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The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease

Facing Off Against Heart Disease

Annual Update 2017

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Staff and Fellows

The staff members and fellows of the Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease include:

Top Row Mahmoud Al Rifai, MD, MPH; Dominique Ashen, PhD, CRNP; Eve-Marie Bensen, MD; Michael J. Blaha, MD, MPH; Roger S. Blumenthal, MD; Miguel Caínzos-Achirica, MD, MPH; Zeina Dardari, MS

second Row Oluwaseun Fashanu, MD; Roberta Florido, MD; Gary Gerstenblith, MD; Ty Gluckman, MD; Sherita Golden, MD, MHS; Eliseo Guallar, MD; Cathy Handy, MD, MPH

ThiRd Row Rupert Hung, BA; Steven Jones, MD; Karan Kapoor, MD; Sina Kianoush, MD, MPH; Seth S. Martin, MD, MHS; Francoise Marvel, MD; Lena Mathews, MD

FouRTh Row J. Bill McEvoy, MBBCh, MHS; Erin Michos, MD, MHS; Hassan Mirbolouk, MD; Khurram Nasir, MD, MPH; Chiadi Ndumele, MD, MHS, PhD; Jaideep Patel, MD; Wendy Post, MD, MS

FiFTh Row Faisal Rahman, MD; Vishal Rao, MD; Elizabeth Ratchford, MD; Vasanth Sathiyakumar, MD; Luke Silverman-Lloyd, BA; Vinita Subramanya, MD; Peter Toth, MD

sixTh Row Martin Tibuakuu, MD; Jane Wang, BA; Stephanie Wang, MD; Seamus Whelton, MD, MPH; Wendy Ying, MD; Di Zhao, PhD

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Message from the Director

Widening Our Focus, Accomplishing Even More

With 2017 almost in the books, I am excited to report that the Johns Hopkins Ciccarone Center has had its

most productive year since its founding in 1990. Much of this productivity can be attributed to our efforts to widen the focus of our work to heart failure, atrial fibrillation, and peripheral vascular disease. dr. elizabeth Ratchford is our prominent Director of Vascular Medicine. As a result, we have now formally changed our name to the ciccarone center for the prevention of cardiovascular disease.

A significant factor driving our success is irene pollin’s $10 million dollar gift in 2013, which has enabled us to develop and expand our clinical research and education initiatives. Irene is a remarkable person, and we are extremely grateful for her generosity and leadership. A pioneer in the field of preventive cardiology herself, with a special focus on women and cardiovascular disease, Irene founded Sister to Sister, which performed large screening and educational programs to educate and motivate women and men to follow better lifestyle habits and achieve better heart disease risk factor control.

As the first Kenneth Jay Pollin Professor of Cardiology, an endowed professorship named in memory of Irene’s and her late husband Abe’s son, who died from complications of congenital heart disease at 13 months of age, I am personally indebted to Irene for her friendship and

partnership in the field of prevention.

Most members of our Ciccarone Center team, in fact, have been involved in research that has been supported by the Pollin gift. drs. seamus whelton and Roberta Florido were our Pollin Cardiovascular Prevention Fellows last year, and Roberta received master’s degree-level training at the Bloomberg School of Public Health. Roberta has worked closely with dr. chiadi ndumele on innovative research projects looking at the important roles that physical activity and diet play in the development of heart failure. She also is pursuing research in the association of a history of cancer and subclinical heart muscle damage as measured by blood tests.

Roberta also received the prestigious Miriam E. Brailey award from the Department of Epidemiology based on her

thesis research and scholastic accomplishments. Our Pollin Cardiovascular Prevention Fellows also have benefitted tremendously from collaborations with the Welch Center for Prevention, Epidemiology, and Clinic Research and their leaders, including drs. elizabeth selvin, eliseo Guallar, Mariana Lazo, Joe coresh, and Larry Appel.

Speaking of seamus, I am very pleased to announce that he joined the Ciccarone Center faculty in July. He recently received a Mentored Clinical and Population Research Award from the American Heart Association (AHA), with dr. Mike Blaha as his mentor. They are studying the role of coronary artery calcium scoring results in predicting cardiovascular vs. cancer causes of death across the lifespan.

Congratulations also go to Mike, our Director of Clinical Research at the Ciccarone Center, for his recent promotion to Associate Professor of Medicine. In 2017, Mike partnered with dr. Kuni Matsushita from the Welch Center to receive an NIH-sponsored R01 grant to describe the role of subclinical cardiovascular disease in adults age 75 and older. He also teamed with dr. Ana navas-Acien to submit another successful R01 grant to the FDA investigating the role of metal exposure and electronic cigarettes on cardiovascular health. Mike also received two other grants from the AHA and he is also co-investigator on two other funded studies in pulmonary hypertension and mobile health.

Mike is working closely with drs. Gary Gerstenblith, Thorsten Leucker, and steve schulman on a randomized controlled trial looking at addition of a novel cholesterol-lowering medication in persons who present to the hospital with a heart attack or unstable angina. Thorsten, our head Cardiology Fellow, is a superb clinician and vascular biologist. He has a special research interest in the role of PCSK9 (a cholesterol receptor controlling protein) on coronary artery endothelial cells, which are intricately involved in heart muscle blood flow and the development of atherosclerosis.

Our Associate Director of the Ciccarone Center, dr. erin Michos, has had another superlative academic year. She continues to do innovative work in vitamin D and cognitive decline, and is a national thought leader in cardiovascular risk assessment. She is our leader in research on women and cardiovascular disease, which has been Irene Pollin’s passion for decades.

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Message from the Director

Erin also has mentored dr. Lena Mathews on projects related to the impact of psychosocial stress on cardiovascular health, as well as sex hormones on endothelial function. In collaboration with drs. di Zhao, Vinita subramanya and wendy Ying, Erin has also examined the relationship of sex hormones with cardiovascular risk, heart failure, left ventricular remodeling, aortic stiffness, and coronary atherosclerosis, as well as brain natriuretic peptides. Erin is also an endurance athlete and completed her 30th state marathon in November — just 20 more states to go!

drs. steve Jones and seth Martin direct our rapidly growing Advanced Lipid Disorder Program and have become national leaders in the care of patients with genetic cholesterol disorders and use of novel lipid-lowering drugs. They have mentored many fellows and residents, including Osler senior resident

dr. Vasant sathiyakumar. Their paper investigating the impact of fasting status on LDL-cholesterol measures was published in Circulation, and they are currently assessing the modern day prevalence of dyslipidemia using the Very Large Database of Lipids that they designed. Their work has had a major clinical impact as exemplified by the growing national and international adoption of their algorithm for LDL-cholesterol, the most common lipid measure used in clinical practice.

dr. seth Martin has led the Ciccarone Center’s pioneering work on digital and mobile health. Seth has partnered with Hopkins Bayview Chief Medical Resident dr. Francoise Marvel in leading a large multi-disciplinary team on the Corrie Project to enhance preventive strategies after a heart attack. With funding from the Coulter Translational Research Partnership, Maryland Innovation Initiative, and Hopkins Patient Safety and Advisory Council, their promising pilot results have been recognized with competitive awards from the American College of Physicians and High Value Practice Academic Alliance. Many of us from the Ciccarone Center were also present to witness Seth’s recent wedding and we look forward to spending many fun occasions in the future with Drs. Seth and Nguyen Martin.

dr. J. Bill Mcevoy recently led an innovative randomized controlled trial, published in Circulation, that looked at the effects of a commonly used medication administered in the cardiac catheterization lab on the absorption of an antiplatelet agent Ticagrelor and its effect on platelet inhibition in persons undergoing percutaneous coronary intervention. He was also the lead author in several important papers dealing with hypertension. And we congratulate Bill and his wife, Katherine, on the birth of their daughter Rose, who joined her big sister, Aoife, in June.

dr. wendy post was recently selected to be in the inaugural group of the Mary Elizabeth Garrett Executive Leadership for Women Faculty Program. She leads the cardiovascular working group of the Multicenter AIDS Cohort Study and is the principal investigator of the Hopkins Field Center for the NIH-funded Multi-Ethnic Study of Atherosclerosis (MESA), which now begins its 18th year. Wendy, Erin, Mike, dr. Khurram nasir, and I have co-authored many important clinical research papers from this landmark study.

chiadi and I are on the writing group of the 2018 ACC/AHA Guidelines on Cholesterol Management, which contains a large section on one of the Ciccarone Center’s main areas of interest — improvements in cardiovascular risk assessment. As co-chair of the ACC/AHA subcommittee on the prevention guidelines, I am very pleased with the recently released 2017 comprehensive hypertension guidelines.

dr. Gary Gerstenblith, Chiadi, and I have led a unique collaboration with the Atlantic Coast Athletic Club to examine the physiologic effects of a multi-faceted intervention to improve cardiovascular health, reduce body fat, and improve physical fitness in adults with the metabolic syndrome (prediabetic state). This project builds upon the pioneering efforts of Irene Pollin to deliver comprehensive lifestyle modification to both women and men.

In summary, the legendary Hall of Fame lacrosse coach and player, Henry Ciccarone, has truly inspired an expanding team of educators, researchers, and clinicians to better prevent and manage cardiovascular disease. And our work is made possible thanks to the leadership and sustained support of our friends, such as nick and suellen paleologos, Mario Manuli, hal and Jane Magruder, Ginger Gomprecht, Thad and Totty shelley, don and Rosie shepard, and so many others. All of our benefactors and research partners are our true Most Valuable Players and All-Americans.

Roger s. Blumenthal, Md, FAcc, FAhA, FnLA The Kenneth Jay Pollin Professor of CardiologyDirector, The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease

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Nick and Suellen Paleologos

Irv and Ginger Gomprecht

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News & Highlights

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This past year has been a momentous one for the Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease. We continue to achieve our goals and our work in creating excellent clinical care, educating health care practitioners, and studying better ways to prevent heart disease, stroke, and peripheral arterial disease.

Congratulations to Tiffany Eatz, a recent graduate of Johns Hopkins University with a triple major in neuroscience, writing seminars, and medicine, and a minor in theater. With assistance from Drs. Roger Blumenthal and Seth Martin, Tiffany published two cardiology-related articles at the US News “Health Care” website, “Patients and Clinicians Unite Part One: the ABCs of Heart Disease,” and “Tailored Treatment Is the Best Fit.” Tiffany also served as the coordinator of Arts for Hearts, a Hopkins-sponsored American Heart Association performing arts benefit showcase, which she created in 2015. Elizabeth Ratchford, MD, also made a contribution to the US News “Health Care” site, providing the April column about peripheral arterial disease (PAD), “Problems Walking? It May Be Your Arteries, Not Your Age.” Dr. Ratchford, a vascular medicine specialist, hopes the article will serves as a good reference for patients who are at risk for PAD.

Drs. Ratchford and Martin also recently co-authored a Patient Information Page entitled “Statins” for Vascular Medicine, the official journal of the Society for Vascular Medicine. Dr. Ratchford serves as the co-editor of the section, which

is an excellent resource on a variety of vascular conditions, and also authored another recent patient article on “The Swollen Leg.”

Kudos to Dr. Martin and Francoise A. Marvel, MD, a Chief Resident in Internal Medicine at Johns Hopkins Bayview Medical Center and a HEXCITE Fellow in the Technology Innovation Center, who were tapped this summer to tell the story of their Corrie Digital Health Project in Cardiology Today. Running in the August issue, the article chronicles the complexities, challenges and ultimate success of creating the first cardiology-focused Apple CareKit app with Apple Watch iOS. Working in close collaboration with Apple Inc., Drs. Martin, Marvel and team developed a digital platform, nicknamed “Corrie,” to enhance the recovery process for acute MI patients across the care continuum from the inpatient setting to home. The app provides an opportunity for patients to become more actively involved in their health care management during hospitalization, to learn medications

and build skills, and to be better prepared for hospital discharge.

Congratulations to Michael J. Blaha, MD, MPH, who was promoted to the rank of Associate Professor of Medicine in the Division of Cardiology in January 2017. Dr. Blaha is one of the most prominent young investigators in the field of preventive cardiology and has emerged as one of the leaders shaping the field worldwide. He joined the Johns Hopkins faculty as Assistant Professor of Medicine and Director of Clinical Research for the Ciccarone Center for the Prevention of Cardiovascular Disease in January 2013, with a joint appointment in the Department of Epidemiology at the Bloomberg School of Public Health. Since then, he has displayed tremendous productivity and international leadership in his field. Dr. Blaha’s promotion was granted based on his research contributions in the field of preventive cardiology and his national recognition with secondary emphasis on his mentorship, teaching, and clinical activities.

Tiffany Eatz

Are fitness trackers good for your heart health? “Yes!” says Seth Martin, MD, MHS, in a nifty new “Health Hack” video series produced by Johns Hopkins. The video, which is featured at http://www.hopkinsmedicine.org/health/healthy_heart, is based on one of Dr. Martin’s many published articles.

Francoise A. Marvel, MD

Elizabeth Ratchford, MD

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News & Highlights

Under the co-directorship of Steven Jones, MD, and Dr. Martin, the Ciccarone Center Advanced Lipid Disorders Program has thrived

this past year. The multidisciplinary program now involves a dietitian, genetic counselor, nurse practitioner, and the specialty pharmacy. The clinic cares for

patients with genetic dyslipidemias, including familial hypercholesterolemia, familial combined hyperlipidemia, and familial hypertriglyceridemia, as well as patients with statin intolerance, HDL disorders, and elevated Lp(a). The program has seen exponential growth, with multiple daily referrals from the Baltimore region, around the country, and internationally. The Ciccarone Advanced Lipid Disorders Clinic sees over 700 new patients per year and has become a national leader in use of novel lipid lowering therapies such as PCSK9 inhibitors. The clinic has a success rate of approximately 90% in gaining insurance coverage for PCSK9 inhibitor therapy in appropriate patients as compared with a national rate of <50%.

Drs. Martin and Jones, along with their Ciccarone colleagues, published a novel algorithm for LDL-C estimation in the Journal of the American Medical Association in 2013. The algorithm uses an adjustable approach to provide a personalized, more precise LDL-C estimate.

This past year, Seamus Whelton, MD, a new Ciccarone Center faculty member, led a collaboration of Hopkins with Mayo Clinic to apply the new LDL-C algorithm to each hospital’s laboratory data, and the nationally representative NHANES cohort. The innovative analysis showed clinically important improvement using the new algorithm. The algorithm has been validated by groups in the US and abroad over the

past year. It is now available as LDL Cholesterol Calculator, a smartphone app in the Apple and Android stores, and has been implemented in practice by the leading laboratory in the US,

Quest Diagnostics. It has also been implemented in laboratories in Brazil, Mexico, Puerto Rico, Japan, and Korea.

Congrats to Cathy Handy, MD, MPH, a medical oncology fellow at the Sidney Kimmel Comprehensive Cancer Center. Her interest in the relationship between cardiovascular disease risk factors

and cancer outcomes earned her a 2017 Young Investigator Award from the American Society of Clinical Oncology. Dr. Handy collaborated with her senior mentor, Dr. Blaha, to create

the FIT-Cancer cohort examining the relationship between fitness and cancer.

Peter Toth MD, PhD, announced that he recently completed a two-year term as president of the American Board of Clinical Lipidology. He was also named chairman of the American Society of Preventive Cardiology’s advanced course on preventive cardiology.

Drs. Chiadi Ndumele, Gary Gerstenblith and Roger Blumenthal recently received a grant from the American Council on Exercise that will help fund a pilot trial of lifestyle intervention in participants with the

metabolic syndrome, a highly prevalent condition that predisposes to diabetes and is associated with markedly elevated risk of cardiovascular events. The program

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Articles for Living a heart-healthy Life Since 2014, the staff of the Ciccarone Center have been contributing cardiovascular health-related articles to “Healthy Heart,” a section of the Johns Hopkins Medicine website devoted to patient-friendly content. Written for a lay audience, the articles are designed to serve as an expert advice column and a resource to patients and others interested in improving their health. The following is a list of some of the articles written and published in the past year:

“Heart Health Tips,” written by Dr. Blaha“Alcohol and Heart Health: Separating Fact from Fiction,” written by Dr. McEvoy“Managing High Blood Pressure: A Personalized Approach,” written by Dr. McEvoy“Older Adults and High Cholesterol: What You Need to Know,” written by Dr. Martin“Erectile Dysfunction and Your Health: 5 Things You Need to Know,” written by Dr. Blaha“Difficult Pregnancies and the Risk of Heart Disease,” written by Dr. Michos“Are You Getting Enough (or Too Much) Calcium?” written by Dr. Michos“Dementia and Heart Health: Are They Related?” written by Dr. Martin“Sitting Disease: How a Sedentary Lifestyle Affects Heart Health,” written by Dr. Michos“Better Care for All,” written by Dr. Golden“Exercise, Good for Heart Health Too!” written by Dr. Ndumele“Obesity, Sugar and Heart Health,” written by Dr. Ndumele

Steven Jones, MD

Seamus Whelton, MD

Cathy Handy, MD

Chiadi Ndumele, MD

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News & Highlights

includes physical activity, nutrition, sleep, and stress assessments with targeted recommendations and interventions delivered at Atlantic Coast Athletic Club (ACAC), a community-based fitness center, over a six-month period. The goal is to assess how well the program can assist the participants in changing their lifestyle goals and habits, maintaining adherence to those goals while in the program and then persistence of those changes during a follow-up period. It will also assess the impact of the program on novel cardiovascular risk factors, including inflammatory markers and mediators.

Dr. Gerstenblith was named a co-investigator on an NHLBI grant awarded to Dr. Robert Weiss that examines energetic profiles in patients with heart failure using magnetic

resonance methodology. Recent studies from the laboratory demonstrated altered skeletal muscle high energy phosphate decline and recovery trajectories during

and following exercise in heart failure patients as compared with those of healthy individuals. The findings were particularly marked in those with the type of heart failure more common in older individuals.

Compliments to Dominique Ashen PhD, CRNP, and Elizabeth Ratchford, MD, whose joint effort between the Ciccarone Center and the Center for Vascular Medicine led to the development of a center of cardiovascular disease (CVD) prevention for firefighters. CVD accounts for approximately 50% of deaths among on-duty firefighters; early detection and treatment of CVD risk factors may prevent disability and death. Drs. Ashen and Ratchford have completed two studies, funded by the National Fallen Firefighters Foundation, that have focused on methods of

detection of subclinical atherosclerosis (CVD without symptoms) and primary prevention of CVD (avoiding its initial occurrence) in firefighters through risk assessment and risk reduction. Strategies for risk assessment and risk reduction include coronary artery calcium scan and blood work, as well as education about a healthy diet, aerobic exercise, maintenance of a normal weight, and tobacco cessation. Their first study was published in the American Journal of Cardiology. They are now working on a second manuscript to include the cost-benefit analysis of a CVD prevention program that can be utilized by fire departments throughout the nation. In September 2017, the CVD prevention program expanded to fire departments in two Maryland counties and two clinics.

Congratulations to Wendy Post, MD, on her selection to participate in the inaugural cohort of the Mary Elizabeth Garrett Executive Leadership for Women Faculty Program sponsored by the Johns Hopkins Office of Women in Science and Medicine.

Roberta Florido, MD, was selected by the Honors and Award Committee at the Johns Hopkins School of Public Health to receive the Miriam E. Brailey Fund award from the department of epidemiology. Dr. Florido, one of only a few students in the school to receive this award, was honored for her background, thesis research, and scholastic accomplishments. She is also working with Erin Michos, MD, looking at the association of physical activity with cardiac structure, function, and fibrosis, using MRI data.

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dr. Blumenthal to collaborate with uc Berkley on cardiology white papersThe Ciccarone Center is pleased to announce that Roger Blumenthal, Md, has begun collaboration with the University of California, Berkeley, School of Public Health, to produce three annual consumer health publications: the “Coronary Heart Disease White Paper,” the “Heart Attack Prevention White Paper,” and the “Hypertension and Stroke White Paper.” The UC Berkeley White Papers are a series of disease-specific publications designed for people with chronic conditions who desire accurate, comprehensive, up-to-date and easy-to-understand information to enable them to better manage their health. Dr. Blumenthal’s involvement with these publications dates to 1996 when they were produced under a former partnership between Remedy Health Media and Johns Hopkins University. Dr. Blumenthal also reviews and edits content for a related website, HealthAfter50.com, which provides the latest evidence-based research and expert advice on the prevention, diagnosis, and treatment of a wide range of health conditions affecting adults in middle age and beyond, including cardiovascular disease.

