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Evaluation: Pharmacology UY1/FMSB/PHCL3XX-L3S514march2011 : 60mins

Section A: Multiple Choice Questions (Choose the ONE best answer

1. What is the drug of choice for the treatment of High-Altitude CerebralOedema (HACE)?

[a] Chlorthalidone[b] Furosemide[c] Acetazolamide[d] Mannitol[e] Descend altitude until symptoms are reduced

2. Which of the following anti-tuberculosis agent is nephrotoxic?[a] Isoniazid[b] Rifampicine[c] Pyrazinamide[d] Ethambutol[e] Streptomycin

3. Which class of diuretics could exhibit cross reactivity in patients allergic tosulphonamides?

[a]Thiazides[b] Loop diuretics[c] Carbonic anhydrase inhibitors[d] Osmotic diuretics[e] Anti-aldosterones

4. Which of the following diuretics should not be combined with drugs known

to be ototoxic?[a] Mannitol[b] Spironolactone[c] Furosemide[d] Hydrochlorothiazide[e] Acetazolamide

5. Which drug family is indicated for treatment of ureter spasm?[a] Anti-muscarinic agents[b] Osmotic diuretics[c] Anti-depressants[d] Agents that acidify

[e] -1 selective agonist6. -1 selective antagonist Tamsulosin (Flowmax) is indicated for

[a] Urinary retention associated with urethritis[b] Urinary retention associated with benign prostatic hypertrophy[c] Urinary retention associated with peripheral neuropathy[d] Acute Prostatitis[e] Bladder atony

7. Which of the following is true in the comparison between cimetidine andranitidine?

[a] Ranitidine does bind to androgen receptors[b] Ranitidine is less likely to cause gynaecomastia[c] Ranitidine has a lower affinity for cytochrome P450[d] Ranitidine penetrates the blood brain barrier to a lesser extend

[e] All the above

8. What is the mechanism of ethanol induced gastritis in human?[a] Stimulation of acid secretion[b] Expose gastric mucosal to acidity after disrupting mucin layer[c] Acidic properties of alcohol itself[d] Increase in vagus stimulus[e] Increases the proliferation of Helicobacter pylori

9. The mechanism of the anti-emetic effects of the neuroleptic Chlorpromazine is[a] Acceleration of gastric emptying

[b] Direct antagonising effects on gastric muscles and diaphragm[c] Blocks serotonin receptors in the Chemoreceptor trigger zone[d] Blocks histamine receptors in the vomiting centre[e] Blocks dopamine receptors in the Chemoreceptor trigger zone

10. Ondansetron[a] Is an anti-diarrhoea agent[b] Is not absorbed after oral administration[c] Is effective in ciplastin induced nausea & vomiting[d] Is effective in motion sickness

[e] Is effective for hiccups (hoquets)11. All of the following receptors are targets for potential anti-emetic drugs EXCEPT

[a] Histamine H1 receptors[b] Opioid mu-receptors[c] Neurokinin (NK)1 receptors[d] Muscarinic receptors

[e] 5-Hydroxytryptamine(5-HT3) receptors12. Sulfasalazine

[a] Is a prodrug[b] Is used for maintenance treatment of ulcerative colilitis[c] Is nephrotoxic[d] Should be avoided in G6PD deficiency[e] All of the Above

13. Which of the following preparations of iodine is used in public health interventions forthe control of cretinism in Cameroon?

[a] iodised oil injections

[b] Iodised table salt[c] Iodised drinking water[d] Lugol solution[e] Iodised milk

14. Which of the following is synthetic progesterone that is commonly used in injectablecontraceptives?

[a] Norethisterone[b] Estrone[c] Levonorgestrel[d] Medroxyprogesterone[e] Ethinyl estradiol

15. Pathologic hyperprolactinemia could be treated with which of the following families ofdrugs?

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[a] Dopamine antagonists[b] Vasopressin analogs[c] Dopamine agonists[d] Oestrogens[e] progestines

16. Which of the following testosterone preparations could ensure prolongedavailability in the body?

[a] Methyl testosterone tablets[b]Testosterone Propionate i.m injection[c] Fluoxymesterone tablets[d]Transdermal patches of testoterone[e] None of the above

17. Which insulin preparation is best for acute diabetic ketoacidosis?[a] Rapid insulin[b] Intermediate acting insulin[c] Long acting insuline[d] Human insulin[e] Porcine insulin

18. Which of the following is best indicated for the treatment of diabetesinsipidus

[a] Oxytocine[b] Desmopressin[c] Insulin[d] Meformin

[e] Furosemide19. What is the standard concentration of all brands of commercially available

insulin preparations?[a] 40iu/ml[b] 60iu/ml[c] 80iu/ml[d] 100iu/ml[e] 120iu/ml

20. Which of the following could be used as muscle relaxant agent in certainneuromuscular disorders?

[a] Levodopa[b] Amitryptyline[c] Ketamine

[d] Atropine[e] diazepam

21. Which of the following anti-convulsant agents is indicated for febrileconvulsions in children?

[a] Phenytoin[b] Aspirine[c] Diazepam[d] Carbamazepine[e] Magnesium sulfate

22. Which of the following is indicated for the treatment of convulsionassociated with pregnancy induced hypertension

[a] Phenytoin[b] Aspirine

[c] Diazepam[d] Carbamazepine[e] Magnesium sulfate

23. Which of the following anti-epileptic induces the metabolism of estrogen and can leadto unwanted pregnancies in woman using oral contraceptive?

[a] Valproate acid[b] Carbamazepine[c] Diazepam[d] Lamotrigine[e] Clonazepam

24. Propofol in comparison with to sodium thiopental[a] Cannot be used for induction anesthesia

[b] Has a much longer half-life[c] Produces a more rapid recovery[d] Is administered by inhalation[e] None of the above is correct

25. Which of the following drugs act by increasing the amount of synaptic monamine?[a] Amitriptyline[b] Flouxetine[c] Paroxetine[d] All of the above[e] None of the Above

Figure i: Dose-Effect relationship of sedative-hypnotic agents A, B, &C(For questions 26-27, refer to figure I above)

26. Curve A represents the Dose-Effect relationship of which of the following class of

sedative-hypnotic agents?[a] Ethanol[b] Barbiturates[c] Benzodiazepines[d] None of the above[e] All of the above

27. Curve B represents the Dose-Effect relationship of which of the following class ofsedative-hypnotic agents?

[a] Ethanol[b] Barbiturates[c] Benzodiazepines

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A

BC

A

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[d] None of the above[e] All of the above

Section B: OPEN Questions

28. Describe the physiopathologic basis of symptoms associated with acuteabuse of laxatives. (3pts)

29. Give a tabulated pharmacologic comparison between oral anti-diabetics Biguanides andSulfonylureas in terms of; (i) the prototype drugs of each group (ii) the respectivemechanism of action (iii) Therapeutic utility (iv)Adverse drug reactions (vi) Drug-drug

interaction. (4pts)

30. Give a tabulated description of the pharmacologic properties of TricyclicAnti-depressants (TCA) and the corresponding possible clinicalconsequences. (3pts)

31. Give a tabulated list of various pharmacologic targets of drugs that act aturinary bladder (vessie) and corresponding pharmacologic effectsincluding the therapeutic uses. (3pts)

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