EXPERIENCE THE BEST OF ASMS WITH WATERS · 3 Poster 353 – Ion Mobility: Applications Enhanced Ion...

WATERS EXHIBIT BOOTH #201June 5, 7:45 pm to 9:30 pm

June 6–8, 9:00 am to 5:00 pm

June 9, 9:00 am to 2:30 pm

Henry B. Gonzalez Convention Center 200 Market St., San Antonio, TX 78205

WATERS HOSPITALITY SUITEJune 6–8, 8:00 pm to 11:00 pm

Grand Hyatt San Antonio 600 E Market St., San Antonio, TX 78205 Texas Ballrooms B & C

WATERS POSTER PRESENTATIONSJune 6–9, 10:30 am to 2:30 pm


WATERS ORAL PRESENTATIONSJune 6–9


¡Room locations and times vary. Refer to the schedule below for complete details.

WATERS BREAKFAST SEMINARSJune 6–9, 7:00 am to 8:00 am

Grand Hyatt San Antonio 600 E Market St., San Antonio, TX 78205 Texas Ballrooms B & C and Convention Center Rooms 301A,B,C

¡Seminar locations vary.

¡Visit www.waters.com/asms for a complete listing and register today.

¡Space is limited. Pre-registration is required.

EXPERIENCE THE BEST OF ASMS WITH WATERSAt this year’s ASMS learn more about Waters latest technologies and innovations that enable superior performance in your lab and allow you to succeed in the science of what’s possible.

Let’s explore the possibilities together

WATERS CORPORATION AT

SAN ANTONIO, TEXASJUNE 5 – 9

ASMS2016

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[ MONDAY, JUNE 6 ] Go to www.asms.org for updated program details.

ORAL S | Locations and times may vary

Main Session: Data Independent Acquisition: Innovative Methods and Applications

Stars 4, 3:10 pm – 3:30 pm Qualitative and Quantitative Characterization of a Novel DIA Method for Omics Analysis and its Application to Biomedical AnalysesArthur Mosley*[1]; Chris Hughes[2]; Erik J. Soderblom[3]; Keith Richardson[2]; Will Thompson[4]; Jason Wildgoose[2]; James Langridge[2]

[1]Duke University School of Medicine, Durham, NC; [2]Waters Corporation, Wilmslow, UK; [3]Duke University School of Medicine, Durham, NC; [4]Duke University School of Medicine, Durham, NC

Main Session: Instrumentation: New Developments in Ionization and Sampling

Stars 1, 3:30 pm – 3:50 pmAutomated High Throughput Identification of Microorganisms Using Rapid Evaporative Ionisation Time of Flight Mass Spectrometry (REIMS-ToF-MS)Zsolt Bodai*[1]; Daniel Simon[2]; Schaffer Richard[2]; Frankie Bolt[1]; Tamas Karancsi[2]; Julia Balog[2]; Tony Rickards[1]; Adam Burke[1]; Simon Cameron[1]; Kate Hardiman[1]; Monica Rebec[1]; Zoltan Takats[1]

[1]Imperial College London, London, UK; [2]Waters Research Center, Budapest, Hungary

POSTERS | 10:30 am – 2:30 pm

Poster 007 – Antibodies & Antibody Drug Conjugates

Monitoring the Critical Quality Attributes of Antibody Drug Conjugates (ADCs) as Part of Biosimilar Development: Case Studies of Ado-Trastuzumab EmtansineLiuxi Chen[1]; Min Du[1]; Henry Y. Shion[1]; Ying-Qing Yu[1]; Lan Wang[2]; Kai Gao[2]; Weibin Chen[1]

[1]Waters Corporation, Milford, MA, USA; [2]National Institutes for food and drug control, Beijing, China

Poster 056 – Data Independent Acquisition

Advances in Targeted Omics Quantitation Using a Novel Scanning Quadrupole DIA MethodChris Hughes*; Keith Richardson; Jason Wildgoose; Martin R. Green; Richard Chapman; Arkadiusz Grzyb; Praveen Harapanahalli; Kirsten Craven

Waters Corporation, Wilmslow, UK

Poster 145 – Environmental Analysis: General

Ultra Low-Level Detection of Perfluoroalkyl Sustances (PFASs) Using LC-MS/MSSarah Dowd*[1]; Lauren Mullin[2]; Jennifer A. Burgess[2]

[1]Waters Corporation, Beverly, MA, USA; [2]Waters Corporation, Milford, MA, USA

Poster 228 – Imaging MS: Instrumentation

DESI Imaging at Varying Acquisition Rates with Real Time Imaging Display for Optimized Tissue ImagingEmrys Jones[1]; Mark Towers[1]; Bindesh Shrestha*[2]; Philiipa Hart[1]; Richard Chapman[1]; Emmanuelle Claude[1]

[1]Waters Corporation, Wilmslow, UK; [2]Waters Corporation, Beverly, MA, USA

Poster 229 – Imaging MS: Instrumentation

Automated High Throughput 3D Imaging Using Desorption Electrospray Ionisation Mass SpectrometryEmrys A. Jones*[1],[2]; Lukasz Migas[3]; Richard Chapman[2]; Emmanuelle Claude[2]; James Langridge[2]; Steven D. Pringle[2]; Zoltan Takats[4]; Mike Morris[2]

[1]Imperial College London, London, UK, London; [2]Waters Corporation, Wilmslow, UK; [3]University of Manchester, Manchester, UK; [4]Imperial College London, London, UK

Poster 241 – Imaging MS: Sample Preparation

Investigation into the Use of Tissue Washing Procedures and the Subsequent Outcomes for DESI-MS Imaging AnalysesPhilippa Hart*; Mark Towers; Emmanuelle Claude


Poster 248 – Imaging MS: Software

Translational Data Analytics for Large Mass Spectrometry Imaging Datasets in Clinical ResearchKirill Veselkov*[1]; Mirnezami Reza[2]; Emmanuelle Claude[3]; James Kinross[2]; James McKenzie[2]; Paolo Inglese[4]; Kieran Neeson[3]; James Langridge[5]; Elaine Holmes[4]; Zoltan Takats[2]; Jeremy K. Nicholson[2]

[1]Imperial College London, London, UK; [2]Imperial College London, London, UK; [3]Waters Corporation, Wilmslow, UK; [4]Imperial College London, London, UK; [5]Waters Corporation, Manchester, UK

Poster 258 – Informatics: Metabolomics

Automatic CCS and MS-MS Library Creation and Application for Large Scale Metabolic ProfilingJonathan P. Williams*[1]; David Eatough[1]; Lee A. Gethings[1]; Christopher. J. Hughes[1]; Mark Towers[1]; Leanne Nye[2]; Steven Lai[3]; Richard Tyldesley-Worster[1]; Johannes P.C. Vissers[1]

