E X P L O R E T H E B E N E F I T S O F B E C O M I N G A S K I N C E U T I C A L S PA R T N E R

O U R M I S S I O N I S TO I M P R O V E S K I N H E A LT H

Dedicated to this purpose, we make one simple promise — to provide advanced skincare backed by science.

Born from decades of skin cancer research that led to pivotal breakthroughs in antioxidants, our high potency

formulas are concentrated in pure actives and proven to optimally penetrate into skin.

Made in the USA, our clinical skincare is used by dermatologists, plastic surgeons, and medi-spas for daily

homecare and to complement aesthetic procedures. We formulate to correct signs of aging, protect healthy

skin, and prevent future damage.

A N T I O X I D A N T P I O N E E R

An early pioneer of cosmeceuticals in the US, SkinCeuticals

innovates critical anti-aging breakthroughs at the forefront of

antioxidant technology.

Evidence proving skin penetration and antioxidant benefits of

our vitamin C formulations is based on the academic research

of Dr. Sheldon Pinnell, a renowned American research

dermatologist from Duke University.

With cutting-edge in-vivo science as the foundation of our

existence, SkinCeuticals has been providing advanced

skincare to medical professionals since 1997.

1937–2013

T H E S K I N C E U T I C A L S S TO R Y

Duke University Dr. Sheldon

Pinnell discovers the parameters

required to stabilize pure vitamin

C, paving the way for the

creation of SkinCeuticals

Pinnell’s landmark study on

percutaneous absorption is

published in Dermatologic Surgery

SkinCeuticals introduces

its cornerstone pillars of

Prevent, Protect, and Correct

Launch of C E Ferulic®: the first

vitamin C antioxidant for 8x

daily environmental protection

Launch of Phloretin CF®: a broad-

spectrum vitamin C antioxidant

for daily environmental protection

1989 2001 2004 2005 2008

138

pinnell et al.: topical l-ascorbic acid

Dermatol Surg 27:2:February 2001

fying Serum C, Dr. Mary Lupo Skin Care Products, NewOrleans, LA) and 10% ascorbyl-6-palmitate (C-Esta Serum,Jan Marini Skin Research, San Jose, CA) were obtainedfresh from the manufacturer and opened just prior to test-ing. Samples were tested as is; the content was not con-firmed. Dehydroascorbic acid 1 M (17.4%) was preparedby taking 1 ml of a 1 M ascorbate solution, adding bromine55

�

l, vortexing vigorously for 30 seconds, and then imme-diately bubbling with nitrogen for 10 minutes.

19

The institu-tional review board of the College of Veterinary Medicine atNorth Carolina State University approved the animal exper-iments.Experiments were conducted in white Yorkshire pigs.The skin was shaved with an electric shaver 24 hours beforethe experiment began to allow healing of any skin nicks.Two hundred

�

l of formulation, the maximal volume of thechamber, was placed under a Hill Top Chamber (Hill TopCo., Cincinnati, OH) for 22–24 hours. The chamber is semi-occlusive and protects the material from smearing. Althoughthe chamber may enhance percutaneous absorption, in sev-eral cases in the experimental results, the baseline skin levelsof L-ascorbic acid were not increased. In some experimentsthe chamber was replaced with fresh solution and changedeach day. In clinical practice, vitamin C solutions are usuallyapplied daily. At the end of the experiment, the formulationwas washed vigorously from the skin with water. Washedskin was tape stripped 15 times to remove surface contami-nation and stratum corneum. The tape strips were dis-carded. Studies have shown that tape stripping removes thestratum corneum layers (data not shown) and removes sur-face radioactivity of topically applied substances bound tothe stratum corneum.

20

,

21

Full-thickness 6 mm punch biopsyspecimens of skin were taken and placed immediately intoliquid nitrogen. Tissue was shattered in liquid nitrogen andweighed aliquots extracted and stabilized in 60% methanol,1 mM EDTA in water, centrifuged, and kept at

�

70

�

C untilanalyzed. Samples were analyzed in a blinded manner forvitamin C by high-performance liquid chromatography(HPLC) with coulometric electrochemical detection.

22

,

23

Themethod is specific for L-ascorbic acid and has a sensitivity of50 fmol. The results are expressed as mean

�

standard devi-ation. Unless otherwise noted,

n

�

3. The

P

values were cal-culated by two-tailed Student’s

t

-test with equal variance.

