will provide housing fot· 250 to 1,000 dogs. Raised spe­cifically for this purpose, newbom animals will be inoculated with se­lected tumor materials from human and canine cases.

Extensive Tests Planned

Extensive laboratory tests and physical examinations will be made to establish evidence of the induc­tion of leukemia or other malignant change. Much of this phase of the research will be done in coopera­tion with the Michigan Depm·tment of Health Laboratories, Lansing.

Other aspects of the project will include establishment of normal and tumor canine cell lines for use in g rowing virus materials, and de­velopment of immunological pro­cedures to characterize the anti­body responses of inoculated dogs.

The principal investigator at Michigan State University will be Dr. Gabel H. Conner, who for the past two years has been conduct­ing, under Public Health Service contract, an epidemiological study of leukemia in cattle.

Dr. John B. Moloney, Head of the Viral Leukemia Section, Lab­oratory of Vil-al Oncology, NCI , will serve as Institute P roject Officer.

!ates has prevented correlation of clinical and epidemiological data from different geographic areas.

Comparison and definition of candidate strains of the numerous rhinovirus serotypes would tax the capacity of most laboratories.

As a typing center, Children's Hospital Research Foundation will develop and maintain a complete collection of fully characterized rhinoviruses and specific rhinovirus antisera.

E ventually all r hinovirus sero­types will be deposited with and distributed by the Virus Reference Reagent P rogram, another NIAID collaborative effort, and t he Ameri ­can Type Culture Collection.

Page 6

Dr. Stewart Wins Federal Woman's Award for 1965

D1·. Sarah E. Stewart, Head of the Human Virus Studies Section, Laborato1·y of Viral Carcinogenesis, National Cancer Institute, was one of six women in Government serv­ice selected from among 70 nomi­nees to receive the 1965 Federal Woman's Award. The winners will receive their awards at a banquet in their honor next Tuesday, March 2, at the Statler-Hilton Hotel in Washington, D.C.

The award, announced by Katie Loucheim, Deputy Assistant Secre-

Dr. Sarah Stewart, Head of the Hu­man Virus Studies Section, l abora­tory of Viral Ca rcinogenesis, NCI, examines o hamste r used in her can­cer research.

tary of State for Community Ad­visory•· Services and Chairman of the Board of Trustees of the Fed­eral Woman's Award, cited Dr. Stewart for her "extraordinary ac­complishments and discoveries in virology which have changed the course of cancer virus research."

Dr. Stewart has already received national and world-wide recogni­tion for her work in the virus-can­cer field and has been invited to present her findings before numer­ous conferences both here and abroad.

Isolates Virus She isolated the polyoma virus

and collaborated with Dr. Bernice E. Eddy, Division of Biologics Standa1:ds, in propagating it in tis­sue culture.

This virus induces parotid gland tumors and a variety of other pri­mary neoplasms in mice and other laboratory animals. Studies of the characteristics of this virus have been a major factor in arousing the interest of investigators in the pos­sible viral causation of cancer.

In addition, Dr. Stewart discov­ered a factor present in rapidly

February 24, 1965

Programed Notebook Written for Nurses On Blood Pressure

A programed notebook for nurses titled "Blood Pressure Measure­ment" has been published by the Clinical Center.

A relatively new kind of educa­tional tool, the notebook consists of a series of statements or items with blanks to be filled in by the student. The statements are set up so that each one gives the appro­priate "fill-in" for the one that preceded it; yet the layout of the book is such that, while filling in one statement, the next statement is not visible to the student.

Method Described This method of teaching, called

progmmed instruction, helps the student learn more effectively and quickly because he ( 1) actively participates, (2) knows whether he is understanding and learning, and (3) can work at his own rate of speed.

Accuracy in measuring blood pressure is of vital importance in the practice of medicine anywhere. And uniformity of method in meas­uring blood pressure is especially important in gaining an accurate i n d i c a ti o n of blood-pressure changes in CC research projects.

Written by the CC Nursing De­partment's former Special Assist­ant for Nursing Research, Jane Wilcox, Sc.D., now with the Divi­sion of Research Grants, the note­book is intended primarily for use in the CC's in-service education program. It may, however, prove equally valuable to other hospitals and some schools of nursing.