[1]Waters Corporation, Wilmslow, UK; [2]Waters Corporation, London, UK; [3]

Waters Corporation, Beverly, MA, USA

Poster 319 – Intact Proteins

Data Independent Characterization of Proteins from 2D CID Fingerprints Generated through Collision Energy ScanningBoris Kozlov*; Jeff Brown; John Hoyes


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Poster 353 – Ion Mobility: Applications

Enhanced Ion Mobility Separation of Derivatized Isobaric Steroids by DESI and MALDI ToF Mass SpectrometryMark Towers[1]; MicShazia Khan[2]; C.Logan C. Mackay[3]; Ruth Andrew[2]; Emmanuelle Claude*[1]

[1]Waters Corporation, Wilmslow, UK; [2]Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK; [3]SIRCAMS, University of Edinburgh, Edinburgh, UK

Poster 417 – LC-MS: Chromatography and Software

Improving Sensitivity in LC-MS with Multi-Dimensional ChromatographyThomas E. Wheat*[1]; Amanda B. Dlugasch[2]; Patricia R. McConville[2]

[1]Waters Corporation, Hopedale, MA, USA; [2]Waters Corporation, Milford, MA, USA

Poster 506 – Microorganisms: Identification and Characterization

Identification of Fungi Using Rapid Evaporative Ionisation Mass SpectrometryFrances Bolt*[1]; Simon Cameron[1]; Ali Abdolrasouli[1]; Johanna Rhodes[1]; Tony Rickards[2]; Kate Hardiman[1]; Adam Burke[1]; Julia Balog[3]; Tamas Karancsi[3]; Daniel Simon[3]; Richard Schaffer[3]; Zsolt Bodai[1]; Monica Rebec[2]; Zoltan Takats[1]

[1]Imperial College London, London, UK; [2]Imperial College Healthcare Trust, London, UK; [3]Waters Research Center, Budapest, Hungary

Poster 535 – Polymers

Analysis for Extractable and Leachable Compounds from Polymeric MaterialsGordon Fujimoto*[1]; Sarah Dowd[1]; Baiba Cabovska[2]; Marian Twohig[2]

[1]Waters Corporation, Beverly, MA, USA; [2]Waters Corporation, Milford, MA, USA

Poster 671 – Small Molecules: Qualitative Analysis

Impurity Profiling of Pharmaceuticals Using a UPLC-ToF Data Independent Acquisition Strategy and Scientific Data and Library Information SystemsJayne Kirk[1]; Russell Mortishire-Smith[1]; Sean McCarthy*[2]; Mark Wrona[2]

[1]Waters Corporation, Wilmslow, UK; [2]Waters Corporation, Milford, MA, USA


Main Session: HRMS for Quantitation in Drug Discovery, Development and Beyond

Stars 1, 9:10 am – 9:30 am Evaluation of Ion Mobility and Targeted QTof Acquisition Modes for the Quantitative Analysis of PeptidesJayne Kirk[1]; Mark Wrona*[2]; Kelly Doering[2]; Russell Mortishire-Smith[1]; Lisa A. Vasicek[3]; Kevin P. Bateman[3]

[1]Waters Corporation, Wilmslow, UK; [2]Waters Corporation, Milford, MA, USA; [3]Merck & Co., West Point, PA, USA

Main Session: New Developments in Ion Detection

Room 221, 3:50 pm – 4:10 pmA Novel Wide Dynamic Range oa-ToF Detection System Based on Dual 10-bit ADCs and FPGA ProcessingMartin Green*; Garry Scott; Stephen Platt; Peter Spreadbury; Darrell Williams; Frank Buckley; Witold Niklewski; Stephen Hinde; Martin Palmer; John Chipperfield


POSTERS | 10:30 am – 2:30 pm


A Sensitive Multidimensional Liquid Chromatography Method for the Characterization of Free Drug Impurities in Antibody-Drug Conjugates Using Mass Spectral DetectionRobert Birdsall*[1]; Sean M. McCarthy[2]; Alain Beck[3]; John Gebler[2]; Weibin Chen[2]

[1]Waters Corporation, Milford, MA, USA; [2]Waters Corporation, Milford, MA, USA; [3]Pierre Fabre, St Julien-en-Genevois, France


Multidimensional ionKey/MS for Antibody Drug Conjugate AnalysisGreg Roman*; James P. Murphy

Waters Corporation, Milford, MA, USA


Using Hydrophilic Interaction Chromatography–Mass Spectrometry for Heightened Product Characterization to Overcome Challenges with Hydrophobic Antibodies and Antibody Drug ConjugatesJacquelynn Smith*[1]; Matthew Lauber[2]; Stephan Koza[2]; Erin Chambers[2]; Jason C. Rouse[3]; Olga Friese[4]

[1]Senior Associate Scientist at Pfizer, Chesterfield, MO, USA; [2]Waters Corporation, Milford, MA, USA; [3]Pfizer, Inc. Andover, MA, USA; [4]Pfizer, Chesterfield, MO, USA

[ TUESDAY, JUNE 7 ]Go to www.asms.org for updated program details.

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[ TUESDAY, JUNE 7 ] Go to www.asms.org for updated program details.

Poster 092 – Data Independent Acquisition (SWATH)

Phospholipid Analysis Utilising a Novel, Data Independent, Mode of Acquisition on a QTof Instrument with a Scanning Quadrupole Mass FilterJayne Kirk[1]; Steven Lai*[2]; Jason Wildgoose[1]; Keith Richardson[1]; Martin Green[1]; Paul Doorbar[1]; Witold Niklewski[1]; Kirsten Craven[1]; Mark Wrona[3]

[1]Waters Corporation, Wilmslow, UK; [2]Waters Corporation, Beverly, MA, USA; [3]Waters Corporation, Milford, MA, USA

Poster 151 – Energy: Hydrocarbon and Petrochemical

High Performance Thin Layer Chromatography (HPTLC) Coupled with DESI-Ion Mobility-Mass Spectrometry: A Novel Approach for Petroleum CharacterisationEleanor Riches*[1]; Caroline Mangote[2]; Delphine Thuault[2]; Pierre Giusti[2]; Carlos Afonso[3]; Peter Hancock[1]

[1]Waters Corporation, Wilmslow, UK; [2]TOTAL Refining & Chemicals, Total Research & Technology Gonfreville, F-76700 Harfleur, France; [3]Normandie Univ, COBRA, UMR6014 and FR3038, Université de Rouen; INSA de Rouen; CNRS, IRCOF, Rouen, France


