Erythropoietin alleviates hepatic insulin resistance via PPARγ ...
Erythropoietin Laboratory - birminghamquality.org.uk · Erythropoietin Distribution : 117 Date :...
Transcript of Erythropoietin Laboratory - birminghamquality.org.uk · Erythropoietin Distribution : 117 Date :...
Date : DD-MMM-YYYY
Feedback
Page 1
Erythropoietin
Distribution : 117
Laboratory :
Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust
and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK
To contact us, email [email protected] or phone us on +44 (0)121 414 7300
© The data in this UK NEQAS report are confidential.
For this Scheme, the Organiser is Dr. Malcolm Hamilton.
www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016
Quality ManagerPathology LaboratoryBiochemistry DepartmentTownCountyPostcodeCountry
This Scheme is essentially web-based. We can alert you to information regarding the Scheme via email. The e-mail address (or addresses) we are currently using to contact your laboratory is shown below in red . If no e-mail address is displayed or the information shown is incorrect, please email us with an appropriate contact e-mail address as soon as possible, using the word 'feedback' in the title line.
Based on the date information you have provided, the transit time from specimen dispatch [ ] to receipt [ ] was day(s), and the subsequent time to analysis [ ] in your laboratory was day(s). (Missing values indicate dates not provided. "0 days" represents same day).
Any comments you made to us are shown below and have been acted upon where necessary
Any specific comments applicable only to laboratory are shown below
Any general comments applicable to all laboratories are shown below
*****Birmingham Quality Participant Survey*****
We are currently undertaking our annual participant survey and would very much welcome your feedback. Your comments are very important to us and will help us to improve the service we provide to you. The survey relates only to the EQA services provided from the Birmingham Quality [UK NEQAS] centre.
A copy of the questionnaire is attached to the back of this report. It is very simple and asks only two questions:
1) What do we do well? and2) What could we do better?
We are very happy for you to submit your comments anonymously but please do provide your contact details on the form ONLY if you would like to receive a response.
Please e-mail the completed survey to [email protected] or FAX to +44 (0) 121 414 1179
Many thanks
The Birmingham Quality Team
Report authorised on Tuesday 30 June 2015 by:
Jane French (Consultant EQA Scientist), Birmingham Quality
Birmingham Quality is a UKAS accredited proficiency testing provider No. 7860. Please see http://www.ukas.com for full details of the accreditation status of our services
Birmingham Quality is proud to offer EQA services that adhere to the Code of Practice and have the badge of quality of UK NEQAS
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Erythropoietin
Distribution : 117 Date : DD-MMM-YYYY
Performance Summary Icons (click graph for details)
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Laboratory :
Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust
and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK
To contact us, email [email protected] or phone us on +44 (0)121 414 7300
© The data in this UK NEQAS report are confidential.
For this Scheme, the Organiser is Dr. Malcolm Hamilton.
www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016
B s
core
C score
Serum Erythropoietin
P-ABCPENR (DASH1)
0 5 10 15 20 25 30
-20
-15
-10
-5
0
5
10
15
20
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Date : DD-MMM-YYYY
Participation summary
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Erythropoietin
Distribution : 117
Laboratory :
Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust
and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK
To contact us, email [email protected] or phone us on +44 (0)121 414 7300
© The data in this UK NEQAS report are confidential.
For this Scheme, the Organiser is Dr. Malcolm Hamilton.
www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016
All our time periods are 'rolling' to give you current information. You may wish to keep you own log of Calendar Year or Financial Year time points if you require 'year-end' statements for your own internal use. Any analytes with out of consensus performance will be highlighted in red and can be clicked for further details.
You have no performance data for:
You have in consensus performance for:
You have out of consensus performance for:
Serum Erythropoietin
Analytical Performance over the last 6 months (rolling time window of 6 distributions)
None
None
This scheme cycle is notionally every four weeks. Analytically, we assess you over a six month time window (6 Distributions). For return rates, late and amended results we assess you over a twelve month period (12 distributions).
