European Forum on PHARMA/BIOTECH IP DUE DILIGENCE · IP Due Diligence. An unparalleled faculty will...
Transcript of European Forum on PHARMA/BIOTECH IP DUE DILIGENCE · IP Due Diligence. An unparalleled faculty will...
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Business InformationIn A Global Context
To register call +44 (0) 20 7878 6888 or register online at www.C5-Online.com/IPDD
Top IP practitioners, experienced in�house counsel, valuation experts andtech�transfer officers will provide you with valuable insight on preparing for your next diligence review and cut through the complexities of:
• Drafting the checklist and managing the due diligence team
• How to reposition your due diligence strategies in light of European and US patent reforms
• The diligence review in transactions involving venture capitalists
• Finding the target’s prior contractual obligations
• Evaluating the scope, validity, and enforceability of the target’s patents
• Complex multi�jurisdictional and multi�party transactions
• Uncovering hidden issues with ownership and inventorship rights
• Competition law issues and their impact on due diligence
Maximise Your Learning With the Post�Conference Master Class on:
Drafting an Effective Due Diligence Report
European Forum on
PHARMA/BIOTECH IP DUE DILIGENCE28 and 29 October 2008Radisson SAS Amsterdam, Netherlands
Get industry insight from:
Leiden University
NKT Holding
Global Bioscience
Development Institute
Lundbeck
Celgene Corporation
IPSEN – SCRAS
Valuation Consulting
Cambridge Healthcare
and Biotech
Columbia University
Bavarian Nordic
AstraZeneca
FACULTY�AT�A�GLANCE:DDrr JJoohhnn KKiillaammaaPresidentGGlloobbaall BBiioosscciieennccee DDeevveellooppmmeenntt IInnssttiittuuttee IInncc
DDrr BBrriiaann DDeell BBuuoonnooDirector, SStteerrnnee KKeesssslleerr GGoollddsstteeiinn FFooxx
RRiicchhaarrdd GGiirraarrddssPatent Counsel, CCeellggeennee CCoorrppoorraattiioonn
RRiicchhaarrdd WWiilllliiaammssPartner, HHaarrrriissoonn GGooddddaarrdd FFoooottee
DDrr LLii WWeesstteerrlluunnddVice President Global IPBBaavvaarriiaann NNoorrddiicc
TTiimm PPoowweellllPartner, PPoowweellll GGiillbbeerrtt SSoolliicciittoorrss
KKeellvviinn KKiinnggDirector, VVaalluuaattiioonn CCoonnssuullttiinngg
AAnneettttee HHeeggnneerrformer IP Manager NKT Holding A/S,founding Partner, HHeeggnneerr && PPaarrttnneerrss AA//SS
AAnniittaa VVaarrmmaaPartner, RRooppeess && GGrraayy LLLLPP
LLaarrss BBoo KKjjeerrrruummggaaaarrddHead of Denmark Patents, LLuunnddbbeecckk AA//SS
AAnnddrree BBoouurrggoouuiinnVice President, Corporate IntellectualProperty, IIPPSSEENN –– SSCCRRAASS
DDrr.. LLiinnccoollnn TTssaannggPartner, AArrnnoolldd && PPoorrtteerr LLLLPP
JJoolllliinngg ddee PPrreeeePartner, DDee BBrraauuww BBllaacckkssttoonnee WWeessttbbrrooeekk
DDrr JJeeffffrreeyy SSeeaarrssAssistant General Counsel, Patent &Licensing Group, CCoolluummbbiiaa UUnniivveerrssiittyy
DDrr BBoobb SSmmaaiilleessDirector Research and InnovationLLeeiiddeenn UUnniivveerrssiittyy
DDrr.. DDaavviidd FFrraazziieerrPartner, FFiinnnneeggaann,, HHeennddeerrssoonn,, FFaarraabbooww,,GGaarrrreetttt && DDuunnnneerr,, LLLLPP
JJeerrooeenn ddeenn HHaarrttooggOf Counsel, HHoowwrreeyy LLLLPP
NNaattaalliiee DDeerrzzkkooSpecial Counsel, CCoovviinnggttoonn && BBuurrlliinngg LLLLPP
MMaarrttyynn PPoossttlleeDirectorCCaammbbrriiddggee HHeeaalltthhccaarree aanndd BBiiootteecchh
SSaannggeeeettaa PPuurraannSenior AssociateMMaayyeerr BBrroowwnn IInntteerrnnaattiioonnaall LLLLPP
JJaammeess MMaarrsshhaallllPartner, TTaayylloorr WWeessssiinngg LLLLPP
PPaattrriicckk LLeeeePartner, AAddvveenntt VVeennttuurree PPaarrttnneerrss LLLLPP