Intrinsic Ion Mobility Peak Width as an Indicator of Isomeric Species Distribution in Petroleum Using Ion Mobility - Mass SpectrometryMathilde Farenc[1][2][3]; Eleanor Riches[4]; Carlos Afonso*[2][3]; Pierre Giusti[1][3]

[1]TOTAL Refining and Chemicals, TRTG Gonfreville l’Orcher, France; [2]

Normandie Univ, CNRS UMR 6014 COBRA Mont St Aignan, France; [3]

TOTAL RC - CNRS Joint Laboratory C2MC :Complex Matrices Molecular Characterization, France; [4]Waters Corporation, Wilmslow, UK


Petroleomics by Atmospheric Solid Analysis Probe Mass Spectrometry (ASAP-MS)Lilian Tose*[1]; Michael Murgu[2]; Boniek Gontijo Vaz[3]; Wanderson Romão[1]

[1]UFES, Vitória, Brazil; [2]Waters Corporation, São Paulo, Brazil; [3]UFG, Goiânia, Brazil


Unispray™ Ion Source Coupled to UHPSFC for the Detection of Oilfield AdditivesEfstathios Andreas Elia*[1]; William Durnie[2]; Ed Sparke[3]; John G. Langley[1]

[1]Chemistry, University of Southampton, Southampton, UK; [2]BP Exploration, Sunbury-on-Thames, Middlesex, UK; [3]Waters Corporation, Wilmslow, UK


Rapid Exploration of the Mechanism of Action of Forskolin via Untargeted Proteomics and Knowledge Based Pathway AnalysisZiad Sahab*[1]; Bindesh Shrestha[2]; Lida Parvin[1]; Peter Nemes[1]; Akos Vertes[1]

[1]George Washington University, Washington, DC; [2]Waters Corporation, Beverly, MA, USA


Determination of Aqueous Film Forming Foam (AFFF) Components Using a Multivariate Analysis ApproachLauren Mullin[1]; Anna Karmann[2]; Gareth Cleland[1]; John Vukovic*[1]; Adam Ladak[1]

[1]Waters Corporation, Milford, MA, USA; [2]MTM Research Centre, Örebro University, Örebro, Sweden

Poster 219 – Food Safety (Pesticides in Food)

A Single LC-MS/MS Method for Confirmation and Quantification of over 400 Pesticides in Complex Matrix Without Compromising Data QualityDimple Shah*[1]; Eimear McCall[2]; Gareth Cleland[3]

[1]Waters Corporation, Milford, MA, USA; [2]Waters Corporation, Wilmslow, UK; [3]Waters Corporation, Milford, MA, USA

Poster 237 – Food’omics MS Characterization of Food and Nutritional Supplements

Discrimination of Honey of Different Botanical Origins Using an Untargeted High-Definition Metabolomic WorkflowJoanne B. Connolly[1]; Sara Stead[2]; Antonietta Wallace[2]; Delano Turner*[2]

[1]Waters Corporation, Manchester, UK; [2]Waters Corporation, Manchester, UK


The Modernisation of Fish Fraud Detection Using Rapid Evaporative Ionisation Mass Spectrometry (REIMS)Connor Black[1]; Olivier Chevallier[1]; Julia Balog[2]; Sara Stead[3]; Steven D. Pringle*[4]; Christopher Elliott[1]; Zoltan Takats[5]

[1]Queens University Belfast, Belfast, UK; [2]Waters WRC, Budapest, Hungary; [3]Waters Corporation, Manchester, UK; [4]Waters Corporation, Wilmslow, UK; [5]Imperial College London, London, UK


HILIC Chromatography Coupled with IMS/MS for Characterization of Phenolic Compounds and Related Pigments in Red WineAndre De Villiers[1]; Andrew Baker*[2]

[1]Department of Chemistry and Polymer Science, Stellenbosch University, Matieland, South Africa; [2]Waters Corporation, Pleasanton, CA, USA

Poster 317 – Imaging MS: Disease Markers

Multimodal Imaging of Lipids in a Zebrafish Melanoma Model by PET and DESI-MSEmrys Jones[1]; Fiona Henderson[2]; Anthony Midey*[3]; Adam Hurlstone[2]; Duncan Foster[2]; Hannah Johnston[2]; Kaye Williams[2]; Adam W. McMahon[2]; Emmanuelle Claude[1]

[1]Waters Corporation, Wilmslow, UK; [2]Wolfson Molecular Imaging Centre, Manchester, UK; [3]Waters Corporation, Beverly, MA, USA

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Linking Lipid Metabolism, Hypoxia, Radiation Therapy and Metastasis Using DESI Imaging Mass SpectrometryErik J. Soderblom*[1]; Kathleen Ashcraft[2]; Matt W. Foster[3]; Emmanuelle Claude[4]; Emrys A. Jones[4]; James Langridge[4]; M. Arthur Moseley[3]; Mark Dewhirst[2]

[1]Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC; [2]Radiation Oncology, Duke University Medical Center, Durham, NC; [3]Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC; [4]Health Sciences, Waters Corporation, Manchester, UK


Molecular Mapping of Gangliosides and Related Lipids Using Mass Spectrometry Imaging with Ion Mobility SeparationBindesh Shrestha[1]; Hernando Olivos[2]; Khaja Muneeruddin[3]; Miguel Sena-Esteves[3]; Scott A. Shaffer*[3]

[1]Waters Corporation, Beverly, MA, USA; [2]Waters Corporation, Beverly, MA, USA; [3]University of Massachusetts Medical School, Worcester, MA, USA

Poster 378 – Informatics: Peptide ID and Quantification

Large Scale Silac Based Quantitative Analysis of Electron Accepter Stressed Azospira Suillums Using Retention and Drift Time ProfilingAnthony T. Iavarone[1]; Matthew D. Youngblut[1]; Emilie Gios[1]; Michael Daly[2]; Hans K. Carlson[1]; Ulla N. Andersen[1]; Johannes P.C. Vissers*[3]; John D. Coates[1]

[1]UC Berkeley, Berkeley, CA, USA; [2]Waters Corporation, Inc. Pleasanton, CA, USA; [3]Waters Corporation, Wilmslow, UK

Poster 408 – Instrumentation: General

Ion Transport Through Zirconia CapillariesJ. A. Jarrell*



Automated Bottom-Up Proteomics Workflow for Liquid AP-MALDI MS-MS Utilising Multiply Charged IonsPavel Ryumin*[1]; Jeff Brown[1][2]; Michael Morris[2]; Rainer Cramer[1]

[1]University of Reading, Reading, UK; [2]Waters Corporation, Wilmslow, UK


A New Conjoined RF Ion Guide for High Efficiency Ion TransmissionDaniel Kenny*; David Gordon; Kevin Giles