Results

pH

Fifteen percent formulations of L-ascorbic acid weretested at pH levels between 2.0 and 5.0 (Figure 1). Tis-sue levels of L-ascorbic acid were enhanced only at for-mulation pH levels less than 3.5. The pKa for L-ascorbicacid is 4.2. Apparently the molecule must be un-ionizedfor percutaneous absorption to occur. Low pH is es-sential for absorption and delivery is enhanced as thepH is reduced to 2.0. The effect of the solutions onskin pH is unknown.

Concentration

L-ascorbic acid concentrations were tested from 5 to30.0% (Figure 2). pH was adjusted to 3.2. Tissue lev-els of L-ascorbic acid increased and were maximal at20%. For unknown reasons, concentration levelshigher than 20% resulted in decreased tissue levels.

Kinetics

Fifteen percent L-ascorbic acid at pH 3.2 was applieddaily for 1–5 days (Figure 3). After 3 days, tissue levelswere apparently saturated. Levels achieved were ap-proximately 20 times normal tissue levels.

Washout

Fifteen percent L-ascorbic acid at pH 3.2 was applieddaily for 5 days to saturate skin levels (Figure 4). Skinlevels of L-ascorbic acid were then measured at dailyintervals, with no further topical application of L-ascor-bic acid, to measure L-ascorbic acid remaining in thetissues. Half-life of L-ascorbic acid in tissues was foundto be approximately 4 days.

Figure 1. Effect of pH on percutaneous absorption. 15% L-ascorbicacid at different pHs were applied to pig skin for 24 hours. Skinlevels of L-ascorbic acid are expressed as mean � SD (n � 3). *Av-erage (n � 2).

Figure 2. Effect of concentration on percutaneous absorption.Varying concentrations of L-ascorbic acid pH 3.2 were applied topig skin for 24 hours. Skin levels of L-ascorbic acid are expressed asmean � SD (n � 3).

© 2001 by the American Society for Dermatologic Surgery, Inc. • Published by Blackwell Science, Inc.ISSN: 1076-0512/01/$15.00/0 • Dermatol Surg 2001;27:137–142

Topical L-Ascorbic Acid: Percutaneous Absorption Studies

Sheldon R. Pinnell, MD,* Huanshu Yang, MD,

‡

Mostafa Omar, PhD,

†

Nancy Monteiro Riviere, PhD,

‡

Holly V. DeBuys, MD,* Linda C. Walker,*Yaohui Wang, MD,

§

and Mark Levine, MD

§

*

Duke University Medical Center, Durham, North Carolina,

†

PhytoCeuticals, Elmwood Park, New Jersey,

‡

College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, and

§

National Institute of Diabetes & Digestive & Kidney Diseases, NIH, Bethesda, Maryland

background.

Reactive oxygen species generated by ultravioletlight result in photocarcinogenic and photoaging changes in theskin. Antioxidants protect skin from these insults.

objective.

This study defines formulation characteristics fordelivering L-ascorbic acid into the skin to supplement the skin’snatural antioxidant reservoir.

methods.

L-ascorbic acid or its derivatives were applied to pigskin. Skin levels of L-ascorbic acid were measured to determinepercutaneous delivery.

results.

L-ascorbic acid must be formulated at pH levels lessthan 3.5 to enter the skin. Maximal concentration for optimalpercutaneous absorption was 20%. Tissue levels were saturatedafter three daily applications; the half-life of tissue disappear-ance was about 4 days. Derivatives of ascorbic acid including

magnesium ascorbyl phosphate, ascorbyl-6-palmitate, and dehy-droascorbic acid did not increase skin levels of L-ascorbic acid.

conclusions.

Delivery of topical L-ascorbic acid into the skinis critically dependent on formulation characteristics.

IN THE PRESENCE of our oxygen-rich atmosphere,ultraviolet light generates reactive oxygen species inskin. In addition to sunlight, other inflammatory in-sults including smoking and pollution generate reac-tive oxygen species. Reactive oxygen species, in turn,cause oxidation of nucleic acids, proteins, and lipids.Reactive oxygen species alter DNA,

1–7

as well as itsrepair,

8

and trigger cytokine cascades that result inphotoaging

9,10

and photocarcinogenesis.

11

The body protects itself naturally from reactive ox-ygen species by using antioxidants to neutralize thembefore they cause damage to the skin and its compo-nents. Vitamin C, or L-ascorbic acid, is the mostabundant antioxidant in skin.

12

Although most plantsand animals synthesize L-ascorbic acid to protectthemselves from free radical attack, a gene necessaryfor its synthesis, L-gulono-

�

-lactone oxidase, has beenmutated in humans.

13

As a result, humans rely on di-etary intake for their supply.

14

L-ascorbic acid is quitewater soluble and serves as the major aqueous phasereductant in the body.

