EXERCISE AND TYPE 1 DIABETES...glucose concentration Intensity and duration of exercise, insulin to...
Transcript of EXERCISE AND TYPE 1 DIABETES...glucose concentration Intensity and duration of exercise, insulin to...
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EXERCISE AND TYPE 1 DIABETES
1
Joseph Henske, MD, FACEDepartment ChairEndocrinology, Diabetes, and MetabolismDuPage Medical Group2/23/19
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Exercise Has Many Benefits for People with T1D
Weight management, increased lean body mass
Reduced heart disease risk
‒ Lower blood pressure
‒ Lower LDL, higher HDL cholesterol
‒ Improved HbA1c and insulin sensitivity
Reductions in microvascular complications
‒ Eyes, Kidneys, Nerves
Psychological benefits
Improved sense of well-being
Improved self-esteem
ADA. Diabetes Care. 2018;41(Suppl 1):S38-50; Bohn B, et al. Diab Care. 2015;38:1536-43. 2
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There are No Limits
3
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KEY POINT #1
DIFFERENT FORMS OF EXERCISE HAVE DIFFERENT EFFECTS
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Wo
rkra
te
Aerobic Mixed Anaerobic
Glucose trends
Main variables
Intensity and duration of exercise, insulin to glucagon ratio, fitness, nutrition, initial glucose concentration
Intensity and duration of exercise, insulin to glucagon ratio, counter-regulatory hormones, lactate concentration, fitness, nutrition, initial glucose concentration
Intensity and number of intervals, insulin concentration, counter-regulatory hormones, lactate concentration, fitness, nutrition, initial glucose concentration
Blood Glucose Effects of Different Types of Exercise
Riddell M, et al. Lancet Diab Endo. 2017;5:377-90. 5
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Resistance Exercise has Can Be a Good Way To Avoid Lows
Adding resistance training before aerobic activity can help minimize lows ‒ Reduces declines in glucose
‒ May reduce need for carbs
10 second sprints during aerobic exercise can increase blood glucose as well
6
Time (min)
-90
-72
-54
-36
-18
0
18
36
∆ Glucose (mg/dL)
-30 -15 0 15 30 45
†*
†*†*
Aerobic exercise
Resistance exercise
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KEY POINT #2
PEOPLE MAINTAIN “NORMAL” GLUCOSE LEVELS THROUGH PHYSIOLOGY
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Normal Physiologic Mechanisms Maintain Tight Glucose Levels During Exercise
Brain‒ Stimulates Adrenaline: sugar goes up
Pancreas‒ Makes Glucagon – sugar goes up
‒ Makes Insulin – sugar goes down
Liver ‒ Sugar released into circulation
Muscles‒ Stores sugar for release, Burns glucose as fuel
Fat‒ Stores sugar as well for release
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KEY POINT #3
EXERCISE IN T1D LEADS TO GLUCOSE IMBALANCE DUE TO ALTERED PHYSIOLOGIC RESPONSES
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Factors that Contribute to Increased Lows During Exercise in T1D
People with diabetes (PWD) can’t turn off insulin that’s already been dosed
There is an increase in skin absorption of insulin from injection/pump site
There is an increase in sugar use by muscles
Exercise blunts counter-regulatory hormone responses
Therefore there is diminished liver glucose production in PWD
Riddell M, et al. Lancet Diab Metab. 2017;5:377-90. 10
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Aerobic Exercise Without Adjusting Insulin Can Cause Blood Sugars to Drop (at Variable Rates!) and May Cause Lows
The Diabetes Research in Children Network (DirecNet) Study Group, et al. Diabetes Care. 2006;29:2200-4. 11
T1D, no insulin adjustment
Δ=~ 63 mg/dL43% become hypoglycemic
0
-25
-50
-75
-100
Baseline 15 min
35min
55 min
75 min
Exercise time
Ch
ange
in G
luco
seT1D, age 8‒17 years, n=4975 min of intermittent aerobic exercise
Exercise
(mg/dL)
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Symptoms of Lows May Be Blunted in T1D
Martin-Timon I, et al. World J Diabetes. 2015;6:912-26. 12
Individuals without diabetes
Individuals with T1D and hypoglycemia unawareness
Deficient glucagon and poor Adrenaline, reduced symptoms
72
54
36
Glu
cose
Release of hormones
Warning symptoms
Brainimpairment(m
g/d
L)
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KEY POINT #4
BLOOD SUGARS CAN DROP DUE TO BOTH INSULIN ACTION AND MUSCLE CONTRACTION
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Both Insulin and Muscle Contraction Increase Glucose Uptake into Muscles via Distinct Mechanisms
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Muscle Contraction
Insulin Receptor
Insulin
Rest
Insulin
glucose
Muscle cell Muscle cell
Insulin Receptor
Insulin
GLUT-4 vesicles
GLUT-4 vesicles
glucose
Insulin
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Insulin Receptor
Insulin
Rest
Insulin
Insulin glucose
Muscle cell
GLUT-4 vesicles
Muscle contraction, increased blood flow
Muscle cell
Insulin Receptor
Insulin
GLUT-4 vesicles
glucose
Too Much Insulin/muscle contraction,
increased blood flow
Muscle cell
Insulin Receptor
Insulin
GLUT-4 vesicles
HYPOGLYCEMIA
Both Insulin and Muscle Contraction Increase Glucose Uptake into Muscles via Distinct Mechanisms –Increased Risk For Lows!