Gary Gerstenblith, MD

Dominique Ashen, PhD, CRNP

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News & Highlights

Kudos to Ty Gluckman, MD, an adjunct faculty member of the Ciccarone Center, who was recently promoted at the Providence Health & Services in Portland, Ore., to Medical Director of a newly formed Center for Cardiovascular Analytics, Research, and Data Science.

Sherita Golden, MD, MHS, who serves as the Hugh P. McCormick Family Professor of Endocrinology and Metabolism, and is Executive Vice-Chair,

Department of Medicine, at Johns Hopkins University, is the 2017 recipient of the Walter Reed Distinguished Achievement Award, presented by the University of Virginia School of Medicine, Medical Alumni Association, and Medical School Foundation.

With the guidance of Dr. Ratchford, the Johns Hopkins Center for Vascular Medicine recently opened a new, comprehensive vascular ultrasound laboratory at Green Spring Station. The new center, which will soon be expanding to Howard County, offers several vascular exams, including screening for blockages in the neck arteries, for abdominal aortic aneurysm, or for blood clots in the leg arteries.

Dr. J. Bill McEvoy was awarded second place nationally in the Junior Clinical Faculty Research Awards competition at the Northwestern Cardiovascular Young Investigators’ Forum 2017 for his article, “Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition during PCI: The PACIFY Randomized Clinical Trial.”

Michael Fliotsos, a second-year medical student at Johns Hopkins, worked as a summer intern in the Ciccarone Center under the supervision of Dr. Michos on a project analyzing the relationship between lifetime weight history and risk of incident heart failure and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Michael worked on the project for his Scholarly Concentration project through the Johns Hopkins University School of Medicine and is preparing an abstract and manuscript for submission. stanley L. Blumenthal, Md cardiology Research AwardsSince 2004, the annual Stanley L. Blumenthal, MD, Preventive Cardiology Research Awards have been presented to the Hopkins postdoctoral fellows, graduate students, or housestaff submitting the best abstracts to major research meetings, such as the American Heart Association or American College of Cardiology Scientific Sessions. The awards were established in 2003 by the family and friends of the late Dr. Stanley L. Blumenthal, a Phi Beta Kappa graduate of Johns Hopkins University and the School of Medicine. Dr. Blumenthal began his pediatrics training at Hopkins before moving to the University of Michigan to be a senior resident and then to Harvard’s Boston Children’s Medical Center to do Pediatric Cardiology training. He then worked at the National Children’s Medical Center in D.C. and George Washington University, and he had a large clinical practice in Silver Spring, Md.

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disrupting the secondary care Model According to seth Martin, Md, Mhs, and the interdisciplinary team behind Corrie, a smartphone app that delivers the knowledge, skills, and tools to help

patients take charge of preventive care, the technology is re-engineering secondary prevention care and has made considerable strides this past year. Dr. Martin and Francoise A. Marvel, Md, have conducted clinical testing at Johns Hopkins Hospital and Johns Hopkins Bayview, with exciting early results on app use and patient outcomes in the first 50 patients. Other hospitals taking notice of Corrie include the University of Michigan, Massachusetts General Hospital, MedStar, and Reading Hospital. The project has received research support from the Wallace H. Coulter Translational Research Partnership,

TEDCO Maryland Innovation Initiative, Hopkins Patient Safety & Advisory Council, Reading Hospital Foundation, iHealth, Stanford Med X/Nokia, and Apple. The Corrie team has been recognized as an innovative digital and mobile health platform by the American College of Physicians, Stanford Medicine X Global Challenge, and at the Johns Hopkins Cardiology Research Retreat. The Corrie team also completed I-Corps, a program that prepares scientists and engineers to extend their focus beyond the university to accelerate the economic and societal benefits of research.

J. Bill McEvoy, MD

Michael Fliotsos

Sherita Golden, MD, MHS

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News & Highlights

Each year, the awards are bestowed following the division’s yearly cardiovascular research retreat. This year’s presentations and awards

ceremony, held May 20, and organized by David Kass, MD, Director, Institute of CardioScience, featured lectures on cutting-edge cardiovascular disease science by Zoltan Arany, MD, PhD, from University of Pennsylvania, Samia Mora, MD, MHS from Harvard Medical School, as well as Narutoshi Hibino, MD, PhD, and Douglas Robinson, PhD, from Johns Hopkins. Cash prizes and handsome certificates

suitable for framing were awarded to the following outstanding young cardiovascular disease researchers.

First place in the ORAL COMPETITION went to former Chief Cardiology Fellow Klitos Konstantinidis, MD, for his presentation, “CaMKII, Methionine Oxidation, and Aortic Aneurysm.” His faculty mentor is Mark Anderson, MD, PhD, The William Osler Professor of Medicine.

Four others tied for second place: 1) Thorsten Leucker, MD, PhD, for “Serum PCSK9, a Nexus for HIV-Induced Coronary Artery Endothelial Dysfunction,” with senior mentors Allison Hays, MD, and Robert Weiss, MD; 2) Kaustubha Patil, MD, for “Studying the Pathophysiology of Pulseless Electrical Activity in a Novel Swine Model,” with senior mentor Henry Halperin, MD; 3) Seamus Whelton, MD, MPH, for “Modeling the Relationship Between Coronary Artery Calcium and Cause-Specific Mortality,” with senior mentors Michael Blaha, MD, MPH and Roger S. Blumenthal, MD; and 4) Aditya Bhonsale, MD, for “Cardiomyopathy/RV Dysplasia Patients with Late Presentation,” with senior mentor Hugh Calkins, MD.

First place in the BASIC SCIENCE POSTER COMPETITION went to Nicola Diny, PhD, for “Eosinophil-derived IL-4 Drives Progression of Myocarditis to Dilated Cardiomyopathy”; her senior mentor was Daniela Cihakova, MD, PhD. Second prize was awarded to Grace Kim, PhD, for “Canonical Transient Receptor Potential Channel 6 Ameliorates Increased Cardiac S-Nitrosylation”; her senior mentor was David Kass, MD. William Schmidt, PhD, took third place for “Influence of Actin Pseudoacetylation on in vivo and in vitro Cardiac Performance”; his senior Mentor was Anthony Cammarato, PhD.

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Focusing on Gender differences in heart diseaseDr. Erin Michos, Associate Director of the Ciccarone Center, continues to do innovative work in vitamin D and cognitive decline, and has emerged as a national thought leader on gender differences in heart disease and for her excellent mentoring skills. Her current projects related to heart disease in women include the following:1. Associations of psychosocial stress and their impact ideal cardiovascular health

(Baptist Health Employee Study). First author Dr. Lena Mathews. Accepted at the Journal of Women’s Health.

2. Associations of sex hormones and risk for cardiovascular disease and heart failure in women (MESA). First author Dr. Di Zhao. Abstract presented at AHA 2017.

3. Associations of sex hormones and left ventricular remodeling in women (MESA). First author Dr. Vinita Subramanya. Published in Maturitas (2017)

4. Associations of sex hormones and aortic stiffness in women (MESA). First author Dr. Vinita Subramanya. Abstract presented at AHA 2017.

5. Association of sex hormones and coronary artery calcium in women (MESA). First author Dr. Vinita Subramanya. Abstract submitted to AHA’s Epidemiology and Prevention 2018.

6. Associations of sex hormones and brachial reactivity in women (MESA). First author Dr. Lena Mathews. Abstract submitted to AHA’s Epidemiology and Prevention 2018.

7. Associations of sex hormones and 10-year change in brain natriuretic peptide (MESA). First author Dr. Wendy Ying. Abstract submitted to AHA’s Epidemiology and Prevention 2018.

Klitos Konstantinidis, MD

Allison Hays, MD

David Kass, MD

Wendy Ying, MD

Grace Kim, PhD

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News & Highlights

Osler Medical Resident Vishal Rao, MD, MPH, took first prize in the EPIDEMIOLOGY POSTER COMPETITION for “Anthropometric Measures vs. CT-Measures of Adiposity and Risk of Incident Heart Failure and

Heart Failure with Preserved Ejection Fraction”; his senior mentor was Erin Michos, MD, MHS. Roberta Florido, MD, earned second place for “Physical Activity and Incident Heart

Failure in High Risk Subgroups”; her senior mentor was Chiadi Ndumele, MD, MHS.

First place in the CLINICAL SCIENCE POSTER COMPETITION went to Francoise Marvel, MD, for “A Novel Digital and Mobile Health Platform to Enhance Recovery from Myocardial Infarction”; her senior mentor was Seth Martin, MD, MHS. Second place went to Jiun-Ruey Hu, MPH, for “Metabolic Footprint of Bariatric Surgery”; his senior mentor was Chiadi Ndumele, MD, MHS.

Congratulations to all the winners!

p.J. schafer cardiovascular Research AwardThe P.J. Schafer Cardiovascular Research Award funds the efforts of clinical investigators seeking a better understanding of how to diagnose premature heart disease and prevent sudden cardiac death. Previous recipients of this prestigious award, which is given to a junior faculty member, include Drs. Erin Michos, Richard George, Saman Nazarian, RhondalynMcLean, Oscar Cingolani, Chiadi Ndumele, Michael Blaha, Allison Hays, J. Bill McEvoy, and Seth Martin.

The 2017-2018 P.J. Schafer award winner is Seamus Whelton, MD, MPH. Dr. Whelton joined the Johns Hopkins cardiology faculty in July as an Assistant Professor of Medicine and is a member of the Ciccarone Center for the Prevention of Cardiovascular Disease. His primary research and clinical focus is cardiovascular prevention and his research includes examining how we can best use coronary artery calcium (CAC) seen on a CT scan of the heart for the prediction of cardiovascular disease events in asymptomatic patients. He is also interested in using CAC and other traditional cardiovascular risk factors, such as fitness, to determine the risks of cardiovascular and cancer mortality.

In addition, Dr. Whelton has performed research investigating high-sensitivity cardiac troponin (a marker of damage to the heart muscle) as a risk factor for diabetes. Clinically, he has a focus on preventive cardiology and he also reads cardiac CT scans to evaluate whether or not patients without typical symptoms of a heart attack may have a narrowed or blocked coronary artery. Hopkins Cardiology is indebted to Paul and Vivian Schafer and the Board of the P.J. Schafer Foundation for their hard work and generous contributions in support of cutting-edge research geared to the prevention of sudden cardiac death, which tragically took the life of their son, P.J.

To make donations or sign up for the P.J. Schafer golf tournament, visit www.pjschafer.com.

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Vishal Rao, MD, MPH

Vasanth sathiyakumar, MdUnder the guidance of Drs. Seth Martin, Steve Jones, and Roger Blumenthal, Vasanth Sathiyakumar, MD, has focused his work

in the past year on investigating the impact of fasting status on low-density lipoprotein cholesterol and assessing the modern-

day prevalence of the Fredrickson-Levy-Lees dyslipidemias. In medical school, he helped publish over

40 articles, primarily in orthopaedics, learning to use “big data” — skills he is applying now to research

involving the Very Large Database of Lipids. He has also been involved in several prospective studies,

including a collaboration with the Bayview Heart Failure Bridge Clinic to study innovative preventive

applications of digital devices on heart failure and a consortium to investigate the prevalence of familial

chylomicronemia syndrome. He plans to continue his work over a dedicated research year at the

Ciccarone Center next year, followed by cardiology fellowship, where he plans to specialize in

preventive cardiology.

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News & Highlights

More Than 250!

The Ciccarone Center publishes important original research articles, editorials, and review articles in many of the world’s top cardiology, internal medicine, epidemiology, and endocrinology journals. From October 2016 to September 2017, the Center showed amazing productivity, publishing more than 250 articles of significant basic and clinical research findings, commentaries, and review articles in many leading medical journals, including:

American Heart Journal (4)

American Journal of Cardiology (12)

American Journal of Epidemiology (2)

American Journal of Medicine (5)

Annals of Internal Medicine (2)

Arteriosclerosis Thrombosis & Vascular Biology (1)

Atherosclerosis (13)

Circulation (12)

Circulation: Cardiovascular Imaging (3)

Circulation: CV Genetics (2)

Circulation: CV Quality & Outcomes (1)

Circulation: Heart Failure (1)

Diabetes Care (4)

European Heart Journal (2)

EHJ: Cardiovascular Imaging (3)

Hypertension (1)

Journal of the American Heart Association (9)

Journal of the American Medical Association (3)

JAMA Cardiology (9)

Journal of the American College of Cardiology (6)

JACC Cardiovascular Imaging (11)

JACC Heart Failure (3)

Journal of Clinical Lipidology (11)

Lancet (1)

Mayo Clinic Proceedings (4)

New England Journal of Medicine (1)

PLoS One (8)

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our donors Make an invaluable differenceThe impact of philanthropy is immeasurable. It enables research, education and clinical care to advance beyond the limitations of budgetary constraints and diminished federal funding. We are truly grateful to our generous contributors. They assist in our efforts and partner with us as we remain at the forefront of scientific investigation and collaboration in all areas of cardiovascular disease prevention.

While our space here is limited, please know our gratitude is not. Philanthropic support of any amount has been greatly appreciated, but we’d like to take this opportunity to thank the following donors for their extraordinary investment in our clinical research and activities over the past year:

Richard and Katherine Amato

Mr. and Mrs. Richard AmatoMr. Michael AmatoMr. David AnsellMr. Terry A. ArensonMr. and Mrs. Leonard J. AttmanMr. Harry BrafmannMr. and Mrs. G. Ronald BrownMr. Edgar I. CalinMr. and Mrs. Edward CaselMr. Frank CurtisMr. William DevineMs. Mary Dickerman Mr. and Mrs. James EllenbergerDr. Michael EzekowitzMr. and Mrs. Mark FischerMrs. Virginia GomprechtMr. John HeymanDr. and Mrs. Martin KaufmanMr. and Mrs. Charles Knudsen IIIMs. Joyce C. KoonsMr. and Mrs. Jerome Leibowitz

Mr. and Mrs. Michael LenkinNorman C. Lerner, Ph.D.Mr. Larry LevyMr. and Mrs. Hal MagruderMr. Mario ManuliDr. Medea MarellaMr. Paul Mellott, Jr.Mr. and Mrs. James MillerMr. Daniel D. Moore, Jr.Mr. and Mrs. Jay MorsteinMr. and Mrs. Nicholas PaleologosMr. and Mrs. Joseph Popovich, Jr.Mr. and Mrs. Paul SchaferMs. Diane SchnitzerMr. and Mrs. Thad ShellyMr. and Mrs. Donald J. ShepardMr. and Mrs. Carter C. ShepherdMr. Daniel WagnerCaprice M. Uhlhorn, Ph.D.Mr. and Mrs. Robert Zucker

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Simple as A B C

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The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease has identified a simple and effective way to reduce one’s risk of cardiovascular disease. our “ABcde” method — which stands for Assessment of risk, Antiplatelet therapy; Blood pressure management; cholesterol management, cigarette/tobacco cessation; diet and weight management, diabetes prevention and treatment; and exercise — organizes the national guidelines into a comprehensive plan for managing prevention. This tool is intended to provide a brief set of instructions for people to discuss with their doctors.

Assessing Your cVd RiskAn adult can estimate his or her risk of heart attack

or stroke over the next 10 years by using the atherosclerotic cardiovascular disease (ASCVD) risk calculator: http://clincalc.com/Cardiology/ASCVD/PooledCohort.aspx.

An Aspirin a dayA small dose of aspirin (81 mg) daily may lower the risk of a heart attack and stroke. In many patients who have had a heart attack or have heart stents, adding another antiplatelet medicine, such as clopidogrel, to daily aspirin can add additional benefit. Aspirin is generally recommended for people with 1) an ASCVD risk estimate >10% (if not at high risk for bleeding); 2) those who have known atherosclerosis; and 3) diabetes (if at least 40 years of age).

Blood pressure — Go LowHigh blood pressure is a significant cause of heart

attack, stroke, kidney disease, and dementia. Hypertension is defined as a blood pressure of >130/80. Recent clinical trial data indicates that a person over age 50 with a cardiac risk factor should likely strive for a systolic blood pressure of <125. Lifestyle interventions, including regular aerobic exercise, eating a diet low in salt and high in fruits and vegetables, losing excess weight, and reducing alcohol intake, all lower blood pressure.

Cholesterol Therapy a MustCholesterol gradually builds up on the walls of arteries

over time, leading to atherosclerosis. Healthier dietary habits and increased exercise remain the two best ways to improve cholesterol, but often a statin and/or other medication is employed to lower cardiovascular risk.

Cigarette/Tobacco cessationSmoking increases the risk of heart attack and stroke and is linked to multiple types of cancers. If you smoke, make every concerted effort to stop. Develop a plan to quit, and set a quit date. Resources are available to help you stop smoking, including nicotine replacement therapies and prescription medications. Contact 1-800-QuiT-now.

Diabetes prevention and TreatmentBoth diabetes and pre-diabetes can lead to heart

disease, stroke, kidney failure, blindness, and amputations. You can help diagnose diabetes by checking a fasting blood sugar or hemoglobin A1c (HbA1c) levels. A measured HbA1c of 5.7-6.4% represents pre-diabetes, while a level of 6.5% or more represents diabetes. Weight loss and improvements in diet and exercise help prevent the development of diabetes. If you are a diabetic, you may need medications, such as metformin or insulin, for optimal diabetes control.

Diet and weight ManagementA healthy diet should be rich in fruits, vegetables, and whole grains, along with low-fat dairy products, poultry, fish, legumes, and nuts. Sweets, sugar-sweetened beverages, red meat, and simple carbohydrates found in white breads, pastas, and white rice should be minimized.

Weight and height are measured to calculate body mass index, or BMI. Normal BMI is 18-24.9 kg/m2; 25-29.9 kg/m2 is considered overweight; and > 30 kg/m2 indicates obesity. Making sustained improvements in diet and exercise can aid in weight loss. The recent guidelines point out that the loss of at least 5% of body weight via a low-calorie diet, combined with an increase in physical activity, can improve many risk factors.

Exercise is KeyExercise helps us lose weight, stay healthy, and feel better. A good exercise

program consists of aerobic activity, strength training, and flexibility exercise. Guidelines recommend 3-4 sessions a week, lasting on average 30-40 minutes per session, involving moderate- to vigorous-intensity physical activity. Reduce sitting time and aim for >10,000 steps/day of walking.

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Take control of your ABcs! For more information, call the Johns hopkins ciccarone center for the prevention of cardiovascular disease at 410-955-7376.www.hopkinsmedicine.org/heart

Personalized prevention advice is the trademark of the Ciccarone Center.

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What is the Ciccarone Center?

since 1990, the mission of the ciccarone center for the prevention of cardiovascular disease has been three-fold:• To create excellent clinical care for

people at risk of developing heart disease

• To educate health care practitioners about how to better identify and care for patients at risk of developing heart disease

• To establish rigorous research programs to study better prevention of cardiovascular disease

Relentless pursuit of these goals over the past two decades has led to the creation of one of the fastest growing clinical and research programs at Johns Hopkins, which is highly regarded for its innovative and effective approaches to cardiovascular disease prevention and treatment.

clinical careThe trademark of the Ciccarone Center is its comprehensive approach, which involves both global assessment and aggressive management of multiple risk factors (not just single risk factors, such as high blood pressure or high cholesterol) contributing to the development and progression of atherosclerosis. Our clinical center is dedicated to:• The detection and management of

individuals at risk for accelerated atherosclerosis (primary prevention) to prevent or delay the onset of cardiovascular disease, and

• The management of patients with established vascular disease (secondary prevention) to reduce recurrent cardiovascular events and decrease mortality.

educationOur educational efforts are aimed at both the medical community and the general public. The Ciccarone Center also serves as a model for teaching the art of prevention of cardiovascular disease to fellows, residents, and students at the Johns Hopkins School of Medicine and the Bloomberg School of Public Health.