Participation 12 distributions out of a possible 12
Satisfactory
0 distributions from the last 12Late Returns
Amendments 0 distributions accepted from the last 12
Satisfactory
Satisfactory
Distributions
Participation and Return Rates
Rating
You can judge, in association with your IQC and other QA measures, if your current performance is a blip or part of a trend.
You have no specimen data for:
In consensus for all specimens for: Serum Erythropoietin
Out of consensus for at least one specimen for:
You are not registered for:
None
Analytical Performance for specimens from distribution 117 only
None
None
The new Participation Summary page is an exciting new feature which we hope you will like. It is currently in prototype mode but will ultimately expand into having the Interpretative analytes as well as the existing ‘numerical’ analytes listed and will contain turnaround graphs etc., too.
For the moment it would be helpful if you could check the accuracy of the data presented, particularly the return-rate elements.
Many thanks, Finlay
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Date : DD-MMM-YYYY
Distribution Summary
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Erythropoietin
Distribution : 117
Laboratory :
Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust
and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK
To contact us, email [email protected] or phone us on +44 (0)121 414 7300
© The data in this UK NEQAS report are confidential.
For this Scheme, the Organiser is Dr. Malcolm Hamilton.
www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016
%biasBResult A score C scorePool CB scoreTargetSpecimen A ¸˛Specimen
504.0
+0.971.4(IU/L)
502.4
Serum Erythropoietin-2.2+0.3
69.912.29117A -3.6
223117B 220
50219 3.9
117C
12.4
If your laboratory is outside of the acceptable limits of performance for any its rolling time-window scores (A, B or C scores), this will be indicated by a red traffic light symbol. It is the responsibility of the laboratory to undertake an internal investigation to establish the underlying cause and put in place corrective and preventive action. Please do not wait to receive a formal notification of performance from the Scheme Organiser or the National Quality Assurance Advisory Panel (NQAAP) before logging the non-conformity and, where necessary, acting upon the data contained in your report. A green traffic light merely reflects that your laboratory is performing as well as the state-of-the-art allows; it does not necessarily mean that your assay / laboratory performance is good enough clinically.
The A scores for Erythropoietin are all based on concentration- dependent degree of difficulty factors and, as such, are in the same ‘currency’ as the A scores in other Schemes. Please see the online 'Explanation of the ABC of EQA' which may be found under the 'Centre' button on the UK NEQAS Results & Reports page. You will need your user-name and password to access this information.
All samples issued have been tested negative by standard methods for HIV, TPHA, Hepatitis B and C.
Gentamycin, penicillin and fluconazole have been added to all specimens.
Please note that any 'spiked' specimens distributed through the scheme will be clearly marked as such. Unless stated otherwise, they will contain non-endogenous Epoetin beta which may not be recovered by the kit assays in the same way as patients’ erythropoietin.
Specimens for Distribution 118 will be dispatched on Monday 6 July 2015, results are due back by Sunday 26 July 2015.
If we have entered your results as 'XPL' , it is because you did not report a result for that analyte, but you did provide an explanation as to why a result was not reported.
You can enter any Late results or Non-analytical errors for Distribution 117 on the web under the usual Results button. Please ensure you select the correct Distribution number from the dropdown. You should include your name and a valid reason. Amending results is at the discretion of the Programme Organiser and is not an automatic entitlement. You have until the close of the Distribution 118 to make requests for any such amendments.
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Date : DD-MMM-YYYY
Analyte : Serum Erythropoietin (IU/L)
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Erythropoietin
Distribution : 117
Laboratory :
Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust
and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK
To contact us, email [email protected] or phone us on +44 (0)121 414 7300
© The data in this UK NEQAS report are confidential.
For this Scheme, the Organiser is Dr. Malcolm Hamilton.
www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016
Pooled human serum donations
223
Pool description / Treatments / Additions
117B Pool 219 + 60 IU/L Epoetin BetaPool 219 + 480 IU/L Epoetin Beta
Pool
220
Spec.