Single free copies of "Blood Pressure Measurement," PHS Pub­lication Number 1191, may be ob­tained from the CC Information Office. Additional copies may be purchased at 45 cents each from the Superintendent of Documents, U. S. Government Printing Office, Washington, D.C. 20402.

growing mammalian tissues which, when added to a chicken cancer virus, enhances its ability to jump species barriers and produce a higher incidence of tumors in mam­mals in a shorter period of time.

This discovery has far-reaching implications regarding the possi­bility of testing human cancer viruses in lower animals.

Born in Tecalitlan, Mexico, Dr. Stewart earned a Bachelor of Science degree from New Mexico Agricultural College, a Master of Science degree from the University of Massachusetts, and a Ph.D. from the University of Chicago.

In 1949 she received an M.D. from Georgetown University Medi­cal School. This institution recently honored her by naming her "Medi­cal Man of Georgetown," the first woman to receive the title.

Her other honors include the

Kenneth Hisaoka Named To NIDR Grants Post

Dr. K. Kenneth Hisaoka has been appointed Assistant Chief of the Research Grants Section, Extra­mural Programs Branch, National Institute of Dental Research.

With Dr. Philip Ross, Chief of the Research Grants Section, Dr. Hisaoka will administer the Insti­tute's research grants in 150 insti­tutions in the United States and 17 foreign countries.

Dr . Hisaoka recently completed a year's on-the-job training in the NIH Grants Associate program, t hrough which scientist administra­tors are recruited and trained for grants administration in the Public Health Service. Dr. Hisaoka's train­ing included work at NIH and in other PHS bureaus and a curricu­lum in public administration.

Born in Mission City, British Co­lumbia (Canada), Di·. Hisaoka was graduated from the University of Alberta, received an M.Sc. from the University of Western Ontario in 1951, and a Ph.D. from Rutgers University in 1953.

Teaching, Research Cite d He was a research and teaching

assistant in the Department of Zoology at Rutgers in 1953 before joining the faculty of Loyola Uni­versity, Chicago. From 1961 to 1964 he was Associate Professor of Bi­ology at Loyola University.

Dr. Hisaoka's research interests are in the field of experimental em­bryology, encompassing teratology, histology, histochemistry, radio­autography, and electron micro­scopy.

Author of numerous publications, Dr. Hisaoka is a Fellow of the American Association for the Ad­vancement of Science and a mem­ber of the American Association of Anatomists, American Society for Cell Biology, Sigma Xi, and several other scientific professional asso­ciations.

Honorary Doctor of Laws degree from New Mexico State Univer­sity, the annual Lucy Wortham James Award from the James Ewing Society in New York, and the G. Lenghi Prize for 1963 awarded in virology by L' Acca­demia 'azionale Dei Lincei of Rome.

On January 11 of this year the Variety Club of Philadelphia chose Dr. Stewart to receive its annual Heart Award for notable service to humanity.

The author of 48 scientific publi­cations, Dr. Stewart came to the NCI in 1952 and now holds the rank of Medical Director in the PHS Commissioned Corps. In addition, she is a member of the Special Virus Cancer Leukemia Working Group on Developmental Research, established last November.

THE NIH RECORD

Dr. Harry Meyer, DBS, To Direct Laboratory Of Viral Immunology

Dr. Harry M. Meyer Jr. has beeu appointed Chief of the Laboratory of Viral lmmunology of the Divi­sion of Biologics Standards.

In his new post, Dr. Meyer will be responsible for a large segment of the Division's re­search program in vaccine - r e I a t e d fields, and for the laboratory's activi­ties in the control of new biologic products.

A native of Pal-o,. Meyer estine, Tex., Dr .

Meyer graduated from Hendrix College, Conway, Ark., in 1949, and in 1953 received his M.D. from the University of Arkansas School of Medicine.

Expe rience listed He interned at the Walter Reed

General Hospital in Washington, D. C., and from 1954 to 1957 serv­ed as Chief of the Virus and Rick­ettsial Diagnostic Section, Waltn Reed Army Institute of Research. For the next two years, he was as­sistant resident in pediatrics at the North Carolina Memorial Hospital.