15

Since skin relies on antioxidants for protectionagainst reactive oxygen species, and since skin pre-dominantly receives and must deal with the free radi-cal assault resulting from UV light, increasing the anti-oxidant defense of skin becomes an attractive strategyfor increased photoprotection.

16

If antioxidants couldbe delivered in high concentration through the stratumcorneum barrier into the skin, then the antioxidantprotective reservoir could be increased and photopro-tection might be enhanced. Indeed, our laboratory hasdescribed a stable aqueous formulation of L-ascorbicacid that gets into skin and provides photoprotectionagainst both UVB and UVA-psoralen phototoxicity bya mechanism that is clearly not a sunscreen effect.

17

Moreover, we have demonstrated that topical L-ascor-bic acid protected against UV immunosuppression andtolerance to contact antigen in mice.

18

In order to maximize the protective effects of topi-cal L-ascorbic acid in skin, we have undertaken thisstudy of formulation composition and kinetics so thatwe can maximize the amount of L-ascorbic acid deliv-ered into the skin.

Materials and Methods

L-ascorbic acid (pharmaceutical grade) was purchased fromRoche (Nutley, NJ). All concentrations of L-ascorbic acidwere made fresh and stabilized in 2% ZnSO

4

, 0.5% biofla-vonoids, 1% hyaluronic acid, 0.1% citrate in glass-distilledwater. pH was adjusted with triethanolamine. Commercialformulations of 13% magnesium ascorbyl phosphate (Vivi-

H. Yang, MD, N. Monteiro-Riviere, PhD, H.V. DeBuys, MD, L.C.Walker, Y. Wang, MD, and M. Levine, MD have indicated no signifi-cant interest with commercial supporters. S.R. Pinnell, MD is a consult-ant for Skinceuticals (Dallas, TX). M. Omar, PhD is president of Phyto-Ceuticals (Elmwood Park, NJ).Address correspondence and reprint requests to: Sheldon R. Pinnell,MD, Duke University Medical Center, Department of Medicine, Divi-sion of Dermatology, P.O. Box 3135, Durham, NC 27707, or e-mail:pinne002@mc.duke.edu.

Expansion of professional services

through superficial medical peels with a

signature dermaplaning technique

SkinCeuticals pioneers its philosophy

of Integrated Skincare with its

breakthrough science of the benefits of

C E Ferulic post-laser procedures

Launch of Body Correct: the first

body technologies designed for use

with aesthetic body procedures

Launch of Resveratrol B E: an

antioxidant night concentrate to repair

and prevent accumulated damage

2010 2012 2013 2014

O U R P H I L O S O P H Y A THREE-STEP PHOTOAGING SOLUTION

P R E V E N T

SkinCeuticals topical antioxidants have been

scientifically shown to provide advanced daytime

environmental protection and promote skin’s natural

nightly repair. SkinCeuticals antioxidants help protect

from environmental aggressors and repair from the

inside for the most complete environmental protection

and outside correction.

1

P R O T E C T

SkinCeuticals advanced sunscreens are skin’s first line

of defense against UV rays. Working from the outside,

SkinCeuticals broad spectrum sunscreens shield skin by

deflecting and absorbing damaging UVA and UVB rays.

Featuring Z-Cote®, transparent zinc oxide, SkinCeuticals

offers a broad range of sunscreens for various skin

types and lifestyles.

2

C O R R E C T

SkinCeuticals corrective products combine reparative,

lightening, and exfoliating ingredients to help rehabilitate

skin and restore a healthier, more youthful appearance.

Our advanced ingredients and technologies correct fine

lines, wrinkles, laxity, hyperpigmentation, acne, and more.

3

O U R C O M M I T M E N T TO S C I E N C E

A N D F O R M U L AT I O N S :

CLINICAL TESTINg CHARTER

At SkinCeuticals, we are committed to supporting the aesthetic medical dispensing channel, and believe

that the physician codes of ethics require strict standards for clinical test substantiation. By utilizing these

stringent testing standards for our formulations and by providing balanced communication of test results,

we strive to deliver evidence-based skincare research to physicians and patients alike.

• Whilewemayusein-vitroandex-vivotestsonindividualingredientstoprovideinitialdataonscientificfeasibility,ourclinicaltestsarealwaysonfinalformulationsin-vivotovalidateefficacyinreal-lifeusage.

• Forclinicalstudiesweundertake,weevaluatethreemajorcomponents:

1. Actioninskinviabiologicalorinstrumentally-assessedefficacy

2. Clinicalendbenefitsthroughindependentprofessionalorphysiciangrading

3. Patientevaluation

• Inadditiontoefficacy,everyformulationwedevelopmustpassstringentsafetyandtolerancetestsonskin.