Poster 453 – Ion Mobility: Applications (Proteins & Peptides)

An LC/ESI-IM-MS/MS Assay for Identification and Quantification of Host Cell Proteins in Therapeutic Monoclonal AntibodiesCatalin Doneanu*[1]; Brad J. Williams[2]; Ian Morns[3]; Andrew Borthwick[4]; Jackson Pope[4]; Ying-Qing Yu[5]; Weibin Chen[5]

[1]Waters Corporation, Milford, MA, USA; [2]Waters Corporation, Beverly, MA, USA; [3]Waters Corporation, Newcastle upon Tyne, UK; [4]Waters Corporation, Newcastle upon tyne, UK; [5]Waters Corporation, Milford, MA, USA

Poster 455 – Ion Mobility Applications (Proteins & Peptides)

Integrating Ion Mobility Separation into Peptide Mapping for Therapeutic Protein Characterization: Qualitative and Quantitative AspectsYing-Qing Yu*; Liuxi Chen; Henry Y. Shion; Weibin Chen


Poster 532 – Metabolomics: Untargeted Metabolite Profiling (Cells/Plants)

Metabolic Phenotyping of Cell Lines by Rapid Evaporative Ionization Mass SpectrometryEmrys Jones[1]; Emmanuelle Claude[1]; James Langridge*[1]; Fiona Henderson[2]; Adam W. McMahon[2]; Zoltan Takats[3]; Steve Pringle[1]

[1]Waters Corporation, Wilmslow, UK; [2]Wolfson Molecular Imaging Centre, Manchester, UK; [3]Imperial College London, London, UK, South Kensington Campus London, UK

Poster 535 – Metabolomics: Untargeted Metabolite Profiling (Cells/Plants)

Identification and Chemical Characterization of Marine Natural Products Using UPLC-QTof-MS Coupled to a Novel Informatics PlatformRoger G. Linington[1]; Kenji L. Kurita[1]; Jimmy Yuk[2]; Kate Yu[2]; Mark Wrona[2]; Giorgis Isaac*[2]

[1]Simon Fraser University, Burnaby, BC, Canada; [2]Waters Corporation, Milford, MA, USA

Poster 548 – Metabolomics: Untargeted Metabolite Profiling

Chemical Profiling of Actaea Species and Commercial Products Using UPLC-QTof-MSJimmy Yuk*[1]; Maged Sharaf[2]; Kate Yu[1]; Mark Wrona[1]; Giorgis Isaac[1]

[1]Waters Corporation, Milford, MA, USA; [2]American Herbal Products Association, Silver Spring, MD


Atmospheric Pressure Gas Chromatography Mass Spectrometry (APGC-MS) Based Metabolomics Profiling of Grape VolatilesManoj Ghaste*[1][2]; Giuseppe Astarita[3]; Fulvio Mattivi[2]; Vladimir Shulaev[1]

[1]University of North Texas, Denton, TX; [2]Fondazione Edmund Mach, San Michele all'Adige TN, Italy; [3]Waters Corporation, Milford, MA, USA

Poster 580 – Nucleic Acids

Developing Novel Integrated LC-MS Workflows for Oligonucleotide Characterization, High Throughput Mass Confirmation and Impurity ProfilingHenry Shion*; Robert Birdsall; Joe Fredette; Ying-Qing Yu


[ TUESDAY, JUNE 7 ] Go to www.asms.org for updated program details.

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Poster 737 – Small Molecules: Quantitative Analysis (Animal, Plant/Insect, and Methodology)

Analysis of Mycotoxins in Coix Seed Using a Prototype Tandem Quadrupole Mass SpectrometerKerri Smith[1]; Kelly B. Doering*[1]; Mark Wrona[1]; Giorgis Isaac[1]; Jimmy Yuk[1]; Sukhdev Bangar[2]

[1]Waters Corporation, Milford, MA, USA; [2]Waters Corporation, Beverly, MA, USA


Monitoring and Quantitating Genotoxic Impurities Using Mass Detection and UV – Sensitive Analysis Aryl Sulfonic Acid EstersMark Wrona[1]; Janet Hammond[2]; Jayne Kirk[2]; Sean Mccarthy[1]; Hillary Hewittson[1]; Margaret Maziarz*[1]

[1]Waters Corporation, Milford, MA, USA; [2]Waters Corporation, Wilmslow, UK


Development of a Sensitive Supercritical Fluid Chromatography (SFC)-MS-MS Method for the Analysis of Potential Genotoxic Impurities of OndansetronJennifer Simeone*; Paula Hong


[ WEDNESDAY, JUNE 8 ]Go to www.asms.org for updated program details.


Main Session: MS in the QC Lab

Hemisfair 2, 8:50 am – 9:10 amMonitoring Product Attributes in Biopharmaceutical Development and QC with LC-HRMS Scott Berger*; Liuxi Chen; Min Du; Henry Y. Shion; Ying-Qing Yu


Main Session: Exposomics: Targeted, Untargeted and Bioinformatics Methodologies

Hall 1, 4:10 pm – 4:30 pmDetection and Identification of Generally Unknown Toxins and Altered Endogenous Components in Poisoned Patients Using Data-Independent Acquisition and Untargeted MetabolomicsCheng Chen[1]; Ziquan Fan[2]; Xiaojie Tan[2]; Hui Xu[3]; Hongliang Jiang[1]; Mingshe Zhu*[4]

[1]Huazhong University of Science and Technology, Wuhan, China; [2]

Waters Technology (Shanghai) Co., Ltd, Shanghai, China; [3]Maternal and Child Health Hospital of Hubei Province, Wuhan, China; [4]Bristol-Myers Squibb, Princeton, NJ

POSTERS | 10:30 am – 2:30 pm


Advancing Attribute Control of Antibodies Drug Conjugates (ADCs) Using High Resolution AnalyticsLiuxi Chen[1]; Henry Y. Shion[1]; Barbara Sullivan[2]; Ying-Qing Yu[1]; Weibin Chen*[3]

[1]Waters Corporation, Milford, MA, USA; [2]Waters Corporation, Beverly, MA, USA; [3]Waters Corporation, Milford, MA, USA

Poster 122 – Carbohydrates (Glycans)

Mobilizing the Library: Using IMS-MS Data to Supplement GU Library Searching for Glycan IdentificationWilliam Alley*; Ying-Qing Yu


Poster 163 – Drug Discovery/DMPK/ADME

Evaluation of Ion Mobility Enabled Collisional Cross Section Measurements for the Differentiation of Acyl and Phenolic Glucuronide MetabolitesCatherine Holdsworth*[1]; Richard Clayton[1]; Daniel Weston[2]; Nick Tomczyk[2]; Martin Palmer[2]; Darren Hewitt[2]