AAnnnnaa GGrriiffffiitthhss��JJoohhnnssoonnSenior Patent Attorney, AAssttrraaZZeenneeccaa
WHO SHOULD ATTEND
In�house IP Counsel at
• Pharmaceutical, Biotech and Life Sciences Companies
Lawyers specialising in
• Life Sciences, Pharmaceuticals and Intellectual Property
ASSOCIATE SPONSOR
Ropes & Gray LLP provides comprehensive legal services to leading businessesand individuals around the world. Clients benefit from expertise combined withunwavering standards for integrity, service, and responsiveness. With offices inpreeminent centers of finance, technology and government, Ropes & Gray isideally positioned to address today's most pressing legal and business issues.
For more information, please visit www.ropesgray.com.
To register call +44 (0) 20 7878 6888 or register online at www.C5-Online.com/IPDD
Best Practices for Conducting Successful and
Cost�Effective IP Due Diligence Reviews
The continued growth of collaborative activity in the life sciences space, rangingfrom M&A, spin�outs and licensing, to divestitures and joint productdevelopment, mean that IP due diligence is a central concern for life sciencescompanies. Failure to conduct due diligence properly can result in significantreputational damages, decreased investment value and open the door forfuture debilitating litigation.
As the person responsible for ensuring the IP’s value, you need to have expertknowledge about deal structure, which assets are important and fullyunderstand the business drivers behind the transaction. The range of duediligence failures by biotech and pharma investors and companies that havecome to light in courtrooms in recent years should serve as a caution to everyperson involved in life sciences to do more than just scratch the surface in IPdue diligence.
With this in mind C5 has developed the European Forum on Pharma/Biotech
IP Due Diligence. An unparalleled faculty will provide you with best practicesfor conducting a successful and cost�effective IP due diligence review.
Add value to your attendance by taking advantage of the Master Class for Draftingan Effective Due Diligence Report. This in�depth workshop will provide practicaladvice and the tools you need to draft a comprehensive report of findings.
Take advantage of ample networking opportunities with your peers andcolleagues and benefit from the extensive written materials prepared by thespeakers especially for event.
Reserve your place at this invaluable conference today! Register now by calling +44 (0) 20 7878 6888, by faxing your registration form to +44 (0) 20 7878 6896 or by registering online at www.C5�Online.com/IPDD
GLOBAL SPONSORSHIP OPPORTUNITIES
CC55, along with its affiliates in New York, AAmmeerriiccaann CCoonnffeerreennccee IInnssttiittuuttee ((AACCII)) and in Toronto, TThheeCCaannaaddiiaann IInnssttiittuuttee ((CCII)), works closely with sponsors to create the perfect business developmentsolution. With over 500 conferences in the US, Europe, Canada, Russia and CIS and China,CC55//AACCII//CCII provides a diverse portfolio of first�class events tailored to the senior level executive.For more information about this event or our global portfolio, please contact: CCoolliinn CCaarrtteerr on++4444 ((00)) 2200 77887788 66993333 or email cc..ccaarrtteerr@@CC55��OOnnlliinnee..ccoomm
Main Conference Day One: October 28 2008
8.00 Coffee and registration
8.35 Chair’s Opening Remarks
Jeroen den HartogOf Counsel, Howrey LLP
8.45 European and US Patent Reform Developments and How They Impact Your Due Diligence
Panellists:
Dr John KilamaPresident, Global Bioscience Development Institute, Inc.
