Fat Subtypes and Breast Cancer Publication

Smith-Warner, S.A., et al. Types of dietary fat and breast cancer: a pooled analysis of cohort studies. International Journal of Cancer. 2001; 92: 767-774.

Sweden Mammography

CohortNurses’ Health Study

Netherlands Cohort Study

New York State Cohort

Iowa Women’s Health Study

Canadian National Breast Screening Study

Adventist Health Study

New York University Women’s

Health Study

Cohort Studies Included in the Pooled Analyses of Fat Subtypes and Breast Cancer

Total = 351,821

# cases = 7,329

Cohort Studies Included in the Pooled Analyses of Fat Subtypes and Breast Cancer

Adventist Health15,172 160Canadian National56,837 419Iowa Women’s 34,406 1,130Netherlands Cohort62,412 887NY State 18,475 367NY University14,006 385Nurses’ Health (a)89,046 1,020Nurses’ Health (b) 68,817 1,638Sweden Mammography 61,467 1,323

TOTAL 351,821 7,329

Study Total # of Cohort Cases

Smith-Warner, et al. 2001

Range of Median Intakes in Control Participants Across Studies

Total 30-41

Saturated (SFAT) 10-16

Monounsaturated (MFAT) 11-16

Polyunsaturated (PFAT) 4-9

Animal (AFAT) 12-29

Vegetable (VFAT) 10-21

Type of Fat Range of Median Intakes (% kcal)

Smith-Warner, et al. 2001

Pooled Multivariate Relative Risks of Breast Cancer for Different Dietary Fats

Total 1.00 (0.98-1.03)0.19

Saturated 1.03 (0.95-1.10)0.04

Monounsaturated 1.00 (0.94-1.07)0.16

Polyunsaturated 1.01 (0.94-1.08)0.48

Animal 1.00 (0.97-1.04)0.08

Vegetable 1.01 (0.98-1.04)0.15

* Increment = 5% kcal

Each fat in a separate model.

Study RR (95% CI)* p-hetero.

Smith-Warner, et al. 2001

Study-Specific Relative Risks of Breast Cancer and Saturated Fat

Relative Risk.5 1 2

Combined

Sweden

Nurses' (b)

Nurses' (a)

NY University

NY State

Netherlands

Iowa

Canada

Adventist

Smith-Warner, et al. 2001

Study-Specific Relative Risks of Breast Cancer and Monounsaturated Fat

Relative Risk.5 1 2.5

Combined

Sweden

Nurses' (b)

Nurses' (a)

NY University

NY State

Netherlands

Iowa

Canada

Adventist

Smith-Warner, et al. 2001

Study-Specific Relative Risks of Breast Cancer and Polyunsaturated Fat

Relative Risk.5 1 2.5

Combined

Sweden

Nurses' (b) Nurses' (a)

NY University

NY State

Netherlands

Iowa

Canada

Adventist

Smith-Warner, et al. 2001

Study-Specific Relative Risks of Breast Cancer and Animal Fat

Relative Risk.67 1.5

Combined

Nurses' (b)

Nurses' (a)

NY University

NY State

Netherlands

Iowa

Canada

Adventist

Smith-Warner, et al. 2001

Study-Specific Relative Risks of Breast Cancer and Vegetable Fat

Relative Risk.67 1.5

Combined

Nurses' (b)

Nurses' (a)

NY University

NY State

Netherlands

Iowa

Canada

Adventist

Smith-Warner, et al. 2001

Pooled Mutually Adjusted Relative Risks of Breast Cancer

Type of fat RR (95% CI)* p-hetero.

Saturated 1.09 (1.00-1.19)

0.25

Monounsaturated 0.93 (0.84-1.03)

0.34

Polyunsaturated 1.05 (0.96-1.16)

0.58

* Increment = 5% kcal

All three fats included in the same model

Smith-Warner, et al. 2001

Pooled Mutually Adjusted Relative Risks of Breast Cancer

Substitution RR (95% CI)*

Sat. for Mono. 1.18 (0.99-1.42)

Sat. for Poly. 0.98 (0.85-1.12)

Mono. for Poly. 0.87 (0.73-1.02)

* Increment = 5% kcal

Smith-Warner, et al. 2001

Cross-Classified AnalysesMFAT-SFAT

# Cases RR (95% CI)

Low SFAT, High MFAT 45 1.00 (ref)

Other combinations 6649 1.06 (0.77-1.45)

High SFAT, Low MFAT 50 1.06 (0.68-1.65)

Smith-Warner, et al. 2001

Pooled Mutually Adjusted Multivariate Relative Risks of Breast Cancer by Menopausal Status

Fat Group RR (95% CI)* p-for- inter.

SFAT Premeno. 1.10 (0.91-1.35)Postmeno. 1.07 (0.93-1.24) 0.61

MFAT Premeno. 0.87 (0.63-1.19)

Postmeno. 0.81 (0.65-1.03) 0.46

PFAT Premeno. 1.12 (0.88-1.41)

Postmeno. 1.28 (0.96-1.69) 0.72

*Increment=5% kcal

Smith-Warner, et al. 2001

Pooled Mutually Adjusted Relative Risks of Breast Cancer

Type of fat RR (95% CI)* p-hetero.Animal 1.01 (0.96-1.06) 0.05

Vegetable 1.01 (0.98-1.04) 0.71

* Increment = 5% kcal

Both fats included in the same model

Smith-Warner, et al. 2001

Pooled Mutually Adjusted Multivariate Relative Risks of Breast Cancer by Menopausal Status

RR (95% CI)* p-for- interaction

Animal fat Premeno. 1.01 (0.91-1.12) Postmeno. 0.99 (0.95-1.03) 0.93

Vegetable fat Premeno. 1.03 (0.93-1.13) Postmeno. 0.99 (0.94-1.04) 0.54

*Increment = 5% kcalSmith-Warner, et al. 2001