Dr . Meyer came to NIH in 1959 as Chief of the General Virology Section, DBS Laboratory of Virnl­ogy and Rickettsiology. Since that time, his group has been r espon­sible for the Division's measles vaccine :\"esearch program, which included a number of pilot studie9 and vaccine field trials in West Africa.

Receives Award In 1963, Dr. Meyer and the two

members of his medical team which conducted these studies were awarded the Chevalier de l'Ordre National by the President of the Republ ic of Upper Volta, West Africa.

The award was presented in rec­ognition of the team's success in directing a mass campaign against measles in which nearly a million Volta children were vaccinated.

Dr. Meyer is certified by the American Board of Pediatrics, and is a member of a number of scien­tific organizations, including the American Association of Immunol­ogists, the Society for Experimen­tal Biology and Medicine, and the Society for Pediatric Research.

He is also active in the Ameri­can Federation for Clinical Re­search and the New York Acad­emy of Sciences.

She enjoys her leisure hours at the house which she and her mother recently built on Chesa­peake Bay, and on the 30-foot cruiser which she and her brother bought together.

THE NIH RECORD

Biochemical Make-Up of Membrane Systems at Molecular Level Sought

A large-scale research effort aimed at blueprinting the biochemi­cal make-up of various membrane systems at the molecula1· level will be conducted at the University of Wisconsin at Madison with support from t he Public Health Service. The grant will be administered by the National Institute of General Medical Sciences.

The university was awarded $213,781 for the first year of a proposed 7-year program which will total more than $2.5 million. Dr. David E. Green, Professor of Enzyme Chemistry and Co-director of the Institute for Enzyme Re­search there, will coordinate t he activities of seven senior scientists and 11 postdoctoral fellows and trainees.

Emphasis on Mitochondria

In the research program, special emphasis will be given to the mito­chondrion, a minute organelle found in most cells. Mitochondria consist chiefly of enzymes pack­aged within a complex membrane system. '

They may be likened to small factories which convert the poten­tial energy of foodstuffs into en­ergy available to power most of the operations of the cell.

Mitochondrial enzymes mediate the energy needed for such prnc­esses as muscle contraction, secre­tion, organ repair, and growth.

Previous work by this group and others has identified basic parts of the mitochondrion and their ar­rangement, and to a large measure defined and documented several chemical processes that underlie mitochondrial function.

Notes Primary N eed

"Of primary importance now," Dr. Green said, "is a correlation of mitochondrial structure at the mo­lecular level with its numerous en­ergy-releasing functions." He added that "with current advances in this field and with available instru­ments and techniques, many impor­tant problems are open to effec­tive attack."

The principal areas of the mito­chondrial problem on which the investigators will concentrate are: how the molecular components of the energy transfer chain fit to­gether within the mitochondrion; how individual complexes arc built from component molecules; and how certain fats are bound to structural protein and enzymes.

The popularity of the automatic dishwasher is due to the fact that most hus bands would rather buy t han be one.-The Washlngton Post.

February 24, 1965

NCI Journal's 25th Year Points Up Its Stature as Cancer Research Reference

Or. Howard B. Ande rvont, Scientific Editor of the Board of Editors of the JNCI (right foreground) presides ot o recent meeting in the Journal's new quar­ters in the Wiscon Building. Seated around the table hom left are: Or. John C. Bailor Ill, Linda Whiting, Journal secretary, Or. Laure nce R. Draper, Or, Jacqueline J. K. Whang, Or. Sherman M. Weissman, and Or. Gregory T, O'Conor.-Phota by Ralph Fernande a;.

The Journal of the National Cancet· Institute, which celebrates its 25th birthday this year, bas come to be regarded by the scientific com­munity as a standard, dependable reference in the cancer research field.

Seymour Kety Receives Honorary Sc.D. Degree

Dr. Seymour S. Kety, Chief of the Laboratory of Clinical Science of the National Institute of Mental Health, was the recipient recently of an Honorary Doctoi· of Science degree from the U n i v e r s i t y of Pennsylvania.

