Faculty of Pathology 37th Annual Symposium & …...Prof. Michael Borg A clinical microbiologist by...
Transcript of Faculty of Pathology 37th Annual Symposium & …...Prof. Michael Borg A clinical microbiologist by...
Faculty of Pathology 37th Annual Symposium &
Annual General Meeting
Thursday 7th & Friday 8th February 2019 Approved for up to 8 CPD credits
Thursday 7th February 2019 (5 CPD)
9.30-10:00 Registration / Stand viewing
10:00 -10:15 Dean’s Address
Session 1
10:15 - 13:00 Breakout Sessions
Corrigan Hall Lecture Theatre
HISTOPATHOLOGY
Cancer biomarkers
Chairs: Dr Clive Kilgallen,
Dr Cynthia Heffron
MICROBIOLOGY/HAEMATOLOGY/
CHEMICAL PATHOLOGY/IMMUNOLOGY
Critical care and Sepsis
Chairs: Dr Una Ni Riain, Dr Ronan
Desmond
Title/ Time Speaker
Title/ Time Speaker
10:15- 10:45
PDL-1
Immunohisto-
chemistry in lung
cancer and
melanoma
Professor Aurelie
Fabre,
Consultant
Histopathologist
and UCD Clinical
Professor
10.20- 10.55
The Surviving
Sepsis
Guidelines
Seem to Work
– but at what
cost?
Dr Patrick Neligan,
Consultant Anaesthetist,
Galway University Hospitals
10.45- 11.15
Great Advances in
Pathology and
Implications for the
real life Oncologist
Dr Deirdre
O’Mahony,
Consultant Medical
Oncologist, Cork
University Hospital
10.55- 11.30
New
diagnostics in
infection in
ICU patients
Dr Claire P Thomas,
Consultant Infectious
Diseases/
Clinical Microbiology,
Hampshire hospitals NHS
Foundation Trust
11.15-11.45
NGS Platforms
Dr Bruce Moran,
St. Vincent's
University Hospital,
Cancer Biology &
Therapeutics
Laboratory, Conway
Institute
11.30- 12.05
Coagulation
Crosstalk
Dr Ruth Gilmore,
Consultant Haematologist,
Galway University Hospitals
11.45-12.30
Keynote Lecture:
Molecular
Biomarkers in
Colorectal Cancer
Professor Phil
Quirke,
Head of Tumour
Biology and
Pathology,
University of Leeds
12.05- 12.40
Immunology
in the
Critically Ill
patient
Dr Tom Ryan,
Consultant in Anaesthesia &
Intensive Care, St James’s
Hospital, Dublin
12.30- 13.00
Histopathology EQA
12.40- 13.00
Questions
13.00- 14.00 Lunch / Poster & Stand viewing
Session 2: General Chair: Dr Joan Power
Time Title Speaker
14:00-14:20
Whither Pathology? Engagement, Recruitment &
Medical Education
Prof Hilary Humphreys, Professor of Clinical
Microbiology, RCSI and Consultant Microbiologist,
Beaumont Hospital
14:20-14:50
Keynote Lecture: The role of behavioral drivers in the delivery of healthcare in Europe
Prof Michael Borg, Head of Departments of Infection Control & Sterile Services, Mater Dei Hospital, Malta
14:50-15:05
Presentation of the George Greene Medal Winner ‘FISH studies in DLBCL: correlations with cell of origin: the Irish Experience.’
Dr Deirdre Timlin
15:10-15:25
Presentation of the John D Kennedy Medal Winner ‘Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study.’
Dr Sean Hynes
15:25- 16:25
Rapid fire poster session
Chairs: Dr Una NiRiain, Dr Cynthia Heffron
16:25-16:40
Announcement of the Winners of the poster, Rapid Fire poster session and student poster prize. Close out.
19.00 Admissions Ceremony
20.00 Dinner
Friday 8th February (3 CPD)
Time Title Speaker
9.00-10.30 AGM
General Session
Chairs: Dr Pat Twomey, Dr Aurelie Fabre
10:30- 11:00 Molecular Pathology: Applications in Solid Tumours
Dr Brendan Doyle, Department of Histopathology Beaumont Hospital
11:00- 11:30 Whole Genome sequencing and its application in diagnosis/typing of Enterobacterales including CPE
Prof Martin Cormican, National Clinical Lead for HCAI and AMR. Professor of Bacteriology, NUI Galway. Consultant Microbiologist, Galway University Hospitals.
