Factors independently associated with odds of fractures

Gage BF et al. Arch Intern Med 2006; 166:241-246.

Factor Adjusted odds ratio (95% CI)

No warfarin Reference group

<1-y warfarin therapy 1.03 (0.82-1.29)

>1-y warfarin therapy 1.25 (1.06-1.48)

Men (>1-y warfarin therapy) 1.63 (1.26-2.10)

Women (>1-y warfarin therapy)

1.05 (0.88-1.26)

Warfarin use on discharge* 0.95 (0.81-1.11)

Age (10-year increase) 1.63 (1.47-1.80)

African American race 0.30 (0.18-0.51)

*Forced into model to prevent confounding

Long-term use of warfarin increases risk of fracture in men [Rheumawire > News; Jan 27, 2006

Factor Adjusted odds ratio (95% CI)

No warfarin Reference group

Male sex 0.54 (0.46-0.62)

Beta-blocker use 0.84 (0.70-1.00)

Heart failure 0.86 (0.75-0.98)

High fall risk 1.78 (1.42-2.21)

Hyperthyroidism 1.77 (1.16-2.70)

Neuropsychiatric impairment

1.51 (1.28-1.78)

Alcoholism 1.50 (1.01-2.24)

Corticosteroid use* 1.24 (0.97-1.58)

Factors independently associated with odds of fractures

*Forced into model to prevent confounding

Gage BF et al. Arch Intern Med 2006; 166:241-246.

Long-term use of warfarin increases risk of fracture in men [Rheumawire > News; Jan 27, 2006