EPILEPSY WEEKLY REPORT 102516

EPILEPSY WEEKLY REPORT 102516

NEWS - 101716-102516

APPROVALSGW PHARMA

MARINUS PHARMA PFIZER

ZYNERBAUCB

MARKET REPORTS EPILEPSY

2016-10-25 13:14 pharmatimes.com

Martindale's oral epilepsy drug bags EU nods

UK-based Martindale Pharma has announced regulatory clearance of an oralformulation of its epilepsy therapy clobazam in Europe....

GW PHARMA 2016-10-21 01:09 nytimes.com

GW Pharma to Cancel London Listing - New York Times

Telegraph.co.uk GW Pharma to Cancel London Listing New York Times (Reuters)- Britains GW Pharmaceuticals Plc, a developer of marijuana-based epilepsytreatments, said it planned to cancel its listing in Londons junior market and wouldretain listing of its American Depositary Receipts (ADRs) on Nasdaq to simplify ...UPDATE 1- Drug developer GW Pharma to cancel London listing Business InsiderIntention to Trade Exclusively on NASDAQ London South East (registration) (blog)all 25 news articles&nbs...

2016-10-20 18:09 businessinsider.com

UPDATE 1-Drug developer GW Pharma to cancel Londonlisting - Business Insider

Telegraph.co.uk UPDATE 1- Drug developer GW Pharma to cancel London listingBusiness Insider Oct 19 (Reuters) - Britains GW Pharmaceuticals Plc , a developerof marijuana-based epilepsy treatments, said it planned to cancel its listing inLondons junior market and would retain listing of its American Depositary Receipts(ADRs) on Nasdaq to ... GW Pharma to Cancel London Listing New York TimesIntention to Trade Exclusively on NASDAQ London South East (registration) (blog)all 24 news articles ...

APPROVALS

2016-10-19 18:40 benchmarkmonitor.com

Mid Cap Losers: GW Pharmaceuticals plc(NASDAQ:GWPH), Exelixis, Inc. (NASDAQ:EXEL),Chemtura Corporation ... - Benchmark Monitor

Mid Cap Losers: GW Pharmaceuticals plc (NASDAQ:GWPH), Exelixis, Inc.(NASDAQ:EXEL), Chemtura Corporation ... Benchmark Monitor GWPharmaceuticals plc (NASDAQ:GWPH) cannabinoid drug Epidiolex has achievedprimary endpoint in treating Lennox-Gastaut syndrome a severe form ofchildhood epilepsy speeding through phase three trials...

2016-10-19 10:08 dailymail.co.uk

Drug developer GW Pharma to cancel London listing -Daily Mail

DIGITALLOOK Drug developer GW Pharma to cancel London listing Daily Mail Oct19 (Reuters) - Britains GW Pharmaceuticals Plc , a developer of marijuana-basedepilepsy treatments, said it planned to cancel its listing in Londons junior marketand would retain listing of its American Depositary Receipts (ADRs) on Nasdaq to ... GW Pharmaceuticals to cancel London listing London South East (registration)(blog) all 12 news articles ...

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MARINUS 2016-10-24 19:10 google.com

Marinus to proceed to Phase 2 with ganaxolone in life-

threatening form of epilepsyResults from a 36-subject Phase 1 dose-escalation study to assess the safety,pharmacokinetics and pharmacodynamics of Marinus Pharmaceuticals ......

2016-10-21 21:09 mmahotstuff.com

Rating Sentiment Summary: This is what analysts haveto say about Marinus Pharmaceuticals Inc(NASDAQ:MRNS ... - MoneyMakingArticles

MoneyMakingArticles Rating Sentiment Summary: This is what analysts have tosay about Marinus Pharmaceuticals Inc (NASDAQ:MRNS ... MoneyMakingArticlesMarinus Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company . Thecompany has a market cap of $23.72 million...

PFIZER 2016-10-24 05:08 reliawire.com

Lyrica: The Epilepsy Drug That Treats Chronic NervePain - ReliaWire

ReliaWire Lyrica: The Epilepsy Drug That Treats Chronic Nerve Pain ReliaWireLyrica is the brand name for a prescription medicine called pregabalin. Although itis an anticonvulsant, or an anti- epileptic drug , pregabalin is commonly prescribedto alleviate nerve or neuropathic pain a type of pain caused by damage to, or a ...Taking pregabalin drug during pregnancy could lead to major birth defects News-Medical...