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KEY POINT #5
EXERCISE HAS BOTH IMMEDIATE AND DELAYED EFFECTS ON BLOOD GLUCOSE
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After Exercising, Blood Sugar “Burn” Remains Highfor Hours to Replenish Muscle Glycogen Stores (i.e. overnight)
Adapted from McMahon SK, et al. J Clin Endocrinol Metabol. 2007;92:963-8. 17
Rest
Glu
cose
up
take
1600 1800 2000 2200 2400 0200 0400
Time
Late hypo riskEarly hypo risk
Moderate-intensity exercise
in afternoon
Starting approximately 7–11 hours after exercise, lasting ~6 hours
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KEY POINT #6
THE BODY ADJUSTS ITS SOURCE OF ENERGY AS INTENSITY OF EXERCISE AND OVERALL FITNESS CHANGE
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The More Intense the Exercise, the More Glucose Is Burned as Fuel to Keep You Going
Lower-intensity exercise‒ High lipid (fat) use
Higher-intensity exercise‒ High muscle glycogen use
‒ High plasma glucose use
Training increases fat burning and spares muscle and liver sugar stores
Romijn JA, et la. Am J Physiol. 1993;265:E380-91; van loon LJ, et al. J Physiol. 2001;536:295-304. 19
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KEY POINT #7
INSULIN SENSITIVITY INCREASES WITH FITNESS
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Training Increases Insulin Sensitivity and May Lower Insulin Requirements
21
0
Insu
lin
Clock Time (hours)
08:00 12:00 16:00 20:00 24:00 04:00
Untrained/overweightTrained/normal weight
Schematic; derived from expert opinion.
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KEY POINT #8
COOLDOWN MINIMIZES INCREASE AFTER-EXERCISE HIGH BLOOD SUGARS
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Cool Down Can Reduce High Blood Sugar Risk After Vigorous Exercise
Counter-regulatory hormones and high lactate levels may increase blood sugar levels after exercising
High blood sugars shortly after exercise can be reduced by a prolonged passive cool down at a moderate intensity (ex. 15-20 min walking)
Monitoring of glucose is essential
Modified from Exercise Physiology Energy, Nutrition, & Human Performance, 6e. Editors: William D. McArdle, Frank I. Katch, Victor L. Katch. 23
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KEY POINT #9
SHORT TERM RISK OF LOWS DURING EXERCISE IS INCREASED BY RECENT HYPOGLYCEMIA AND RECENT EXERCISE
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Dangerous Cycle of Hypoglycemia and Exercise
Ertl AC, Davis SN. Diabetes Metab Res Rev. 2004 Mar-Apr;20(2):124-30. 25
Exercise
Hypoglycemia
Bluntedcounter-regulatory responses
Bluntedcounter-regulatory
responses
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Summary
1. Different forms of exercise have different effects
2. Physiologic mechanisms maintain tight blood sugar levels during exercise in people without diabetes
3. Exercise in T1D leads to blood sugar imbalance due to altered physiology
4. Blood sugar uptake is high due to both insulin action and muscle contraction
5. Exercise has both immediate and delayed effects on blood sugar
6. The body adjusts its source of energy as intensity of exercise and overall fitness change
7. Insulin sensitivity increases with fitness
8. Cooldown minimizes increase in blood glucose levels after exercise
9. Short term risk of hypoglycemia during exercise is increased by recent hypoglycemia and recent exercise
26
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GLUCOSE AND INSULIN MANAGEMENT
A CASE-BASED LOOK: MANAGING BLOOD SUGARS BEFORE, DURING, AND AFTER EXERCISE
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18 year old, has had T1D for 15 years
Uses an insulin pump
HbA1c 8.1%
Has struggled with her weight
Daily calorie intake is approximately 2300 calories
Exercise:
‒ Wants to start with 3-4 days per week
‒ Plans to use elliptical, also some weight lifting
Exercise goals:
‒ Weight loss, improved mental health, fitness, glucose control
How should she adjust her insulin before, during, and after exercise?