• Wefrequentlytestourproductsinmultiplecountriesandonmulti-ethnicpanelstounderstandandcommunicateontheendbenefitsacrossabroadpanelofpatients.

• Whendesigningstudies,weuseboththird-partylaboratoriesanddermatologistresearchorganizations,consistentlyworkingwithmembersofthemedicalandscientificcommunitytovalidateourtestmethodologies.

• Weregularlyincorporatebiomarkeranalysisaswellasplacebocomparisonsinordertoprovethespecificbiologicalmechanismofactionandeffectivenessofourtechnologies.

• Whenreferringtoscientificknowledgeorpublicationinformationnotbasedonfinalformulation,weclearlycommunicatethistoreaders.

• Wedonotengageintheuseofdisclaimersaroundindividually-varyingpatientresults,andalwaysshowbeforeandafterphotographsthatarerepresentativeofaverageresults.

• Werefrainfromusingclaimsbasedsolelyonpatientperceptionorsatisfaction.

A N T I O X I D A N T A U T H O R I T YA HIGHER MEASURE OF ANTI-AGING PERFORMANCE By THE #1 ANTIOXIdANT AUTHORITy

As the pioneer of topical vitamin C antioxidants, SkinCeuticals has set the industry standard in

efficacious, potent topical antioxidants.

STRICT FORMULATION PARAMETERS FOR PENETRATION IN SKIN

ANTIOXIdANT SyNERGy FOR ENHANCEd EFFICACy

dEMONSTRATEd BIOLOGICAL ANd CLINICAL PROOF

12

3

30+ 24+ 20+ 7+

YEARS

OF RESEARCH

CLINICAL STUDIES

wORLDwIDE

INTERNATIONAL

DERMATOLOgICAL PUBLICATIONS

US PATENTS /

PATENTS PENDINg

Nighttime Repair

•Boosts skin’s internal antioxidant defense system to

help repair and prevent accumulated damage

daytime Protection

•Increases skin’s natural environmental protection by

up to 8x and prevents oxidative damage caused by

UV and IRA exposure

•Prevents the degradation of collagen

S K I N C E U T I C A L S A N T I O X I d A N T S A R E P R O V E N T O P R O V I d E :

A C O M P R E H E N S I V E A N T I O X I D A N T A P P R O A C H

TO P R E V E N T I O N + R E PA I R

For the most complete protection against free radical damage, SkinCeuticals

recommends a multi-prong antioxidant approach to supplement skin’s supply

of antioxidants and boost its own antioxidant defense mechanisms.

S U P P L E M E N T I N G A N T I O X I d A N T S F O R d Ay T I M E

E N V I R O N M E N TA L P R O T E C T I O N

SkinCeuticals vitamin C topical antioxidants like C E Ferulic® and

Phloretin CF® have been clinically proven and evaluated to neutralize

free radical damage from external sources like UV, infrared, and

pollution. As the skin cannot naturally produce vitamin C, daily

topical supplementation is essential.

C E Ferulic® provides 8x skin’s natural environmental protection.

Phloretin CF® and Phloretin CF® Gel match its activity in skin.

B O O S T I N G I N T E R N A L A N T I O X I d A N T S F O R

N I G H T Ly R E PA I R

The skin naturally contains a powerful antioxidant defense system

responsible for neutralizing excessive intrinsic free radical damage

and promoting skin’s natural repair. With age, this internal defense

loses its efficiency, leading to accelerated signs of damage such as

loss of radiance, elasticity, and density. SkinCeuticals Resveratrol B E

is scientifically shown to boost skin’s internal defense system to help

repair and prevent accumulated damage.

AM

PM

D AY T I M E E N V I R O N M E N TA L P R OT E C T I O N :

V I TA M I N C

PROVEN PENETRATION OF POTENT ANTIOXIdANTS

SkinCeuticals vitamin C antioxidants have been clinically evaluated and proven to reduce signs

of premature aging by:

•Neutralizing UV- and IRA-induced free radicals

•Supporting skin’s endogenous repair

One of the most essential and well studied antioxidants is vitamin C. Although inherently unstable,

SkinCeuticals has proven that vitamin C can actually get into skin when formulated properly.

TOPICAL VITAMIN C MUST MEET THE FOLLOwING THREE CRITERIA TO PENETRATE SKIN:

PURE L-ASCORBIC ACID

Leading brand derivatives such as ascorbyl palmitate and

magnesium ascorbyl phosphate do not penetrate skin.

