Farmacologia y placenta
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Transcript of Farmacologia y placenta
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FISIOLOGIA Y FARMACOLOGIA PERINATAL
KAREM A. MARTINEZ F.RESIDENTE ANESTESIOLOGIA Y
REANIMACION HSB
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Cigoto: Diploide
Blastomeras: Una celula origina 2:
Morula
Blastomeras: reservas nutritivas Ovulo
Morula: Absorcion fluido tubarico
5 dia pierde la zona pelucida y aumenta su
absorcion
Blastocisto: Blastocele-Trofoblasto-
EmbrioblastoTrofoblasto-Decidua:
placenta
Nidacion: Trofoblasto polar: perfora capa
compacta endometrio
Trofoblasto se difencia Citotrofoblasto-
sincitiotrofoblasto: Placentacion
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Dia 9 sincitiotrofoblasto: Hormona
corionicogonadotropica (involucion cuerpo luteo)
Mesodermo caudal embrion: tallo de fijacion (Cordon
umbilical)
Blastocele: cavidad corionica
Dia 21-23 Se establece comunicacion vasos
alantiodeos y corionicos de la placa corionica placentaria
En el tallo de fijacion se forman los vasos alantoides:
Futuros vasos umbilicales
Dia 14 Saco vitelino+mesodermo: Islotes
sanguineos –vasos vitelinos(aposicion celulas)
Circulacion fetoplacentaria3° mes hasta termino
crecimiento placentario
Periodo prevellositario:- Decidua basal
- Las lagunas- Las arterias espiraladas
Periodo vellositario:- Vellosidades coriales
- Vasos coriales- Placa corionica-vasos
corionicos
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Ovalada y plana
• Diametro 18,5 cm• 500 gramos• Espesor 23 mm
Crecimiento placenta y
fetal
• Flujo 600 ml/min (200 espirales)
• Aumento diametro de los vasos, reduce flujo y presion
• Intercambio placentario: Vellosidades terminales
Aumento superficie
de intercambio
• Arterias corionicas: 4-8 coletiledones
• Espesor-membranas : tasa de difusion
• Esteroides: Estrogeno y progesterona
• Hormona gonadotropica corionica-lactogeno
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FLUJO SANGUINEO PLACENTARIO
• Disminucion reactividad muscular y promover vasodilatacion, reduciendo la resistencia
• Sangre materna en espacio intervelloso alos cotiledones 70-80 mmHg
• El flujo de sangre feto-placentario es autorregulado (no definido) Prostaciclina 25 y oxido nitrico
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MECANISMOS DE TRANSPOTE
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• Flujo materno-fetal• Union de la placenta• Metabolismo placentario• Capacidad de difusion• Plama materno-fetal union a proteinas• Edad gestacional (gradientes de PH-
Atrapamiento ionico)• Enfermedades concomitantes
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• El efecto Bohr aumenta la transferencia de oxigeno de la madre al feto y es responsable del 2-8% de la transferencia de O2
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Solubilidad Lipidica
Union a proteinas (edad
gestacional y comorbilidades)
Pka -PHFlujo sanguineo
La union a tejidos
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BIBLIOGRAFIA
1. Chesnut, D. Polley, L. Chesnut s obstetrics Anesthesia Principles and pratice. 4ta edition. Mosby elsevier
2. Romero, J, sarmiento ,A, Romero, X. Obstetricia. Coleccion educacion medica. Universidad el bosque. Vol 35, 2004.