Modulation of transforming growth factor beta signalling pathway
FcɛRI Signalling Pathway
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Transcript of FcɛRI Signalling Pathway
FcɛRI Signalling Pathway
The Ligand : IgE
Mast and Basophil Cells
• Fc receptors bind tail region of IgE antibodies.
•Histamine, proteases,
The Receptor
Tyrosine Kinases
Lyn
Syk
The Pathway
•Binding of IgE•Aggregation of receptors
Syk activation Cascade of reactions Degranulation
Lyn binds beta unit of one receptor and transphosphorylates the beta ITAM, gamma ITAM, and Syk associated with adjacent receptor.
Syk can also phosphorylate syk associated with adjacent receptor
Allergy sufferers are at a lower risk of developing cancer
•Inverse association between IgE and malignancies
•IgE-mediated immune responses against tumor cells
•IgE-based treatment options
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LevelHistogram not generating all first passage times
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But it wasn't so bad
Bngl easy to understand Easy to define chemical
reactions Can manipulate molecule
concentrations Can set time period of reaction