Sheldon R. Pinnell, MD et al. (2001). Topical L-Ascorbic Acid: Percutaneous Absorption Studies. Dermatol Surg. 27:137-142

HIGH CONCENTRATIONS OF L-ASCORBIC ACID

10-20% concentrations provide meaningful levels of

vitamin C in skin.

FORMULATED AT AN ACIDIC PH

pH above 3.5 does not penetrate skin.

new Science

C E FERULIC: INFRARED RADIATION A PROTECTION

In-vivo, C E Ferulic significantly reduced the upregulation

of MMP-1 by 62% (p≤0.05). MMP-1 is the main collagen-

degrading enzyme in human skin.

in-vivo, Phloretin cF and Phloretin cF Gel actives showed equally

significant reduction of MMP-1 upregulation.

4

3

2

1

0

MM

P-1

/ 1

85

RR

NA

UNIRRADIATED INFRARED A C E FERULIC

100

80

60

40

20

0

dEMONSTRATEd BIOLOGICAL EFFECTS IN SKIN

The most relevant way to measure the efficacy of antioxidants is by analyzing key biomarkers – indicators of

processes taking place in skin. All SkinCeuticals vitamin C antioxidants have been proven effective on several

key biomarkers.

PHLORETIN CF: REDUCTION OF THyMINE DIMERS

Caused by UVA radiation, thymine dimers are DNA mutations associated with skin cancer.

In-vivo, Phloretin CF significantly reduced thymine dimer count by 92% versus vehicle when exposed to solar-simulated light (p≤0.0001).

Phloretin cF Gel and c e Ferulic showed equally significant

clinical results on thymine dimer reduction as Phloretin cF. MEA

N N

UM

BER

TH

yM

INE

DIM

ERS

PLACEBO PHLORETIN CF UNExPOSED

ENVIRONMENTAL PROTECTION

C E Ferulic: The combination of vitamins C, E, and ferulic acid yielded unprecedented results: 8x skin’s natural environmental protection.

Phloretin cF, and Phloretin cF Gel match its environmental

protection and provide broad-spectrum activity in skin.

C E F E R U L I C :

8xE N V I R O N M E N TA L

P R OT E C T I O N

PRO

TEC

TIO

N

VEHICLE VITAMIN C VITAMIN E C + E C + E + FERULIC ACID

ANTIOXIdANT SyNERGy FOR ENHANCEd EFFICACy

new : PROTECTION AGAINST IRA

N I g H T LY R E PA I R : R E S V E R AT R O L B E

Antioxidant night concentrate boosts skin’s internal antioxidant defense system to

help repair and prevent accumulated damage.

RESVERATROL B E HAS BEEN CLINICALLy EVALUATEd ANd PROVEN TO:

•NEUTRALIZE age-accelerating internal free radicals

•PROMOTE skin’s natural repair to diminish the signs of accumulated damage

•STRENGTHEN functionality to resist new damage

For increased radiance, density, and elasticity.

FORMULATION INNOVATION:

1. MAxIMIZED CONCENTRATIONS OF PURE RESVERATROL

It is believed that resveratrol works as an intracellular effector to modulate the signaling pathways responsible

for age-related deterioration and functional decline. In the body, resveratrol has been proven to provide a broad

range of beneficial effects including cardioprotective, neuroprotective, and chemoprotective properties.

2. SyNERGISTIC COCkTAIL ENHANCED WITH

0.5% baicalin and 1% vitamin E for improved efficacy

% O

F R

ES

VE

RA

TR

OL

L E A D I N G P R O D U C T S C O N T A I N I N G R E S V E R A T R O L

0.6

0.8

1

1.2

0.4

0.2

0 SKINCEUTICALS:Resveratrol B E

COMPETITORA

COMPETITORB

COMPETITORC

COMPETITORD

COMPETITORE

COMPETITORF

COMPETITORG

COMPETITORH

Leading competitive products containing resveratroL

RESVERATROL B E CONTAINS A MAXIMIzEd CONCENTRATION OF PURE, STABLE RESVERATROL.

dEMONSTRATEd BIOLOGICAL EFFECTS IN SKIN

Resveratrol B E has been proven effective on several key biomarkers related to the prevention and repair

of accumulated damage.

Heme-oxygenase 1 is a protective antioxidant

that modulates the production of other key internal

antioxidants. Heme-oxygenase 1 is a primary target

of skin’s endogenous antioxidant defense system.

collagen iii is a key constituent of the

extracellular matrix and considered a structural

protein responsible for density and firmness.

BOOSTS INTERNAL ANTIOxIDANT DEFENSE SySTEM

PROMOTES ANTI-AGING CORRECTION

3

2

1

0 Week 12Baseline

FO

LD C

HA

NG

E V

S.