ZYNERBA 2016-10-25 16:09 dailyquint.com

Zynerba Pharmaceuticals Inc. (ZYNE) Stock RatingUpgrade by The Zacks Investment Research - DailyQuint

Zynerba Pharmaceuticals Inc. (ZYNE) Stock Rating Upgrade by The ZacksInvestment Research DailyQuint According to Zacks, "Zynerba Pharmaceuticals,Inc. is a specialty pharmaceutical company which focuses on developing andcommercializing proprietary synthetic cannabinoid therapeutics formulated fortransdermal delivery...

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2016-10-21 06:08 com-unik.info

Zynerba Pharmaceuticals Inc. (ZYNE) Upgraded at Zacks ... - Community Financial News

Community Financial News Zynerba Pharmaceuticals Inc. (ZYNE) Upgraded atZacks ... Community Financial News Zynerba Pharmaceuticals Inc.(NASDAQ:ZYNE) was upgraded by Zacks Investment Research from a "sell" ratingto a "hold" rating in a research note issued on ... Zynerba Pharmaceuticals Inc(NASDAQ:ZYNE) has been upgraded to Hold in a statement by Zacks Investment ... Breaking Finance News all 5 news articles ...

2016-10-20 17:09 com-unik.info

Zynerba Pharmaceuticals Inc. (ZYNE) Upgraded at ZacksInvestment Research - Community Financial News

Community Financial News Zynerba Pharmaceuticals Inc. (ZYNE) Upgraded atZacks Investment Research Community Financial News Why Alibaba = Google +Facebook +Amazon. Alizila. Find out ... According to Zacks, "ZynerbaPharmaceuticals, Inc...

2016-10-19 23:09 baseballnewssource.com

Equities Analysts Set Expectations for ZynerbaPharmaceuticals Inc.'s FY2019 Earnings (ZYNE) - BBNS

Equities Analysts Set Expectations for Zynerba Pharmaceuticals Inc.s FY2019Earnings (ZYNE) BBNS Zynerba Pharmaceuticals logo Zynerba PharmaceuticalsInc. (NASDAQ:ZYNE) Research analysts at Roth Capital reduced their FY2019earnings per share (EPS) estimates for Zynerba Pharmaceuticals in a reportreleased on Monday...

UCB 2016-10-25 04:16 medscape.com

EMA Recommends Safety Measures for Levetiracetam inEpilepsy - Medscape

EMA Recommends Safety Measures for Levetiracetam in Epilepsy Medscape Tocombat accidental overdose, the European Medicines Agency (EMA) isrecommending several safety measures when using the oral solution version of ...and more ...

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2016-10-25 03:54 labiotech.eu

New Partnership comes to the Rescue in NeurologicalDiseases - Labiotech.eu (blog)

New Partnership comes to the Rescue in Neurological Diseases Labiotech.eu(blog) Developing effective treatments for neurological diseases is a big challengein medicine. But here come UCB and Evotec with a new partnership that could helpthose suffering from epilepsy and Parkinsons...

MARKET REPORTS 2016-10-25 03:54 medgadget.com

Epileptic Anticonvulsants Market Trends and industryAnalysis 2020 - Medgadget (blog)

Epileptic Anticonvulsants Market Trends and industry Analysis 2020 Medgadget(blog) A detailed profile of the top key players is presented in the report. Some ofthe key corporations in the epileptic anticonvulsants market include Novartis AG,Johnson & Johnson (J&J), UCB Group, Abbot Laboratories, Pfizer Inc...

EPILEPSY 2016-10-25 04:10 news-medical.net

New study reveals conversion of oral cannabidiol to THCby acidic fluids in the stomach - News-Medical.net

News-Medical.net New study reveals conversion of oral cannabidiol to THC byacidic fluids in the stomach News-Medical.net A new study demonstrating theconversion of oral cannabidiol (CBD) to the psychoactive componenttetrahydrocannabinol (THC) in the presence of gastric fluids could explain whychildren given CBD to treat epilepsy had an unexpectedly high rate of ......