How will she be able to lose weight?
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I N T R O D U C T I O N T O T H E PAT I E N T
Sara
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5 Factors to Consider
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Type of exercise
1
Duration and intensity of
exercise
2
Timing of exercise in relation to time of day
and food intake
3
Insulin on board
4
Impact of previous
exercise and previous
hypoglycemia
5
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Frequent Glucose Monitoring Is Critical During Exercise
Riddell M, et al. Lancet Diab Endo. 2017;5:377-90. 30
1. The best way to avoid hypoglycemia is to regularly monitor/check glucose level before, during, and after exercise
2. People with T1D should not exercise if their glucose meter (or CGM) and strips are not readily available
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BEFORE EXERCISE
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Bolus Insulin Dose Adjustment Before Aerobic Exercise
Mauvais-Jarvis F, et al. Diabetes Care. 2003;26:1316-7; Hernandez JM, et al. Med Sci Sports Exerc. 2000;32:904-10;Rabasa-Lhoret R, et al. Diabetes Care. 2001;24:625-30; West, et al. Diabetic Med. 2009;26:60; DirecNet Study Group,
et al. Diabetes Care. 2006;29:2200-4. 32
Recommendations
Consider the amount of insulin on board!!
This is the most important recommendation! The key to exercising successfully is matching the amount of insulin on board to the exercise and carb intake
Exercise ≤ 2 hours after bolus insulin dose
Reduce pre-exercise insulin dose by 25–75%
Exercise > 2 hours after bolus insulin dose
Possibly no insulin adjustment (otherwise will run very high after meal)
If blood glucose is running low, must consume carbohydrate
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Taking Additional Carbs Can Offset Insulin On Board
Nosek L, et al. Diabetes Obes Metab. 2013;15:77-83; Riddell M, et al. Lancet Diab Endo. 2017;5:377-90. 33
Re
lati
ve In
sulin
Eff
ect
Time (h)2 hours
If blood glucose is running low, must consume carbohydrate
Reduce pre-exercise insulin dose Consume carbohydrate with low
glycemic index
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T1D Athlete Protocol
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“On Board” or “Active” Insulin Levels(basal and bolus)
Glu
cose
Lev
els
(m
mo
l/L)
35
70
110
145
180
215
250
Low High
Initiate carb intake to maintain target:~15 g/hr ~30 g/hr ~60 g/hr
350
Glu
cose
Levels (m
g/d
L)
Removal from play—monitor for ketones (if ketones are positive, suspend play); Consider insulin correction bolus (by syringe is preferred)
Consume 15–20 g of fast-acting carb before resuming play; if glucose <70 mg/dL, wait 15 min or until glucose is restored
Glucose in target range
2
4
6
8
10
12
14
19.5
16.7
90Glucose below target
Glucose above target range(athlete ok to play— drink water only)
300
Riddell M, et al. Lancet Diab Endo. 2017;5:377-90.
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Adjusting Basal Insulin
Basal insulin provides background insulin that the body needs even in the fasted state (overnight and between meals) and for exercise
Basal insulin, delivered either by pump or long-acting insulin analog, generally reaches a steady, stable level
Therefore, in preparation for exercise, basal insulin needs to be reduced in advance of planned exercise
67Expert opinion.
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Basal Insulin
Basal insulin delivered by pump needs to be reduced about 90 minutes before exercise to reduce circulating insulin levels for exercise
Changes to basal insulin delivered by injection needs to be individualized due to differences in long-acting analogs; some can be reduced in the morning of the planned exercise
Following exercise, basal insulin can be reduced in the evening or at bedtime to reduce risk of nocturnal hypoglycemia
68Expert opinion.