117A
117C
219 3.9
The B limit is +/-
Your B score is
The A limit is15.0
50
20.0
Your A score is-3.6
The C limit is
200
Your C score is
Based on the information you have provided, your reagent lot number is [] and your calibrator lot number is []. (Missing values indicate data not provided).
All methods Siemens Imm 2000/XPi [DC11]
Specimen : 117A
8.0 10.1 12.2 14.3 16.4Serum Erythropoietin (IU/L)
0
5
10
15
20
no. o
f lab
orat
orie
s
6.00.77
Not stated, please specify
12.29
10.81
7
Meann
10.94
46
Beckman DXi [SF5]
1.237 11.4
3.60.16
R and D systems [RN1]12.81
4
Beckman Access [SF6]
1
10.84
13.50
Siemens Imm 2000/XPi [DC11]
73
13.65
SD
10.2
8 1.5
1.25
CV(%)
Siemens Immulite 1 [DC7]
0.39
All methods [ALTM](ALTM)
transformed bias
12.4Your result
+11
Method mean
+0.9Your specimen:
12.29
(Siemens Imm 2000/XPi [DC11])
Standard Uncertainty
%bias
11
12.81
0.19
Accuracy Index
Target value
Specimen : 117B
50 61 72 83 94Serum Erythropoietin (IU/L)
0
5
10
15
20
no. o
f lab
orat
orie
s
5.44.0
Not stated, please specify
71.4
61.1
7
Meann
65.0
46
Beckman DXi [SF5]
8.47 13.7
7.51.4
R and D systems [RN1]74.6
4
Beckman Access [SF6]
1
64.0
72.0
Siemens Imm 2000/XPi [DC11]
73
77.3
SD
9.6
8 2.1
6.9
CV(%)
Siemens Immulite 1 [DC7]
4.9
All methods [ALTM](ALTM)
transformed bias
69.9Your result
-27
Method mean
-2.2Your specimen:
(Siemens Imm 2000/XPi [DC11])
71.4
Standard Uncertainty
27
%bias
74.6
Accuracy Index
1.07
Target value
Specimen : 117C
376 439 502 565 628Serum Erythropoietin (IU/L)
0
5
10
15
20
25
30
no. o
f lab
orat
orie
s
4.422.7
Not stated, please specify
502.4
465.5
7
Meann
456.0
46
Beckman DXi [SF5]
80.56 17.3
3.016.7
R and D systems [RN1]517.6
4
Beckman Access [SF6]
1
456.8
440.0
Siemens Imm 2000/XPi [DC11]
72
561.5
SD
8.3
8 3.7
41.8
CV(%)
Siemens Immulite 1 [DC7]
13.9
All methods [ALTM](ALTM)
transformed bias
504.0Your result
+4
Method mean
+0.3Your specimen:
(Siemens Imm 2000/XPi [DC11])
502.4
Standard Uncertainty
4
%bias
517.6
Accuracy Index
6.53
Target value
B s
core
Serum Erythropoietin Median and IQRs of B scores
P-BWABCBR
SF
6
SF
5
RN
1
DC
11
-20
-15
-10
-5
0
5
10
15
20
All
Met
hod
C s
core
Serum Erythropoietin Median and IQRs of C scores
P-BWABCCR
SF
6
SF
5
RN
1
DC
11
0
5
10
15
20
25
30
All
Met
hod
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Pool
(exclusion)
[Type]
Distribution 112
25-Jan-2015
result target %bias
Distribution 113
22-Feb-2015
result target %bias
Distribution 114
22-Mar-2015
result target %bias
Distribution 115
26-Apr-2015
result target %bias
Distribution 116
31-May-2015
result target %bias
Distribution 117
28-Jun-2015
result target %bias
Distribution
result target %bias
5.2 5.31 -2.0211 7.5 7.17 +4.6208 6.9 7.62 -9.4 7.5 7.74 -3.1216 8.4 8.43 -0.4210
9.4 10.13 -7.2212 10.0 10.56 -5.3204
12.4 12.29 +0.9219 13.3 13.60 -2.2224
14.7 17.10 -14.0213 18.7 19.10 -2.1205 41.2 45.1 -8.6206
69.9 71.4 -2.2220 118.0 122.8 -3.9217
118.0 125.6 -6.0225 231.0 239.4 -3.5218
233.0 244.0 -4.5226 504.0 502.4 +0.3223
MethodmeanA scoreB scoreC score
DC11-5.3
96-7.56.9
DC11-1.7
79-5.16.6
DC11-7.7
69-4.46.1
DC11-3.5
56-3.45.1
DC11-4.2
54-3.74.0
DC11-0.3
50-3.63.9
Date : DD-MMM-YYYY
Analyte : Serum Erythropoietin (IU/L)
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Erythropoietin
Distribution : 117
Laboratory :
Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust
and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK
To contact us, email [email protected] or phone us on +44 (0)121 414 7300
© The data in this UK NEQAS report are confidential.
