Pacemaker currents in neurons and excitable cells Emilio Carbone
Faizan Kalwar. Basal cells – replace receptor neurons (a feature unique to the olfactory neurons)...
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Transcript of Faizan Kalwar. Basal cells – replace receptor neurons (a feature unique to the olfactory neurons)...
Faizan Kalwar
Basal cells – replace receptor neurons (a feature unique to the olfactory neurons)
Sustenacular cells – scattered throughout epithelium, secretory granules empty contents on mucosal surface
Receptor neurons
- Humans have ~40 million- Bipolar neurons- Dendrites extend into
mucosal surface-Cilia on surface of
dendritic knobs-Receptors on cilia make
contact with odorants-One receptor for each
neuron- Axons lead into glomerus
-Odor molecule binds to receptor protein on surface of cilia
-Receptor conformation changes activates G-protein (Golf)
-Adenylate cyclase activation produces cAMP
-cAMP opens ion channels Na+ and Ca2+ enter
- Depolarization occurs at dendritic region which leads to generation of an action potential
-Activation of multiple receptors allows molecules that have never been encountered to be characterized
-ORNs are sensitive to a subset of odorants which makeup its tuning curve
- Some ORNs are very selective while others are much broader
-Different thresholds exist for a given odorant between neurons with the same receptor
- Adaptations occur