2016-10-25 04:10 news-medical.net

New technique can help detect brain regions that triggerseizures in people with epilepsy - News-Medical.net

News-Medical.net New technique can help detect brain regions that triggerseizures in people with epilepsy News-Medical.net Scientists at the University ofExeter have developed a pioneering new technique that could revolutionise thesurgical treatment of epilepsy . The team of scientists, led by Dr Marc Goodfellowand Professor John Terry, have developed the ground-breaking ... and more ...

2016-10-24 06:09 upi.com

Newer epilepsy drugs may be safer during pregnancy -UPI.com

UPI.com Newer epilepsy drugs may be safer during pregnancy UPI.com But thecommonly prescribed anti- seizure drug valproate was linked with lower IQs inchildren, especially when taken at higher doses, researchers say...

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2016-10-23 21:08 ganjapreneur.com

Australian Hospital Begins CBD Epilepsy Drug Trial forChildren - Ganjapreneur

Ganjapreneur Australian Hospital Begins CBD Epilepsy Drug Trial for ChildrenGanjapreneur The Childrens Hospital Network in Australia is conducting a clinicaltrial of Epidiolex, a CBD-rich, cannabis-derived drug , to determine its effectivenessfor children suffering from epilepsy , according to a report by the MaitlandMercury...

2016-10-22 09:09 upi.com

Study: Risk for autism increased by relative withepilepsy - UPI.com

UPI.com Study: Risk for autism increased by relative with epilepsy UPI.comLINKPING, Sweden, June 17 (UPI) -- Having a diagnosis of epilepsy in childhoodincreases risk for autism spectrum disorder, though just having a family memberwith the condition may also significantly raise the risk...

2016-10-22 07:09 upi.com

Changes in heart activity linked to epilepsy - UPI.com

UPI.com Changes in heart activity linked to epilepsy UPI.com CLEVELAND, March9 (UPI) -- Researchers found they can detect epilepsy based on changes to heartactivity, even in the absence of seizures , according to a new study...

2016-10-22 07:09 upi.com

2016-10-23 21:08 medicalxpress.com

Epilepsy drug could help treat Alzheimer's disease -Medical Xpress

Medical Xpress Epilepsy drug could help treat Alzheimers disease Medical XpressIn this newest research, Dr. Haakon Nygaard, the Fipke Professor in AlzheimersResearch in UBCs Faculty of Medicine, tested the effects of brivaracetam, ananticonvulsant drug still in clinical development for epilepsy , and closely related to ... and more ...

2016-10-23 11:09 upi.com

Epilepsy may triple ADHD risk, Danish study finds -UPI.com

UPI.com Epilepsy may triple ADHD risk, Danish study finds UPI.com Theinvestigators found those with epilepsy seemed to have nearly three times the riskof developing ADHD compared to children without epilepsy . And children who hadfever-related seizures appeared to have an almost 30 percent increased risk ofADHD...

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2016-10-21 19:10 upi.com

Epilepsy drugs may induce some psychotic disorders,study says - UPI.com

UPI.com Epilepsy drugs may induce some psychotic disorders, study saysUPI.com 9 (UPI) -- Epilepsy patients are already at increased risk for psychiatricconditions and psychosis, though drugs used to treat the condition have beensuspected of increasing risk for psychotic episodes, and a new study shows thismay be true ... and more ...

2016-10-19 18:40 healthaim.com

Cannabis Oil: The Truth Behind This Cancer Cure -Health Aim

Health Aim Cannabis Oil: The Truth Behind This Cancer Cure Health Aim Amyleasparents have been seeking for a cure for her seizures caused by a rare form ofepilepsy . In a spark of luck, the doctors at the Childrens Hospital in Aurora,Colorado allowed the administration of Charlottes Web, a type of cannabis oil, on......

2016-10-19 18:40 scopeblog.stanford.edu

Newfound brain pathway may let epilepsy patients steeraround medical marijuana's nasty side effects - Scope(blog)

Scope (blog) Newfound brain pathway may let epilepsy patients steer aroundmedical marijuanas nasty side effects Scope (blog) While its association withmental illness (for example, schizophrenia) is still debated, its component activesubstances are known to saturate endocannabinoid receptors in an all-importantpart of the brain called the hippocampus, obliterating both ......