BA

SE

LIN

E

H E M E - O X Y G E N A S E I*

INSTRUMENTAL RESULTS

As shown by ultrasound measurement, Resveratrol B E increases skin density by 18.9%.

Accumulation of green pixels after 12 weeks indicates a repairing of skin resulting in improved density.

BeFore

aFter

12 WeeKs

* Statistically significant improvement versus baseline p ≤ 0.05 Week 12Baseline

2

1

0

FO

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E V

S.

BA

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C O L L A G E N I I I

*

K E Y T E C H N O L O g I E S : P R E V E N T, P R OT E C T,

A N D C O R R E C T

dAyTIME

Providing advanced environmental protection by neutralizing free radicals produced by UVA, UVB, and infrared

Delivering broad spectrum protection, SkinCeuticals flagship sunscreens protect skin across the full UVA/UVB

spectrum with 100% mineral filters.

C E FERULIC®

winner of the 2011, 2012, and 2013 inStyle Best Beauty Buys Awards

•Increases firmness and replenishes lipids to reduce wrinkles

•Ideal for dry, normal, and sensitive skin

PHLORETIN CF®

winner of the 2008, 2010, and 2011 Allure Best of Beauty Awards

•Diminishes hyperpigmentation and accelerates cellular renewal to retexture skin

•Ideal for oily, problematic, and normal skin

PHLORETIN CF® GEL

winner of the 2012 and 2013 Allure Best of Beauty Awards

•Diminishes hyperpigmentation and accelerates cellular renewal to retexture skin

•Ideal for normal and combination skin types or those who cannot tolerate a serum

RESVERATROL B E

•Improves radiance, elasticity, and density

•Ideal for all skin types

PHySICAL FUSION UV DEFENSE SPF 50

winner of the 2013 Allure Best of Beauty Awards

•Sheer fluid enhances natural skin tone and boosts daily radiance

•Provides universal tint for all skin tones, tested on all ethnicities

®

®

NIGHTTIME

By boosting the endogenous antioxidant defense system, Resveratrol B E enhances natural self-repair and

rebuilds defenses against sun damage, to diminish visible signs of aging.

SkinCeuticals flagship correct products combine reparative, lightening, and exfoliating ingredients to help

rehabilitate the skin, restoring a healthier and more youthful appearance.

RETINOL 0.5 & 1.0

•Helps reduce the appearance of fine lines, wrinkles, age spots, blemishes, and blotchiness

•Preserves optimal retinol stability and minimizes erythema commonly associated with the use

of retinol

ADVANCED PIGMENT CORRECTOR

winner of the 2013 Allure Beauty Breakthrough Awards

•Multi-layer treatment as effective as the leading medical standard in treating discolorations

•Reduces stubborn discolorations and prevents reoccurrence

BLEMISH + AGE DEFENSE

winner of the 2011 Redbook Most Valuable Product Awards

•As effective as two leading prescriptions for acne and aging

•Reduces blemishes, helps prevent future breakouts, and diminishes fine lines and wrinkles

A.G.E . INTERRUPTER

winner of the 2009 Health Magazine Beauty Awards

•Slows down the process of advanced glycation end-product (A.G.E.) formation, preventing

the rigidification of collagen and elastin fibers

•Stimulates GAG synthesis, restoring water and nutrients to the dermal epidermal junction

AdVANCEdHOMECARE

PROFESSIONALTREATMENTS

I N T E g R AT E D S K I N C A R E

CLINICALPROCEdURES

= L O N G L A S T I N Gc o M P r e h e n s i v e r e s u l t s

Our belief is simple: long lasting comprehensive results are achieved through the combination of state-of-the-art

clinical procedures, advanced homecare, and professional treatments.

integrated skincare is a program built around clinical procedures. Designed for use before, during,

and after in-office procedures, SkinCeuticals offers advanced skincare products to maximize patient benefits and

enhance in-office results.

To maintain and complement results we also offer in-office professional treatments such as chemical peels and

anti-aging protocols to improve the health and appearance of all skin types.

the benefits of integrated skincare are clear: increased visit frequency and patient satisfaction —

a patient for life.

®

it would be a big mistake to perform iPL to remove brown spots and not do other

things to prevent them from reoccurring to complement that procedure in the office.

Patients will do something at home, and i can help to control that by offering a

high end, scientifically-based line like Skinceuticals.

John Despain, M.D.

columbia, MO

Skincare is an integral part to our aesthetic practice. All of our patients, who are

primarily surgical patients, are referred directly to our skincare practice as part of

the surgical package. They are there both before and after surgery, and receive

products as part of their surgical package, and ultimately, they are building a bond

with our staff.

isaac Starker, M.D.