Our physicians and nurse practitioners are also lecturers for medical and nursing students and physicians at Hopkins and at national meetings. Hopkins Medicine also organizes meetings to address educational issues for the public.

ResearchAs part of Johns Hopkins, the Ciccarone Center for the Prevention of Cardiovascular Disease is committed to conducting cutting-edge research on atherosclerosis and risk factors for heart disease. We conduct research on two levels:• Clinical research studies of

cardiovascular disease involving informed, consenting adults, and

• Basic research and experiments to decipher the molecular reactions leading to atherosclerotic vascular disease.

A personalized, comprehensive Approach The Ciccarone Center specializes in managing adults who are at high risk for future cardiovascular disease because of the presence of multiple cardiac risk factors (such as hypertension, dyslipidemia, diabetes, smoking, sedentary lifestyle, or overweight status) or a history of known cardiovascular or peripheral arterial disease.

The Ciccarone Center’s personalized, comprehensive approach to lifestyle and medical management can slow the progression of cardiovascular disease and decrease one’s future risk of a heart attack, stroke, bypass surgery, angioplasty, or stenting. We also sponsor research that includes both clinical trials and basic molecular studies.

Several groups of patients have been of particular interest to the Ciccarone Center:• Women and ethnic minorities• Patients with metabolic disorders, in

particular, inherited dyslipidemias, the metabolic syndrome, and diabetes

• Patients with accelerated atherosclerosis

• Persons with a family history of coronary heart disease or stroke

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Khurram nasir Md, Mph Now an adjunct faculty member of the Ciccarone Center, Khurram Nasir MD, MPH, has had a busy year. Dr. Nasir served as the Executive Director of the Baptist Health South Florida Research Institute, as well as Director of the Center for Healthcare Advancement & Outcomes and the principal investigator for the prospective Miami Heart Study. He also currently sits on the Board of Directors of the American

Society of Preventive Cardiology and serves as Associate Editor for Circulation: Quality of Care and Outcomes and an editorial board member for Circulation. Dr. Nasir says his major focus lately has been on population health and learning health system research, with an interest in four specific areas: 1) facilitating integrative data analytics architecture to support information driven healthcare decisions; 2) creating a framework to assess processes of care to improve quality, outcomes and efficiency; 3) evidence appraisal to facilitate the transition from current fee-for-service to a value-based model; and 4) optimizing prevention programs for population health management, with an emphasis on preventing financial risk.

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What is the Ciccarone Center?

• Persons with recurrent chest pain but no established cardiovascular disease

• Persons who have been intolerant of standard cholesterol or blood pressure medications

state-of-the-Art TestingWe are especially interested in individuals who develop cardiovascular disease before the age of 65. We have special expertise in the screening and management of asymptomatic family members of persons with premature atherosclerotic disease. Our team may selectively employ state-of-the-art testing to help identify factors contributing to heart disease clustering in families.

For an individual patient, we may use the latest assessment techniques to measure lipoproteins (total cholesterol, high-density lipoprotein-cholesterol [HDL-C], LDL-C, and triglyceride levels) and apolipoproteins (Lp[a], apolipoprotein B) as well as nontraditional risk factors, such as high-sensitivity C-reactive protein (hsCRP), and measurements of lipoprotein size and number. However, for many individuals these emerging risk factors are often not needed to optimize their management in a cost-effective manner.

Advanced diagnostic Tools Among asymptomatic adults with no history of cardiovascular disease, we may use a 64-slice or a 320-slice multidetector computed tomography (MDCT) scan of the chest to measure the amount of coronary artery calcification. The presence of elevated coronary artery calcification (e.g. > 75th percentile for one’s age and gender) or thickened carotid arteries is a sign of accelerated atherosclerosis for one’s age and may lead to more aggressive attempts at comprehensive risk factor changes through both medical management and lifestyle modification. Occasionally, a cardiac CT angiogram may also be indicated in patients with atypical chest pain and inconclusive stress test results. After an initial comprehensive evaluation, we can inform a patient whether his/her management might be changed by some of the more sophisticated laboratory and diagnostic testing that we can provide.

improving Lifestyle habitsDominique Ashen, PhD, CRNP, and Kathy Byrne, CRNP, nurse practitioners who specialize in helping people improve their lifestyle habits, assist patients with behavior changes such as:• Following healthier diets• Maintaining a prudent body weight• Smoking cessation• Maintaining a regular aerobic

program• Coping better with stress

our Mission

We have built the Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease with the following goals in mind:

1. Provide a center dedicated to clinical patient care and the global assessment of risk factors for cardiovascular disease, which enables patients to receive:

• the latest information on the prevention of atherosclerotic vascular disease,

• comprehensive management of risk factors for cardiovascular disease, and

• high-quality care that is integrated into the other health promotional resources of Johns Hopkins.

2. Create a center at Johns Hopkins for the education of health care providers in the area of prevention of cardiovascular disease. Teaching by our physicians and nurse practitioners broadly targets Hopkins nurses, medical students, fellows, and physicians as well as the community at large.

3. Foster cardiovascular research, including both clinical trials and translational research.

Faisal Rahman, MdOver the past year, Dr. Faisal Rahman published an article on the adverse outcomes of low diastolic blood pressure, or the J-curve phenomenon. His current research areas of interest include exploring outcomes of patients admitted with cardiovascular disease to the hospital and preventing prolonged hospitalization and readmissions. Dr. Rahman received his medical degree from the University of Oxford, England, and did his residency at Boston University Medical Center, where he was also chief medical resident before coming to Johns Hopkins for a cardiology fellowship. He performed research on atrial fibrillation and flutter with the Framingham Heart Study while he was at Boston University.

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Research Publications

A listing of the publications by the staff of The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, from October 2016 through September 2017.

Assessment of cVd Risk1. Patel J, Al Rifai M, Caínzos-Achirica M, Kandula NR, Kanaya AM, Khera A, Blumenthal RS, Nasir K, Blaha MJ, Joshi PH. Family History of CHD Is Associated With Severe CAC in South Asians: Comparing the MASALA and MESA Studies. JACC: Cardiovascular Imaging. 2017 Aug;10(8):958-960. Summary: A family history of coronary disease was associated with a severe coronary artery calcium (CAC) burden in a South Asian population living in the U.S. similar to other ethnic groups.

2. Blaha MJ, Whelton SP, Al Rifai M, Dardari ZA, Shaw LJ, Al-Mallah MH, Matsushita K, Rumberger JA, Berman DS, Budoff MJ, Miedema MD, Nasir K. Rationale and design of the coronary artery calcium consortium: A multicenter cohort study. Journal of Cardiovascular Computed Tomography. 2017 Jan - Feb;11(1):54-61.Summary: The consortium data set is uniquely positioned to expand the understanding of CAC as a predictor of mortality risk across the spectrum of disease states.

3. Sharma K, Al Rifai M, Ahmed HM, Dardari Z, Silverman MG, Yeboah J, Nasir K, Sklo M, Yancy C, Russell SD, Blumenthal RS, Blaha MJ. Usefulness of coronary artery calcium to predict heart failure with preserved ejection fraction in men versus women (from the Multi-Ethnic Study of Atherosclerosis). American Journal of Cardiology. 2017 Aug 7. pii: S0002-9149(17)31295-X.Summary: Measurement of coronary artery calcium may stratify risk of heart failure with preserved ejection fraction beyond traditional risk factors for women.

4. Kianoush S, Mirbolouk M, Makam RC, Nasir K, Blaha MJ. Coronary artery calcium scoring in current clinical practice: How to define its value? Current Treatment Options in Cardiovascular Medicine. 2017 Sep 25;19(11):85.Summary: Detecting subclinical atherosclerosis with coronary artery calcium supports a stronger recommendation for its use in future prevention guidelines.

5. Hecht HS, Cronin P, Blaha MJ, Budoff MJ, Kazerooni EA, Narula J, Yankelevitz D, Abbara S. 2016 SCCT/STR guidelines for coronary artery calcium scoring of noncontrast noncardiac chest CT scans: A report of the Society of Cardiovascular Computed Tomography and Society of Thoracic Radiology. Journal of Thoracic Imaging. 2017 Sep;32(5):W54-W66 and Journal of Cardiovascular Computed Tomography. 2017 Jan-Feb;11(1):74-86. Summary: These guidelines will improve clinical care but situations will arise where additional information may be needed to better inform patient management.

6. Joshi PH, Blaha MJ, … Agatston AS, Blankstein R, Blumenthal RS, Nasir K. The 10-year prognostic value of zero and minimal CAC. JACC: Cardiovascular Imaging. 2017 Aug;10(8):957-958.Summary: The presence of just minimal CAC is associated with a 2-fold higher risk of CVD as compared to the absence of CAC in age-matched controls.

7. Hong JC, Blankstein R,...Blumenthal RS, Blaha MJ, Krumholz HM, Nasir K. Implications of coronary artery calcium testing for treatment decisions among statin candidates according to the ACC/AHA Cholesterol Management Guidelines: A cost-effectiveness analysis. JACC: Cardiovascular Imaging. 2017 Aug;10(8):938-952.Summary: Clinicians should account for individual preferences in context of shared decision-making to guide statin prescribing decisions.

8. Blaha MJ, Mortensen MB, Kianoush S, Tota-Maharaj R, Caínzos-Achirica M. Coronary artery calcium scoring: Is it time for a change in methodology? JACC: Cardiovascular Imaging. 2017 Aug;10(8):923-937. Summary: This review discusses a conceptual model for developing an improved CAC score, reviewing the approaches most likely to lead to meaningful improvement in the Agatston CAC score.

9. Criqui MH, … Blaha MJ, Allison MA. Coronary artery calcium volume and density: Potential interactions and overall predictive value: The Multi-Ethnic Study of Atherosclerosis. JACC: Cardiovascular Imaging. 2017 Aug;10(8):845-854.

Summary: CAC volume and density provide the strongest prediction for CVD events and the highest correct reclassification.

10. Gupta A, … Blaha MJ, Wong ND, Blumenthal RS, Budoff MJ, Umscheid CA, Nasir K, Blankstein R. The identification of calcified coronary plaque is associated with initiation and continuation of pharmacological and lifestyle preventive therapies: A systematic review and meta-analysis. JACC: Cardiovascular Imaging. 2017 Aug;10(8):833-842.

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Ty Gluckman, MdTy Gluckman, MD, an adjunct faculty member of the Ciccarone Center, recently took a position with Providence Health & Services in Portland, Oregon, as Medical Director of a newly formed Center for

Cardiovascular Analytics, Research, and Data Science. He served an author on the “2017 ACC Expert Consensus

Decision Pathway for Periprocedural Management of Anticoagulation in Patients With Nonvalvular Atrial Fibrillation,” a report of the American College of Cardiology (ACC) Clinical Expert Consensus Document Task Force, published in the Journal of the American College of Cardiology in February. He continues to hold several other positions with the ACC, including Patient Navigator Program Clinical Quality Expert, Patient Navigator Program-MI Chair, PINNACLE Steering Committee Member, Anticoagulation Consortium Roundtable Co-Chair, and Cardiovascular Summit Planning Committee Member. He is also a member of the National Cardiovascular Data Registry Rapid Registry Response Work Group, and the National Cardiovascular Data Registry Evidence to Practice (E2P) Work Group Member, and the chair of the National Cardiovascular Data Registry Interprofessional Practice (IPP) Work Group.

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Summary: Identifying calcified coronary plaque significantly increases the likelihood of initiation or continuation of pharmacological and lifestyle therapies.

11. Ogunmoroti O, Oni E, Michos ED, … Blumenthal RS, Veledar E, Szklo M, Blaha MJ, Nasir K. Life’s simple 7 (LS7) and incident heart failure: The Multi-Ethnic Study of Atherosclerosis. Journal of the American Heart Association. 2017 Jun 27;6(6). pii: e005180. Summary: A lower risk of heart failure with more favorable LS7 indicates that efforts to achieve ideal cardiovascular health would greatly reduce heart failure.

12. McClelland RL, Blaha MJ. Incorporating coronary artery calcium into global risk scoring. JACC: Cardiovascular Imaging. 2017 Jun 9. pii: S1936-878X(17)30448-5. Summary: CAC helps predict total mortality as well as CVD events.

13. Salami JA, Valero-Elizondo J,...Arrieta A, Blaha MJ, Veledar E, Nasir K. Association between modifiable risk factors and pharmaceutical expenditures among adults with atherosclerotic cardiovascular disease in the United States: 2012-2013 Medical Expenditures Panel Survey. Journal of the American Heart Association. 2017 Jun 9;6(6). pii: e004996.Summary: Worsening modifiable risk factors were proportionally associated with higher annual pharmaceutical expenditures among patients with established atherosclerotic cardiovascular disease (ASCVD).

14. Yeboah J, Blaha MJ, Michos ED, et al. Adult height, prevalent coronary calcium score, and incident cardiovascular outcomes in a multi-ethnic cohort. American Journal of Epidemiology. Forthcoming 2017. Summary: Adult height may signal interactions between genetic and environmental factors and provide risk information independent of traditional risk factors and CAC score.

15. Fujiyoshi A, Jacobs DR Jr, Fitzpatrick AL...Blaha MJ, Luchsinger JA, Rapp SR. Coronary artery calcium and risk of dementia in MESA (Multi-Ethnic Study of Atherosclerosis). Circulation: Cardiovascular Imaging. 2017 May;10(5). pii: e005349. Summary: Higher baseline CAC was significantly associated with increased risk of dementia independent of vascular risk factor, APOE-ε4, and incident stroke.

16. Okunrintemi V, … Blaha MJ, … Nasir K. Patient-provider communication and health outcomes among individuals with atherosclerotic cardiovascular disease in the United States: Medical Expenditure Panel Survey 2010 to 2013. Circulation: Cardiovascular Quality and Outcomes. 2017 Apr;10(4). pii: e003635.Summary: There is a strong relationship between patient-provider communication and patient-reported outcomes, utilization of evidence-based therapies, resource utilization, and expenditures.

17. Hecht HS, Cronin P, Blaha MJ, et al. Erratum to “2016 SCCT/STR guidelines for coronary artery calcium scoring of noncontrast noncardiac chest CT scans a report of the society of Cardiovascular Computed Tomography and Society of Thoracic Radiology” [Journal of Cardiovascular Computed Tomography 11 (2017) 74-84]. Journal of Cardiovascular Computed Tomography. 2017 Mar - Apr;11(2):170.

18. Hecht H, Blaha MJ, Berman DS, Nasir K, Budoff M, Leipsic J, Blankstein R, Narula J, Rumberger J, Shaw LJ. Clinical indications for coronary artery calcium scoring in asymptomatic patients: Expert consensus statement from the Society of Cardiovascular Computed Tomography. Journal of Cardiovascular Computed Tomography. 2017 Mar - Apr;11(2):157-168. Summary: This statement summarizes the data regarding the prognostic value of CAC and its ability to refine risk prediction.

19. Feldman DI, … Blaha MJ, Veledar E, Nasir K. Favorable cardiovascular risk factor profile is associated with lower healthcare expenditure and resource utilization among

adults with diabetes mellitus free of established cardiovascular disease: 2012 Medical Expenditure Panel Survey (MEPS). Atherosclerosis. 2017 Mar;258:79-83. Summary: A favorable risk factor profile is associated with lower healthcare expenditures and utilization in CVD-free individuals across diabetes mellitus status, suggesting that these individuals require aggressive individualized prescriptions targeting lifestyle modifications and therapeutic treatments.

20. Gepner AD, … Blaha MJ, Post WS, Michos ED, Kaufman J, Stein JH. Comparison of carotid plaque score and coronary artery calcium score for predicting cardiovascular disease events: The Multi-Ethnic Study of Atherosclerosis. Journal of the American Heart Association. 2017 Feb 14;6(2). pii: e005179. Summary: CAC score improved prediction, discrimination, and reclassification of CVD events better than carotid ultrasound measures, although prediction and discrimination were similar for stroke/TIA.

21. Ogunmoroti O, … Michos ED, Rundek T, Rana JS, Blankstein R, Blumenthal RS, Blaha MJ, Veledar E, Nasir K. Association between life’s simple 7 and noncardiovascular disease: The Multi-Ethnic Study of Atherosclerosis. Journal of the American Heart Association. 2016 Oct 20;5(10). pii: e003954.Summary: Improving cardiovascular health will also reduce the burden of cancer and other chronic diseases.

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sherita Golden, Md, MhsSherita Golden, MD, MHS, who serves as the Hugh P. McCormick Family Professor of Endocrinology and Metabolism, and is Executive Vice-Chair, Department of Medicine, at Johns Hopkins University, is the

2017 recipient of the Walter Reed Distinguished Achievement Award. The annual award, presented by the University of

Virginia School of Medicine, Medical Alumni Association, and Medical School Foundation, recognizes professional accomplishment, outstanding innovation, and exemplary leadership in the field of medicine. Other highlights from the past year include being nominated to the Association of American Physicians, a physician honor society, and being elected to the American Clinical and Climatological Association.

David Feldman, BA

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22. Blaha MJ, Matsushita K. Coronary artery calcium: need for more clarity in guidelines. JACC: Cardiovascular Imaging. 2017 Feb;10(2):154-156.

23. DeFilippis AP, Young R, McEvoy JW, Michos ED, … Blaha MJ. Risk score overestimation: the impact of individual cardiovascular risk factors and preventive therapies on the performance of the American Heart Association-American College of Cardiology-Atherosclerotic Cardiovascular Disease risk score in a modern multi-ethnic cohort. European Heart Journal. 2017 Feb 21;38(8):598-608. Summary: Clinicians treating older individuals, and those with factors associated with more risk overestimation, should interpret absolute ASCVD risk estimates with caution.

24. Blaha MJ, Budoff MJ, Tota-Maharaj R, Dardari ZA, Wong ND, Kronmal RA, Eng J, Post WS, Blumenthal RS, Nasir K. Improving the CAC score by addition of regional measures of calcium distribution: Multi-Ethnic Study of Atherosclerosis. JACC: Cardiovascular Imaging. 2016 Dec;9(12):1407-1416.Summary: The number of coronary arteries with calcified plaque, indicating increasingly “diffuse” multi-vessel subclinical atherosclerosis, adds significantly to the traditional Agatston CAC score for the prediction of events.

25. Nakanishi R, Li D, Blaha MJ, Whelton SP, Darabian S, Flores FR, Dailing C, Blumenthal RS, Nasir K, Berman DS, Budoff MJ. All-cause mortality by age and gender based on coronary artery calcium scores. European Heart Journal: Cardiovascular Imaging. 2016 Nov;17(11):1305-1314. Summary: CAC is strongly associated with the long-term risk of mortality in young and middle-aged men and women; in older patients, the long-term risk stratification of CAC is lower.

26. Wong ND, Zhao Y, Quek RGW, Blumenthal RS, et al. Residual atherosclerotic cardiovascular disease risk in statin-treated adults: The Multi-Ethnic Study of Atherosclerosis. Journal of Clinical Lipidology. 2017 Sep - Oct;11(5):1223-1233. Summary: Residual risk of ASCVD remains high despite statin treatment and is predicted by specific risk factors and subclinical atherosclerosis.

27. Streed CG Jr, Harfouch O, Marvel F, Blumenthal RS, Martin SS, Mukherjee M. Cardiovascular disease among transgender adults receiving hormone therapy: a narrative review. Annals of Internal Medicine. 2017 Aug 15;167(4):256-267.Summary: There is a lack of randomized controlled trials comparing various routes and formulations of cross-sex hormone therapy, as well as the paucity of prospective cohort studies.

28. Lewis EF, … Blumenthal RS, Weng J, Rueschman M, Redline S. Impact of continuous positive airway pressure and oxygen on health status in patients with coronary heart disease, cardiovascular risk factors, and obstructive sleep apnea: A Heart Biomarker Evaluation in Apnea Treatment (HEARTBEAT) analysis. American Heart Journal. 2017 Jul;189:59-67. Summary: CPAP improves vitality, sleepiness, mental health, social functioning, and depressive symptoms in patients with sleep apnea and established CHD or risk factors.