The degree was awarded during a Special Founder's Day Convocation in celebration of the Bicentennial Year of the University's School of Medicine, which is the na­ Or. Kety

t ion's oldest medical school. Both a graduate and former pro­

fessor at the University of Penn­sylvania, Dr. Kety was one of six persons to be so honored. The others were Senator Lister Hill, Dr. Carl F. Schmidt, Dr. George Packer Berry, Dr. Rene Dubos and Dr. John H. Gibbon Jr.

Research Praised

Praised for his contributions to research and the practice of medi­cine, Dr. Kety was cited for his de­velopment of a technique for the measurement of cerebral blood flow in man, whkh has made possible much valuable research and brought him world-wide acclaim.

Dr. Kety is past Henry Phipps Professor and Chairman of the De­partment of Psychiatry at the Johns Hopkins University School of Medicine and is the recipient of many honors.

He is a member of the National Academy of Sciences and of numer­ous professional societies in bio­logical and psychiatric areas, and is Editor-in-Chief of the Journal of Psychiatric Research.

Established in 1940 and publish­ed bi-monthly, the J ournal was modest in size and format but its aim was high-to insure wide­sp1-cad dissemination of knowledge acquired as a 1·esult of r esearch and investigations conducted by the newly created NCI.

Its success in publishing reports on national and world-wide cancer research is reflected by its position of eminence in American medical literature.

The Journal's Board of Editors, headed by Scientific Editor Dr. Howard B. Andervont, Laboratory of Biology, consists of the follow­ing associate members:

Othe r Me mbers Liste d

Dr. Laurence R. Draper, Labora­tory of Physiology; Dr. Jacqueline J. K. Whang, Medicine Branch; Dr. J ohn C. Bailar III, Head, De­mography Section, B i om e t r y Branch; Dr. Gregory T. O'Conor, Pathologic Anatomy Branch; and Dr . Sherman M. Weissman, Office of the Director. Mrs. Doris Chaney serves as Managing Editor.

This rotating, working board of six active NCI scientists is respon­sible for keeping the Journal both timely and comprehensive. The board reviews all articles submitted to the Journal, evaluating each for its scientific value. In addition, it approves a!J NCI scientific manu­scripts slated for publication else­where.

A manuscript submitted for pub­lication is first assigned to the as­sociate editor most familiar with the subject matter, who then sum­marizes it for the board's next weekly meeting. The board then selects reviewers, regardless of lo­cation or affiliation, on the basis of their participation in the research field covered by the paper.

After an evaluation of the r e­viewers' comments, the associate editor discusses the manuscript

Page 7

Booklet Outlines Role of Schools in Preventing Emotional Disorders

Steps primary and secondary schools can take toward the pre­vention of mental and emotional disorders in children are outlined in a new mental health monograph published last week by the Na­tional Institute ,of Mental Health.

In "The Protection and Promo­tion of Mental Health in Schools," eight educators and behavioral sci­entists discuss the role of the school in the development of per­sonality and its potential to assist in preventing learning and behavior problems in children.

Although many schools have es­tablished preventive programs in the behavioral field over the past years, the booklet states, they have chiefly focused on children in trou­ble rather than on true prevention.

Prior Action Stressed

The monograph emphasizes the need for action before the problems grow to full size, and if possible, before they even have a foothold. Thus, preventive programs must aim at building strengths in chil­dren that will help them avoid be­havior problems.

The authors discuss the impor­tance and potential of such preven­tive programs, followed by the presentation of specific programs and how they may be applied to the work of school personnel.

Single copies of the monograph, PHS Publication No. 1226, are available from the Public Informa­tion Section, National Institute of Mental Health, Bethesda, Md., 20014.

Multiple copies are available from the Superintendent of Docu­ments, U.S. Government Printing Office, Washington, D.C. 20402, for 40 cents each.

with the board and relays the board's and the reviewers' sugges­tions to the author.

Over a 10-year period an aver­age of 60 to 80 percent of sub­mitted material is published in the Journal.