Dr Brian Del BuonoDirector, Sterne Kessler Goldstein & Fox P.L.L.C
Morag PeberdyOf Counsel, Herbert Smith LLP
Tim PowellPartner, Powell Gilbert Solicitors
• How proposals to reform US Patent Law will affect the diligence process � reforms to give judges authority to direct juries on infringement
compensation� post�grant review and establishing cost�effective alternatives
to litigation � complex applications and the need for patent quality at the front
end of the process• Assessing the consequences GlaxoSmithKline v USPTO injunction
� the reason for the objection to the rule changes � impact on European companies with US portfolios
• European Commission proposed patent reform- the European Patent Litigation Agreement (EPLA)- establishing a ‘European Patent Court’ and a workable litigation
scheme for European patents• Revival of applications for unintentional versus unavoidable abandonment
9.30 Assessing the Scope of Due Diligence Required Accordingto the Importance and Complexity of the Transaction
Richard GirardsPatent Counsel, Celgene Corporation
Kate TaylorSenior Associate, Harrison Goddard Foote
• Identifying what “IP due diligence” means to the parties involved andadjusting strategies accordingly
• Conducting a cost�effective due diligence review based on thecompany’s needs
• Timing of due diligence actions: what should come first?- balancing the risk of “contamination” and potential walk away
disputes against the need to be first to the deal• Determining the appropriate scope, depth and budget of IP due
diligence necessary for� internal IP assessment� auctions� venture based financing� strict licensing deals� strategic alliances� spin outs� mergers and acquisitions
• Multijurisdictional transactions- which jurisdictions are covered by the transaction?- establishing which jurisdiction will lead the due diligence work
• Dealing with the issue of worldwide rights• Patent portfolio development with future due diligence in mind
� thinking proactively about multi jurisdictional patent applications � discrepancies between owner and inventor in China and Japan
10.15 Morning Refreshments
10.45 Tips For Drafting the Checklist and Selecting andManaging the Due Diligence Team
Dr Li WesterlundVice President Global IP, Bavarian Nordic
• Defining technologies and focussing on the most important issues� obtaining the full list of IP assets � defining the term of patents
• Identifying and prioritising business considerations • Updating the checklist based on the type of the transaction
� patent life cycle issues� violative marketing or pricing concerns� fraud and abuse or anti�kickback issues� clinical trials� regulatory considerations� product supply and manufacture issues� trade secrets and other proprietary information� what is in the pipeline?
• When should you deviate from the checklist? • Choosing and managing the team
� getting in�house IP and patent counsel involved early in the deal� outside counsel selection � are other experts necessary?
• Creating and incentivising a core IP diligence team• Assigning roles for senior management and involving the
supporting players• Developing mechanisms for supporting cross�functional teams and
optimising their efficiency• Minimising liability and expenses by managing the process with
respect to timelines, budget and resources• Examples from different checklists
11.30 Valuation Methodologies Critical to the Due Diligence Review
Kelvin KingDirector, Valuation Consulting
• The nature of valuation for patent�protected products and relatedintangibles such as brands
• Identifying the factors that business executives use to arrive at astarting value
• Factors impacting IP valuation including type of acquisition, dealobjectives and type
• Balancing investment risks, rewards and adjusting diligence reviewduring the valuation process
• Assessment of valuation methodologies - unique IP due diligence concerns- impact of licensing transactions on IP due diligence
• How securitisation/monetisation of IP and royalty streams affect valuation
12.15 Lunch
13.45 Mayer Brown/Cambridge Healthcare and BiotechResearch Report Findings on the Valuation of PartDeveloped Projects in the Pharma Sector
Martyn PostleDirector, Cambridge Healthcare and Biotech
Sangeeta PuranSenior Associate, Mayer Brown International LLP
Get first�hand insight into the results of a recent study conducted with lifesciences market participants on the methods being used to identifycommercially viable innovation, including differences in approaches taken,key challenges in forecasting and valuation and financial deal terms(including upfront and events payments). Further analysis will be given viaanalysis of recent license, co�development and alliance deals in relation to:
• Key legal diligence issues relevant to addressing assumptions andrisks underlying valuations.