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Patients on MDI
Basal insulin dose adjustment is not routinely recommended
If on twice daily basal, one could consider reducing one or both of the basal doses by 20%
Basal Insulin Dose Adjustment Before Aerobic Exercise
Riddell M, et al. Lancet Diab Endo. 2017;5:377-90. 37
Patients on Insulin Pumps
Basal insulin dose reduction of50–80% may be useful for exercise over 45–60 minutes
Dose could be reduced up to 90 minutes before exercise
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Effect of pump disconnection on basal insulin levels
Disconnection/suspension during 30 minutes of exercise eliminates basal pulses for 30
minutes
Ex, exerciseScheiner, G: Schematic representation of basal insulin delivery, based on pharmacokinetics of rapid insulin analogs.
38
Insu
lin le
vel
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Level of active basal insulin resulting from disconnection/suspension during 30 minutes of
exercise
Effect of pump disconnection on basal insulin levels
Disconnection during a short exercise session has minimal effect on insulin levels
Scheiner, G: Schematic representation of basal insulin delivery, based on pharmacokinetics of rapid insulin analogs.
39
Insu
lin le
vel
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Nutrition Before Exercise
1‒4 Hours Within 10–15 Minutes
Carbohydrate A meal based on low-fat, lower blood sugar impacting carbohydrate
Depending on blood sugar level,insulin on board and activity type
Protein Include low-fat, high-quality protein (eg, lean meat, fish, milk, yogurt)
Not required
Fluid 5–10 mL/kg body weight in the 2–4 hours before exercise
Between 150–300 mL fluiddepending on age/sex/environment
Thomas DT, et al. J Acad Nutr Diet. 2016;116:501-28; Burke LM, et al. J Sports Sci. 2011;29 Suppl 1:S17-S27; Coyle EF. J Sports Sci. 2004;22:39-55; Phillips SM. Sports Med. 2014;44 Suppl 2:149-53; Phillips SM, et al. Int J Sport Nutr Exerc Metab. 2007;17:S58; Riddell M, et
al. Lancet Diab Endo. 2017;5:377-90. 40
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Recommendations Based on Starting Blood Glucose
Riddell M, et al. Lancet Diab Endo. 2017;5:377-90. 41
Blood Sugar Concentrations Recommendation
<90 mg/dL Ingest 10–20 g of glucose before exercise
Delay exercise until blood glucose >90 mg/dL
90–124 mg/dL Ingest 10 g of glucose
Exercise can be started, anaerobic and high-intensity interval training may be started without CHO
125–180 mg/dL Aerobic exercise can be started
Anaerobic exercise and high-intensity interval training may be started, but levels may rise
181–270 mg/dL Aerobic exercise can be started
Anaerobic exercise can be started, but glucose concentrations may rise
>270 mg/dL Check blood ketones and perform low-intensity exercise if ketones are not elevated, small corrective dose of insulin may be needed
If modestly elevated (0.6‒1.4 mmol/L), exercise should be restricted to a light intensity for only a brief duration (<30 min), small corrective dose of insulin may be needed
If blood ketones are ≥1.5 mmol/L, exercise is contraindicated and corrective insulin dose should be given
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Avoiding HYPERglycemia before exercise
42Riddell M, et al. Lancet Diab Endo. 2017;5:377-90.
Cutting down insulin too much in advance may result in high blood glucose
Recommendations:
Eat pre-workout meal 3-4 hours before
If eating close to workout time and reducing or skipping insulin, choose lower glycemic index or slower digested carbs
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DURING EXERCISE
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CarbohydrateNeed
Factors
Carbohydrate Needs Vary Based on Many Factors
Riddell M, et al. Lancet Diab Endo. 2017;5:377-90. 44
Aerobic exercise Longer duration More insulin on board/no prior adjustment
Competition New sport/unfamiliar activity
Anaerobic exercise Short duration Exercise without insulin on board Insulin dose reduced (adjusted) with meal before exercise
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1 hour run
3 sensors: DEXCOM G5, Medtronic 670g, and FreeStyle Libre CGM
All sensors can overestimate blood glucose during periods of rapid decline
Zaharieva, D. Henske, J. Journal of Diabetes Science and Technology 2019
Comparing the Accuracy of CGM vs Fingerstick Glucose During Exercise
-20 -10 0 10 20 30 40 50 60 70 800
50
100
150
200
250
300
350
Time (minutes)
Glu
cose
Con
cent
ratio
ns (m
g•dL
1 )
E X E R C I S E
Rt-CGM1
SMBG
Rt-CGM2
Flash GM
#
*
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Nutrition Needs During Exercise
30 mins 30‒60 mins >60 mins
Carbohydrates(drink/gel)
• Not needed unless blood sugar dropping
• May be needed if very strenuous activity or no insulin adjustment
• May be needed for fuel• 30–60 g/h (0.5–1 g/kg for a
child)• For ultraendurance (>3 hr) up