For this Scheme, the Organiser is Dr. Malcolm Hamilton.
www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016
A s
core
Serum Erythropoietin Median and IQRs of A scores
P-BWABCAT
SF
6
SF
5
RN
1
DC
11
0
50
100
150
200
250
300
All
Met
hod
B s
core
Serum Erythropoietin Median and IQRs of B scores
P-BWABCBR
SF
6
SF
5
RN
1
DC
11
-20
-15
-10
-5
0
5
10
15
20
All
Met
hod
B s
core
C score
Serum Erythropoietin B score is -3.6 and C score is 3.9 Siemens Imm 2000/XPi [DC11]
P-ABCPENR
0 5 10 15 20 25 30-20
-15
-10
-5
0
5
10
15
20Your labYour methodOverall (n=72)Your method (n=44)
C s
core
Serum Erythropoietin Median and IQRs of C scores
P-BWABCCR
SF
6
SF
5
RN
1
DC
11
0
5
10
15
20
25
30
All
Met
hod
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Date : DD-MMM-YYYY
Serum Erythropoietin IU/L
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Erythropoietin
Distribution : 117
Laboratory :
Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust
and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK
To contact us, email [email protected] or phone us on +44 (0)121 414 7300
© The data in this UK NEQAS report are confidential.
For this Scheme, the Organiser is Dr. Malcolm Hamilton.
www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016
Spe
cim
en A
ccur
acy
Inde
x
Distribution
Specimen Accuracy Indexfor each specimen in time-window
P-ABCATS (ABC1)
112 113 114 115 116 1170
50
100
150
200
250
300
A s
core
Distribution
A score by distributionYour current A score is 50
P-ABCAT (ABC1)
106 107 108 109 110 111 112 113 114 115 116 1170
50
100
150
200
250
300
All
Met
hod
Spe
cim
en %
bias
Distribution
Specimen %biasfor each specimen in time-window
P-ABCBRS (ABC1)
112 113 114 115 116 117-20
-15
-10
-5
0
5
10
15
20
B s
core
Distribution
B score by distributionYour current B score is -3.6
P-ABCBR (ABC1)
106 107 108 109 110 111 112 113 114 115 116 117-20
-15
-10
-5
0
5
10
15
20
All
Met
hod
Diff
eren
ce (
IU/L
)
Concentration (IU/L)
Difference (result - target)for each specimen in time-window
P-BA1FS1A (ABC1)
0 50 100 150 200 250-20
-15
-10
-5
0
5
10
15
20
C s
core
Distribution
C score by distributionYour current C score is 3.9
P-ABCCR (ABC1)
106 107 108 109 110 111 112 113 114 115 116 1170
10
20
30
All
Met
hod
Spe
cim
en %
bias
Concentration (IU/L)
Specimen %biasfor each specimen in time-window
P-BA1FS1P (ABC1)
0 50 100 150 200 250-20
-15
-10
-5
0
5
10
15
20
B s
core
C score
Serum Erythropoietin B score is -3.6 and C score is 3.9 Siemens Imm 2000/XPi [DC11]
P-ABCPENR (ABC1)
0 5 10 15 20 25 30-20
-15
-10
-5
0
5
10
15
20Your labYour methodOverall (n=72)Your method (n=44)
Spe
cim
en A
ccur
acy
Inde
x
Concentration (IU/L)
Specimen Accuracy Indexfor each specimen in time-window
P-YSTMOD (ABC1)
0 50 100 150 200 2500
50
100
150
200
250
300 ALTMMLTM
CV
%
Concentration (IU/L)
Between-laboratory agreementSiemens Imm 2000/XPi [DC11]
P-PROFILE (ABC1)
0 50 100 150 200 2500
5
10
15
20
25
30
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Birmingham Quality Participants’ Questionnaire
This is a very brief questionnaire specifically about the EQA services provided by the Birmingham Quality
[UK NEQAS] Centre. Your feedback is very important to us and will help us to improve our service to you
so please be as specific as possible when answering the questions below. A brief ‘memory jogger’ has
been provided overleaf but please do comment on any aspect of our service.
