Roberto Bilbao Director

Basque biobank

Basque Government

Spain

National Perspective Spain

The Basque Biobank: a tool to serve the needs of personalized medicine and biospecimen research

Roberto Bilbao

Director, Basque biobank Basque Government Spain

http://www.google.es/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&docid=5y_WO0RfQKY07M&tbnid=loRmNEmlvcwF2M:&ved=0CAcQjRw&url=http://www.witchcraftandwitches.com/trials_basque.html&ei=h78cVLvzIIPYOenKgYAG&bvm=bv.75775273,d.bGQ&psig=AFQjCNEqsjOqyCovBu8o2ytga-F7i_xJMg&ust=1411255939921343

Value chain of PM

4 Taken from: The Cooksey report (A review of UK health research funding), 2006.

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Biological samples

Clinical data

Hospital University, research

center, companies

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Where can I find the samples and data I need for my collaborative research project?

Geneticist

• 8 laboratories and a coordination center, 25

technicians, 10M€ investment (2004-14)

• Covers the whole Basque Health System

• Prospective collection of human samples with

informed consent linked to full medical

information for large-scale “-omic” medicine

• Retrospective cohorts: 500.000 people of the

Neonatal Sreening Program for metabolic

disorders (First case in Spain)

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Infraestructure

Objetives

• Enable personalised medicine

• Identify gene-environmental/lifestyle

interactions

• Understand the molecular basis of disease

• Identify new targets for therapy

• Enhance development in drug discovery

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Results

• 310 clients :

• public reseach center 37%, University

15%, Biotech and pharmaceutical

companies 16%, Hospitals 33%

• 80 research projects and 5.000

samples/year

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Sample release to external projects

R&D in biobanking

How to improve our services: R&D in biobanking Increase accessibility to samples and clinical information from EHR

R&D: increase access to samples

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Biobank 2

Biobank n

Biobank 3

Biobank 1

Many queries based on diagnosis for each biobank

40 rare tumors

3. SITUATION BEFORE THE BIOPOOL PROJECT

Issues to be solved

Data dispersion

Different languages

Different data set format

• TEXT DATA SET

Less usage of data

Less accessibility

Many queries to find a specific sample or enough

number of samples

http://www.google.es/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&docid=dnCi4q4JBtZ9TM&tbnid=dfrRGuhCPVRw9M:&ved=0CAUQjRw&url=http://powertripberkeley.com/guggenheim-museum-imagesguggenheim-bilbao-jan05/&ei=if5aUprQGeXK0AWx1YHIBg&bvm=bv.53899372,d.d2k&psig=AFQjCNGvnPQwiQEi7Bi3xJDMADeTFvd0nA&ust=1381781506144455

IDEA: search samples across biobanks based on images queries

Tumor surgically removed Lung tumor processed to histological slide

Lung with tumor

Digital scanning of histological sections

Central server of Biobank

Histological images

Associated Clinical

data Tumor Image

Clinical Data

Biobank 3

Biobank 4

Biobank n

Biobank 1

Biobank 2

Tumor surgically removed

Lung tumor processed to histological slide

Lung with tumor

Digital scanning of histological sections

Central server of Biobank

Histological images

Associated Clinical data

Text and image queries

IDEA: search samples across biobanks based on images queries

Use cases for BIOPOOL

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Antibody test

Tissue microarrays

Application to the call: FP7 ICT 2011.4.1 SME initiative on digital content and

languages

www.biopoolproject.eu

BIOPOOL prototype

Search engine result

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Big Data in biobanking

Big data: sets so large and complex that exceeds processing capacity of conventional database systems. Data is too big, moves too fast and doesn’t fit an architecture. Cloud computing: large groups of remote servers are networked to allow sharing of data-processing tasks

Basque Biobank and Big Data

• We have developed a private cloud to store LIMS and

medical images

• Our goal is to make clinical information systems

accessible for research and data mining

• Develop data entry and search interphase for research

programs/investigators

• H2020: NEW PROPOSAL Recruitment of partners with

competency in medical database mining, natural

language processing, search engines and algorithms,

controlled vocabularies, etc.

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Value chain of PM

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Case study • Based on sample collection of Basque

Biobank a aging-associated

metabolomic signature has been

developed

• Basque Health System has a stratified

population, a centralized EHR and PM

tools such as biobank

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Looking for partners or other

initiatives

• H2020: PHC24: Piloting

personalised medicine in health

and care systems Pilots of new models of care, based on the concept of

personalised medicine to be conducted in existing health

care environments and should take into account

Europe's (national and regional) diversity in health

system organisation

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Roberto Bilbao

Director

Basque Biobank

bilbao@bioef.org

www.basquebiobank.com

www.bioef.org

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