[1]Covance, Harrogate, UK; [2]Waters Corporation, Wilmslow, UK

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Poster 164 – Drug Discovery/DMPK/ADME

Resolution and Characterisation of Co-eluting Isomeric Metabolites by Collision Cross Section Measurements Using a Novel Geometry Travelling-Wave IMS-QTof Mass SpectrometerRichard Clayton*[1]; Catherine Holdsworth[1]; Daniel Weston[2]; Nick Tomczyk[2]; Martin Palmer[2]; Darren Hewitt[2]

[1]Covance, Harrogate, UK; [2]Waters Corporation, Wilmslow, UK

Poster 200 – Environmental Analysis: Water Quality

Environmental Screening of Water Samples Utilizing Ion Mobility Enable High Resolution Mass SpectrometryLauren Mullin; Douglas Stevens*; Gareth Cleland; Adam Ladak


Poster 224 – Food Safety: Other Contaminants

Rapid Determination of Lactulose in Heat Treated Milk Using Ultraperformance Convergence Chromatography Coupled with Mass SpectrometryFang Wen*[1]; Yao Tian[1][2]; Yongwei Xu[3]; Nan Zheng[1][2]; Qinglong Sun[3]; Songli Li[1][2]; Jiaqi Wang[1][2]

[1]Ministry of Agriculture Laboratory of Quality & Safety Risk Assessment for Dairy Products (Beijing), Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China; [2]Ministry of Agriculture - Milk and Dairy Product Inspection Center (Beijing), Beijing, China; [3]Waters Corporation, Shanghai, China

Poster 344 – Imaging MS: Method Development

Targeted DESI Mass Spectrometry Imaging in Ovarian CancerLuisa Doria*[1]; James McKenzie[1]; Anna Mroz[1]; Abigail Speller[1]; Francesca Rosini[1]; David Phelps[1]; Emrys A. Jones[2]; Renata Soares[1]; Kirill Veselkov[1]; Sadaf Ghaem-Maghami[1]; Zoltan Takats[1]

[1]Imperial College London, London, UK; [2]Waters Corporation, Manchester, UK

Poster 367 – Informatics: Algorithms and Statistical Advances

Improved Qualitative and Quantitative Analysis of the Human Mitochondrial Proteome by Hybrid AcquisitionMaurizio Ronci[1]; Enrico Cilio[1]; Steven Ciavarini[2]; Curt Devlin[2]; Brad Williams[2]; Scott Geromanos*[2]; Chris Hughes[3]; Johannes Vissers[4]; Andrea Urbani[1]

[1]University of Rome Tor Vergata, Rome, Italy; [2]Waters Corporation, Milford, MA, USA; [3]Waters Corporation, Wilmslow, UK; [4]Waters Corporation, Wilmslow, UK

Poster 427 – Instrumentation: New Developments in Ionization and Samplings

Interfacing UPLC to Mass Spectrometry via a Liquid-junction, Secondary Ultrasonic API SourceSteve Bajic; David S. Douce*; Gordon A. Jones

Waters Corporation, Manchester, UK

Poster 436 – Instrumentation: New Developments in Ionization and Samplings

AP-to-vacuum inlet with new features - Optimization of desolvation conditions in liquid AP-MALDI MSJeff Brown*[1][2]; Pavel Ryumin[1]; Michael Morris[2]; Rainer Cramer[1]


Poster 441 – Ion Mobility: Fundamentals

Predicting Theoretical Collision-Cross Sections for Peptides and Peptide FragmentsBela Paizs*[1]; Oscar Hernandez[1]; Daniel Chaplin[1]; Ash Buck[1]; Keith Richardson[2]; Jeff Brown[2]; Kevin Giles[2]; Zoltan Takats[3]

[1]Bangor University, Bangor, UK; [2]Waters Corporation, Wilmslow, UK; [3]

Imperial College London, London, UK

Poster 483 – LC-MS: Sample Preparation

Improved Recovery, Reproducibility and Matrix Effects with an Advanced Technology in Solid Phase Extraction (SPE) –Oasis PRiME HLBXin Zhang*; Jonathan Danaceau; Erin Chambers


Poster 522 – Lipids: Profile Analysis

Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS) Based on Fragmentation Profile of GlycerophospholipidsRichard Schäffer*[1]; Tamas Juhasz[1]; Tamas Karancsi[1]; Steven D. Pringle[2]; Zoltan Takats[3]; Julia Balog[1][3]

[1]Waters Research Center, Budapest, Hungary; [2]Waters Corporation, Wilmslow, UK; [3]Imperial College London, London, UK


The Rapid Evaporative Ionisation Mass Spectrometry (REIMS) iKnife Identifies Gynecological Tissue with Excellent Accuracy in the Ex-Vivo and In-Vivo SettingDavid L. Phelps*[1]; Julia Balog[1][2]; Louise Gildea[1]; Mona El-Bahrawy[1]; Abigail Speller[1]; Robert Brown[1]; Sadaf Ghaem-Maghami[1]; |Zoltan Takats[3]

[1]Imperial College London, London, UK; [2]Waters Corporation, Budapest, Hungary; [3]Imperial College London, London, UK, South Kensington Campus London, UK


REIMS has the Potential to Improve Diagnostic of Hepatocellular Carcinoma Liver – Perspectives towards Intraoperative Molecular DiagnosticsTiffany Porta*[1]; Julia Balog[2]; Flora Olivier[1]; Pierre-Maxence Vaysse[1]; Ulf P. Neumann[3]; Steven W.M. Olde Damink[4]; Thorsten Cramer[3]; Ron M.A. Heeren[1]

[1]M4I Institute - Maastricht University, Maastricht, The Netherlands; [2]Waters Corporation, Wilmslow, UK; [3]RWTH Aachen, Aachen, Germany; [4]Maastricht University Medical Center +, Maastricht, The Netherlands

[ WEDNESDAY, JUNE 8 ] Go to www.asms.org for updated program details.