• Typical contractual controls relevant to risks and assumptionsunderlying financial modelling used to address completion of� development (discovery, pre�clinical, clinical, regulatory) phases:
discovery, pre�clinical and clinical� commercialisation phases
• Launch, promotion and pricing within forecasted timelines andcontrols in connection within investments.
• Grant of rights underlying market forecasts
To register call +44 (0) 20 7878 6888 or register online at www.C5-Online.com/IPDD
14.15 Finding the Target’s Prior Contractual, Licensing and Third Party Obligations
Anette HegnerFormer IP Manager NKT Holding A/S, Founding Partner, Hegner &Partners A/S
• Conducting a detailed review of the target’s prior agreements � have they been properly drafted? � are assignments that have been granted sufficient? � in and out licensing: reviewing terms and evaluating consequences � special issues under consultancy and employee arrangements and
lack of agreements� evaluating conditions for and consequences of termination
of agreements• Evaluating existing third party rights and obligations
� potential for infringement/breach of agreement � are there any potential claims to the invention from third parties? � identifying terms that decrease the value of the patent portfolio
• Projecting how a review of the target’s prior agreements affects thevalue and terms of the transaction � key terms to review in connection with the transaction� transfer of prior licenses or other rights to third parties� sub�licensing and conditions� identifying concerns related to collaborative, contract, and
sponsored research agreements
14.50 Freedom to Operate: Ensuring the Purchaser/LicenseeCan Commercialise the IP at Issue
Anita VarmaPartner, Ropes & Gray LLP
Anna Griffiths�JohnsonSenior Patent Attorney, AstraZeneca
• Assessing the scope and strength of the target’s exclusive rights- patent exclusivity
- assessing the target’s patent portfolio - understanding patent term and claim scope - assessing inventorship and ownership
- regulatory exclusivity - dealing with issues of market exclusivity - addressing asserted orphan drug status and other relevant
non�patent exclusivities- assessing competition from generics and follow�on biologics
• Conducting an FTO assessment of technology - developing an effective search strategy - understanding the in�licensed rights - assessing potential infringement risks - if FTO analysis was previously performed, what are the risks and
benefits from opinion sharing? • Mitigating the identified risks
- patent related solutions - transactional solutions
15.30 Evaluating the Scope, Validity and Enforceability of the Target’s Patents
Lars Bo KjerrumgaardHead of Denmark Patents, Lundbeck A/S
• Strategic analysis of patent rights supporting the technology � will they stand up to challenge? � are there issues with the duration of patents?
• Assessing the intellectual property’s realistic scope and significance• Is the core technology covered by IP protection?• Examining the enforceability of the target’s patent
� pending litigation� potential exclusivity issues, including generics
• Are there sufficient barriers for entry for competitors? • Are there any technical defects or encumbrances?• Ensuring no outstanding fees or re�examinations/oppositions pending• Predicting the strength of a pending patent application especially
considering evolving standards and case law• Overcoming the challenges of evaluating an IP portfolio with
international components• Analysing the validity of the target’s patent
� claim construction requirements� written description and enablement standards� prior art searches� recent case law that impacts the patent validity
� Lundbeck
16.10 Afternoon Refreshments
16.30 The Growing Importance of Secondary�Patents andResulting Impact on the Due Diligence Process
Andre BourgouinVice President, Corporate Intellectual Property, IPSEN – SCRAS
• How recent case�law decisions on secondary�patents have affectedthe due diligence process
• Assessment of key developments in inventions and the resultantchallenges relating to� new chemical entities
- salts - enantiomers - metabolites
� pharmaceutical compositions - new formulations in particular slow release formulations - new combinations
� medical use of the product - new indications - new group of patients - new regimen of administration
17.00 Update on Regulatory Provisions and Regulator Enforcement Priorities Affecting the Due Diligence Process
Dr. Lincoln TsangPartner, Arnold & Porter LLP
• Understanding the risks related to the regulatory process and toproduct development generally - regulatory exclusivity
• How past regulatory non�compliance affects the product value andwhat this means for your report
• Assessing the acquirer’s intention for the product and the regulatoryimpact of the intended final use
• Working with the US FDA on transactions affecting US assets - FDA critical path and it’s impact on due diligence
• EMEA perspective on transactions involving IP• Collaborative pharma/bio regulation between the FDA and EMEA:
how will this affect multi�jurisdictional deals?