29. Sammut A, Shea S, Blumenthal RS, et al. Albuminuria in rheumatoid arthritis: associations with RA characteristics and subclinical atherosclerosis. Arthritis Care & Research. 2017 Mar 3. Summary: There was no association in the rheumatoid arthritis group of elevated urine albumin:creatinine with measures of atherosclerosis or with cardiometabolic risk factors.

30. Sathiyakumar V, Blumenthal RS, Nasir K, Martin SS. Addressing knowledge gaps in the 2013 ACC/AHA Guideline on the assessment of cardiovascular risk: a review of recent coronary artery calcium literature. Current Atherosclerosis Reports. 2017 Feb;19(2):7.Summary: We address knowledge gaps about and further highlight the potential for CAC scanning to enrich future randomized controlled trials.

31. Kavousi M, Desai CS, Ayers C, Blumenthal RS, et al. Prevalence and prognostic implications of coronary artery calcification in low-risk women: a meta-analysis. Journal of the American Medical Association. 2016 Nov 22;316(20):2126-2134. Summary: Among women at low CVD risk, CAC was present in approximately one-third and was associated with an increased risk of atherosclerotic CVD and improvement in prognostic accuracy.

32. Miller PE, Zhao D, Frazier-Wood AC, Michos ED, Averill M, Sandfort V, Burke GL, Polak JF, Lima JA, Post WS, Blumenthal RS, Guallar E, Martin SS. Associations of coffee, tea, and caffeine intake with coronary artery calcification and cardiovascular events. The American Journal of Medicine. 2017 Feb;130(2):188-197.e5.

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Thorsten Leucker, MdSince joining Johns Hopkins, Dr. Thorsten Leucker, currently the Henry Kravis Chief Cardiology Fellow, has distinguished himself as a vascular expert with a special interest in the impact of HDL and PCSK9, a cholesterol receptor controlling protein, on vascular function. The blood vessels forming cells are often the scene of the initial injury leading to downstream cardiovascular diseases, such as heart attacks and heart failure. Dr. Leucker’s innovative bench-to-bedside approach, in

collaboration with several members of the Ciccarone Center, have led to several clinical trial designs to directly improve the function of blood vessels and positively impact the health of our patients. He is on track to continue his path of becoming a clinician-scientist combining his clinical and research interests in preventive Cardiology. In addition, he is spearheading the efforts to build the Johns Hopkins Integrative Vascular Center to combine the research and clinical strength of our institution.

Chintan Desai, MD

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Summary: Moderate tea drinkers had slower progression of CAC and reduced risk for cardiovascular events.

33. Okwuosa IS, … Blumenthal RS, Russell SD. The ABCs of managing systolic heart failure: Past, present, and future. Cleveland Clinic Journal of Medicine. 2016 Oct;83(10):753-765.Summary: We summarize factors associated with the development of heart failure in an ABCDE format.

34. Yun KE, … Caínzos-Achirica M, Zhao D, Pastor-Barriuso R, Shin H, Guallar E, Ryu S. Coexistence of colorectal adenomas and coronary calcification in asymptomatic men and women. Journal of Clinical Gastroenterology. Forthcoming 2017.Summary: In a large population of apparently healthy Korean adults, the authors observed a graded association between CAC burden and concurrent presence of colorectal adenomas.

35. Caínzos-Achirica M, Tota-Maharaj R. Breast arterial calcification for personalized cardiovascular risk assessment: Where do we stand? Atherosclerosis. 2017 Apr;259:101-103.Summary: This article summarizes the evidence on the potential roles that breast arterial calcification may play for CVD risk assessment.

36. Crim MT, … Gerstenblith G, Hill P, Korley FK. Novel emergency department risk score discriminates acute coronary syndrome among chest pain patients with known coronary artery disease. Critical Pathways in Cardiology. 2016 Dec;15(4):138-144.Summary: Application of risk scores may reduce the number of potentially avoidable admissions and their associated hazards and costs.

37. Goyal A, Gluckman TJ, Tcheng JE. What‘s in a name? The new ICD-10 (10th revision of the International Statistical Classification of Diseases and Related Health Problems) codes and type 2 myocardial infarction. Circulation. 2017 Sep 26;136(13):1180-1182.

38. Joseph JJ, … Golden SH. Aldosterone, renin, cardiovascular events and all-cause mortality among African Americans: The Jackson Heart Study. Journal of American College of Cardiology: Heart Failure. 2017 Sep;5(9):642-651.

Summary: Elevated aldosterone and plasma renin activity may play a significant role in the development of CVD and all-cause mortality among African Americans.

39. Moon KA, … Guallar E, et al. A dose-response meta-analysis of chronic arsenic exposure and incident cardiovascular disease. International Journal of Epidemiology. Forthcoming 2017.Summary: This analysis supports quantitatively including CVD in inorganic arsenic risk assessment, and strengthens the evidence for an association between arsenic and CVD.

40. Jones MR, … Guallar E, Post WS, Kaufman JD, Navas-Acien A. Estimation of inorganic arsenic exposure in populations with frequent seafood intake: Evidence from MESA and NHANES. American Journal of Epidemiology. 2016 Oct 15;184(8):590-602.

41. DeMazumder D, … Guallar E, Jones SR, Tomaselli GF. Entropy of cardiac repolarization predicts ventricular arrhythmias and mortality in patients receiving an implantable cardioverter-defibrillator for primary prevention of sudden death. Europace. 2016 Dec;18(12):1818-1828.

42. O’Neal WT, Efird JT, Nazarian S, Alonso A, Michos ED, Szklo M, Heckbert SR, Soliman EZ. Mitral annular calcification progression and the risk of atrial fibrillation: results from MESA. European Heart Journal of Cardiovascular Imaging. Forthcoming 2017.

43. Ogunmoroti O, … Nasir K. Association between self-rated health and ideal cardiovascular health: The Baptist Health South Florida Employee Study. Journal of Public Health. 2017 Oct 17:1-8. Summary: Favorable self-rated health was consistently associated with better CV health.

44. Bittencourt MS, Nasir K. Not every coronary artery calcium is the same: Implications of novel measurements for clinical practice? Circulation: Cardiovascular Imaging. 2017 Oct;10(10). pii: e006953.

45. Khosa F, Khan MS, Bhulani N, Miao TL, Butler J, Nasir K, Raggi P. Leadership in cardiology. European Heart Journal. 2017 Aug 7;38(30):2323.

46. Singh A, … Nasir K, Di Carli MF, Bhatt DL, Blankstein R. Study of young patients with myocardial infarction: Design and rationale of the YOUNG-MI Registry. Clinical Cardiology. Forthcoming 2017.Summary: Our findings provide important insights regarding prevention, risk stratification, treatment, and outcomes of cardiovascular disease in an understudied population.

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elizabeth Ratchford, MdWith the guidance of Elizabeth Ratchford, MD, the Johns Hopkins Center for Vascular Medicine opened a new, comprehensive vascular ultrasound laboratory at Green Spring Station, the headquarters for the Ciccarone Center, in 2017. The new center, which will soon be expanding to Howard County, offers vascular exams, including carotid duplex (to check for blockages in the neck arteries), aorta duplex (to screen for abdominal aortic aneurysm), vein ultrasounds (to look for blood clots), and leg artery tests (to look for peripheral artery disease, or PAD). Other additions to Dr. Ratchford’s vascular medicine program include a smoking cessation clinic and a clinic focused on fibromuscular dysplasia (FMD) in collaboration with Dr. John Sperati (Nephrology). Dr. Ratchford also sees a number of patients with erythromelalgia, a rare vascular disorder characterized by burning pain, warmth, and redness of the hands, feet, and face. Also, Dr. Ratchford announced that the Centers for Medicare & Medicaid Services has decided to cover supervised exercise therapy (SET) for the treatment of leg symptoms related to PAD. The Johns Hopkins Clinical Exercise Center at Green Spring Station will lead the way in developing SET protocols, and Dr. Ratchford will serve at the Medical Director for this new PAD exercise program.

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47. Ali SS, … Nasir K. Noninvasive assessment of subclinical atherosclerosis in persons with symptoms of depression. Atherosclerosis. 2017 Sep;264:92-99. Summary: Depressive symptoms may be a potentially modifiable risk factor for early prevention of cardiovascular disease, especially in younger patients.

48. Yano Y, … Nasir K, et al. Association of coronary artery calcium score vs age with cardiovascular risk in older adults: An analysis of pooled population-based studies. Journal of the American Medical Association: Cardiology. 2017 Sep 1;2(9):986-994. Summary: Coronary artery calcium may be an alternative marker besides age to better discriminate between lower and higher CHD risk in older adults.

49. Beckman AL, Herrin J, Nasir K, Desai NR, Spatz ES. Trends in cardiovascular health of US adults by income, 2005-2014. Journal of the American Medical Association: Cardiology. 2017 Jul 1;2(7):814-816.

50. Nasir K, Keeley B, Krumholz HM. Living longer in good cardiovascular health: Prevention and wellness makes economic cents. Circulation. 2017 May 2;135(18):1702-1704.

51. Osondu CU, … Nasir K. Favorable cardiovascular health is associated with lower health care expenditures and resource utilization in a large US employee population: The Baptist Health South Florida employee study. Mayo Clinic Proceedings. 2017 Mar 13. pii: S0025-6196(17)30088-5.

52. Aziz M, … Nasir K. Association of subjective and objective sleep duration as well as sleep quality with non-invasive markers of sub-clinical cardiovascular disease (CVD): A systematic review. Journal of Atherosclerosis and Thrombosis. 2017 Mar 1;24(3):208-226. Summary: There is a relationship between abnormal sleep duration and quality with increased subclinical CVD burden.

53. Ahmad FS, Chan C, Rosenman MB, Post WS, et al. Validity of cardiovascular data from electronic sources: The Multi-Ethnic Study of Atherosclerosis and HealthLNK. Circulation. 2017 Sep 26;136(13):1207-1216. Summary: These findings illustrate the limitations and strengths of electronic data repositories in comparison with information collected by traditional epidemiological approaches.

54. Foster MC, … Post WS, Shlipak MG. Non-GFR determinants of low-molecular-weight serum protein filtration markers in the elderly: AGES-Kidney and MESA-Kidney. American Journal of Kidney Diseases. 2017 Sep;70(3):406-414. Summary: In community-dwelling elders, cystatin C, beta-microglobulin, and beta-trace protein levels are less affected than creatinine level by age and sex and are not affected by ethnicity. 55. Inker LA, Levey AS, Tighiouart H, Shafi T, Eckfeldt JH, Johnson C, Okparavero A, Post WS, Coresh J, Shlipak MG. Performance of glomerular filtration rate estimating equations in a community-based sample of Blacks and Whites: the multiethnic study of atherosclerosis. Nephrology, Dialysis, and Transplantation. Forthcoming 2017.

56. Polonsky TS, … Post WS, Sacco RL, Szklo M, Lloyd-Jones DM. Association of cardiovascular health with subclinical disease and incident events: The Multi-Ethnic Study of Atherosclerosis. Journal of the American Heart Association. 2017 Mar 20;6(3). Summary: There is a graded inverse association between CV health scores and measures of subclinical and overt cardiovascular disease that is similar across race/ethnic groups.

57. Inker LA, … Post WS, Coresh J, Levey AS, Shlipak MG. Effects of race and sex on measured GFR: The Multi-Ethnic Study of Atherosclerosis. American Journal of Kidney Disease. 2016 Nov;68(5):743-751. Summary: Factors other than measured glomerular filtration rate must account for the disproportionately higher burden of kidney failure in older blacks versus whites.

58. Oren O, Vaishnav J, Blumenthal RS, McEvoy JW. Cardiovascular risk assessment: making sense of an ever-expanding universe. 2017 April. ACC.org. Summary: In the future there will be a growing role for genetic testings and selective use of blood based biomarkers to improve risk prediction.

59. Michos ED, Blaha MJ, Blumenthal RS. Use of the coronary artery calcium score in the discussion for the initiation of statin therapy in primary prevention. Mayo Clinic Proceedings. 2017. Nov 3.Summary: Selective use of a coronary artery calcium score is the best way to improve ASCVD risk prediction.

60. Michos ED, Blaha MJ, Martin SS, Blumenthal RS. Screening for atherosclerotic cardiovascular disease in asymptomatic individuals. In Chronic Coronary Artery Disease: A Companion to Braunwald’s Heart Disease (DeLemos J ed) 2017; Chapter 29. Summary: We present an update on ways to better identify those who are at risk for premature ASCVD and those who are at very low long-term risk of ASCVD.

61. Gordois AL, Toth PP, et al. Productivity losses associated with cardiovascular disease: a systematic review. Expert Review of Pharmacoeconomics & Outcomes Research. 2016;16(6):759-769.

Antiplatelet/Anticoagulant Rx62. McEvoy JW, Ibrahim K, … Blumenthal RS, Thiemann DR, Resar JR, Schulman SP. Effect of intravenous fentanyl on ticagrelor absorption and platelet inhibition among patients undergoing percutaneous coronary intervention: The PACIFY randomized clinical trial. Circulation. 2017 Oct 18.Summary: Routine use of fentanyl for sedation in patients undergoing PCI reduces ticagrelor absorption and delays platelet inhibition without good evidence of improved comfort.

63. Kakouros N, Gluckman TJ, et al. Differential impact of serial measurement of nonplatelet thromboxane generation on long-term outcome after cardiac surgery. Journal of the American Heart Association. 2017 Nov2;6(11).Summary: Long-term nonplatelet thromboxane generation after coronary artery bypass graft surgery is a non risk factor for 5-year adverse outcomes including death.

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Wendy Post, MD

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64. Doherty JU, Gluckman TJ, Hucker WJ et al. 2017 ACC Expert Consensus Decision Pathway for periprocedural management of anticoagulation in patients with nonvalvular atrial fibrillation: a report of the ACC Clinical Expert Consensus Document Task Force. Journal of the American College of Cardiology. 2017 Feb 21;69(7):871-898.Summary: This consensus document discusses all aspects of starting and interrupting anticoagulation in patients with atrial fibrillation.

65. McCarthy CP, … McEvoy JW. Time-honored treatments for the initial management of acute coronary syndromes: Challenging the status quo. Trends in Cardiovascular Medicine. 2017 Oct;27(7):483-491. Summary: This review examines updated evidence for the risks and benefits of the traditional acute-phase acute coronary syndrome agents.

66. McCarthy CP, McEvoy JW. The narrative review on morphine in acute coronary syndrome: Recognizing opioidergic cardioprotection-reply. American Heart Journal. 2016 Oct;180:e7-8.

67. Chaudhary R, … Toth PP, Franzese C, Gesheff M, Pandya S, Gurbel P. Statin therapy and inflammation in patients with diabetes treated with high dose aspirin. Journal of Diabetes Complications. 2016;30(7):1365-70.

68. Bliden KP, … Toth PP, Mathew DP, Chaudhary R, Gurbel PA. Thrombin-induced platelet-fibrin clot strength identified by thrombelastography: A novel prothrombotic marker of coronary artery stent restenosis. Journal of Interventional Cardiology. 2016;29(2):168-78.

Biomarkers69. McEvoy JW, Blaha MJ. Response by McEvoy and Blaha to letter regarding article, “Coronary Artery Calcium to Guide a Personalized Risk-Based Approach to Initiation and Intensification of Antihypertensive Therapy.” Circulation. 2017 Jun 6;135(23):e1113-e1114.

70. Rebholz CM, … McEvoy JW, Grams ME, Coresh J. Plasma galectin-3 levels are associated with the risk of incident chronic kidney disease. Kidney International. 2017 Aug 30. pii: S0085-2538(17)30497-0.Summary: Higher plasma galectin-3 levels were associated with an elevated risk of developing kidney disease, particularly among those with hypertension.

71. McCarthy CP, … McEvoy JW. High sensitivity troponin and valvular heart disease. Trends in Cardiovascular Medicine. 2017 Jul;27(5):326-333. Summary: High sensitivity troponin is a promising biomarker in valvular heart disease.

72. McCarthy CP, … McEvoy JW. High-sensitivity troponin as a biomarker in heart rhythm disease. American Journal of Cardiology. 2017 May 1;119(9):1407-1413. Summary: High-sensitivity troponin has value as a prognostic biomarker in atrial fibrillation and as a screening marker for patients at high risk of sudden cardiac death.

73. Whelton SP, McEvoy JW, Lazo M, Coresh J, Ballantyne CM, Selvin E. High-sensitivity cardiac troponin T (hs-cTnT) as a predictor of incident diabetes in the atherosclerosis risk in communities study. Diabetes Care. 2017 Feb;40(2):261-269.Summary: Measurement of hs-cTn identifies individuals at an increased risk for diabetes and CVD in order to provide early, more intensive risk factor modification.

74. Liang M, McEvoy JW, Chen Y, Sharrett AR, Selvin E. Association of a biomarker of glucose peaks, 1,5-Anhydroglucitol, with subclinical cardiovascular disease. Diabetes Care. 2016 Oct;39(10):1752-9. Summary: In people with diabetes, 1,5-AG was associated with chronic subclinical myocardial damage.

75. Ishigami J, Jaar BG, Rebholz CM, Grams ME, Michos ED, et al. Biomarkers of mineral and bone metabolism and 20-year risk for hospitalization with infection: the ARIC Study. The Journal of Clinical Endocrinology and Metabolism. Forthcoming 2017. Summary: Mineral and bone disorder biomarkers were associated with subsequent risk of infection.

76. Younus A, … Nasir K. Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease: A systematic review. Journal of Clinical Lipidology. 2017 Mar - Apr;11(2):328-337. Summary: There is a variable association between lipoprotein-associated phospholipase A2 and subclinical disease.

77. Pokharel Y, … Ndumele CE, Solomon SD, Bozkurt B, Selvin E, Ballantyne CM, Deswal A. Myocardial injury, obesity, and the obesity paradox: The ARIC Study. JACC: Heart Failure. 2017 Jan;5(1):56-63. Summary: Although greater pre-existing subclinical myocardial injury was associated with higher mortality after incident heart failure hospitalization, it did not explain the obesity paradox.

78. Pokharel Y, Sun W, Villareal DT, Selvin E, Virani SS, Ndumele CE, et al. Association between high-sensitivity troponin T and cardiovascular risk in individuals with and without metabolic syndrome: The ARIC study. European Journal of Preventive Cardiology. 2017 Apr;24(6):628-638. Summary: High-sensitivity troponin T is useful for identifying patients with increased hazards for coronary heart disease, death and particularly heart failure.

79. Chandler PD, … Post WS, Ridker PM, Manson JE, Buring JE, Lee IM, Mora S. Association of N-Linked Glycoprotein Acetyls and Colorectal Cancer Incidence and Mortality. PLoS One. 2016 Nov 30;11(11):e0165615.

80. Wu C...Nasir K, Bhatt DL, Blankstein R. Causes of troponin elevation and associated mortality in young patients. American Journal of Medicine. 2017 Oct 26. Summary: Most non-heart attack causes of troponin elevation are associated with increased risk of early mortality.

81. Michos ED, Blumenthal RS. Treatment concentration of high-sensitivity C-reactive protein. Lancet. 2017 Nov 13. Summary: Great reductions in hsCRP are associated with a lower risk of ASCVD events.

Blood pressure82. Rahman F, Al Rifai M, Blaha MJ, Nasir K, Budoff MJ, Psaty BM, Post WS, Blumenthal RS, McEvoy JW. Relation of diastolic blood pressure and coronary artery calcium to coronary events and outcomes (from the Multi-Ethnic Study of Atherosclerosis). American Journal of Cardiology. 2017 Aug 8. pii: S0002-9149(17)31300-0.Summary: Diastolic blood pressure <60 mm Hg was associated with increased risk of coronary events and all-cause mortality, especially in individuals with elevated amounts of subclinical atherosclerosis. 18

Mahmoud Al Rifai, MD

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83. McEvoy JW, Martin SS, Dardari ZA, Miedema MD, Sandfort V, Yeboah J, Budoff MJ, Goff DC Jr, Psaty BM, Post WS, Nasir K, Blumenthal RS, Blaha MJ. Coronary artery calcium to guide a personalized risk-based approach to initiation and intensification of antihypertensive therapy. Circulation. 2017 Jan 10;135(2):153-165. Summary: Combined CAC imaging and assessment of ASCVD risk can guide personalized systolic blood pressure goals, particularly among adults with mild hypertension.