Please provide your contact details overleaf ONLY if you would like us to respond to your comments.
We are always happy to receive anonymous feedback.
What do we do well?
What could we do better?
Please use this space to suggest improvements or make recommendations
Please complete and return to Birmingham Quality by e-mail: [email protected] or
FAX +44 (0) 121 414 1179
Date : DD-MMM-YYYY Page 8
Erythropoietin
Distribution : 117
Laboratory :
Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust
and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK
To contact us, email [email protected] or phone us on +44 (0)121 414 7300
© The data in this UK NEQAS report are confidential.
For this Scheme, the Organiser is Dr. Malcolm Hamilton.
www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016
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Memory Jogger
Our interaction with participants
• Joining / signing-up to EQA programmes
• E-mail notifications of specimen dispatch / reportpublication
• Information on the Birmingham Quality website(www.BirminghamQuality.org.uk)
• Entering your results online
• Viewing your reports online
• Updating your information (methods, contact e-mailaddresses etc)
• Responses to telephone enquiries
• Should we use other forms of social media tocommunicate with participants? E.g. Twitter,Facebook, Instagram etc
• Meetings / training days
• Invoicing
• Payment
EQA programmes
• Are there any additional programmes / analytes thatyou would like us to provide EQA services for?
• What could we do to improve / enhance any of ourexisting EQA programmes?
• Interpretative EQA programmes e.g. UK NEQAS forInterpretative Comments
• Fees
EQA specimens
• Number of specimens per distribution
• Frequency of distributions
• Type of material provided
• Volume of material provided (scheme-specific)
• Sample tubes
• Packaging
• Mechanism of delivery (postal service etc)
• Information on results documents
• Booking-in process
EQA reports
• Information contained in the report e.g. tables,statistics (mean, SD, CV%, median, IQR) etc
• Information about your performance e.g. ParticipationSummary page, numerical scores (ABC of EQA), trafficlights, colour-coded symbols, etc
• Graphs (e.g. histograms, pie charts, penalty box plotsetc)
• Network reports
Problem solving
• Notification of (poor) performance
• Availability / usefulness of help and advice fromBirmingham Quality
Your contact details*
Your UK NEQAS laboratory number (if known):
Title: Job title:
First name:
Surname:
Organisation:
Address 1:
Address 2:
Postcode: Country:
E-mail address:
Mobile tel no: Work tel no:
*Your details will only be used for the purposes of responding to your comments and will not be shared with any third parties.
Date : DD-MMM-YYYY Page 9
Erythropoietin
Distribution : 117
Laboratory :
Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust
and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK
To contact us, email [email protected] or phone us on +44 (0)121 414 7300
© The data in this UK NEQAS report are confidential.
For this Scheme, the Organiser is Dr. Malcolm Hamilton.
www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016
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