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An Untargeted Metabolomics Approach for Determining Biomarkers Involved in Spontaneous Pre-term Birth (sp-PTB) Delivery, Using a Label-free LC-DIA-MS ApproachShirish Yakkundi*[1]; Lee Gethings[2]; James Langridge[2]; Louise Kenny[3][4]

[1]Cork University Maternity Hospital, Cork, Ireland; [2]Waters Corporation, Wilmslow, UK; [3]Cork University Maternity Hospital, Cork, Ireland; [4]

University College Cork, Cork, Ireland


IMS-DIA-MS Characterisation and IMS-MRM QconCAT Quantitation of the Lipidome and Apolipoprotein Complements of Obesity and Diabetes CohortsLee A. Gethings*[1]; Johannes P.C. Vissers[1]; Jose Castro-Perez[2]; Yvonne Woolerton[3]; Lynn McLean[3]; Robert Beynon[3]; James I. Langridge[1]

[1]Waters Corporation, Wilmslow, UK; [2]Waters Corporation, Milford, MA, USA; [3]Centre for Proteome Research, Institute of Integrative Biology, University of Liverpool, Liverpool, UK


Evaluation of Ion Mobility/Tof Mass Spectrometry with Multiple LC Method Parameters for Enhanced Detection in Metabolic ProfilingPaul Rainville[1]; David Heywood*[1]; James Langridge[2]; Robert Plumb[1]; Jose Castro-Perez[1]

[1]Waters Corporation, Milford, MA, USA; [2]Waters Corporation, Manchester, UK

Poster 578 – Nanoscale and Microfluidic Separations and MS

Sensitivity Gains Using Microflow LC-MS for Oligonucleotide AnalysisMichael Donegan*; James P. Murphy


Poster 580 – Nanoscale and Microfuidic Separations and MS

Decreasing Cycle Time While Maintaining Analytical Sensitivity in Microflow LC-MS Utilizing a Novel Valve Switching AlgorithmJay S. Johnson*[1]; James P. Murphy[2]

[1]Water Corporation, Milford, MA, USA; [2]Waters Corporation, Milford, MA, USA

Poster 581 – Nanoscale and Microfuidic Separations and MS

Post-column Addition as a Tool to Enhance Performance in Microflow LC-MSAngela Doneanu*; Catherine Tremblay; Michael P. Donegan; James P. Murphy


Poster 612 – Plant ‘omics’

REIMS (Rapid Evaporative Ionization Mass Spectrometry) and Multi-variant Statistics, Two Tools in Support of Weed Grass Speciation and Phenotype CharacterizationSara Stead[1]; Jackson Pope*[2]; Robert Edwards[3]; Melissa Brazier-Hicks[3]; Catherine Tetard-Jones[3]; Zoltan Takats[4]

[1]Waters Corporation, Manchester, UK; [2]Waters Corporation, Wilmslow, UK; [3]University of Newcastle, Newcastle upon Tyne, UK; [4]Imperial College London, London, UK

Poster 613 – Plant ‘omics’

DESI-MS Imaging with Ion mobility and Multivariate Analysis for the Determination of Weed Grass Species and Surface Level CharacteristicsPhilippa Jayne Hart[1]; Sara Stead[1]; Emmanuelle Claude[1]; Hernando Olivos*[2]; Melissa Brazier-Hicks[3]; Catherine Tetard-Jones[3]; Robert Edwards[3]

[1]Waters Corporation, Wilmslow, UK; [2]Waters Corporation, Beverly, MA, USA; [3]Newcastle University, Newcastle upon Tyne, UK

Poster 627 – Protein Therapeutics: Quantitative Analysis

The Use of Generic Surrogate Peptides for the Quantitative Analysis of hIgG1 in Pre-clinical Species with High-Resolution Mass SpectrometryChristian Lanshoeft[1][2]; Thierry Wolf[1]; Olivier Heudi[1]; Sarah Cianférani[2]; Samuel Barteau[1]; Markus Walles[1]; Kelly B. Doering[3]; Guillaume Bechade*[4]; Franck Picard[1]; Olivier Kretz[1]

[1]Novartis Institutes for Biomedical Research, Drug Metabolism and Pharmacokinetics, Basel, Switzerland; [2]Université de Strasbourg, Laboratoire de Spectrométrie de Masse BioOrganique, Institut Pluridisciplinaire Hubert Curien, Strasbourg, France; [3]Waters Corporation, Milford, MA, USA; [4]Waters AG, Baden-Daettwil, Switzerland


Quantification of the Antibody Drug Conjugate, Trastuzumab Emtansine and the Monocolonal Antibody, Trastuzumab in Plasma Using a Generic Kit-Based ApproachHua Yang; Mary E. Lame; Erin E. Chambers*; Sherri Naughton



Applying a Standardized, Kit-based Approach to Achieve 10 ng/mL Infliximab from 35 µL PlasmaMary E. Lame*; Hua Yang; Erin E. Chambers; Sherri Naughton


Poster 686 – Proteomics: Quantitative

Evaluation of a Novel Tandem Quadrupole Mass Spectrometer for the Quantitative Analysis of Peptides Using a Multi-Point Internal Calibration MethodBilly Molloy*[1]; Donald J.L. Jones[2][3]; Donald P. Cooper[4]; Johannes P.C. Vissers[4]; James I. Langridge[4]

[1]Waters Corporation, Wilmslow ; [2]Department of Cancer Studies, University of Leicester, Leicester, UK; [3]Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK; [4]Waters Corporation, Wilmslow, UK

[ WEDNESDAY, JUNE 8 ] Go to www.asms.org for updated program details.

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[ THURSDAY, JUNE 9 ] Go to www.asms.org for updated program details.

ORAL S | LOCATIONS AND TIMES MAY VARY

Main Session: Translational Success with MS

Stars 2 – 3, 8:50 am – 9:10 amDevelopment of a Novel Rapid Evaporative Ionisation Mass Spectrometry (REIMS) Platform 'iEndoscope' for In Vivo Chemical Histology During Colonoscopy.James Alexander[1]; Louise Gildea*[1]; Julia Balog[2]; Abigail Speller[1]; Anna Mroz[1]; Alasdair Scott[1]; James McKenzie[1]; Kirill Veselkov[1]; Robert Goldin[1]; James Kinross[1]; Jonathan Hoare[1]; Julian P. Teare[1]; Zoltan Takats[1]

[1]Imperial College London, London, UK; [2]Waters Corporation, Manchester, UK

Main Session: New Developments in Ionization and Sampling for DMPK

Stars 2, 9:50 am – 10:10amNovel Acoustic Interface for Ultra-high-throughput Mass Spectrometry Utilizing Multiple Ambient Ionization TechniquesIan Sinclair*[1]; Jonathan Wingfield[2]; Martin Bachman[1]; Steven D. Pringle[3]; Luke Ghislain[4]; Eric Hall[4]; Rick Stearns[4]; Sammy Datwani[4]; Lars Majlof[4]; Michael Morris[3]

[1]AstraZeneca, Macclesfield, UK; [2]AstraZeneca, Cambridge, UK; [3]Waters Corporation, Wilmslow, UK; [4]Labcyte Inc, Sunnyvale, CA, USA