Florham Park, nJ

THE BENEFITS

THE FINANCIAL MOdEL

While correction starts with clinical procedures, homecare designed to support in-office clinical skincare

generates physician revenue. Once integrated with homecare and peels, a typical patient generates $1,970

in revenue versus only $485 with procedure alone.

FOR THE PRACTICE:

•Increased satisfaction

•Greater touch points with patients

•Increased revenue stream

FOR THE PATIENT:

•Reduced downtime

•Complementary results

•Protection of results

PROCEDURE ALONE

BUNDLING

i n t e G r A t e D s K i n c A r e

PER PATIENT PHySICIAN OFFICE REVENUE POTENTIAL

INjECTABLE

$485

$485

$485

0

$295

$295

0

0

$600

0

0

$590

$485

$780

$1,970

HOMECARE PEELS

(Series of 5)

HOMECARE

(2x Replenishment)

TOTAL

REDUCES DOWNTIME

RETURN TO SOCIAL ACTIVITIES EARLIER

In clinical studies combining C E Ferulic with laser resurfacing treatments,

patients using C E Ferulic both immediately post laser and in a continued

homecare regimen reported a decrease in redness and swelling, reducing

downtime up to 2 days.1

PROTECTS RESULTS

PREVENT NEW DAMAGE FROM REOCCURING

C E Ferulic delivers 8x skin’s natural environmental protection, helping

to maintain laser results on skin over time.

T H E S C I E N C E S U P P O R T I N G I N T E G R AT E d S K I N C A R E

EXAMPLE: C E FERULIC POST-LASER

MAxIMIZES PATIENT RESULTS

1. elford eL, Loncaric A et al. Treatment of photoaged skin using fractional non-ablative laser in combination with topical antioxidants. Presented at ASLMS 2012. April 20-22; Kissimmee, Fl. in joint collaboration with Solta Medical and Skinceuticals LLc, 2013.

CU

MU

LAT

IVE

PE

RM

EA

TIO

N (

mg

/ c

m2)

A C C E L E R AT E D T O P I C A L U P TA K E

TIME (hours)

Laser + C E Ferulic

C E Ferulic alone

2

1.8

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17x

A C C E L E R AT E d T O P I C A L U P TA K E

vitAMin c

P R O F E S S I O N A L T R E AT M E N T S

Medically-exclusive in-office treatments designed to complement clinical procedures, continue correction, and

improve the health and appearance of all skin types.

CHEMICAL PEELS

Customizable range of exclusive peel procedures formulated with pharmaceutical-grade ingredients to correct

existing skin damage.

•Dramatically improves fine lines and wrinkles, pigmentation, texture, and acne

•Available in various strengths with glycolic, salicylic, lactic, citric, and mandelic acids

•Ideal for all skin types including sensitive

K E y T E C H N I Q U E

dERMAPLANING

Manual exfoliation technique that efficiently removes surface debris with SkinCeuticals exclusive Dermaplane

Blades, and primes skin for the chemical peeling solution.

•Increases the rate of absorption of pharmaceutical and skincare products

•Immediately diminishes the appearance of fine lines

•Provides a healthier, more radiant appearance

D R I V I N g D E M A N D

As the #1 dispensing cosmeceutical brand in the media, physicians, skincare professionals, and the media

alike recommend SkinCeuticals. Our products are often in the spotlight, gracing pages of magazines around

the world and winning awards year after year, including Allure’s Best of Beauty and Beauty Breakthrough

awards, driving patients to your offices in search of our products.

THE VERY BEST

BEAUTY PRODUCTS

8x M E d I A I M P R E S S I O N S O F

C L O S E S T C O M P E T I T I O N

O V E R 1 Billion M E d I A

I M P R E S S I O N S I N 2 0 1 3 A L O N E

Source: cision Brand editorial Ratings YTD november 2013

SkinCeuticals: 1.3 Billion

Skinmedica: 170 Million

Obagi: 126 Million

16 A w A R d S I N 2 0 1 3

B U I L D I N g T H E PAT I E N T P H Y S I C I A N

R E L AT I O N S H I P

Traditional press is just one vehicle for SkinCeuticals to help build the relationship between a patient and

physician. Powerful digital and social platforms are designed to drive patients to seek professional

guidance and provide additional product and science education.

S K I N C E U T I C A L S . C O M A N d S O C I A L M E d I A

These two platforms provide the latest information on science, products and where to find SkinCeuticals.

The magnitude of reach enables us to educate patients and drive them to physician offices for professional

treatments and advice.