to 90 g/h; consider choices with more significant blood sugar impact
Fluid • Water should be adequate for hydration
• Drink appropriate amount* of fluids to replace sweat losses so that total body fluid deficit is <2% BW
• May benefit from use of sports drinks (exercise >60 minutes)
Thomas DT, et al. J Acad Nutr Diet. 2016;116:501-28. 46
* Depends on exercise intensity, duration, fitness, heat acclimatization, altitude, and environment (eg, humidity)
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Avoiding HYPERglycemia
During Aerobic Exercise
Hyperglycemia duringexercise is usually due to:‒ rapid-acting carbohydrate just
before exercise
‒ anxiety about blood sugars
‒ adrenaline during the competition
‒ too much decrease in basal insulin rate
Recommendations:‒ ingest 20 g carbohydrate if
blood sugars are below target before exercise
‒ use CGM to monitor changes
‒ reduce competition-related anxiety with meditation or visualization
‒ use extra caution with insulin boluses during exercise
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AFTER EXERCISE
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Basal Insulin Dose Adjustment After Exercise: MDI vs Insulin Via Pump
Riddell M, et al. Lancet Diab Endo. 2017;5:377-90. 49
MDI
Consider basal adjustment
Encourage increased carbohydrate consumption to prevent nocturnal hypoglycemia
Check blood sugar during the night
Pump
Reduce insulin dose by 20% for up to 6 hours (eg, 9 p.m. to 3 a.m.)
Encourage increased carbohydrate consumption
Check blood sugar during the night
All night 3 a.m.
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Nutrition After Moderate-to-Intense Exercise
Thomas DT, et al. J Acad Nutr Diet. 2016;116:501-28. 50
Carbohydrate Aim for 1 g/kg body weight carbohydrate eaten
within 1–2 hours after exercise to replenish glycogen stores
Protein Protein should be consumed within 30-60 minutes of
training for optimal muscle protein synthesis Addition of 15–25 g protein to a meal along with
carbohydrate can help to reduce hypoglycemia risk and enhance glycogen synthesis
Fluid Drink fluids post exercise with food to maximize
rehydration
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Managing HYPERglycemia
After Aerobic Exercise
Hyperglycemia after exercise is usually due to:
‒ persistent adrenaline combined with decreased glucose needs from muscle
‒ delayed glucose absorption from carbohydrate used during exercise
‒ decreased basal insulin rate
Recommendations
‒ Because insulin sensitivity is still increased, consider a conservative bolus of 50% of usual correction at first
‒ low-intensity cooldown of 10-15 minutes of walking
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OTHER CAVEATS AND CONSIDERATIONS
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Some Situations Require Additional Considerations
Insulin adjustments may be more complex for those using hybrid closed-loop pumps or ultra-long-acting basal insulins
Consider differences in absorption times for various insulin preparations (inhaled, faster acting, etc.)
Impact of emerging therapies for T1D such as SGLT2 inhibitors on glycemic control during exercise are largely unknown
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GLUCOSE AND INSULIN MANAGEMENT
CASE WRAP UP
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Exercise Recommendations
For planned 30 minutes of elliptical at gym:‒ Decrease pump basal rate by
50% 1 hour before, during, and 1 hour after exercise
‒ Reduce carbohydrate bolus by 50% for meals and correction doses within 2 hours of planned exercise—both before and after—to limit the need for extra carbohydrates to prevent hypoglycemia while working on weight management and glycemia
Reduce basal rate 20% x 4‒6 hours at bedtime after exercise in the afternoon to avoid nocturnal hypoglycemia
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Eating Plan Recommendations
Continue carbohydrate counting
Aim for modest calorie restriction of 1800‒2000/day; eat3 meals and 1 snack each day:‒ Carbohydrates: 50% of calories
‒ Protein: 20% of calories
‒ Fat: 30% of calories
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Summary of Considerations for Balancing Blood Sugar Control and Exercise
You and your doctor should discuss your individual goals for exercise
Type, duration, and intensity of exercise play a significant role in management
Timing of exercise and meals is important
Assess insulin “on board” (active insulin) at exercise time
Consider the impact of previous exercise and/or hypoglycemia
Delivery modality is an important factor in management
Patients and their healthcare team should discuss glucose targets, trends, and available tools to measure
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Thank you for you participation and attention!
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