84. Whelton SP, Blumenthal RS. Beyond the headlines: insights on potassium supplementation for the treatment of hypertension from the Canadian Hypertension Education Program Guidelines (CHEP). Circulation. 2017 Jan 3;135(1):3-4.Summary: Increased dietary intake of potassium can significantly lower high blood pressure readings.

85. McEvoy JW, … Blumenthal RS, Coresh J, Selvin E. Diastolic blood pressure, subclinical myocardial damage, and cardiac events: implications for blood pressure control. Journal of the American College of Cardiology. 2016 Oct 18;68(16):1713-1722. Summary: Low diastolic blood pressure was associated with subclinical myocardial damage and CHD events.

86. Rahman F, McEvoy JW. The J-shaped curve for blood pressure and cardiovascular disease risk: Historical context and recent updates. Current Atherosclerosis Reports. 2017

Aug;19(8):34.Summary: This review summarizes the evidence for a J-curve in the treatment of hypertension.

87. McEvoy JW, Chen Y, Selvin E. Reply: Diastolic blood pressure: Myocardial damage and coronary ischemic events. Journal of the American College of Cardiology. 2017 Mar 28;69(12):1648-1649.

88. McCarthy CP, McEvoy JW. Let us not forget the long-term safety concerns of Sacubitril/Valsartan. Journal of the American Medical Association: Cardiology. 2017 Jul 1;2(7):818-819.

89. McEvoy JW, Whelton SP, Blumenthal RS. Dyslipidemia. In Hypertension: A Companion to Braunwald’s Heart Disease (Bakris GL, Sorrentino MJ eds). 2017; Chapter 38: 353-360. Summary: We discuss the ways to lower the risk of hypertensive individuals who have cholesterol profile abnormalities.

90. Bromfield SG, Ngameni CA,…Toth PP, Muntner P. Blood pressure, antihypertensive polypharmacy, frailty, and risk for serious fall injuries among older treated adults with hypertension. Hypertension. 2017;70(2):259-266.

cholesterol/Lipids91. Underberg JA, Blaha MJ, Jackson EJ, Jones PH. Developing optimized treatment plans for patients with dyslipidemia in the era of proprotein convertase subtilisin/kexin type 9 inhibitor therapeutics. American Journal of Medicine. 2017 Jul 21. pii: S0002-9343(17)30723-4.Summary: PCSK9 inhibitors help physicians to achieve low-density lipoprotein cholesterol targets in their patients.

92. Mortensen MB, Budoff MJ, Li D, Nasir K, Blaha MJ, et al. High quality statin trials support the 2013 ACC/AHA Cholesterol Guidelines after HOPE-3: The Multi-Ethnic Study of Atherosclerosis. Circulation. 2017;136:1863-5.

Summary: The ACC/AHA recommendations for statin therapy are supported by currently available, high-quality, randomized controlled trials evidence.

93. Mortensen MB, Falk E, Li D, Nasir K, Blaha MJ, et al. Statin trials, cardiovascular events, and coronary artery calcification: Implications for a trial-based approach to statin therapy in MESA. JACC: Cardiovascular Imaging. 2017 Jun 9.Summary: CAC scoring can be used to optimize statin allocation among individuals for whom trial-based evidence supports efficacy of statin therapy.

94. Goulart AC, … Blaha MJ, Jones S, Toth PP, Kulkarni K, Benseñor IM. The relationship between migraine and lipid sub-fractions among individuals without cardiovascular disease: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Cephalalgia. 2017 Jan 1:333102417699181.Summary: In middle-aged participants without CVD or lipid disorders requiring medication, the worst lipid profile was determined by the highest levels of triglyceride-rich lipoprotein cholesterol (TRL-C) and their cholesterol-rich remnants.

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Gary Gerstenblith, MdThis past year, Dr. Gary Gerstenblith, along with Roger Blumenthal, MD, and Chiadi Ndumele, MD, received a grant from the American Council on Exercise that will help to fund a pilot trial of lifestyle intervention in participants with the metabolic syndrome, a highly prevalent condition that predisposes to diabetes and is associated with markedly elevated risk of cardiovascular events. The program includes physical activity, nutrition, sleep, and stress assessments with targeted recommendations and interventions delivered in a community-based fitness center (ACAC) over a six-month period. The goal is to assess how well the program can assist the participants in changing their lifestyle goals and habits, maintaining adherence to those goals while in the program and then persistence of those changes during a follow-up period. It will also assess the impact of the program on novel cardiovascular risk factors including inflammatory markers and mediators. Dr. Gerstenblith also served as a co-investigator on an NHLBI grant, awarded to Dr. Robert Weiss, examining energetic profiles in patients with heart failure using magnetic resonance methodology. Recent studies from the laboratory demonstrated altered skeletal muscle, high-energy phosphate decline and recovery trajectories during and following exercise in heart failure patients, as compared with those of healthy individuals. The findings were particularly marked in those with the type of heart failure more common in older individuals.

Faisal Rahman, MD

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95. Quispe R, Hendrani A, Elshazly MB, Michos ED, McEvoy JW, Blaha MJ, Banach M, Kulkarni KR, Toth PP, Coresh J, Blumenthal RS, Jones SR, Martin SS. Accuracy of low-density lipoprotein cholesterol estimation at very low levels. BioMed Central: Medicine. 2017 Apr 20;15(1):83.Summary: Estimation of very low levels of LDL-C values (by Friedewald method) is often inaccurate.

96. Edwards MK, Blaha MJ, Loprinzi PD. Atherogenic index of plasma and triglyceride/high-density lipoprotein cholesterol ratio predict mortality risk better than individual cholesterol risk factors, among an older adult population. Mayo Clinic Proceedings. 2017 Apr;92(4):680-681. Summary: The triglyceride/HDL-cholesterol ratio appears to be a stronger predictor of mortality than individual components of total cholesterol.

97. Salami JA, … Blaha MJ, Blumenthal RS, Lloyd-Jones D, Nasir K. National trends in statin use and expenditures in the US adult population from 2002 to 2013: insights from the medical expenditure panel survey. Journal of the American Medical Association: Cardiology. 2017 Jan 1;2(1):56-65.Summary: Statin use increased substantially in the last decade among US adults, although the uptake was suboptimal in high-risk groups.

98. Sathiyakumar V, Park J, Golozar A, Lazo M, Quispe R, Guallar E, Blumenthal RS, Jones SR, Martin SS. Fasting vs non-fasting and low-density lipoprotein-cholesterol accuracy. Circulation. 2017 Oct 16.Summary: Novel adaptable LDL-C estimation performs better in non-fasting samples than the fixed Friedewald estimation, especially in settings of low LDL-C and high triglyceride.

99. Whelton SP, Meeusen JW,...Blumenthal RS, Jones SR, Martin SS. Evaluating the atherogenic burden of individuals with a Friedewald-estimated low-density lipoprotein cholesterol <70 mg/dL compared with a novel low-density lipoprotein estimation method. Journal of Clinical Lipidology. 2017 Jul - Aug;11(4):1065-1072. Summary: Approximately one-fifth of individuals with the targeted Friedewald-estimated LDL-C level experienced significantly higher median concentrations using a novel equation.

100. Kwan AC, Aronis KN, Sandfort V, Blumenthal RS, Bluemke DA. Bridging the gap for lipid lowering therapy: plaque regression, coronary computed tomographic angiography, and imaging-guided personalized medicine. Expert Review of Cardiovascular Therapy. 2017 Jul;15(7):547-558. Summary: We discuss the potential ability of coronary CTA to guide lipid-lowering therapy, as well as the potential barriers to its use.

101. Blumenthal RS, Aslam MI, McEvoy JW. Using trial eligibility to personalize statin therapy appears no more accurate than a coin flip in determining high-risk status. JACC: Cardiovascular Imaging. 2017 Jun 9. pii: S1936-878X(17)30403-5.Summary: Traditional ASCVD risk estimation is often no more accurate than successfully calling heads on a coin toss.

102. Driver S, Martin SS, Gluckman TJ, Clary JM, Blumenthal RS, Stone NJ. Reply: lipid measurements: fasting or nonfasting, women or men. Journal of the American College of Cardiology. 2016 Oct 11;68(15):1710-1711.

103. Awad K, Serban MC, Penson P, Mikhailidis DP, Toth PP, Jones SR, et al. Effects of morning vs evening statin administration on lipid profile: A systematic review and meta-analysis. Journal of Clinical Lipidology. 2017 Jul - Aug;11(4):972-985.e9.

Summary: This study synthesizes evidence about effects of morning vs evening statin administration on lipid profile.

104. Sahebkar A, … Toth PP, Jones SR,..Banach M; Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group. The effects of tamoxifen on plasma lipoprotein(a) concentrations: Systematic review and meta-analysis. Drugs. 2017 Jul;77(11):1187-1197.Summary: Meta-analysis suggested a statistically significant reduction of Lp(a) levels following tamoxifen treatment.

105. Joshi PH, Miller PE, Martin SS, Jones SR, Massaro JM, D’Agostino RB Sr, Kulkarni KR, Sponseller C, Toth PP. Greater remnant lipoprotein cholesterol reduction with pitavastatin compared with pravastatin in HIV-infected patients. AIDS. 2017 Apr 24;31(7):965-971.Summary: In patients with HIV, pitavastatin 4 mg/dl lowered both remnant lipoprotein-cholesterol (RLP-C) and established apolipoprotein and lipid risk ratios more so than pravastatin 40 mg/dl.

20

P. Elliott Miller, MD

Michael Blaha, MdIn 2017, Dr. Michael Blaha, Director of Clinical Research at the Ciccarone Center, was promoted to to Associate Professor of Cardiology and Epidemiology at Johns Hopkins. He partnered with Dr. Kuni Matsushita from the Welch Center to receive an NIH-sponsored R01 grant to describe the role of subclinical cardiovascular disease in adults age 75 and older. He also teamed with Dr. Ana Navas-Acien to submit another successful R0I grant to the FDA investigating the role of metal exposure and electronic cigarettes on cardiovascular health. Additionally, Dr. Blaha received two grants from the American Heart Association, is partnering with Vanderbilt University on two other grants in the fields of pulmonary arterial hypertension and mobile health (mHealth), and is working with the Amgen Foundation on a large grant to begin in early 2018. Dr. Blaha also spent 2017 working closely with Drs. Gary Gerstenblith, Thorsten Leucker, and Steve Schulman on a randomized controlled trial looking at addition of a novel cholesterol-lowering medication in persons who present to the hospital with a heart attack or unstable angina. And he was named a standing member of the Endocrinologic and Metabolic Drug Advisory Committee of the FDA, working on approvals of new lipid-lowering and diabetes drugs.

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106. Amrock SM, Duell PB, Knickelbine T, Martin SS, et al. Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry. Atherosclerosis. 2017 Oct 6;267:19-26.Summary: Health disparities contribute to the undertreatment of US familial hypercholesterolemia patients.

107. Pokharel Y, … Martin SS, Virani SS, Spertus JA. Association of low-density lipoprotein pattern with mortality after myocardial infarction: Insights from the TRIUMPH study. Journal of Clinical Lipidology. 2017 Oct 3. pii: S1933-2874(17)30447-6.Summary: The objective of this study was to examine association of LDL pattern after MI and death.

108. Ratchford EV, Martin SS. Statins. Vascular Medicine. 2017 Oct;22(5):442-445.

109. Brown WV, Handelsman Y, Martin SS, Morris PB. JCL roundtable: Future of the lipid laboratory: Using the laboratory to manage the patient (part 2). Journal of Clinical Lipidology. 2017 Jul - Aug;11(4):846-854.Summary: Lipoprotein management is a central feature of cardiology practice.

110. Brown WV, Handelsman Y, Martin SS, Morris PB. JCL roundtable: Future of the lipid laboratory: Using the laboratory to manage the patient (part 1). Journal of Clinical Lipidology. 2017 May - Jun;11(3):587-595.

111. McCarthy CP, McEvoy JW. Relativism and low-density lipoprotein cholesterol: Absolute or relative truth? Journal of the American College of Cardiology. 2017 Jun 6;69(22):2773-2774.

112. Power MC, … Michos ED, et al. Association of midlife lipids with 20-year cognitive change: A cohort study. Alzheimers and Dementia. 2017 Sep 12. pii: S1552-5260(17)33691-9.Summary: Elevated total cholesterol, low-density lipoprotein cholesterol, and triglycerides in midlife were associated with greater 20-year cognitive decline.

113. Cao J, … Michos ED, Kizer JR, Post WS, Tsai MY. Evaluation of lipoprotein(a) electrophoretic and immunoassay methods in discriminating risk of calcific aortic valve disease and incident coronary heart disease: The Multi-Ethnic Study of Atherosclerosis. Clinical Chemistry. 2017 Nov;63(11):1705-1713. Summary: This study evaluated whether lipoprotein(a) mass and particle concentration differentially discriminated risk of calcific aortic valve disease or incident coronary disease.

114. Steffen BT, Bielinski SJ, Decker PA, Berardi C, Larson NB, Pankow JS, Michos ED, et al. Low high-density lipoprotein cholesterol and particle concentrations are associated with greater

levels of endothelial activation markers in Multi-Ethnic Study of Atherosclerosis participants. Journal of Clinical Lipidology. 2017 Jul - Aug;11(4):955-963.e3.Summary: There is a modest to moderate relation of HDL and circulating levels of endothelial activation markers in humans.

115. Virani SS, … Nasir K, Michos ED, Bittner VA, Petersen LA, Ballantyne CM. Estimation of eligibility for proprotein convertase subtilisin/kexin type 9 inhibitors and associated costs based on the FOURIER Trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk): Insights From the Department of Veterans Affairs. Circulation. 2017 Jun 20;135(25):2572-2574. Summary: Uptitration of statin dose and improvement in statin adherence would greatly reduce the eligibility of high risk patients for consideration of a PCSK9 inhibitor.

116. Aaron CP, … Michos ED, Post WS, et al. Pulmonary vascular volume, impaired left ventricular filling and dyspnea: The MESA Lung Study. PLoS One. 2017 Apr 20;12(4):e0176180. Summary: Smoking-related pulmonary vascular changes contribute to symptoms and impair cardiac filling and function without evidence of impaired ventricular relaxation.

117. Flueckiger P, Qureshi W, Michos ED, Blaha M, Burke G, Sandfort V, Herrington D, Yeboah J. Guideline-based statin/lipid-lowering therapy eligibility for primary prevention and accuracy of coronary artery calcium and clinical cardiovascular events: The Multi-Ethnic Study of Atherosclerosis (MESA). Clinical Cardiology. 2017 Mar;40(3):163-169. Summary: We test the hypothesis that ACC/AHA guidelines are more accurate in identifying persons at risk for CVD.

118. Arrieta A, Hong JC, Khera R, Virani SS, Krumholz HM, Nasir K. Updated cost-effectiveness assessments of PCSK9 inhibitors from the perspectives of the health system and private payers: Insights derived from the FOURIER trial. Journal of the American Medical Association: Cardiology. Forthcoming 2017. Summary: We used trial results to determine the cost-effectiveness of a PCSK9 inhibitor and statin treatment strategy compared with a statin alone strategy.

119. Pokharel Y, Tang F, Jones PG, Nambi V, Bittner VA, Hira RS, Nasir K, et al. Adoption of the 2013 American College of Cardiology/American Heart Association cholesterol management guideline in cardiology practices nationwide. Journal of the American Medical Association: Cardiology. 2017 Apr 1;2(4):361-369.Summary: Adoption of the 2013 ACC/AHA Cholesterol Management Guideline in cardiology practices was modest.

120. Arrieta A, Page TF, Veledar E, Nasir K. Economic evaluation of PCSK9 inhibitors in reducing cardiovascular risk from health system and private payer perspectives. PLoS One. 2017 Jan 12;12(1):e0169761. Summary: At current prices, PCSK9 inhibitors do not add value to the U.S. health system and their provision is not profitable for private payers.

121. Bajaj A, Damrauer SM, Anderson AH, Xie D, Budoff MJ, Go AS, He J, Lash JP, Ojo A, Post WS, et al. Lipoprotein(a) and risk of myocardial infarction and death in chronic kidney disease: Findings from the CRIC Study (Chronic Renal Insufficiency Cohort). Arteriosclerosis, Thrombosis, and Vascular Biology. 2017 Oct;37(10):1971-1978. Summary: Among adults with chronic kidney disease, elevated Lp(a) is independently associated with myocardial infarction and death. 21

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Erin Michos, MD

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122. Kent ST, … Post WS, et al. PCSK9 loss-of-function variants, low-density lipoprotein cholesterol, and risk of coronary heart disease and stroke: Data from 9 studies of blacks and whites. Circulation: Cardiovascular Genetics. 2017 Aug;10(4):e001632. Summary: PCSK9 variants were associated with lower LDL-C and coronary heart disease incidence, not stroke risk.

123. Afshar M, … Post WS, et al. Association of triglyceride-related genetic variants with mitral annular calcification. Journal of the American College of Cardiology. 2017 Jun 20;69(24):2941-2948. Summary: Genetic predisposition to elevated triglyceride levels was associated with the presence of mitral annular calcification, a risk factor for clinically significant mitral valve disease.

124. Oren O, Okada DR, Blumenthal RS, Martin SS. Momentum builds for PCSK9 inhibition at ACC.17: even lower LDL-C is even better. Acc.org May 11, 2017.

125. Hamo CE, Martin SS, Blumenthal RS. A novel approach to low-density lipoprotein estimation. Acc.org 2017. October. Summary: Calculated LDL-cholesterol < 70 mg/dL is often inaccurate in the setting of an elevated triglyceride or low HDL-cholesterol level.

126. Chaudhary R, Mathew D, Bliden K,… Toth PP, Gurbel PA. Low-density lipoprotein 4: a novel predictor of coronary artery disease severity. Current Medical Research and Opinion. 2017 Sep 1:1-6.

127. Bays HE, Leiter LA,...Toth PP. Alirocumab treatment and achievement of non-high-density lipoprotein cholesterol and Apolipoprotein B goals in patients with hypercholesterolemia: Pooled results from 10 phase 3 ODYSSEY Trials. Journal of the American Heart Association. 2017;6(8). pii: e005639.

128. Awad K, Mikhailidis DP, Toth PP, Jones SR, et al. Efficacy and safety of alternate-day versus daily dosing of statins: a systematic review and meta-analysis. Cardiovascular Drugs and Therapies. Forthcoming 2017.

129. Toth PP, Stevens W, Chou JW. Why published studies of the cost-effectiveness of PCSK-9 inhibitors yielded such markedly different results. Journal of Medical Economics. 2017; 20(7):749-751.

130. Toth PP, Danese M, et al. Estimated burden of cardiovascular disease and value-based price range for evolocumab in a high-risk, secondary-prevention population in the US payer context. Journal of Medical Economics. 2017;20(6):555-564.

131. Toth PP, Descamps O,…Wasserman SM; PROFICIO Investigators. Pooled safety analysis of evolocumab in over 6000 patients from double-blind and open-label extension studies. Circulation. 2017;135(19):1819-1831.

132. Punekar RS, … Toth PP. Lipid-lowering treatment modifications among patients with hyperlipidemia and a prior cardiovascular event: a US retrospective cohort study. Current Medical Research and Opinion. 2017;33(5):869-876.

133. Baum SJ, Toth PP, et al. PCSK9 inhibitor access barriers-issues and recommendations: Improving the access process for patients, clinicians and payers. Clinical Cardiology. 2017;40(4):243-254.

134. Rashid N, Sharma PP, Scott RD, Lin KJ, Toth PP. All-cause and acute pancreatitis health care costs in patients with severe hypertriglyceridemia. Pancreas. 2017;46(1):57-63.

135. Toth PP, et al. Effect on fasting serum glucose levels of adding ezetimibe to statins in patients with nondiabetic hypercholesterolemia. American Journal of Cardiology. 2016;118(12):1812-1820.