O N L I N E P H y S I C I A N L O C AT O R

The most trafficked digital asset on skinceuticals.com

with 6,500 unique views per month

PAT I E N T R E F E R R A L S

Directly drives patients from skinceuticals.com

to physician offices

O U R C O M M I T M E N T

SkinCeuticals offers real business tools to successfully develop your business

and satisfy patients:

G L O B A L P O d I U M P R E S E N C E

Learn the latest breakthroughs in science, skincare, and dispensing at any of our 25+ per year local

and global medical congresses.

I M C A S

A S L M S

A A d

T S L M S

A M w CC O S M E T I C B O OTC A M P

A L A B A M A d E R M S O C I E T y

C O N T R OV E R S I E S

FA L L C L I N I C A L

5 C O N T I N E N T S C O N G R E S S

P E E R T O P E E R P R O G R A M S

Roundtable discussions with key opinion leaders where you can learn the latest

research and techniques to integrate skincare into your practice.

S K I N C E U T I C A L S C E N T E R

T R A I N I N G & E D U C AT I O N

for

BUSINESS BUILDING

Industry experts lead these programs with physicians, estheticians, and practice managers to

identify how to drive practice revenue. Through this session, you will identify new ways to

gain, retain and maximize patients through key topics such as marketing your practice,

the patient experience, SkinCeuticals Integrated Skincare as well as how to generate

additional revenue through skincare and social media.

SkINCEUTICALS CONTINUING EDUCATION

Education is an ongoing process and we are committed to developing your staff’s

clinical expertise to best differentiate your practice. We conduct regular training

programs for estheticians, nurses, and practice managers on our Integrated Skincare

philosophy, the importance of advanced skincare backed by science, professional

treatments, and business building techniques to increase profits.

ADVANCED ACCOUNT TRAINING

Hands-on training is essential to gaining the confidence necessary to perform

clinical treatments. Our SkinCeuticals Clinical Educators are committed to training you

and your staff on our turn-key protocols that can be implemented to enhance your existing

skincare services, as stand-alone offerings, or integrated into the existing medical services

provided by the office such as injectables, laser procedures, or prepping the skin for surgery.

SkINCEUTICALS SyMPOSIUM

The signature event is available to our most elite accounts which have demonstrated an

eagerness to take their practice to the next level. Meet and mingle with the SkinCeuticals

Leadership Team, key opinion leaders, industry experts, and an incredibly talented group of

peers to learn about the latest trends and discoveries in the cosmeceutical industry. we will

equip you with the tools to thrive in an increasingly dynamic medical environment

by exposing you to the very best in dermatology and plastics practice management

and preparing you to fast-track your practice.

SkinCeuticals delivers incomparable educational support and service via a uniquely

synergistic approach of multiple educational events designed to maximize your success.

SKINCEUTICALS

CONNECT MEdICAL

PREMIUM INTEGRATEd

MEdICAL

P R O d U C T S A V A I L A B L E

w H AT y O U G E T

T R A I N I N G

M A R K E T I N G M AT E R I A L S

P R O d U C T

M E R C H A N d I S I N G

N E w A C C O U N T O F F E R I N g S

SkinCeuticals offers a comprehensive menu of flexible offerings customized

to fit your practice.

A variety of marketing materials, products and merchandising are available through complimentary Business

Building Credits, our loyalty program, and to new accounts.

TESTER BAR DRAMATIzERSCATALOg ORgANIzERSPRODUCT HIgHLIgHTERS

TESTER BAR PRODUCT CARDS CONSUMER BROCHURES PRESCRIPTION PAD

FULL RETAIL CATALOg FULL RETAIL CATALOg

PROFESSIONAL SIzESDELUXE SIzE SAMPLES TESTERS

EXCLUSIVE CLINICAL TREATMENTS

R O B U S T PA R T N E R S H I P P R O g R A M

skinceuticals rewards gives you the flexibility to choose from a variety of business

building tools to support your practice’s individual business needs. Redeem your

rewards points for SkinCeuticals retail & professional products, exclusive events,

merchandising tools, and premium perks.

RETAIL AND PROFESSIONAL

PRODUCTS ExCLUSIVE EVENTS

MERCHANDISING TOOLS

PREMIUM PERkS

R E d E E M F O R B U S I N E S S B U I L d I N G R E w A R d S T O d Ay !

R EWARDSA PREMIUM MEDICAL PROGRAM

S K I N C E U T I C A L S P R O D U C T L I N E r e t A i l

S K I N C E U T I C A L S P R O D U C T L I N E P r o

( 20, 30 ) ( 20, 30 ) ( GL, SM )

exclusive ProfessionAl technoloGy

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