11:30-11:45 Coffee
11:45- 12:15 Molecular techniques in
lymphoma malignancies
Prof Elisabeth Vandenberghe,
Consultant Haematologist, St James’s
Hospital, Dublin
12:15- 12:45 Genetics of Familial
Hypercholestrolaemia
Dr Vivion Crowley, Consultant Chemical
Pathologist, St James Hospital, Dublin
12:45- 13:15 The Liquid Biopsy: Circulating
tumour DNA for lung cancer
management. Promises &
Pitfalls
Dr Stephen Finn, Consultant Pathologist,
St. James's Hospital
13:15- 13:30 General Discussion and Q&A
13.30 Closing Address from Dean Prof Louise Burke,
Department of Histopathology
Cork University Hospital
Guest Speaker Biographies
Prof Aurelie Fabre Prof Aurelie Fabre is a Consultant Histopathologist, and UCD Clinical
Professor at the Department of Histopathology, St Vincent's University
Hospital, Dublin, with a special interest in Thoracic Pathology.
She is also the Heart and Lung Transplant Pathologist of the National
Transplant Unit at the Mater Misericordiae University Hospital.
She is the Lead in Pulmonary Pathology and runs/participate ate weekly
MDTs, cancer and non-cancer including interstitial lung diseases.
She graduated from Trinity College Dublin in 1996, then got a Master in
Medical Sciences in Pathology at University College Dublin in 1998 and
went on to train in Histopathology in Paris and in London, and got my
MRCPath in 2002.
She then completed a PhD thesis on the pathogenesis of lung fibrosis in
parallel to a Fellowship in Thoracic Pathology at Bichat Hospital, Paris in
2007 and 2012. Her main interests include interstitial lung diseases,
lung cancer, heart and lung transplant pathology, and
cardiac/cardiovascular pathology. She has developed diagnostic and
predictive profiling of lung cancer in the department and have
facilitated the implementation of PD-L1 testing in non small cell lung
cancer in Ireland. At research levels, she provide expertise in tissue and
cell morphology, image analysis, animal models and
immunohistochemistry. She is the founder/Director of the Research
Pathology Core technology at the Conway integrating Research
Immunohistochemistry and Digital Pathology
http://www.ucd.ie/conway/research/coretechnologies/researchpathologycore/
Dr Patrick Neligan
Patrick Neligan is a Consultant Anaesthetist and Intensive Care Medical
Director at Galway University Hospitals, and Honorary Professor of
Anaesthesia and Intensive Care at National University of Ireland,
Galway. He trained in medicine and anaesthesia in Ireland, and did his
critical care training in the USA at Duke University and University of
Pennsylvania, where he was on staff from 2002-2008. He is co-editor of
“An Evidence Based Practice of Critical Care –now in its third edition.”
Dr Deirdre O’Mahony
Dr Deirdre O’Mahony is a UCC graduate. She undertook her Medical
Oncology training in Beaumont and St James’s Hospitals in Dublin, in
addition to completing a Masters in Molecular medicine from Trinity
College Dublin in 2002. She completed a post graduate fellowship in the
National Cancer Institute in Bethesda, Maryland. She continued there as
a Consultant, continuing her research into viral associated malignancies.
In 2008, she returned to St James’ Hospital, Dublin specializing in virally
associated malignancies, lymphoma, sarcoma and Head and Neck
Cancer. She is a long-standing member of the Lymphoma Forum of
Ireland and co-founded the Irish Sarcoma Group. She moved to serve
the Cork / Kerry region in 2012; specialty interests in Breast, Lymphoma
and Sarcoma. She has been active in clinical, academic and research
programs. She is the president of the Irish Society of Medical Oncology
and committee member of the ASCO International Quality Task Force
(IQTF).
Dr Claire Thomas
Dr Claire Thomas trained at Oxford and St Bartholomews hospital in
London. She gained her PhD in virology, in Oxford, and trained in
InfectiousDiseases and clinical Microbiology at Impeial. She has worked
as a consultant in Imperial, Singapore General Hospital, and currently is
Director of Infection control, at hampshire Hospitals NHS Trust UK. Her
research interests are Antibiotic resistance, rapid diagnostics, and their
role in patient safety and outcomes.
Dr Bruce Moran
Bruce Moran is a bioinformatician with the Ireland East Hospital Group
working in the Department of Histopathology, St. Vincent’s University
Hospital. His general interest is in the use of ‘next-generation’
sequencing data to investigate the molecular basis of cancer. This is of
use in both clinical and research settings: in the former as a diagnostic
utility, the latter to understand disease occurrence and progression.