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https://pro110.intelligence2day.com/cc/view/article.cfm?infoelementid=301687https://pro110.intelligence2day.com/cc/view/article.cfm?infoelementid=301687https://www.ganjapreneur.com/australian-hospital-begins-cbd-epilepsy-drug-trial-children/https://pro110.intelligence2day.com/cc/view/article.cfm?infoelementid=301686https://pro110.intelligence2day.com/cc/view/article.cfm?infoelementid=301686http://medicalxpress.com/news/2015-05-epilepsy-drug-alzheimer-disease.htmlhttps://pro110.intelligence2day.com/cc/view/article.cfm?infoelementid=301563https://pro110.intelligence2day.com/cc/view/article.cfm?infoelementid=301563http://www.upi.com/Health_News/2016/07/13/Epilepsy-may-triple-ADHD-risk-Danish-study-finds/7951468426573/

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Federal Cannabis Production License Issued to the Green Organic Dutchman LtdIssued By: Green Organic Dutchman Ltd Publication Date: 31-Dec-2016...eco-friendly, carbon sensitive design. With a 10 kw solar array and geothermal heating in addition to our reforestation efforts, we value ecological practices on our 25-acre farm.Jeannette's daughter Breanne passed away in 2003 as a result of a severe epilepsy disorder, very likely Dravet syndrome. Breanne was never given cannabis as reports of cannabis for seizure treatment weren't widely available at the time. My hope is that cannabis medicines will help to reduce the devastating impact of sei... Clobazam Oral Suspension Approved in Seven European CountriesIssued By: Martindale Pharma Publication Date: 24-Oct-2016...world's first oral liquid suspension version of clobazam to receive regulatory approval, which has been available from Martindale Pharma under the tradename Tapclob since May 2013. Clobazam oral suspension is used principally as an adjunctive therapy for epilepsy with the formulation particularly suitable for children and young adults. Epaclob/Silocalm are approved in two strengths, 5mg/5ml and 10mg/5ml, and will be supplied in packs containing dosing syringes and dosage cups to facilitate accurat... US FDA Considers Newron's Re-Submitted NDA for Xadago to be a Complete, Class 2 Response to Complete Response LetterIssued By: Newron Pharmaceuticals SpA; Zambon Co SpA; US WorldMeds LLC Publication Date: 21-Oct-2016MILAN--(BUSINESS WIRE)--Newron Pharmaceuticals S.p.A. (Newron) (SIX: NWRN), a biopharmaceutical company focused on the development of novel therapies for patients with diseases of the central nervous system (CNS) and pain, and its partners Zambon S.p.A. and US WorldMeds, LLC, announced today that the US Food and Drug Administration (FDA) considers the September 2016 re-submission of the US NDA by Newron to be a complete, Class 2 response to FDA's March 28, 2016 Complete Response Letter (CRL), and has dete... Pacira Pharmaceuticals Continues to Build Out Robust Commercial Leadership Team Company Appoints Thomas Sluby as Vice President, Sales and Matthew Lehmann as Vice President, MarketingIssued By: Pacira Pharmaceuticals Inc Publication Date: 20-Oct-2016...Sluby also held several management roles during a 15-year period at Eisai, Inc., including National Sales Director of Neurology, Gastroenterology and LTC/Hospital, where he drove revenue in therapeutic areas ranging from Alzheimer's and acid reflux to epilepsy and low-molecular-weight heparin.Prior to Pacira, Mr. Lehmann held various executive positions during a 21-year career at AstraZeneca, most recently as Head of the Neuroscience Franchise where he was responsible for the successful market bui... Sage Therapeutics and Collaborators Publish New Pre-clinical Data in Neuropharmacology Demonstrating a Novel Metabotropic Mechanism of Sage Compounds Resulting in Enhanced EffectsIssued By: SAGE Therapeutics Inc Publication Date: 20-Oct-2016...findings are profoundly relevant for Sage and our portfolio of novel GABA compounds, particularly as reduced expression of extrasynaptic GABAA receptors has been demonstrated in human and rodent models of status epilepticus, postpartum depression and forms of epilepsy, said Jim Doherty, PhD, Senior Vice President of Research at Sage. We believe the potential ability of neuroactive steroids, and Sage's compounds in particular, to restore tonic inhibition by increasing the surface expression and t...