The postwar era marked the be­ginning of expansion and vitaliza­tion for the Journal after the han­dicaps of the war years.

By 1956, when the advisory working board was named Board of Editors, the Joumal began pub­lication on a montl1ly basis. Great­ly improved in color, format, qual­ity of paper, and photography, the Journal actively and successfully invited significant research papers from outside the Institute.

By 1960 there had been a 50-fold increase of such papers, with 25 percent of this increase coming from other countries, indicating that the Journal is becoming truly representative of the world-wide scientific community.

Page 8

Ors. Simon and Arnhoff Appointed to New Posts In Mental Health Branch

Dr. Ralph Simon has been ap­pointed Special Assistant for Pro­gram Planning of the Training an<l Manpower Resou rces Branch, Na­tional Institute of Mental Health. He was previously Chief of the Program Analysis Section of that branch, a position to which Dr. Franklyn N. Arnhoff has been ap­pointed.

Dr. Simon will be responsible for evaluating program data as they relate to existing areas of support, and he will serve as prin­cipal advisor to the Branch Chief, Dr. Eli A. Rubinstein, in the de­velopment of overall program p lanning.

Dr. Simon was with the Division of Research Grants for three years before joining the NIMH staff in 1962. From 1951 to 1955, he served as Chief of Clinical Psychology Service at the VA Hospital, Butler,

Dr. Simon Dr. Arnhoff

Pa., and for the following four years, was on the staff of the VA Hospital, Perry Point, Md.

A native of Brooklyn, N. Y., Dr. Simon received his A.B. degree from Rrooklyn College in 1947 and Ph.D. deg1·ee from Syracuse Uni­versity in 1952.

He is a Fellow of the American Psychological Association, the American Association for the Ad­vancement of Science, the Mary­land Psychological Association, and a member of the Eastern Psy­chological Association.

Formulates Plans

As Chief of the Program Analy­sis Section, Dr. Arnhoff will be re­sponsible for formulating plans and procedures for a comprehen­sive program of analysis and clas­sification of all NIMH training grants.

Prior to this, he was a Grant Associate with the Division of Re­search Grants. From 1957 to 1960, he was Associate Reseanh Scien­tist with the New York State De­partment of Mental Hygiene, after which he became Associate Pro­fessor of Psychology at the Uni­versity of Miami.

A native of New York City, D r. Arnhoff received his B.S. degree from Long Island University in 1948, his M.A. degree from New York Univerr,ity in 1949, and Ph. D. degree from Northwestern Uni­versity in 1953.

February 24, 1965

Dr. Justin M. Andrews, forme r Director of the Notional Institute of Alle rgy and Infectious Diseases (right), acce pts congrotulotions of Dr. Dorland J. Davis, present Director (left), Mildred Brosky, his former secretary, and Ke n­neth H. Brown, NI AI D Executive Officer, afte r receiving Brown University's bice ntennial medallion for distinguished ach ievement in the eradication of communicable diseases. Dr. Andrews wos one of 26 a lumni cited by the uni­versity ot on Alumni Convocation in Providence, R. I., February 6 , in cele• bration of its 200th a nniversary.- Photo by Rolph Fe rnandez.

DHEW Approves Grants For University-Affiliated Retardation Facilities

Approval of applications for Federal grants totaling $3.9 mil­lion for two university-affiliated facilities for the mentally retarded was announced recently by Secre­tary of Health, Education, and Welfare Anthony J. Celebrezze.

The Children's Rehabilitation Institute, Reisterstown, Md., an af­filiate of J ohns Hopkins University Medical Center, Baltimore, will re­ceive $2.4 mil lion, and Georgetown University Medical Center, Wash­ington, D. C., $1.5 million.

These grants are the first to be approved under the program of Federal assistance for the con­struction of university-affiliated fa­cilities for the mentally retarded.

The Children's Rehabilitation In­stitute plans to construct, at a to­tal cost of more than $3 million, a clinical facility to be known as the John F. Kennedy Institute.

The new faci lity, which will be located at the Johns Hopkins Uni­versity Medical School, will serve as a training site for specialists engaged in caring for the mentally retarded.