Current projects include ongoing patient exome analyses. This is applied
in diagnostically challenging cases and involves sequencing all protein-
coding regions of the genome which can then be assessed for
potentially cancer-related variants. This is particularly useful when ‘non-
canonical’ variants in known oncogenes are not found by standard
diagnostic molecular methods. It also allows molecular characterisation
of metastases and recurrences. From an analysis standpoint, he is very
interested in the reproducibility of data analysis and in transparency of
scientific methods.
Dr Ruth Gilmore
Dr Ruth Gilmore graduated from NUIG in 1998. She completed her
Higher Specialist Training in Haematology in 2007 and completed an MD
in thrombin generation in 2009. Her main areas of interest include
Haemostasis and Thrombosis, Obstetric Haematology and Paediatric
Haematology. She returned to Galway as a Consultant Haematologist in
2011 where she practises as a Coagulation Specialist.
Professor Phil Quirke BM, PhD, FRCPath, FMedSci, FRCSEd (ad hominem) Is the Yorkshire Cancer Research Centenary Professor of Pathology in the School of Medicine at the University of Leeds, UK and honorary Consultant Pathologist, Leeds Teaching Hospitals NHS Trust. He leads the section of pathology and tumour biology in the University of Leeds and has a major research interest in Bowel cancer, molecular and digital pathology and postgraduate academic education. Honorary Fellow/ honorary member of six international surgical societies and Fellow of the Academy of Medical Sciences, UK. Phil’s major achievements have been: To identify the cause of local recurrence in rectal cancer and open up the way to minimise this occurrence. To show that simple observations of anatomy and cancer surgery and the specimens that are removed by surgeons can identify the quality of the operating surgeon and that educational interventions using excellent surgeons can improve outcomes in a number of countries. With Gina Brown contributed to evaluation of the value of MRI imaging in rectal cancer. Pathology, molecular ad digital pathology contributions to the QUASAR, CLASICC, CR07, ROLARR, FOCUS1-4, FOXTROT, TREC and many other clinical trials. Leads the Pathology of the English Bowel Cancer Screening programme since 2006 and coordinated the Pathology chapter of the European guidelines on bowel cancer screening. Newer areas of work: Identifying variations in clinical practice and the use of big data to understand multidisciplinary team clinical results and improve outcomes with Professor Eva Morris. Exploration of the impact of the microbiome on causation, screening and treatment of colorectal cancer.
Dr Tom Ryan Dr Ryan has been a Consultant in Intensive Care and Anesthesia since 1997. He began his training in Ireland, followed by sub-specialty training at the University of Washington in the US. He undertook additional Intensive Care and Anesthesia training at the Mayo Clinic in Minnesota and was a consultant in the Cleveland Clinic, before returning to Ireland to his position in St. James’s Hospital.
Prof Hilary Humphreys Hilary Humphreys is Professor of Clinical Microbiology at the RCSI and Consultant Microbiologist at Beaumont Hospital Dublin. He has been Dean of the Faculty of Pathology at the RCPI since 2016, has a longstanding commitment to medical education and training, and he has a particular professional and research interest in hospital infections. In November 2018, he became President of the Healthcare infection Society
Prof. Michael Borg
A clinical microbiologist by training, Prof. Michael A. Borg heads the
Department of Infection Prevention and Control at Mater Dei Hospital
in Malta and chairs the country’s National Antibiotic Committee. He is a
past president of the International Federation of Infection Control (IFIC)
and has an expert to the European Centre for Disease Control (ECDC) on
the prevention & control of healthcare associated infections and the
prudent use of antimicrobial agents in human medicine.
Michael has been involved in several EU funded projects on the
epidemiology of antimicrobial resistance, prevention and control of
healthcare associated infections and antibiotic use within Europe and
the Mediterranean region. He has authored or collaborated in more
than 80 publications on these subjects within peer reviewed journals.
His latest research interests focus especially on human behaviour and
change management and their role in infection prevention and control
as well as antibiotic stewardship.