136. Banach M, Stulc T, Dent R, Toth PP. Statin non-adherence and residual cardiovascular risk: There is need for substantial improvement. International Journal of Cardiology. 2016; 225:184-196.

137. Toth PP. Novel therapies for low-density lipoprotein cholesterol reduction. American Journal of Cardiology. 2016;118(6 Suppl):19A-32A.

138. Sniderman AD, Toth PP, Thannasoulis G, Furberg CD. An evidence-based analysis of the National Lipid Association recommendations concerning non-HDL-C and apoB. Journal of Clinical Lipidology. 2016; 10(5):1248-58.

139. Rashid N, Sharma PP, Scott RD, Lin KJ, Toth PP. Severe hypertriglyceridemia and factors associated with acute pancreatitis in an integrated health care system. Journal of Clinical Lipidology. 2016;10(4):880-90.

140. Baspinar O, Bayram F, Korkmaz S,…Toth PP. The effects of statin treatment on adrenal and sexual function and nitric oxide levels in hypercholesterolemic male patients treated with a statin. Journal of Clinical Lipidology. 2016; 10(6):1452-1461.

cigarette smoking141. Kianoush S, Yakoob MY, Al-Rifai M, DeFilippis AP, Bittencourt MS, Duncan BB, Bensenor IM, Bhatnagar A, Lotufo PA, Blaha MJ. Associations of cigarette smoking with subclinical inflammation and atherosclerosis: ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health). Journal of the American Heart Association. 2017 Jun 24;6(6).Summary: Smoking status, burden, and intensity were associated with inflammation (hsCRP) and subclinical atherosclerosis (carotid intima-media thickness, ankle-brachial index, CAC).

142. Al Rifai M, DeFilippis AP, McEvoy JW, Hall ME, … Blaha MJ. The relationship between smoking intensity and subclinical cardiovascular injury: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2017 Mar;258:119-130. Summary: Smoking intensity was associated with early biomarkers of cardiovascular disease, particularly markers of systemic inflammation such as hsCRP.

143. Jones MR, Magid HS, Al-Rifai M, McEvoy JW, … Post WS, Blaha MJ, Navas-Acien A. Secondhand smoke exposure and subclinical cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis. Journal of the American Heart Association. 2016 Dec 19;5(12). Summary: There is an association of second-hand smoke exposure with inflammation and peripheral arterial disease.

144. Tibuakuu M, Kamimura D, Kianoush S, DeFilippis AP, Al Rifai M, … Blaha MJ. The association between cigarette smoking and inflammation: The Genetic Epidemiology Network of Arteriopathy (GENOA) study. PLoS One. 2017 Sep 18;12(9):e0184914. Summary: We found no significant association of smoking intensity or burden with biomarkers of inflammation among current smokers. 22

Martin Tibuakuu, MD

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145. Sussan TE,...Blaha MJ, Holbrook JT, Biswal S. Electronic cigarette use behaviors and motivations among smokers and non-smokers. BioMed Central Public Health. 2017 Sep 8;17(1):686.Summary: Electronic cigarettes users who were previously non-smokers have different motivations and perceptions than those of current and former smokers.

146. Kianoush S, Bittencourt M, Lotufo P, Bensenor I, Jones SR, DeFilippis AP, Toth P, … Blaha MJ. Association between smoking and serum GlycA and high-sensitivity C-reactive protein levels: The Multi-Ethnic Study of Atherosclerosis (MESA) and Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Journal of American Heart Association. 2017 Aug 23;6(8).Summary: Acute and chronic exposure to tobacco smoking is associated with inflammation, as quantified by both the biomarker glycoprotein acetylation (GlycA) and high-sensitivity C-reactive protein (hsCRP).

147. Leigh JA, … Blaha MJ, et al. Smoking intensity and duration is associated with cardiac structure and function: the ECHOcardiographic Study of Hispanics/Latinos. Open Heart. 2017 Jun 14;4(2):e000614.Summary: A dose-response relationship exists between intensity and duration of cigarette smoking with unfavorable changes in cardiac structure and function.

148. Nance R, Delaney J, McEvoy JW, Blaha MJ, et al. Smoking intensity (pack/day) is a better measure than pack-years or smoking status for modeling cardiovascular disease outcomes. Journal of Clinical Epidemiology. 2017 Jan;81:111-119. Summary: The association of smoking with incident CVD events was well captured by including a simple term for baseline smoking intensity.

149. Reynolds LM, … Blaha MJ, Navas-Acien A, Liu Y. Secondhand tobacco smoke exposure associations with DNA methylation of the aryl hydrocarbon receptor repressor. Nicotine & Tobacco Research. 2017 Apr 1;19(4):442-451. Summary: High levels of recent indoor secondhand smoke exposure may be inversely associated with DNA methylation of aryl hydrocarbon receptor repressor in human monocytes.

150. Nasir K, Patel J. Risk of ASCVD and secondhand tobacco exposure: All smoke and mirrors? No more. JACC: Cardiovascular Imaging. 2017 Jun;10(6):660-662.

151. Ursoniu S, Mikhailidis DP, Serban MC, Penson P, Toth PP, et al. The effect of statins on cardiovascular outcomes by smoking status: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research. 2017; 122:105-117.

152. Ratchford EV, Evans NS. Smoking cessation. Vascular Medicine. 2016 Oct;21(5):477-479.

153. Ye C, … Nasir K. Subclinical cardiovascular disease in patients with chronic obstructive pulmonary disease: a systematic review. Quarterly Journal of Medicine. 2017 Jun 1;110(6):341-349. Summary: Our review presents significant evidence in support of increased subclinical CVD burden in COPD patients independent of smoking status.

cV imaging with cT/peT/MR154. Mathews L, Iantorno M, Schär M, Bonanno G, Gerstenblith G, Weiss RG, Hays AG. Coronary endothelial function is better in healthy premenopausal women than in healthy older postmenopausal women and men. PLoS One. 2017 Oct 26;12(10):e0186448. Summary: Premenopausal women have two-fold better mean coronary endothelial function compared to postmenopausal women.

155. Hays AG, … Gerstenblith G, Weiss RG. Local coronary wall eccentricity and endothelial function are closely related in patients with atherosclerotic coronary artery disease. Journal of Cardiovascular Magnetic Resonance. 2017 Jul 6;19(1):51.Summary: There is a significant inverse and independent relationship between coronary endothelial macrovascular function and the degree of local coronary wall eccentricity.

156. Sandfort V, Bluemke DA, Vargas J, Brinker JA, Gerstenblith G, et al. Coronary plaque progression and regression in asymptomatic African American chronic cocaine users with obstructive coronary stenoses: A preliminary study. Journal of Addiction Medicine. 2017 Mar/Apr;11(2):126-137.

Summary: Continued cocaine use is associated with noncalcified plaque progression, whereas reduced cocaine use may be associated with modest noncalcified plaque regression.

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seth s. Martin, Md, MhsSeth S. Martin, MD, MHS, a former Pollin Cardiovascular Disease Prevention Fellow and the Ciccarone Center’s Associate Director of the Advanced Lipid Disorders Clinic, Dr. Martin currently serves as an assistant professor of medicine in the Johns Hopkins Division of Cardiovascular Medicine and associate

faculty member in the Welch Center for Prevention, Epidemiology, and Clinical Research in the Johns Hopkins School of Public

Health. In March 2017, Dr. Martin was named one of Cardiology Today’s “Next Gen Innovators,” a group of early career cardiologists who the editorial board has identified as innovators in the field. Dr. Martin leads the Ciccarone Center’s efforts to transform cardiovascular care using mobile health technology, and he serves as faculty clinical coach and educator for the Osler Medicine Residency (Janeway Firm) and on the Hopkins Bedside Medicine Faculty. Additional accomplishments from the past year include being appointed to the Planning Committee for the ACC Scientific Sessions and serving as Abstract Captain for the Prevention Track; being elected Chair of the AHA Greater Baltimore Advocacy Coordinating Committee and serving as co-chair for the AHA Late-Breaking Clinical Trial session on lipids; serving on the Maryland State Advisory Council on Heart Disease and Stroke Prevention; getting selected an associate editor for the Journal of Clinical Lipidology; and an election to the Board of Directors for the American Society of Preventive Cardiology.

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157. Leucker TM, Valenta I, Schindler TH. Positron emission tomography-determined hyperemic flow, myocardial flow reserve, and flow gradient-quo vadis? Frontiers in Cardiovascular Medicine. 2017 Jul 17;4:46.

158. Valenta I, Antoniou A, Marashdeh W, Leucker T, Kasper E, Jones SR, et al. PET-measured longitudinal flow gradient correlates with invasive fractional flow reserve in CAD patients. European Heart Journal of Cardiovascular Imaging. 2017 May 1;18(5):538-548.

159. Podolanczuk AJ, … Michos ED, Raghu G, Kawut SM, Lederer DJ. High attenuation areas on chest CT and clinical respiratory outcomes in community-dwelling adults. American Journal of Respiratory and Critical Care Medicine. Forthcoming 2017. Summary: Areas of increased lung attenuation are a novel risk factor for interstitial lung disease hospitalization and mortality.

160. Poor HD, … Michos ED, Prince MR, Barr RG. Pulmonary hyperinflation due to gas trapping and pulmonary artery size: The MESA COPD Study. PLoS One. 2017 May 2;12(5):e0176812.Summary: Increased residual volume was associated with a larger pulmonary artery in COPD, suggesting that gas trapping may contribute to pulmonary hypertension in COPD.

Vitamin d161. Chin K, Zhao D, Tibuakuu M, Martin SS, Ndumele CE, Florido R, Windham BG, Guallar E, Lutsey PL, Michos ED. Physical activity, vitamin D, and incident atherosclerotic cardiovascular disease in whites and blacks: The ARIC Study. Journal of Clinical Endocrinology and Metabolism. 2017 Apr 1;102(4):1227-1236.Summary: Physical activity is linearly associated with higher vitamin D levels in whites, and both ethnicities may have synergistic beneficial effects on atherosclerotic CVD risk.

162. Zhao D, Ouyang P,...Guallar E, Siscovick DS, Post WS, Kalyani RR, Billups KL, Michos ED. Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA). Maturitas. 2017 Feb;96:95-102.

163. Faridi KF, Lupton JR, Martin SS, Banach M, Quispe R, Kulkarni K, Jones SR, Michos ED. Vitamin D deficiency and non-lipid biomarkers of cardiovascular risk. Archives of Medical Science. 2017 Jun;13(4):732-737.Summary: Deficient vitamin D is associated with elevated levels of many biomarkers of cardiovascular risk, particularly among US women.

164. Faridi KF, Zhao D, Martin SS, Lupton JR, Jones SR, Guallar E, Ballantyne CM, Lutsey PL, Michos ED. Serum vitamin D and change in lipid levels over 5 y: The Atherosclerosis Risk in Communities study. Nutrition. 2017 Jun;38:85-93.Summary: Deficient vitamin D was prospectively associated with lower total cholesterol and HDL-C and a greater ratio of cholesterol to HDL-C after considering diabetes and adiposity.

165. Michos ED, Selvin E, Misialek JR, McEvoy JW, Ndumele CE, et al. 25-Hydroxyvitamin D levels and markers of subclinical myocardial damage and wall stress: The Atherosclerosis Risk in Communities Study. Journal of the American Heart Association. 2016 Nov 7;5(11).Summary: Vitamin D deficiency was associated with increased 6-year change in high-sensitivity cardiac troponin T levels.

166. de Boer IH, Bangalore S, Benetos A, Davis AM, Michos ED, Muntner P, Rossing P, Zoungas S, Bakris G. Diabetes and hypertension: A position statement by the American Diabetes Association. Diabetes Care. 2017 Sep;40(9):1273-1284.

167. Rooney MR, Harnack L, Michos ED, Ogilvie RP, Sempos CT, Lutsey PL. Trends in use of high-dose vitamin D supplements exceeding 1000 or 4000 international units daily, 1999-2014. Journal of the American Medical Association. 2017 Jun 20;317(23):2448-2450.

168. Tibuakuu M, Zhao D, de Boer IH, Guallar E, … Michos ED. Relation of serum vitamin D to risk of mitral annular and aortic valve calcium (from the Multi-Ethnic Study of Atherosclerosis). American Journal of Cardiology. 2017 Aug 1;120(3):473-478. Summary: Results suggest a possible link between serum vitamin D and the risk for incident mitral annular calcium, but future studies with longer follow-up are needed.

169. Robinson-Cohen C, … Michos ED, et al. Associations of vitamin D-binding globulin and bioavailable vitamin D concentrations with coronary heart disease events: The Multi-Ethnic Study of Atherosclerosis (MESA). The Journal of Clinical Endocrinology and Metabolism. 2017 Aug 1;102(8):3075-3084. Summary: High vitamin D-binding globulin concentration was associated with CHD events in all racial and ethnic groups.

24

Luke silverman-Lloyd, BAA 2016 graduate of Washington University in St. Louis and an excellent shooting guard on their basketball team, Luke Silverman-Lloyd spent the past year working on the mActive-Smoke study with Drs. Seth Martin, Michael Blaha and Sina Kianoush, a former Ciccarone Fellow, helping to coordinate the study and collect and analyze data. Silverman-Lloyd got connected with the mActive Team through a shared interest in mobile health methods and technologies. He presented some preliminary results at a poster session during the 8th Annual Cardiovascular Research Retreat in May 2016, and has since been finalizing analyses and working on a corresponding manuscript slated for publication. Most recently, he and Drs. Martin and Blaha have been collaborating with researchers at Vanderbilt University to develop a mobile health intervention for patients with pulmonary arterial hypertension (PAH). The intervention, derived from the original mActive study conducted by Dr. Martin and other Ciccarone researchers, is currently being integrated into a clinical trial of PAH patients at Vanderbilt. With degrees in anthropology and Spanish, Silverman-Lloyd is currently applying to medical school and plans to continue working with Drs. Martin and Blaha during the coming year on various mHealth studies and initiatives.

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170. Kim SM, Lutsey PL, Michos ED. Vitamin D and cardiovascular disease: Can novel measures of vitamin D status improve risk prediction and address the vitamin D racial paradox? Current Cardiovascular Risk Reports. 2017 Jan;11(1). pii: 3.Summary: An update on some emerging measures of vitamin D status and how assessment of key metabolites might improve prognostication of risk for CVD outcomes.

171. Mazidi M, Michos ED, Banach M. The association of telomere length and serum 25-hydroxyvitamin D levels in US adults: the National Health and Nutrition Examination Survey. Archives of Medical Science. 2017 Feb 1;13(1):61-65. Summary: Our findings support a possible positive association between vitamin D levels and telomere length.

172. Rapson IR, Michos ED, et al. Serum 25-hydroxyvitamin D is associated with incident peripheral artery disease among white and black adults in the ARIC study cohort. Atherosclerosis. 2017 Feb;257:123-129. Summary: Deficient serum 25-hydroxyvitamin D was associated with increased risk of peripheral artery disease in black and white participants.

173. Chin K, Appel LJ, Michos ED. Vitamin D, calcium, and cardiovascular disease: A“D”vantageous or “D”etrimental? An era of uncertainty. Current Atherosclerosis Reports. 2017 Jan;19(1):5.Summary: An update on the most recent evidence regarding the effects of vitamin D and calcium supplements on CVD clinical outcomes.

174. Buta B, … Michos ED, et al. The association of vitamin D deficiency and incident frailty in older women: The role of cardiometabolic diseases. Journal of the American Geriatrics Society. 2017 Mar;65(3):619-624. Summary: Low serum vitamin D concentration, associated with incident frailty in older women, is no longer significant after accounting for the presence of cardiometabolic diseases.

175. Anderson JJ, … Michos ED. Calcium intake from diet and supplements and the risk of coronary artery calcification and its progression among older adults: 10-Year follow-up of the Multi-Ethnic Study of Atherosclerosis (MESA). Journal of the American Heart Association. 2016 Oct 11;5(10). pii: e003815.

Summary: High total calcium intake was associated with a decreased risk of incident atherosclerosis over long-term follow-up.

176. Lutsey PL, … Michos ED, Eckfeldt JH, Selvin E. Short-term variability of vitamin D-related biomarkers. Clinical Chemistry. 2016 Dec;62(12):1647-1653.

177. Kopecky SL, Bauer DC, Gulati M, Nieves JW, Singer AJ, Toth PP, et al. Lack of evidence linking calcium with or without vitamin D supplementation to cardiovascular disease in generally healthy adults: A clinical guideline from the National Osteoporosis Foundation and the American Society for Preventive Cardiology. Annals of Internal Medicine. 2016;165(12):867-868.

diet/weight/nutrition178. Blumenthal RS, Gluckman TJ, Martin SS. Trends in the use of moderate-intensity to high-intensity statin and nonstatin lipid-lowering therapy: turning off the faucet is much more valuable than mopping up the floor. JAMA: Cardiology. 2017 Apr 1;2(4):355-356.Summary: Effective primary prevention with lifestyle improvements is less costly than treating patients who have advanced ASCVD.

179. Caínzos-Achirica M, Bilal U, Kapoor K, Quispe Ayala R, McEvoy JW, Pladevall-Vila M, Blumenthal RS, Blaha MJ. Methodological issues in nutritional epidemiology research – Sorting through the confusion. Current Cardiovascular Risk Report. Forthcoming 2017. Summary: We discuss methodological issues often seen in observational nutritional research and provide recommendations to help minimize them.

180. Khan N, Marvel FA, Wang J, Martin SS. Digital health technologies to promote lifestyle change and adherence. Current Treatment Options in Cardiovascular Medicine. 2017 Aug;19(8):60.Summary: We review recent studies addressing health technologies to promote lifestyle change and medication adherence, including text messaging, applications, and wearable devices.

181. Plante TB, Martin SS. Wearable technology and long-term weight loss. Journal of the American Medical Association. 2017 Jan 17;317(3):318-319.

182. Levine GN, … Michos ED, et al. Meditation and cardiovascular risk reduction: A scientific statement from the American Heart Association. Journal of the American Heart Association. 2017 Sep 28;6(10).Summary: Studies of meditation suggest a possible benefit on cardiovascular risk, although the overall quality/quantity of study data are modest.

183. Ogunmoroti O, Utuama OA, Michos ED, … Nasir K. Does education modify the effect of ethnicity in the expression of ideal cardiovascular health? The Baptist Health South Florida Employee Study. Clinical Cardiology. Forthcoming 2017. Summary: Higher educational attainment had variable associations with achieved levels of ideal CV health across race/ethnic groups.

184. Zaheer S, … Michos ED, et al. Fibroblast growth factor 23, mineral metabolism, and adiposity in normal kidney function. The Journal of Clinical Endocrinology and Metabolism. 2017 Apr 1;102(4):1387-1395. Summary: We tested the hypothesis that greater adiposity results in higher growth factor 23 levels among individuals with normal estimated glomerular filtration rate.

185. Hulten EA, … Nasir K, Blaha M, et al. Obesity, metabolic syndrome and cardiovascular prognosis: from the Partners coronary computed tomography angiography registry. Journal of Cardiovascular Diabetology; 2017;16(1):14.Summary: Within each BMI category, metabolically unhealthy patients had greater extent of CAD compared to metabolically healthy patients.

186. Aziz M, … Nasir K. The association of sleep duration and morbid obesity in a working population: The Baptist Health South Florida Employee Study. Metabolic Syndrome and Related Disorders. 2017 Mar;15(2):59-62.Summary: Short sleep duration (<6 hr) is significantly associated with a higher risk of morbid obesity.

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Jane Wang, MD

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187. Osondu CU, … Nasir K. The effectiveness of a worksite lifestyle intervention program on high-risk individuals as potential candidates for bariatric surgery: My Unlimited Potential (MyUP). Population Health Management. 2016 Oct;19(5):368-75. Summary: Workplace wellness programs help achieve weight loss and lessen the need for bariatric surgery, and potentially reduce costs.

188. Blumenthal RS, Ambinder DE, McEvoy JW. Cardiovascular health: simplified. Journal of the American College of Cardiology. Forthcoming 2017.Summary: Lifestyle habits are important determinants of ASCVD risk.

189. Cicero AFG, Colletti A, Bajraktari G,…Toth PP,..Banach M. Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Archives of Medical Science. 2017;13:965-1005.