17.30 Spotting and Responding to Competition Law Red Flagsin Target IP Portfolios
Jolling De PreePartner, De Brauw Blackstone Westbroek
• Recent competition enforcement activity in the pharma/biotech sector- EU Commission dawn raids� new approach to evaluation of licensing arrangements on the EU
and national level� how is unreasonable conduct currently being interpreted- potential for abuse of market power with the use of intangible assets - current definition of dominant position
• Identifying possible infringements of competition law in target IPportfolios to avoid future fines, damages and invalidity actions� field of use, territorial and other limitations in existing
licensing agreements� previous mergers and transactions
• What to do if you find evidence of anti�competitive behaviour• Utilising patent pools in the biotech industry to prevent
non�compliance with competition law
18.00 Chair’s Closing Remarks and End of Day One
Main Conference Day Two: October 29 2008
8.50 Chair’s Opening Remarks
Jan Pieter HustinxPartner, De Brauw Blackstone Westbroek
9.00 Unique Due Diligence Challenges When Dealing withIndustry/University Collaborations and Licenses
Dr Jeffrey SearsAssistant General Counsel, Patent & Licensing GroupColumbia University
Dr Bob SmailesDirector Research and Innovation, Leiden University
Fax order form to +44 (0) 20 7878 6896 or register online at www.C5-Online.com/IPDD
• What makes the academic perspective different from the commercialperspective?� missions and objectives� organisational structure and culture� applicable laws
• Demonstrating respect for the university’s perspective while stillmeeting the company’s business goals
• Knowing what universities can and cannot do with regards to their IP� commercial research restrictions � contract requirements� publishing rights� US Bayh�Dole Act
• Avoiding conflicts of interest during the deal - disputes relating to ownership: inventor versus institution
• Tackling complex record keeping provisions with regard touniversity/industry collaborations and licenses
• Factoring statutory research exemptions into the IP audit
9.40 What Do Venture Capitalists Expect from the DueDiligence Process?
Patrick LeeGeneral Partner, Advent Venture Partners LLP
• Meeting VC expectations and using IP to drive the success of the deal- what information needs to be provided?- what IP assets are VC’s most interested in?- VC approach to assessing IP risks and strengths- streamlining the diligence analysis for VCs
• Are VC’s due diligence budgets realistic? • When can you use existing reports and previous diligence information
when working with VCs?• IP portfolio considerations for investor�side deals vs. mature portfolios
for M&A• Resolving conflicts associated with investments and VCs• How the diligence goals of angel investors and pharmaceutical
company funds differ from traditional non VC�driven diligence reviews
10.30 Protecting Confidentiality, Trade Secrets, and PrivilegeDuring a Diligence Review
Dr. David FrazierPartner, Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
• Maintaining the balance between the need for communication and thecreation of a potentially damaging record- what privileged information should be disclosed and when?- who will have access to privileged documents?
• Protecting your findings with future litigation in�mind - the use of records in subsequent patent infringement litigation: US
discovery powers and risk of triple damages• Safeguarding privilege during the due diligence process
� confidentiality and common�interest agreements� verbal communications� giving documents to a third�party to pass off to suitor� handling privileged communication: what should be put in writing?