Dr Brendan Doyle
Brendan graduated Trinity College, Dublin in 2003 with a degree in
medicine. He trained in histopathology in Dublin, the Brigham and
Women's Hospital, Boston and in the Beatson Institute for Cancer
Research in Glasgow, where he received a PhD in Molecular Pathology
and Cancer Studies from the University of Glasgow. He worked as a
lecturer in Trinity College before taking up his current post as a
consultant pathologist in Beaumont Hospital. He has a particular
interest in molecular pathology as it applies to personalised medicine
and is the clinical lead for solid tumour molecular diagnostics in
Beaumont/RCSI.
In addition to his clinical/diagnostic work he has published original
research papers, review articles and a book chapter in the area of
molecular pathology. He has received international awards from the
Pathological Society of Great Britain and Ireland and the US and
Canadian Association of Pathology for his work.
Prof Martin Cormican
Graduated from NUI Galway 1986. Trained in Ireland, UK and USA.
Appointed Consultant Microbiologist GUH and Professor of Bacteriology
NUI Galway in 1999. Since May 2017 – National Lead for Healthcare
Associated Infection and Antimicrobial Resistance. Research interests
are antimicrobial resistance, foodborne infection and the links between
environment and human health.
Professor Elisabeth Vandenberghe
Professor Elisabeth Vandenberghe qualified from University College
Dublin, and initially trained in Ireland before working on the genetic
characterization of Mantle Cell Lymphoma at the University of Leuven
(KUL) in Belgium for which she was awarded a PhD, before moving to
University College London Hospital to complete specialist training in
haematology. She worked briefly at Sheffield Trust Hospitals, setting up
a haematology molecular diagnostics service and leading the bone
marrow transplantation service before returning to St James Hospital
and Trinity College Dublin in 2002 where she is currently lymphoma
clinical lead and co-director of the Cancer Molecular Diagnostics
Department. She sits on a number of European committees including
the lymphoma working party of the European Bone Marrow
Transplantation group, European Research Initiative on CLL and the
European Mantle Cell Lymphoma group and has co-authored over 80
articles, mainly on the diagnosis and management of lymphoid
malignancies
Dr Vivion Crowley
Dr Vivion Crowley is a graduate of University College Cork Medical
School and is Consultant Chemical Pathologist and Head of the
Biochemistry Department in St James’s Hospital, Dublin. He trained in
Chemical Pathology in Dublin, Manchester and Cambridge, where he
also obtained a Wellcome Trust Research Training Fellowship,
undertaking research into the genetics of obesity and diabetes with Prof
Sir Stephen O’Rahilly in the Department of Clinical Biochemistry,
Cambridge University. He was subsequently appointed as a Consultant
Chemical Pathologist in Addenbrooke’s and Hinchingbrook Hospitals,
Cambridge, before taking up his current post in 2004. He has a specific
interest in clinical and laboratory diagnostic aspects of acute porphyrias
and genetic dyslipidaemias. He is the current National Speciality
Director in Chemical Pathology.
Professor Stephen Finn
Professor Stephen Finn is a consultant pathologist at St. James’s
Hospital and Associate Professor of Pathology at the University of
Dublin, Trinity College Dublin. Dr. Finn is Co-Director of the Cancer
Molecular Diagnostics Laboratory at St. James’s and has subspecialist
expertise in cancer molecular diagnostics of solid tumours. Dr. Finn
qualified from University College, Cork (UCC) in 1998, completed his
higher professional training in histopathology in 2005 and subsequently
worked as staff pathologist and Senior Scientist at the Centre for
Molecular Oncologic Pathology (CMOP) at the Dana Farber Cancer
Institute in Boston, USA. He returned to Ireland in 2008 and worked as
Consultant pathologist at the Mid Western Regional Hospital Limerick
before moving to his current position.
His PhD is from Trinity College Dublin (2005) and he is a Fellow of the
Royal College of Pathologists, UK. Dr. Finn is a member of the European
Thoracic Oncology Platform (ETOP) and leads the thoracic oncology
research group at St. James’s Hospital, Dublin. Dr. Finn’s primary
research interests are focused on lung and prostate cancers, including
obesity and metabolic syndrome in prostate cancer progression, the
molecular significance of dietary and exercise interventions, noncoding
RNA signatures of advanced prostate cancer, circular RNAs as
biomarkers and the utility of circulating DNA and Circulating Tumor Cells
as a liquid biopsy. In addition, Dr. Finn has interests relating to human
cancer molecular diagnostics particularly in relation to the use of Next
Generation Sequencing for routine molecular diagnostics.
This event has been supported by way of unrestricted educational grants from:
GOLD Sponsors:
SILVER Sponsors:
NOTES: