Erasmus MC Incubator

Michel Bergh PhD

Director

Erasmus MC Technology Transfer Office

Project leader, Incubator

May 28, 2013

Erasmus MC

Largest UMC in the Netherlands

Centrally located, Sophia Children’s

Hospital, Daniel Den Hoed Cancer Clinic,

Havenziekenhuis

Total budget € 1.2 B

14,000 employees

~ 3,100 students

~1,000 grad students

> 1,500 medical and scientific staff

Research budget €138 M/yr

Desiderius Erasmus (1466-1536)

Erasmus MC : Patient Care

Top clinical and referral patient care (last resort referrals)

Regional center

36.000 admissions/yr (1,200 beds)

> 500.000 visits outpatient clinics

Erasmus MC : Research Key Areas

Cardiovascular

Oncology

Virology

Cell Biology & Genetics

Endocrinology

Immunology & Haematology

Neurosciences

Pediatrics

Medical Technology/Imaging

Epidemiology and Public Health

Health Policy and Management

5

Technology Transfer Mission

It is our mission to transfer Erasmus MC’s research results

and technologies into useful products and services, thereby

creating value for society in general and health care in

particular, and income to support research, education and

patient care

Technology Transfer Scope

Broad spectrum of startups From e-learning to AML diagnostics

Promising new licenses From image analysis to antivirals

New software applications Smart phone registration/itemization of patient care activities

Innovations in patient care Improved care AND cost reductions

Geboortecentrum

Diabetes Station

Smart phone pre-conception consultation

A-Z: from Invention Disclosure to License or Start-up

Innovative approach for photodynamic therapy using nanoparticles. Licensed to start-up Nano4Therapy

Novel protease inhibitor platform with broad applications in virology Company formation in progress

Predicting eye and hair color from crime scene DNA Diagnostic test in forensic field.

Licensed

Quantitative MRI image analysis for improved diagnosis

Licensed to start-up company, funded by multinational and EZ (Innovatiekrediet)

Technology Transfer: Success Stories

Financial success: Pompe’s disease

Therapeutic enzyme (α-glucosidase) for hereditary disease

Erasmus MC production technology

Significant royalty income for Erasmus MC and inventors

Business Model Success: Viroclinics

Healthy business in providing vaccine testing services

Societal success: Geboortecentrum (Birthing Center)

Life saving by close proximity to OR

Physical distance: 2 minuten

Technology Transfer: Patient Care Innovations

Das Abklebebuch/Plakboek

Improving toddler

compliance with orthoptic

eye patches for amblyopia

Lachgas Protocol

Delivery under sedation by nitric oxide

Developed by Erasmus MC

Obstetrics, licensed to Careyn

Maternity Care and other midwife

providers

Geboortecentrum (Birthing

Center)

Technology Transfer: Patient Care Innovations

DiabetesStation

Integrated self-diagnosis cabin for

diabetes patients

Slimmer Zwanger

Smartphone app for pre-pregnancy

consultation

Technology Transfer Office KPIs

KPIs 2008 2009 2010 2011 2012

Invention

disclosures

56 48 38 62 38

Patent

applications

11 12 11 15 13

Granted

patents

14 20 28 15 12

Total patent

(application)s

151 163 163 172 163

License

agreements

3 4 10 14 15

Licensing

income

€ 2.0 M

€ 2.1 M € 2.2 M € 2.7 M € 2.8 M

Start-up

companies

10 6 3 1 5

Total # companies in portfolio 20

Total # agreements reviewed (SRAs, consortium agmts. etc.) ~ 640

Erasmus MC Start-ups

Skyline Diagnostics

Harbour Antibodies

Cavadis

Viroclinics

Vironovative

Arcarios

DiabetesStation

Nano4Therapy

AgenD

Quantib

ABCDEsim

Luminostix

River D International

Skintec

IDMC

CQ Path

Practocol

Photonics Healthcare

CardiogenX

Fagotrace

Erasmus MC Incubator

First Erasmus MC Incubator housed in Faculty Building

> 5 tenants

Renovation of ’60s building

Need for new space

Office tower “Europoint” on Marconiplein

Built in 1975

Original designation office space

Renovated for use by high tech firms

Renamed “Rotterdam Science Tower”

Erasmus MC Incubator

EFRO support essential to create unique laboratory facilities

Addresses need for lab space

Scarcety of laboratory facilities in the region

ML1, ML2 safety level

Erasmus MC Incubator moves into Rotterdam Science Tower

Offering mix lab/office space

Creating turnkey solutions for start-up needs

Sign lease on Monday, move in Tuesday, start work on Wednesday

Erasmus MC Incubator

Specifically companies with connection to the Erasmus MC

Committee for approving the start-up acceptance

Start-up facilities for fast growth

Physical: good location close to Erasmus MC

“Soft” benefits: expert external advice allowing focus on core business

Providing a safe haven for 3 years in the right neigborhood

18th floor: Erasmus MC Incubator

1st – 7th floor: Zadkine College (technicians, interns)

10th floor: Start-up Campus

19th – 20th floor: Viroclinics

After 3 years, other facilities are available 10 feet away

Erasmus MC creates 800 m2 Incubator

Mixed lab and office space

Turn-key solutions

MLI, MLII safety level

etc.

Supported by

Erasmus MC

EFRO

City of Rotterdam

Fortress Real Estate

Managed by

Carola Immerzeel-Goosens, Duko Drijfhout

Erasmus MC Incubator