PRESS RELEASE, THOMSON REUTERS CORTELLIS

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PixarBio Corporation, Expands PPM to $40,000,000, Extends PPM One Week to Close October 28, 2016 and Promotes Ken Stromsland to Vice President, CIO & External CommunicationsIssued By: PixarBio Corp Publication Date: 20-Oct-2016...pharmaceutical/biotechnology company focused on pre-clinical and commercial development of novel neurological drug delivery systems for post-operative pain. PixarBio researches and develops targeted delivery systems for drugs, cells, or biologics to treat pain, epilepsy, Parkinson's disease, and spinal cord injury. Our lead product platform, NeuroRelease, has achieved sustained therapeutic release of non-opiate drugs for post-operative, acute and chronic pain in pre-clinical models. For more infor... Evotec and UCB Sign Multi-Year CNS Pharmacology AgreementIssued By: Evotec AG Publication Date: 20-Oct-2016...UCB has over 7,700 employees worldwide with research and early development scientists based in Belgium (Central Nervous System) and UK (immunology) supporting an innovative pipeline of novel therapeutics. UCB's core products are treating patients with epilepsy, rheumatoid arthritis and Parkinson's disease. UCB recognises that the identification of new and innovative protein targets remains a core challenge for the pharmaceutical industry. UCB therefore continues to invest internally, externally an... XOMA Announces Significant Step Toward Initiating Pediatric Phase 2 Clinical Study for XOMA 358 in Children with Congenital HyperinsulinismIssued By: XOMA Corp Publication Date: 19-Oct-2016...is the major physiologic hormone for controlling blood glucose levels. Abnormal increases in insulin secretion can lead to profound hypoglycemia (low blood sugar), a state that can result in significant morbidities, including brain damage, seizures and epilepsy. XOMA, leveraging its scientific expertise in allosteric monoclonal antibodies, developed the XMet platform, consisting of separate classes of selective insulin receptor modulators (SIRMs) that could have a major effect on treating patients... Ganaxolone Phase 1 Data Supports Progressing to Phase 2 in Patients with Status EpilepticusIssued By: Marinus Pharmaceuticals Inc Publication Date: 19-Oct-2016...Pharmaceuticals, Inc. (Nasdaq:MRNS), a biopharmaceutical company dedicated to the development of innovative therapeutics to treat epilepsy and neuropsychiatric disorders, today announced that in its Phase 1 dose-escalation study, ganaxolone intravenous (IV) achieved...mechanism of action, demonstrated efficacy and safety and convenient dosing, to improve the lives of patients suffering from epilepsy and neuropsychiatric disorders. Ganaxolone is a CNS-selective GABAA modulator that acts on a... Vitality Biopharma Reports on Initial Cannabinoid Drug Formulation StudiesIssued By: Vitality Biopharma Inc Publication Date: 19-Oct-2016...where an individual's immune system attacks their intestines, rectum, and other parts of their digestive tract. This disease afflicts 1.4 million Americans and often affects children, with most patients receiving their diagnosis prior to age 30. As with epilepsy, dramatic clinical trial results have been documented through the use of cannabinoids, including an ability to induce remission of Crohn's disease. Large state-funded and independently-managed clinical trials are now underway to further do...

GW Pharmaceuticals plc Announces Intention to Continue Trading Exclusively on NASDAQ and Planned Cancellation of Trading of Ordinary Shares on AIMIssued By: GW Pharmaceuticals plc Publication Date: 19-Oct-2016...its investigational product for the treatment of a number of rare childhood-onset epilepsy disorders, as well as advance its cannabinoid product pipeline.BackgroundHaving...outside the United States. GW is advancing an orphan drug program in the field of epilepsy with a focus on Epidiolex (cannabidiol), which is in Phase 3 clinical development...candidates which includes compounds in Phase 1 and 2 trials for glioma, schizophrenia and epilepsy. For further information, please visit ww... Pediatric Research Consortia announce CAVATICA Platform for Analyzing Research Data on Pediatric Cancers and Rare DiseasesIssued By: Childrens Hospital of Philadelphia Publication Date: 17-Oct-2016...CAVATICA, which also launches out of beta today, will enable researchers to collaboratively access, share and rapidly analyze data collected about diseases impacting children, including pediatric cancers, congenital disorders and rare diseases such as epilepsy and autism.By making large volumes of genomic and other types of data from multiple diseases available, within a system researchers can use to share and analyze it, CAVATICA is answering the Cancer Moonshot's call to de-silo data and make it... Zynerba Provides Clinical Update for Lead Development Candidates ZYN001 and ZYN002Issued By: Zynerba Pharmaceuticals Inc Publication Date: 17-Oct-2016...in the first half of 2017. Two Phase 2 clinical trials are ongoing for ZYN002, in adults with refractory epilepsy and in knee pain associated with osteoarthritis. Phase 2 clinical trials in patients with Fragile X Syndrome...2016, the company initiated the Phase 2 STAR 1 (Synthetic Transdermal Cannabidiol for the Treatment of Epilepsy) clinical trial of ZYN002 CBD gel in refractory epilepsy patients with focal seizures. In August 2016, the Phase 2 STOPI(Synthetic Transdermal Cannabid... Addex Therapeutics to Conduct Phase IIa Proof of Concept Study of Dipraglurant in Focal Cervical DystoniaIssued By: Addex Therapeutics Ltd Publication Date: 17-Oct-2016...dystonia is being investigated with support from the Dystonia Medical Research Foundation (DMRF). Addex's second clinical program, ADX71149 (mGluR2 positive allosteric modulator or PAM) is being developed in collaboration with Janssen Pharmaceuticals, Inc for epilepsy. In addition, ADX71441 (GABAB receptor PAM) has received regulatory approval to start phase I and is being investigated for its therapeutic use in Charcot-Marie-Tooth Type 1A disease (CMT1A), cocaine and alcohol use disorder and nico...

Report 2016-10-25 Published By: Andrea Malizia

EPILEPSY REPORT 1025162016-10-25 13:14 pharmatimes.comMartindale's oral epilepsy drug bags EU nods2016-10-21 01:09 nytimes.comGW Pharma to Cancel London Listing - New York Times2016-10-20 18:09 businessinsider.comUPDATE 1-Drug developer GW Pharma to cancel London2016-10-19 18:40 benchmarkmonitor.comMid Cap Losers: GW Pharmaceuticals plc2016-10-19 10:08 dailymail.co.ukDrug developer GW Pharma to cancel London listing -2016-10-24 19:10 google.comMarinus to proceed to Phase 2 with ganaxolone in life-2016-10-21 21:09 mmahotstuff.comRating Sentiment Summary: This is what analysts have2016-10-24 05:08 reliawire.comLyrica: The Epilepsy Drug That Treats Chronic Nerve2016-10-25 16:09 dailyquint.comZynerba Pharmaceuticals Inc. (ZYNE) Stock Rating2016-10-21 06:08 com-unik.infoZynerba Pharmaceuticals Inc. (ZYNE) Upgraded at Zacks2016-10-20 17:09 com-unik.infoZynerba Pharmaceuticals Inc. (ZYNE) Upgraded at Zacks2016-10-19 23:09 baseballnewssource.comEquities Analysts Set Expectations for Zynerba2016-10-25 04:16 medscape.comEMA Recommends Safety Measures for Levetiracetam in2016-10-25 03:54 labiotech.euNew Partnership comes to the Rescue in Neurological2016-10-25 03:54 medgadget.comEpileptic Anticonvulsants Market Trends and industry2016-10-25 04:10 news-medical.netNew study reveals conversion of oral cannabidiol to THC2016-10-25 04:10 news-medical.netNew technique can help detect brain regions that trigger2016-10-24 06:09 upi.comNewer epilepsy drugs may be safer during pregnancy -2016-10-23 21:08 ganjapreneur.comAustralian Hospital Begins CBD Epilepsy Drug Trial for2016-10-23 21:08 medicalxpress.comEpilepsy drug could help treat Alzheimer's disease -2016-10-23 11:09 upi.comEpilepsy may triple ADHD risk, Danish study finds -2016-10-22 09:09 upi.comStudy: Risk for autism increased by relative with2016-10-22 07:09 upi.comChanges in heart activity linked to epilepsy - UPI.com2016-10-22 07:09 upi.comExperimental compounds stop epilepsy progression, not2016-10-21 19:10 upi.comEpilepsy drugs may induce some psychotic disorders,2016-10-19 18:40 healthaim.comCannabis Oil: The Truth Behind This Cancer Cure -2016-10-19 18:40 scopeblog.stanford.eduNewfound brain pathway may let epilepsy patients steerBlank PageBlank PageBlank Page