Georgetown University wiU build a $2 million facility which would include such services as complete diagnostic evaluations, manage­ment and rehabilitation of the men­tally retarded, and specialized training of medical, paramedical, and non-medkal personnel.

H e is associate editor of P sycho­logical Reports and a Fellow of the Gerontological Society. He is also a member of the American Psycho­logical Association, the American Association for the Advancement of Science, the Psychonomic So­ciety, and the American Associa­tion of University Professors.

DR. BRAUNWALD (Contimwd from Paac 1)

His work also has produced knowledge of the effects in man of digitalis, a widely prescribed d1·ug for improving the efficiency of the heart, and of the role of the sympa­thetic nervous system in cardiac peiiormance.

An ingenious technique developed last year by Dr. Braunwald's g roup allows measurements to be made in intact, unanesthetized patients of the changes in the external dimen­sions of individual heart chambers throughout the cardiac cycle. Such measurements had never been made before.

Clips Sewn to Heart

With silver-tantalum clips sewn safely to the surface of the heart to provide a means of measuring volumes or dimensions, a variety of interventions, such as drugs, res­piration and exercise, can be stud­ied.

Under Dr. Braunwald, the Cardi­ology Branch also has developed a variety of improved diagnostic techniques, such as transseptal left heart catheterization and precor­dial scanning, which are now in wide use in medical centers.

In addition to his position since 1960 as an NHI B1·anch Chief, Dr. Brnunwald currently is a Clinical Associate Professor of Medicine and Professorial Lecturer in Physi­ology at Georgetown University and Lecturer in Medicine at the Johns Hopkins University School of Medicine.

Before joining the NHI staff in 1955, Dr. Braunwald served as As­sistant Resident of the Osler Medi­cal Service, The Johns Hopkins Hospital; Research Fellow at Belle­vue Hospital, N.Y.; and Fellow in the Department of Medicine, Co­lumbia College of Physicians and

THE NIH RECORD

NIH Stientists Present Papers on Infections of The Nervous System

Infections of the nervous system was the subject of three papers presented by scientists of the Na­tional Institutes of Health at the 44th annual meeting of the Asso­ciation for Research in Nervous and Mental· Disease, held recently in New York City.

Dr. John P. Utz, of the Labora­tory of Clinical Investigations, Na­tional Institute of Allergy and Infectious Diseases, spoke on "His­toplasma and Cryptococcus Menin­gitis," fungus infections that have been studied at the Clinical Center for several years. Results of these studies have helped delineate the quite different clinical features of each and to establish successful treatment for both of them.

Drs. William J. Hadlow and Carl M. Eklund, of NIAID's Rocky Mountain Laboratory, were the authors of "Scrapie-A Virus In­duced Chronic Encephalopathy," a paper describing their findings on a slow-acting virus that produces de­generative changes in the central ne1·vous system of certain animals after a long incubation period.

Studies Important

Because most viruses have gen­ernlly been considered to require relatively short incubation periods, the scrapie studies represent an important reorientation in viral re­search.

Further research on this possi­bility of "slow viruses" causing certain degenerative diseases of the nervous system in man was presented by Dr. D. Carleton Gaj­dusek in "Slow, Latent and Tem­perate Viral Infections of the Cen­tral Nervous System.''

D1-. Gajdusek, Chief of the Sec­tion for Study of Child Growth and Development and Disease Patterns in Primitive Cultures, National In­stitute of Neurological Diseases and Blindness, discussed briefly a genetic basis for susceptibility and mentioned the gene for Chediak­Higashi leukocytic abnormality in man.

Surgeons, N. Y. He received his A.B. and M.D. degrees from New York University.

Last yea1· Dr. B1·aunwald was in­vited to deliver the annual Haile Selassie Lecture before the Royal Society of Medicine in London. He is the first American to be honored with this lectureship, endowed by the Emperor of Ethiopia.

Re currently serves on the Edi­torial Boards of the Journal of Clinical Investigation, American Journal of Physiology, the Journal of Applied Physiology, the Annals of Internal Medicine, Circulation, and the Journal of Pharmacology and Experimental Therapeutics,