Extra-mesenchymal Chondrosarcoma
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Transcript of Extra-mesenchymal Chondrosarcoma
References
Discussion
Background
A CASE OF MESENCHYMAL CHONDROSARCOMADepartment of Anatomical Pathology, University of Limpopo-MEDUNSA
CAMPUS
Objective Materials & Methods
Conclusion
1.Arch Pathol Lab Med—Vol 131, February 2007
2.Weis S, Goldblum J. Cartilaginous Soft Tissue Tumors. In: Weis S, Goldblum J, editors. Enzinger and Weis’s Soft Tissue Tumors, 4th Edition. 2001. p 1361-1388.
A 41 year female with a large left thigh mass.She also has a small mass on the back of the right shoulder which has a remarkable increase in contrast uptake on nuclear scan. She has a previous history of an excision of a thyroid mass done at a private institution and the biopsy result was that of a Chondrosarcoma..
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The gross, histological features and immunohistochemical profile of this tumour are those of a extraskeletal mesenchymal chondrosarcoma.
An incisional biopsy of the left thigh mass was performed and the result was a mesenchymal chondrosarcoma.
Then an excisional biopsy was done.
Immunohistochemistry –
S100 - Positive
Vimentin - Positive;
Cytokeratin AE/13 - Negative. .
Microscopic findings –
The sections show a diffuse proliferation of pleomorphic small, round to oval cells.
In some areas, a haemangiopericytoma-like growth pattern is present.
Cartilagenious areas with mild pleomorphism of chondrocytes in the lacunae and calcifications are present.
H & E
SKOSANA KC, BIDA MN
Vimentin
S100
AE1/AE3
Results
IntroductionMesenchymal chondrosarcomas constitute less than 2 % of all chondrosarcomas. Approximately two thirds of cases of mesenchymal chondrosarcoma occur in bone while the rest occur in places outside of the bone—i.e.in extraskeletal locations.They are aggressive lesions with a high propensity for metastases.Mesenchymal chondrosarcoma is a fast growing tumor that spreads more often. They can remain dormant for long periods of time.
This case illustrates multi-focality, recurrence and metachronous nature of a extraskeletal mesenchymal chondrosarcoma.