• Preserving confidential information in the event the deal falls through� controlled release of information and information partitioning
on a need to know basis• Complying with obligations to protect confidential personally
identifiable private information• Shielding trade secrets during diligence
� identifying whether there are trade secrets involved� balancing protection of trade secrets with the need to know� looking at trade secret compliance and potential violations
11.10 Morning Refreshments
11.30 Preparing and Communicating the Due DiligenceAnalysis Results
Jeroen den HartogOf Counsel, Howrey LLP
• Deciding what form the results of the diligence review should take� providing a written diligence report
• Sharing results with business decision makers� explaining the inherent uncertainties in the IP diligence process� communicating problems identified in the diligence process
• Reviewing and relying on analysis results � when making representations and warranties� developing wish lists, haves, and must haves� negotiating indemnification� highlighting potential competition law issues ©C5, 2008
12.10 How Do the US Hatch�Waxman Backdrop and PossibleDevelopments in Follow�On Biologics and BiosimilarsImpact Due Diligence?
Natalie DerzkoSpecial Counsel, Covington & Burling LLP
• How will recent changes affect a global IP portfolio?• The European Medicines Agency (EMEA) approval scheme for
distinguishing biosimilars and generic drugs� why has the generic approach been deemed inappropriate?
• Clarifying the US statutory pathway for the approval of follow�on biologics• Understanding the complexities of biologics when compared with small
molecule chemical drugs- identifying critical aspects of FDA regulation relative to an IP due
diligence review- pharmaceutical patent life cycles and related Hatch�Waxman
Act backdrop - 1984 law and MMA reforms- patent and non�patent exclusivities- 30 month stay- patent extensions- safe harbor provisions
• How the “useful” life cycle of a patent impacts transaction value andassociated risks
• Projecting the scope of exclusionary rights on the product- confirming the target’s analysis of the expiration date of the patent- assessing patent terms through adjustments and extensions
12.50 Chair’s Closing Remarks
1.00 Lunch for Workshop Delegates
Post�Conference Master Class: 29 October 2008
14.00 – 17.30
Drafting an Effective Due Diligence Report
James MarshallPartner, Taylor Wessing LLP
The surge of M&As, private equity investments, and IPOs in the lifesciences industry, as well as the need to present findings by IP right,product, and R&D activity have made drafting an effective due diligencereport a critical skill.
This master class is designed to provide you with to tools to enableefficient and comprehensive drafting of the due diligence report.Common mistakes and pitfalls will be indentified and best practiceexamples given during an intensive, expert–led session. Your masterclass leader will instruct you on how to draft a comprehensive andeffective report of due diligence findings. You will discover how to tailoryour diligence report to your specific business needs while taking intoconsideration the following:
• Ascertaining the structure and essential elements of due diligencereports for� private equity investments� acquisitions� IPOs� plain technology transfers
• Determining the scope of, and any limitations on the investigation• Drafting the executive summary• Presenting the search results and patentability/validity analysis• Assessing the scope of available patent protection• Addressing any obligations associated with the use of the
technology to be transferred• Presenting the freedom�to�operate search results and analysis• Identifying other risks or problems and stating whether they have
been resolved• Assessing potential exposure and the chance of the adverse party
prevailing in litigation• Weighing the effect of any disclaimers and limitations of liability• Factoring in risks associated with future products and agreements
in the works• Noting post�completion recommendations: what the buyer should
do once the deal is finalised• Knowing what else should be included in (and excluded from)
the report• Limiting distribution of the report to preserve confidentiality
and privilege
To register call +44 (0) 20 7878 6888 or register online at www.C5-Online.com/IPDD
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Post�Conference Workshop Drafting an Effective Due Diligence Report
Date: 29 October 2008
Time: 2.30pm – 5.30pm
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Business InformationIn A Global Context
European Forum on
PHARMA/BIOTECHIP DUE DILIGENCE 28 and 29 October 2008
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