190. Maki KC, Palacios OM, Bell M, Toth PP. Use of supplemental long-chain omega-3 fatty acids and risk for cardiac death: An updated meta-analysis and review of research gaps. Journal of Clinical Lipidology. 2017 Sep - Oct;11(5):1152-1160.e2.

191. Patti AM, Toth PP, Giglio RV,…Rizzo M. Nutraceuticals as an important part of combination therapy in dyslipidemia. Current Pharmaceutical Design. 2017;23(17):2496-2503.

diabetes/Metabolic syndrome/endocrine192. Kianoush S, Blaha MJ. Early interventions for optimal control of prediabetes and diabetes: Critical to prevent cardiovascular disease? Atherosclerosis. 2016 Oct;253:265-267.

193. Chruściel P, … Jones SR, Mosteoru S, Blaha MJ, Martin SS, Rysz J, Toth PP, et al.Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms. Atherosclerosis. 2016 Oct;253:194-208. Summary: There is a significant increase in plasma adiponectin levels following statin therapy, suggesting that the mechanism for this is unlikely due to a reduction in adiponectin expression.

194. Martin SS, Daya N, Lutsey PL, Matsushita K, Fretz A, McEvoy JW, Blumenthal RS, et al. Thyroid function, cardiovascular risk factors, and incident atherosclerotic cardiovascular disease: The Atherosclerosis Risk in Communities (ARIC) study. The Journal of Clinical Endocrinology and Metabolism. 2017 Sep 1;102(9):3306-3315. Summary: Hypothyroidism is associated with hyperlipidemia, but the magnitude is small in mild hypothyroidism, and cardiac outcomes are similar between thyroid function groups.

195. Hong YS, Chang Y, Ryu S, Caínzos-Achirica M, Kwon MJ, Zhang Y, Choi Y, Ahn J, Rampal S, Zhao D, Pastor-Barriuso R, Lazo M, Shin H, Cho J, Guallar E. Hepatitis B and C virus infection and diabetes mellitus: A cohort study. Scientific Reports. 2017 Jul 4;7(1):4606.Summary: In a very large population of asymptomatic Korean adults, diabetes is an additional metabolic complication of hepatitis B and C virus infection.

196. Xia C, Goud A, D’Souza J, Dahagam C, Rao X, Rajagopalan S, Zhong J. DPP4 inhibitors and cardiovascular outcomes: safety on heart failure. Heart Failure Reviews. 2017 May;22(3):299-304. Summary: This review discusses recent advances in the heart failure effects of a novel class of oral anti-diabetic medications.

197. Joseph JJ, … Golden SH. Modifiable lifestyle risk factors and incident diabetes in African Americans. American Journal of Preventive Medicine. 2017 Nov;53(5):e165-e174.Summary: A combination of modifiable lifestyle factors are associated with a lower risk of diabetes among African-Americans, particularly among those without obesity.

198. Qiao Y, … Guallar E, Wasserman BA. Racial differences in prevalence and risk for intracranial atherosclerosis in a US community-based population. JAMA Cardiology. Forthcoming 2017.Summary: Midlife smoking and diabetes were strongly associated with late-life intracranial atherosclerosis in blacks only, whereas midlife hypertension and hyperlipidemia were associated with late-life intracranial atherosclerosis in both races.

199. Kim SM, Zhao D, … Guallar E, … Michos ED. Association of parathyroid hormone with 20-year cognitive decline: The ARIC study. Neurology. 2017 Aug 29;89(9):918-926.Summary: Our work does not support an independent influence of parathyroid hormone on cognitive decline in this population-based cohort study.

200. Hughes TM, … Michos ED, Luchsinger JA, Fitzpatrick AL, Hayden KM. Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis. Alzheimers and Dementia. 2017 Mar 31;8:18-25.Summary: Cognitive performance was associated with antecedent abnormalities in glucose metabolism and blood pressure increases.

201. Rooney MR, … Michos ED, Lutsey PL. Serum calcium and incident type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study. American Journal of Clinical Nutrition. 2016 Oct;104(4):1023-1029. Summary: Elevated serum calcium was found to be associated with a greater risk of type 2 diabetes.

202. Virani SS, Akeroyd JM,...Nasir K, et al. Health care resource utilization for outpatient cardiovascular disease and diabetes care delivery among advanced practice providers and physician providers in primary care. Population Health Management. Forthcoming 2017. Summary: Health care resource utilization among diabetes or CVD patients receiving care from advanced practice providers or physicians appears comparable.

203. Aziz M, … Nasir K. Effect of thyroxin treatment on carotid intima-media thickness (CIMT) reduction in patients with subclinical hypothyroidism (SCH): a meta-analysis of clinical trials. Journal of Atherosclerosis and Thrombosis. 2017 Jul 1;24(7):643-659. Summary: Thyroxin therapy in subjects with hypothyroidism significantly decreases carotid intima-media thickness and improves lipid profile, modifiable CVD risk factors.

26

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204. Blankstein R, Gupta A, Rana JS, Nasir K. The implication of coronary artery calcium testing for cardiovascular disease prevention and diabetes. Endocrinology and Metabolism. 2017 Mar;32(1):47-57. Summary: This review highlights some of the recent data on CAC testing, while focusing on the implications of those findings on patient management.

205. Virani SS, Akeroyd JM, Ramsey DJ, Chan WJ, Frazier L, Nasir K, S Rajan S, Ballantyne CM, Petersen LA. Comparative effectiveness of outpatient cardiovascular disease and diabetes care delivery between advanced practice providers and physician providers in primary care: Implications for care under the Affordable Care Act. American Heart Journal. 2016 Nov;181:74-82. Summary: Regardless of provider type, there is a need to improve performance on eligible measures in diabetes or CVD patients.

206. Bradshaw PT, Reynolds KR, Wagenknecht LE, Ndumele CE, Stevens J. Incidence of components of metabolic syndrome in the metabolically healthy obese over 9 years follow-up: the Atherosclerosis Risk In Communities study. International Journal of Obesity. Forthcoming 2017. Summary: Even among apparently healthy individuals, obesity and overweight are related to more rapid development of at least one cardiometabolic risk factor.

207. Hess PL, … Post WS, et al. The metabolic syndrome and risk of sudden cardiac death: The Atherosclerosis Risk in Communities Study. Journal of the American Heart Association. 2017 Aug 23;6(8). pii: e006103.Summary: The metabolic syndrome was associated with a significantly increased risk of sudden cardiac death irrespective of sex or race.

208. Malik S, Zhao Y, Budoff MJ, Nasir K, Blumenthal RS, Bertoni AG, Wong ND. Utility of coronary artery calcium score in risk classification and prediction of long-term cardiovascular disease in those with diabetes and metabolic syndrome: MESA. JAMA Cardiology. 2017. Nov 8.Summary: A surprisingly high percentage of patients with diabetes and metabolic syndrome have no or minimal CAC and are at relatively low risk of an ASCVD event over the next decade.

209. Yakoob MY, et al. Impact of dietary and metabolic risk factors on cardiovascular and diabetes mortality in South Asia: Analysis from the 2010 Global Burden of Disease Study. American Journal of Public Health. 2016 Dec;106(12):2113-2125. Summary: Important similarities and differences are evident in cardiometabolic mortality burdens of modifiable dietary and metabolic risks across these countries.

210. Mazidi M, Toth PP, Banach, M. C-reactive protein is associated with prevalence of the metabolic syndrome, hypertension, and diabetes mellitus in US adults. Angiology. 2017 Jan 1:3319717729288.

211. Lee AK,...McEvoy JW,...Selvin E. The association of severe hypoglycemia with incident cardiovascular events and mortality in adults with type 2 diabetes. Diabetes Care. 2017 Nov 10. Summary: Episodes of marked hypoglycemia are a marker of a high risk of cardiovascular events and premature death.

212. Sattar N, Toth PP, et al. Effect of the proprotein convertase subtilisin/kexin type 9 inhibitor evolocumab on glycemia, body weight, and new-onset diabetes mellitus. American Journal of Cardiology. 2017. pii: S0002-9149(17)31220-1.

213. Nikolic D, Castellino G, Banach M, Toth PP, et al. PPAR agonists, atherogenic dyslipidemia and cardiovascular risk. Current Pharmaceutical Design. 2017 Mar 26;23(6):894-902.

exercise/Fitness214. Aladin AI, Al Rifai M, Rasool SH, Keteyian SJ, Brawner CA, Blumenthal RS, Blaha MJ, Al-Mallah MH, McEvoy JW. Relation of resting heart rate to incident atrial fibrillation (from the Henry Ford Hospital Exercise Testing Project). American Journal of Cardiology. 2017 Jan 15;119(2):262-267.Summary: Adults with low resting heart rate at all levels of exercise capacity are at increased risk of atrial fibrillation and may benefit from heart rhythm surveillance, particularly in the presence of other risk factors.

215. Same RV, Al Rifai M, Feldman DI, Billups KL, Brawner CA, Dardari ZA, Ehrman JK, Keteyian SJ, Al-Mallah MH, Blaha MJ. Prognostic value of exercise capacity among men undergoing pharmacologic treatment for erectile dysfunction: The FIT Project. Clinical Cardiology. 2017. Aug 14.Summary: Higher baseline fitness is associated with improved cardiovascular prognosis in middle-aged men treated for ED.

216. Al Rifai M, Patel J, Hung RK, Nasir K, Keteyian SJ, Brawner CA, Ehrman JK, Sakr S, Blumenthal RS, Blaha MJ, Al-Mallah MH. Higher fitness is strongly protective in patients with family history of heart disease: The FIT Project. American Journal of Medicine. 2017 Mar;130(3):367-371. Summary: Higher cardiorespiratory fitness is strongly protective in all patients regardless of family history status, supporting recommendations for regular exercise in all adults.

217. Al-Mallah MH, … Blaha MJ, Ahmed HM, Ehrman JK, Keteyian SJ, Sakr S. Using machine learning to define the association between cardiorespiratory fitness and all-cause mortality (from the Henry Ford Exercise Testing Project). American Journal of Cardiology. 2017 Aug 30. pii: S0002-9149(17)31399-1.Summary: Machine learning provides better accuracy and discrimination of the prediction of all-cause mortality among patients undergoing stress testing.

218. Shaya GE, Juraschek SP, Feldman DI, … Blaha MJ. Relation of exercise capacity to risk of development of diabetes in patients on statin therapy (the Henry Ford Exercise Testing Project). American Journal of Cardiology. 2017 Sep 1;120(5):769-773. Summary: Higher exercise capacity is associated with a lower risk of incident diabetes regardless of statin use.

219. Ahmed HM, … Zhao DI, Guallar E, Blaha MJ, Michos ED. Sex-specific maximum predicted heart rate and its prognosis for mortality and myocardial infarction. Medicine and Science in Sports and Exercise. 2017 Aug;49(8):1704-1710. Summary: Sex-specific formulas more accurately estimated peak heart rate than the traditional formula and were similarly associated with risk of MI and death.

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220. O’Neal WT, Qureshi WT, Blaha MJ, Dardari ZA, et al. Chronotropic incompetence and risk of atrial fibrillation: The Henry Ford ExercIse Testing (FIT) Project. Journal of American College of Cardiology: Clinical Electrophysiology. 2016 Nov;2(6):645-652.Summary: Patients with inadequate heart rate response during exercise have an increased risk for developing atrial fibrillation.

221. Edwards MK, Blaha MJ, Loprinzi PD. Influence of sedentary behavior, physical activity, and cardiorespiratory fitness on the atherogenic index of plasma. Journal of Clinical Lipidology. 2017 Jan - Feb;11(1):119-125.Summary: Interventions targeting improvements in lipid profile may wish to promote adequate moderate-to-vigorous physical activity over cardiorespiratory fitness or decreased sedentary behavior.

222. Ehrman JK, Brawner CA, Al-Mallah MH, Qureshi WT, Blaha MJ, Keteyian SJ. Cardiorespiratory fitness change and mortality risk among black and white patients: Henry Ford Exercise Testing (FIT) Project. American Journal of Medicine. 2017 Oct;130(10):1177-1183.Summary: Among black and white patients, change in cardiorespiratory fitness from low to intermediate/high fitness was associated with a 35% and 59% lower risk of all-cause mortality, respectively.

223. Kupsky DF, Ahmed AM, Sakr S, Qureshi WT, Brawner CA, Blaha MJ, et al. Cardiorespiratory fitness and incident heart failure: The Henry Ford ExercIse Testing (FIT) Project. American Heart Journal. 2017 Mar;185:35-42.Summary: Higher levels of fitness are associated with a lower incidence of heart failure (HF) independent of HF risk factors.

224. Brawner CA, Al-Mallah MH, Ehrman JK, Qureshi WT, Blaha MJ, Keteyian SJ. Change in maximal exercise capacity is associated with survival in men and women. Mayo Clinic Proceedings. 2017 Mar;92(3):383-390. Summary: In adults referred for an exercise stress test, change in maximal exercise capacity over time is inversely related to risk of all-cause mortality.

225. Vella CA, … Michos ED, Blaha MJ. Physical activity and adiposity-related inflammation: The MESA. Medicine & Science in Sports & Exercise. 2017 May;49(5):915-921.Summary: Moderate-to-vigorous physical activity was associated with more favorable inflammatory markers, independent of cardiometabolic disease risk factors, including central obesity.

226. Hung RK, Al-Mallah MH, Whelton SP, Michos ED, Blumenthal RS, Ehrman JK, Brawner CA, Keteyian SJ, Blaha MJ. Effect of beta-blocker therapy, maximal heart rate,

and exercise capacity during stress testing on long-term survival (from The Henry Ford Exercise Testing Project). American Journal of Cardiology. 2016 Dec 1;118(11):1751-1757. Summary: The prognostic value of percentage of age-predicted maximal heart rate was significantly attenuated by beta-blocker therapy.

227. Florido R, Ndumele CE,... Blumenthal RS, Folsom AR, Coresh J, Ballantyne CM, Selvin E. Physical activity, obesity, and subclinical myocardial damage. JACC: Heart Failure. 2017 May;5(5):377-384. Summary: Physical activity might lessen the association between obesity and subclinical myocardial damage, which could represent a mechanism by which exercise reduces heart failure risk.

Genetics/electrophysiology228. Alexander-Shani R, Mreisat A, Smeir E, Gerstenblith G, Stern MD, Horowitz M. Long-term HIF-1α transcriptional activation is essential for heat-acclimation-mediated cross tolerance: mitochondrial target genes. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2017 May 1;312(5):R753-R762.

229. Ashar FN, … Guallar E, Arking DE. Association of mitochondrial DNA copy number with cardiovascular disease. JAMA Cardiology. Forthcoming 2017.Summary: Mitochondrial DNA copy number was independently associated with incident CVD in 3 large prospective studies and may improve CVD risk classification.

230. Chen H, … Post WS, et al. Multi-ethnic meta-analysis identifies RAI1 as a possible obstructive sleep apnea related quantitative trait locus in men. American Journal of Respiratory Cell and Molecular Biology. Forthcoming 2017.

231. Shendre A, … Post WS, Shrestha S. Admixture mapping of subclinical atherosclerosis and subsequent clinical events among African Americans in 2 large cohort studies. Circulation: Cardiovascular Genetics. 2017 Apr;10(2). pii: e001569.

232. Wang Z, … Post WS, et al. Genetic associations with lipoprotein subfraction measures differ by ethnicity in the multi-ethnic study of atherosclerosis (MESA). Human Genetics. 2017 Jun;136(6):715-726. Summary: Our study emphasizes the importance of ethnicity in genetic risk for CVD and highlights the need to identify ethnicity-specific genetic variants associated with risk.

233. Avery CL, … Post WS, et al. Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations. Heart Rhythm. 2017 Apr;14(4):572-580.

234. Cade BE, … Post WS, et al. Genetic associations with obstructive sleep apnea traits in Hispanic/Latino Americans. American Journal of Respiratory and Critical Care Medicine. 2016 Oct 1;194(7):886-897.Summary: These findings identify novel associations in inflammatory, hypoxia signaling, and sleep pathways.

hiV235. Nakanishi R, Post WS, … Blaha MJ, Brown TT, Kingsley L, Haberlen SA, Dailing C, Budoff MJ. Multicenter AIDS cohort study quantitative coronary plaque progression study: rationale and design. Coronary Artery Disease. 2017 Aug 2.Summary: This study investigated incidence and progression of atherosclerosis assessed by serial coronary computed tomography angiography (CTA) among HIV-infected and uninfected men.

28

Rupert Hung, MD

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236. Lai S, Gerstenblith G, et al. Cocaine use may modify HIV/ART-associated myocardial steatosis and hepatic steatosis. Drug and Alcohol Dependence. 2017 Aug 1;177:84-92.Summary: This study explores whether antiretroviral therapy use is independently associated with steatosis, and examines how cocaine use influences any associations of therapy use with steatosis.

237. Iantorno M, … Gerstenblith G, Weiss RG, Hays AG. Coronary artery endothelial dysfunction is present in HIV-positive individuals without significant coronary artery disease. AIDS. 2017 Jun 1;31(9):1281-1289.

238. Korada SKC, Zhao D, Tibuakuu M, Brown TT, Jacobson LP, Guallar E, Bolan RK, Palella FJ, Margolick JB, Martinson JJ, Budoff MJ, Post WS, Michos ED. Frailty and subclinical coronary

atherosclerosis: The Multicenter AIDS Cohort Study (MACS). Atherosclerosis. 2017 Aug 26. pii: S0021-9150(17)31248-0.Summary: Frailty was independently associated with subclinical coronary atherosclerosis among HIV-uninfected men, but not among HIV-infected men.

239. Osibogun O, Ogunmoroti O, Michos ED, Spatz ES, Olubajo B, Nasir K, Madhivanan P, Maziak W. HIV/HCV coinfection and the risk of cardiovascular disease: A meta-analysis. Journal of Viral Hepatitis. 2017 Nov;24(11):998-1004.Summary: Individuals with HIV/HCV coinfection had an increased CVD risk compared to those with HIV monoinfection.

240. Price JC, … Post WS, Thio CL. The association of inflammatory markers with nonalcoholic fatty liver disease differs by human immunodeficiency virus serostatus. Open Forum Infectious Disease. 2017 Jul 23;4(3):ofx153. Summary: Fatty liver is associated with a heightened inflammatory state independent of visceral adiposity in HIV-uninfected men.

241. Drozd DR, … Post WS, Saag MS, Moore RD, Crane HM. Increased risk of myocardial infarction in HIV-infected individuals in North America compared with the general population. Journal of Acquired Immune Deficiency Syndromes. 2017 Aug 15;75(5):568-576. Summary: Early suppressive antiretroviral treatment and aggressive management of traditional risk factors are necessary to reduce heart attack risk.

242. Hanna DB, Lin J, Post WS, et al. Association of macrophage inflammation biomarkers with progression of subclinical carotid artery atherosclerosis in HIV-infected women and men. Journal of Infectious Disease. 2017 May 1;215(9):1352-1361.Summary: Macrophage inflammation may play an important role in atherogenesis among HIV-positive persons.

243. Natsag J, … Post WS, Brown TT. HIV infection is associated with increased fatty infiltration of the thigh muscle with aging independent of fat distribution. PLoS One. 2017 Jan 6;12(1):e0169184. Summary: Lower muscle quality among HIV-infected persons may be a risk factor for impairments in physical function with aging.

244. Lake JE, Popov M, Post WS, et al. Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status. Journal of Neurovirology. 2017 Jun;23(3):385-393. Summary: The risk for central nervous system effects may be amplified in HIV-positive men.

245. Thomas GP, Li X, Post WS, et al. Associations between antiretroviral use and subclinical coronary atherosclerosis. AIDS. 2016 Oct 23;30(16):2477-2486.Summary: Among virally suppressed HIV-infected men with extensive antiretroviral therapy (ART), there were no consistent associations between the use of specific ART drugs and plaque presence and extent.

246. Roy SK, … Post WS, Palella FJ Jr. Glomerular filtration rate and proteinuria associations with coronary artery calcium among HIV-infected and HIV-uninfected men in the Multicenter AIDS Cohort Study. Coronary Artery Disease. 2017 Jan;28(1):17-22.