Main Session: Food Safety and Chemistry: Non-targeted Screening

Hall 1, 2:30 pm – 2:50 pmComprehensive Pesticide Screening in Complex Matrices by Collision Cross Section Using a Novel Geometry Travelling Wave IMS-QTof Mass SpectrometerOlivier Saperas[1]; Brigitte Ogundeji[1]; Jennifer Unsworth[2]; Nick Tomczyk[2]; Martin Palmer[2]; Darren Hewitt[2]; Christophe Siroit[2]; Davy Petit[2]; Daniel J. Weston*[2]

[1]Lacapa, Toulouges, France; [2]Waters Corporation, Wilmslow, UK

Main Session: Ambient Ionization: Instrumentation and Applications

Stars 2 – 3, 3:50 pm – 4:10 pmBack to Basics - Redesigning the DESI Sprayer for Optimal Performance in Biological Tissue ImagingJocelyn Tillner*[1]; James McKenzie[1]; Emrys A. Jones[1][2]; Steven D. Pringle[2]; Tamas Karancsi[2]; Anna Mroz[1]; Dipa Gurung[1]; Josephine Bunch[3]; Ian Gilmore[3]; Zoltan Takats[1]

[1]Imperial College London, London, UK; [2]Waters Corporation, Manchester, UK; [3]National Physical Laboratory, Teddington, UK

Main Session: Food Safety and Chemistry: Non-targeted Screening

Hall 1, 3:50 pm – 4:10 pmInstantaneous Determination of Cocoa Content and Cocoa Bean Origin of Commercial Products with Rapid Evaporative Ionization Mass SpectrometryJulia Balog*[1][2]; Richard Schäffer[1]; Tamas Juhasz[1]; Tamas Karancsi[1]; Steven D. Pringle[3]; Zoltan Takats[2]

[1]Waters Research Centre, Budapest, Hungary; [2]Imperial College London, London, UK; [3]Waters Corporation, Wilmslow, UK

POSTERS | 10:30 am – 2:30 pm

Poster 024 – Ambient Ionization: Fundamentals and Instrumentation

Using Rapid Evaporative Ionisation Mass Spectrometry (REIMS) to Identify Microorganisms at Species Level from Pure and Mixed CulturesSimon Cameron*[1]; Frankie Bolt[1]; Adam Burke[1]; Zsolt Bodai[1]; Alvaro Perdones-Montero[1]; Julia Balog[2]; Tamas Karancsi[2]; Daniel Simon[2]; Richard Schaffer[2]; Tony Rickards[3]; Kate Hardiman[1]; Monica Rebec[3]; Zoltan Takats[1]

[1]Imperial College London, London, UK; [2]Waters Research Center, Budapest, Hungary; [3]Imperial College Healthcare NHS Trust, London, UK

Poster 066 – Biomarkers: Quantitative Analysis

A Simultaneous Quantification Method Oftricarboxylic Acid Cycleprecursors and IntermediatesPaul Rainville*; Robert Plumb; Jose Castro-Perez; James Langridge


Poster 092 – Drug Metabolism: Quantitative Analysis

Evaluation of QTof HRMS Platform for Highly Sensitive Analysis of Raltegravir in Plasma in Support of Human MicrodosingLi Sun*[1]; Kevin Bateman[1]; Sukhdev Bangar[2]; Yun W. Alelyunas[3]; Mark Wrona[3]; Sheila Breidinger[1]; Eric Woolf[1]

[1]Merck & Co., Inc., West Point, PA, USA; [2]Waters Corporation, Beverly, MA, USA; [3]Waters Corporation, Milford, MA, USA


Use of Ambient Ionization Mass Spectrometry for the Rapid Authentication of Food and Dietary SupplementsKari Organtini; Gareth Cleland; Beth Loecken*; Adam Ladak



Accessible and Efficient Screening of Multiclass Contaminants in FoodEimear McCall*[1]; Ramesh Rao[1]; Adam Ladak[2]; Jennifer Burgess[2]

[1]Waters Corporation, Wilmslow, UK; [2]Waters Corporation, Milford, MA, USA

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Quantitative Determination of Veterinary Drug Residues in Eggs by UPLC-MS/MS Using a Simple, Rapid and Effective Cleanup ApproachSujie XIa[1]; Dimple Shah[2]; Jeremy C. Shia[2]; Michael S. Young[2]; Adam Ladak[2]; Laura Suhadolnik*[2]

[1]Shanghai Institute for Food and Drug Control, Shanghai, China; [2]Waters Corporation, Milford, MA, USA

Poster 186 – H/D Exchange: Protein Structure/Function

Probing Protein Surface Chemistry and Unfolding Pathways by Coupling Gas-phase HDX and Native MSShane A. Chandler*[1]; Todd H. Mize[1]; Michael R. Morris[2]; Justin L. P. Benesch[1]

[1]Oxford University, Oxford, UK; [2]Waters Corporation, Wilmslow, UK

Poster 213 – Imaging MS: Method Development

An Investigation of MALDI Imaging with Higher Speed Sample Stage “Rastering” from an Ion Mobility Enabled Q-Tof Mass SpectrometerTowers Mark[1]; Paul Murray*[1]; Migas Lukasz[2]; Claude Emmanuelle[1]; Hoyes Emmy[1]; Chapman Richard[1]

[1]Waters Corporation, Wilmslow, UK; [2]University of Manchester, Manchester, UK

Poster 246 – Imaging MS: Small Molecules

Evaluating DESI Imaging and High Resolution Mass Spectrometry to Improve an Industrial Component Cleaning ProcessPeter Hancock*; Jonathan Jones; Eleanor Riches; Vikki Turner; Gordon Jones; Timothy Harford


Poster 271 – Informatics: Protein ID and Quantification

Analysis Workflow for Quantitative Proteomics, Employing Triplex Dimethyl Labelling and Ion Mobility Assisted Data Independent AcquisitionAndrew Paul Collins*[1][2]; Antony McCabe[1][2]; Ian Morns[3]; Chris J. Hughes[4]; Johannes P.C. Vissers[4]; Andrew Robert Jones[1][2]

[1]University of Liverpool, Liverpool, UK; [2]Omic Analytics, Liverpool, UK; [3]Nonlinear Dynamics Limited, Newcastle upon Tyne, UK; [4]Waters Corporation, Wilmslow, UK

Poster 290 – Instrumentation: New Developments in Ionization and Sampling

An Aerodynamic Perspective on Impactor API SourcesSteve Bajic*



Further Development of an Integrated Acoustic Electrospray Source for High-throughput Label-free Mass Spectrometry Biochemical ScreeningIan Sinclair[1]; Jonathan Wingfield[2]; Bachman Martin[1]; Steven D. Pringle[3]; Hall Eric[4]; Lucien Ghislain*[5]; Lars Majlof[4]; Stearns Rick[4]; Sammy Datwani[4]

[1]AstraZeneca, Maccelsfield, UK; [2]AstraZeneca, Cambridge, UK; [3]Waters Corporation, Wilmslow, UK; [4]Labcyte, Inc., Sunnyvale, CA, USA; [5]Labcyte Inc, Sunnyvale, CA, USA


Exploring the REIMS Interface Using the DSMC Method and Particle Tracing in Realistic Low Pressure Gas FlowsAthanasios Zacharos*[1]; Julia Abda[2]; Alexander Lekkas[1]; Dimitris Papanastasiou[1]; Emmanuel Raptakis[1]; Tamas Karancsi[3]; Zoltan Takats[2]

[1]Fasmatech, Athens, Greece; [2]Imperial College London, London, UK; [3]

Waters Research Centre, Budapest, Hungary


Optimization of Matrix Assisted Rapid Evaporative Ionisation Mass Spectrometry (MAREI-MS) SystemDaniel Simon*[1]; Tamas Karancsi[2]; Julia Balog[2]; Emrys A. Jones[3]; Steven Pringle[3]; Zoltan Takats[4]

[1]Waters Research Center Ltd., Budapest, Budapest; [2]Waters Research Center, Budapest, Hungary; [3]Waters Corporation, Wilmslow, UK; [4]Imperial College London, London, UK

Poster 314 – Ionization Mechanisms

Application of Chemical Supercharging Electrospray Ionization to Small Organic MoleculesAndrew T. Ball[1]; Anthony W.T. Bristow[2]; Martin Sims[2]; Mike Morris[3]; Jackie Mosely*[1]

[1]Durham University, Durham, UK; [2]AstraZeneca, Maccelsfield, UK; [3]Waters Corporation, Wilmslow, UK

Poster 361 – Lipids: Quantitative Analysis

Development of a Wide-targeted Quantitative Lipidomics Methodology by Supercritical Fluid Chromatography Coupled with Fast-Scanning Triple Quadrupole Mass SpectrometryHiroaki Takeda*[1]; Yoshihiro Izumi[1]; Thanai Paxton[2]; Noriko Kato[2]; Shinnosuke Horie[2]; Katsutoshi Nagase[2]; Takeshi Bamba[1]

[1]Medical Institute of Bioregulation, Kyushu Univ. Fukuoka, Japan; [2]Nihon Waters K.K., Tokyo, Japan

Poster 389 – MALDI: Sample Preparation

Optimized Multiply Charged Ion Production by Liquid MALDI – from High Molecular Protein Ions to Bottom-up Proteomics Using LC-MALDI MS-MSPavel Ryumin[1]; Jeffrey Brown[1][2]; Michael Morris[2]; Rainer Cramer*[1]



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Poster 479 – Peptides: Quantitative Analysis

Improvements in Sensitivity for Biotherapeutics Using a Prototype Tandem Quadrupole Mass SpectrometerNikunj Tanna*[1]; Kerri Smith[1]; Mark Wrona[1]; Leonard Dillon[2]; Mark Roberts[2]

[1]Waters Corporation, Milford, MA, USA; [2]Waters Corporation, Wilmslow, UK

Posters 496 – Peptides: Quantitative Analysis

Ultra Performance Liquid Chromatography−Tandem Quadrupole Mass Spectrometry for High-Sensitivity Profile Analysis of Blood Pressure Modulators Angiotensin PeptidesMeng Qi*[1]; Hui Wang[2]; Jie Wang[1]; Li Yang[1]; Zhengtao Wang[1]

[1]Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai; [2]Waters Corporation, Shanghai, China

Poster 531 – Protein Therapeutics: Structural Characterization

Profiling Released High Mannose and Complex N-Glycan Structures from Monoclonal Antibodies Using Optimized Hydrophilic Interaction ChromatographyScott McCall*; Matthew Lauber; Stephan Koza; Erin Chambers



Comprehensively Characterizing the N and O-Linked Glycosylation of a Recombinant Human EPO Using HILIC-MSMatthew Lauber*; Stephan Koza; Erin Chambers



Innovator and Biosimilar Infliximab: Comparability Assessment of the Host Cell Proteins and Protein Higher Order StructureJing Fang*[1]; Catalin E. Doneanu[1]; William R. Alley[1]; Ying-Qing Yu[1]; Asish Chakraborty[1]; Alain Beck[2]; Weibin Chen[1]

[1]Waters Corporation, Milford, MA, USA; [2]Centre d’Immunologie Pierre Fabre, Saint-Julien-en-Genevois, France

Poster 695 – Small Molecules: Quantitative Analysis

How Low Can We Go? Analysis of Aldosterone Using a High Sensitivity Tandem Quadrupole Mass Spectrometer for Clinical ResearchDominic Foley*; Lisa Calton


Poster 725 – Toxicology

Definitive Drug and Metabolite Screening in Urine by UPLC-MS/MS Using a Novel Calibration TechniqueThomas G. Rosano[1][2]; Patrice Y. Ohouo[2]; John J. LeQue[2]; Scott M. Freeto[3][3]; Michelle Wood*[4]

[1]Forensic Toxicology Laboratory, Department of Pathology and Laboratory Medicine, Albany Medical Center Hospital and College, Albany, NY, USA; [2]

Clinical and Forensic Toxicology Laboratory, National Toxicology Center, Schuylerville, NY, USA; [3]Waters Corporation, Beverly, MA, USA; [4]Waters Corporation, Wilmslow, UK

Poster 735 – Toxicology

Dilute-and-shoot Method for Determination of Tobacco-specific Nitrosamines (TSNAs) in Tobacco and e-Cigarette Products by UPLC-MS/MSNarendra Meruva[1]; Xiaojie Tan[2]; Dimple Shah[1]; Adam Ladak[1]; Larissa Fenn*[1]

[1]Waters Corporation, Milford, MA, USA; [2]Waters Corporation, Shanghai, China


Waters, The Science of What’s Possible, CORTECS, ACQUITY UPLC, UPLC, UPC,2 UNIFI, Xevo, SYNAPT, ACQUITY QDa, Progenesis, and MassLynx are registered trademarks of Waters Corporation. MALDI, REIMS, iKnife, UniSpray, Enzymate, AutoPurification, ProteinWorks, T-Wave, DynamX, Vion, and ionKey/MS are trademarks of Waters Corporation. All other trademarks are the property of their respective owners.

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EXPERIENCE THE BEST OF ASMS WITH WATERS · 3 Poster 353 – Ion Mobility: Applications Enhanced Ion...

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