Vascular disease/Aortic disease/heart Failure247. Cohoon KP, … Blaha MJ, Decker PA, Durazo R, Liu K, Kramer H. Relationship of aortic wall distensibility to mitral and aortic valve calcification: The Multi-Ethnic Study of Atherosclerosis. Angiology. 2017 Jan 1:3319717730636. Summary: Aortic valve calcification was independently associated with aortic distensibility after adjusting for age, gender, and ethnicity.

248. Benjamin EJ, Blaha MJ, … Nasir K, et al. Heart disease and stroke statistics: 2017 update: a report from the American Heart Association. Circulation. 2017 Mar 7;135(10):e146-e603.

249. Kim J, Budoff MJ, Nasir K, Wong ND, Yeboah J, Al-Mallah MH, Shea S, Dardari ZA, Blumenthal RS, Blaha MJ, Caínzos-Achirica M. Thoracic aortic calcium, cardiovascular disease events, and all-cause mortality in asymptomatic individuals with zero coronary calcium: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2017 Feb;257:1-8.Summary: In a multi-ethnic US population of asymptomatic individuals with zero CAC, the prevalence of thoracic aortic calcium was low and did not improve 10-year estimation of prognosis beyond traditional risk factors.

250. Kotani K, … Jones SR, Martin S, Blaha MJ, Toth PP, et al. Lipoprotein(a) levels in patients with abdominal aortic aneurysm. Angiology. 2017 Feb;68(2):99-108.Summary: This meta-analysis confirmed a higher level of circulating Lp(a) in patients with abdominal aortic aneurysm compared to controls.

251. Remigio-Baker RA, … Blumenthal RS, Ouyang P, Criqui MH. Race/ethnic and sex disparities in the non-alcoholic fatty liver disease-abdominal aortic calcification association: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2017 Mar;258:89-96.Summary: Significant concurrent interaction by race/ethnicity (Chinese and Blacks vs. Whites) and sex was found in the relationship between non-alcoholic fatty liver disease and increasing abdominal aortic calcification.

29

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Di Zhao, PhD

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252. D’Souza J, Malhotra D, Goud A, Dahagam C, Everett G. Brugada syndrome in a patient with vascular Ehlers-Danlos syndrome: Sudden death risk amplified. Cureus. 2017 Apr 19;9(4):e1178. Summary: Discussion of a patient with two rare conditions that share some common clinical presentations, including a propensity for sudden death.

253. D’Souza J, Shah R, Abbass A, Burt JR, Goud A, Dahagam C. Invasive cardiac lipoma: a case report and review of literature. BMC Cardiovascular Disorders. 2017 Jan 14;17(1):28.Summary: We discuss prognosis and treatment of a patient with a simple lipoma who underwent partial resection to relieve symptoms.

254. Florido R, Smith KL, Cuomo KK, Russell SD. Cardiotoxicity from human epidermal growth factor receptor-2 (HER2) targeted therapies. Journal of the American Heart Association. 2017 Sep 22;6(9). pii: e006915.

255. Weiss K, … Gerstenblith G, Russell SD, Weiss RG. Fatigability, exercise intolerance, and abnormal skeletal muscle energetics in heart failure. Circulation: Heart Failure. 2017 Jul;10(7). pii: e004129. Summary: We discuss factors contributing to exercise intolerance in heart failure, skeletal muscle energy metabolic abnormalities, and increased fatigability in HF patients.

256. McCarthy CP, McCarthy KJ, McEvoy JW. Declining risk of sudden death in heart failure. New England Journal of Medicine. 2017 Nov 2;377(18):1793.

257. Thomas IC, McClelland RL, Michos ED, Allison MA, Forbang NI, Longstreth WT Jr, Post WS, et al. Density of calcium in the ascending thoracic aorta and risk of incident cardiovascular disease events. Atherosclerosis. 2017 Oct;265:190-196.Summary: We tested the hypothesis that ascending thoracic aorta calcium volume and density predict incident CVD events independently of CAC.

258. Forbang NI, Michos ED, et al. Greater volume but not higher density of abdominal aortic calcium is associated with increased cardiovascular disease risk: MESA (Multi-Ethnic Study of Atherosclerosis). Circulation: Cardiovascular Imaging. 2016 Nov;9(11). pii: e005138.

Summary: The Agatston method of upweighting calcium scores for greater density may be inappropriate for CVD risk prediction in both the abdominal aorta and coronary arteries.

259. Forbang NI, McClelland RL, Remigio-Baker RA, Allison MA, Sandfort V, Michos ED, et al. Associations of cardiovascular disease risk factors with abdominal aortic calcium volume and density: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2016 Dec;255:54-58. Summary: Several CVD risk factors were associated with higher abdominal aortic calcium volume, but lower density.

260. Kianoush S, Al Rifai M, Caínzos-Achirica M, … DeFilippis AP, Longstreth W, Nasir K, Budoff MJ, Matsushita K, Blaha MJ. Thoracic extra-coronary calcification for the prediction of stroke: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2017 Oct 7;267:61-67. Summary: In MESA, the incremental predictive value of thoracic extra-coronary calcification beyond traditional risk factors and CAC appears to be minimal.

261. Ratchford EV. Medical management of claudication. Journal of Vascular Surgery. 2017 Jul;66(1):275-280.Summary: Optimal medical management is required for each patient, irrespective of the decision regarding lower extremity revascularization.

262. Ratchford EV, Evans NS. Approach to lower extremity edema. Current Treatment Options in Cardiovascular Medicine. 2017 Mar;19(3):16.

263. Evans NS, Ratchford EV. The swollen leg. Vascular Medicine. 2016 Dec;21(6):562-564.

264. Cooper M, Hicks C, Ratchford EV, Salameh MJ, Malas M. Diagnosis and treatment of uncomplicated type B aortic dissection. Vascular Medicine. 2016 Dec;21(6):547-552. 265. Padala SK, … Toth PP. Antianginal therapy for stable ischemic heart disease. Journal of Cardiovascular Pharmacology and Therapeutics. 2017 Nov;22(6):499-510.

266. Brie D, Penson P, Serban MC, Toth PP, Simonton C, Serruys PW, Banach M. Bioresorbable scaffold: A magic bullet for the treatment of coronary artery disease? International Journal of Cardiology. 2016; 215:47-59.

267. Farré N, Vela E, Clèries M, Bustins M, Caínzos-Achirica M, et al. Real world heart failure epidemiology and outcome: A population-based analysis of 88,195 patients. PLoS One. 2017 Feb 24;12(2):e0172745.

Summary: Researchers evaluated the epidemiologic features of heart failure patients, the 1-year key health outcomes of the disease, and the independent predictors of those outcomes.

268. Comín-Colet J, Enjuanes C, Lupón J, Caínzos-Achirica M, Badosa N, Verdú JM. Transitions of care between acute and chronic heart failure: Critical steps in the design of a multidisciplinary care model for the prevention of rehospitalization. Revista Española de Cardiología. 2016 Oct;69(10):951-961. Summary: The authors review critical steps in the management of patients with chronic heart failure, with a special focus on the transitions between the hospitalization phase (acute decompensation) and the chronic management of the disease.

269. Karagiannis AD, Liu M, Giannopoulos AG, Toth PP, et al. Pleiotropic anti-atherosclerotic effects of proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors. Current Atherosclerosis Reports. Forthcoming 2017.

270. Mazidi M, Kengne AP, Toth PP, Banach M. Association between telomere length and peripheral arterial disease in a large American cohort. Frontiers in Human Biology. Forthcoming 2017. 271. Toth PP, Cannon CP, Colhoun HM, Rader DJ, et al. Alirocumab LDL-C-lowering efficacy in patients with and without moderate CKD. Kidney International. Forthcoming 2017.

272. Toth PP, Sattar N, Blom DJ, Martin SS, Jones SR, et al. Effect of evolocumab on lipoprotein particles. American Journal of Cardiology. Forthcoming 2017.

30

Miguel Caínzos-Achirica, MD

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Research Presentations

35

A listing of the late-breaking clinical research data presented at major cardiology meetings by the faculty and fellows of the Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease.

Presentations at the 2017 Scientific Sessions of the American Heart Association (AHA), November 11-15; Anaheim, CA.

1. Tibuakuu M, Kianuoush S, DeFilippis AP, McEvoy JW, Zhao D, Guallar E, Ballantyne CM, Hoogeveen RC, Blaha MJ, Michos ED. The role of lipoprotein-associated phospholipase A2 activity and high-sensitivity C-reactive protein in identifying high risk smokers for incident atherosclerotic cardiovascular disease: The Atherosclerosis Risk in Communities (ARIC) Study.

2. Tibuakuu M, Jones MR, Navas-Acien A, Zhao D, Guallar E, Gassett AJ, Sheppard L, Budoff MJ, Kaufman JD, Michos ED. Exposure to ambient air pollution and calcification of the mitral annulus and aortic valve: The Multi-Ethnic Study of Atherosclerosis (MESA).

3. Florido R, Zhao D, Guallar E, Bluemke DA,...Lima JA, Ndumele CE, Michos ED. Associations of change in physical activity levels with changes in cardiac structure and function in the Multi-Ethnic Study of Atherosclerosis (MESA).

4. Subramanya V, Ambale-Venkatesh B, Ohyama Y, Zhao D, Nwabuo CC, Post WS, Guallar E, Ouyang P, Shah SJ, Allison MA, Ndumele CE, Vaidya D, Bluemke DA, Lima JA, Michos ED. Association of sex hormone levels with aortic stiffness among men and women with preserved ejection fraction: The Multi-Ethnic Study of Atherosclerosis (MESA).

5. Zhao D, Guallar E, Ouyang P, Subramanya V, Vaidya D, Ndumele CE,...Post WS, Michos ED. Endogenous sex hormone levels and risk for incident cardiovascular disease and heart failure in post-menopausal women: the Multi Ethnic Study of Atherosclerosis (MESA).

6. Rao VN, Zhao D, Allison MA, Guallar E, Sharma K, Criqui MH, Cushman M, Blumenthal RS, Michos ED. Anthropometric measures vs. CT-measures of adiposity

and risk of incident heart failure with preserved ejection fraction: The Multi-Ethnic Study of Atherosclerosis (MESA).

7. Benson E-M, Tibuakuu M, Akinkuolie AO, Zhao D,...Mora S, Michos ED. Associations of ideal cardiovascular health by the AHA Life Simple 7 criteria with N-linked glycoprotein acetyl (GlycA), a novel inflammatory marker: The Multi-Ethnic Study of Atherosclerosis (MESA).

8. Nasir, K. Burden of catastrophic health expenditures for acute myocardial infarction and stroke hospitalizations among uninsured in the United States.

9. Nasir, K. Impact of the Affordable Care Act on insurance status of non-elderly US adults with atherosclerotic cardiovascular disease.

10. Okunrintemi V,...Virani S, Blaha M, Blankstein R, Krumholz H, Nasir, K. Racial disparities in the utilization of cardiovascular disease preventive care services in the United States: Insight from the Medical Expenditure Panel Survey 2014.

11. Nasir, K. Cost, utilization, quality of care, and outcomes for acute myocardial infraction (AMI) related events: Result from the 2014 Medical Expenditure Panel Survey.

12. Okunrintemi V,...Virani S, Blaha M, Blankstein R, Nasir, K. Does the gender of the healthcare provider influence health outcomes among patients with atherosclerotic cardiovascular disease in the United States: Insight from the Medical Expenditure Panel Survey (MEPS) 2010-2013.

13. Kianoush S, Dardari Z, Graham G, McEvoy WJ, Miedema MD, Nasir K,…Blaha MJ. The role of coronary artery calcium for stratifying cardiovascular risk in patients with hypertension: A Subgroup Analysis of Coronary Artery Calcium Consortium.

14. Al Rifai MS, McEvoy J, Blaha M,...Ehrman JK. The pulse pressure stress index: A simple and novel exercise-based risk factor for adverse cardiovascular outcomes. Results from the Henry Ford ExercIse Testing (FIT) Project.

15. Kianoush S, DeFilippis AP, Rodriguez CJ, Al Rifai M, Benjamin EJ, Hall ME, Ouyang P, Allison MA, Blaha MJ. Race/ethnicity-specific associations between smoking, serum leptin, and abdominal fat: The Multi-Ethnic Study of Atherosclerosis.

16. Miedema MD, Dardari Z, Kianoush S,...Nasir K, Blaha MJ. Statin eligibility, coronary artery calcium, and subsequent cardiovascular events according to the 2016 USPSTF Statin Guidelines: The Multi-Ethnic Study of Atherosclerosis.

17. Okunrintemi V,...Blaha M, Blankstein R, Krumholz H, Nasir K. Patient provider communication and patient-centered outcomes among patients with atherosclerotic cardiovascular disease in United States: Medical Expenditure Panel Survey 2010-2013.

18. Patel J, Dardari Z, Berman DS, Budoff MJ, Miedema MD, Nasir K, Shaw LJ, Rumberger JA, Rozanski A, Blumenthal RS, Blaha MJ. Family history of CHD predicts a more diffuse CAC distribution in the CAC consortium.

19. Osawa K, Budoff MJ, McClelland RL, Blaha MJ, Blankstein R, McEvoy JW, Stein JH. Coronary artery calcification and carotid artery intima-media thickness identify individuals that may not need statin therapy to prevent incident cerebrovascular events: The Multi Ethnic Study of Atherosclerosis; MESA.

20. Ding N,...Blaha MJ, Allison MA, Heiss G, Selvin E, Coresh J, Matsushita K. Smoking, its cessation, and future risk of peripheral artery disease.

Eliseo Guallar, MD

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36

The ciccarone center for the prevention of cardiovascular disease was founded in 1989 in memory of henry A. “chic” ciccarone, a legendary athlete and lacrosse coach at Johns Hopkins who died at age 50 after his third heart attack.

But he was more than that. In the way he led his teams and his life, Chic embodied all that Johns Hopkins itself represents: dedication, excellence, leadership.

With intense, energetic competitiveness, pride, and engaging, infectious humor, Chic compiled an extraordinary record of achievements in athletics. As a three-time All-American midfielder and team captain, he won nearly every major Hopkins lacrosse award and was

named to the All-Time hopkins lacrosse team upon his graduation in 1962.

In 1989, the friends and former players of Coach Ciccarone began raising funds for the development of a comprehensive program geared toward the prevention

of coronary heart disease events. The Ciccarone Center sought to unite the proud traditions of Hopkins lacrosse and Hopkins Medicine.

we all have a stake in winning the battle against heart disease. By joining the team at the Ciccarone Center, by sharing our enthusiasm and dedication to it, your support of coronary disease prevention will protect your life and the lives of those you love.

Uniting the Proud Traditions of Hopkins

Research Presentations

21. Al-Mallah MH, Blaha MJ,…Keteyian SJ. Cardiorespiratory fitness and incident cerebrovascular accidents: The FIT (Henry Ford ExercIse Testing) Project.

22. Ajlan M, Sakr S, Blaha M,...Al-Mallah MH. Interaction between exercise capacity and CHA2DS2-VASC score in predicting ischemic stroke in patients with atrial fibrillation: The Henry Ford Exercise Testing (FIT) Project.

23. Ehrman JK, Brawner CA, Blaha MJ, Keteyian SJ, Al-Mallah M. Exercise capacity is related to all-cause mortality in individuals tested for surgical clearance: The Henry Ford Exercise Testing (FIT) Project.

24. Wong ND, Cordola-Hsu A, Fan W, Blaha MJ, Budoff MJ, Nasir K, Whelton S, Miedema MD, Rumberger J, Berman DS. Coronary artery calcium and mortality from coronary heart disease, cardiovascular disease, and all causes in women vs. men with diabetes: The Coronary Calcium Consortium.

25. Jensen JC, Dardari Z, Blaha MJ,...Miedema MD. The association of body mass index with coronary artery calcium and subsequent mortality: The Coronary Artery Calcium Consortium.

26. Miedema MD, Dardari ZA, Nasir K,...Blaha MJ. The association of coronary artery calcium with cause-specific mortality in adults aged 30-49 years: The CAC Consortium.

27. Wang F,…Nasir K, Shaw LJ, Rumberger JA, Blumenthal RS, Blaha MJ, Berman DS. Use of coronary artery calcification for prediction of cardiovascular death in elderly patients.

28. Post WS, Haberlen S, Witt MD,… Budoff M. Inadequate HIV suppression is associated with progression of coronary stenosis: The Multicenter AIDS Cohort Study (MACS) Longitudinal Coronary CT Angiography Study.

29. Jaber RM, Mirbolouk M, DeFilippis AP,…Blaha MJ, Nasir K. Electronic cigarette use prevalence and pattern by cigarette smoking status among United States adults: Findings From NHANES 2013-2014.

30. Mirbolouk M, Kianoush S, Dardari Z, McEvoy JW, Shaw L, Miedema M, Al-Mallah MH, Rozanski A, Rumberger J, Berman DS, Budoff MJ, Nasir K, Blaha

MJ. Prognostic significance of coronary artery calcium (CAC) score among current smokers and nonsmokers of Coronary Artery Calcium Consortium: A Multicenter Cohort Study.

31. Mathews L, Ishigami J, Hoogeveen RC, Kucharska-Newton A, Ballantyne CM, Gottesman RFSelvin E, Matsushita K. High sensitivity cardiac troponin-T and subsequent risk of hospitalization with bleeding: The Atherosclerosis in Communities (ARIC) Study.

Zeina Dardari, MS

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How to Contact the Ciccarone Center

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heart disease is America’s #1 killer — more than cancer and accidents combined. Our goal at the Ciccarone Center is to stop heart disease before it develops, through an aggressive program of risk assessment and comprehensive lifestyle and medical management.

Like all pioneering medical programs, however, we are in constant pursuit of funding to accelerate our progress. We depend on the support of generous donors to thrive.

The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease has just completed its 28th year of service and is going strong. When you give to the Ciccarone Center, you’re ensuring that, if you or a loved one is at risk for heart disease or stroke, you’ll have a

program to help prevent it. Or if you already have heart disease, you’ll maximize your opportunity for an active and enjoyable life.

You can help support this program by contributing to the future of cardiovascular disease research, education, and patient care. Make a tax-deductible donation to the Ciccarone Center today and help save lives tomorrow.

Gifts may be made in the form of cash, check, credit card, securities, real estate or personal property. For more information, please call the development office at 443-287-7384, email [email protected] or visit http://www.hopkinsmedicine.org/heart_vascular_institute/about_us/charitable_giving/.

we see patients Monday through Friday at the Johns hopkins ciccarone center at Green spring station and on Mondays, Tuesdays, and Fridays at the Johns hopkins outpatient center. Dr. Michos also sees patients at Odenton. At each location we can perform exercise stress tests, treadmill stress echo tests, echo Doppler tests, EKGs, Holter monitors, and refer patients for cardiac CT scans. Vascular ultrasound testing and consultations are available at Green Spring Station. Vascular Medicine consultations are also available at White Marsh.

Appointments at the Johns hopkins ciccarone center at Green spring station, 10755 Falls Road, pavilion i, suite 360, Lutherville, Md 21093 location can be scheduled at 443-997-0275. (Drs. Blumenthal, Post, Ashen, Ratchford, Whelton, and Blaha)

Appointments at the Johns hopkins outpatient center, 601 north caroline street, Baltimore, Maryland 21287, can be scheduled at 443-997-0270. (Drs. Jones, Ndumele, Blumenthal, Martin, McEvoy, and Gerstenblith)

Appointments at the Johns hopkins cardiology center at odenton, 1132 Annapolis Road, suite 104, odenton, Md 21113, can be scheduled at 443-997-0275 or 410-874-1520. (Dr. Michos)

Appointments for Vascular Medicine consultations or vascular ultrasound testing can also be scheduled through Dr. Ratchford’s Center for Vascular Medicine scheduling line at 443-997-1800. Dr. Elizabeth Ratchford serves as the Medical Director of the vascular ultrasound laboratory at Green Spring Station.

Support the Prevention of Cardiovascular Disease

The Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Diseasewww.hopkinsmedicine.org/heart

410-955-7376

Photo by John Strohsacker

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