Epidemiology in the Epidemiology in the Hospital SettingHospital Setting

Benjamin A. Rybicki, PhDSenior Scientist, Henry Ford Hospital

Henry Ford Health Henry Ford Health SystemSystem

Age Females Males Total

0 - 17 63458 66583 130041

18 - 29 42306 39189 81495

30 - 39 38462 32150 70612

40 - 49 51924 46138 98062

50-59 52733 47000 99733

60-69 31578 29638 61216

70-79 13773 11710 25483

80+ 9943 6764 16707

Total 304177 279172 583349

Females Males Total

Age # % of pop # % of pop # % of pop

0-17 10529 7.6% 10814 7.8% 21343 15.4%

18-29 8887 6.4% 7667 5.5% 16554 11.9%

30-39 6543 4.7% 4775 3.4% 11318 8.1%

40-49 10761 7.7% 8362 6.0% 19123 13.8%

50-59 14400 10.4% 11498 8.3% 25898 18.6%

60-69 11186 8.0% 9816 7.1% 21002 15.1%

70-79 7846 5.6% 6053 4.4% 13899 10.0%

80+ 5855 4.2% 3976 2.9% 9831 7.1%

Total 76007 54.7% 62961 45.3% 138968 100.0%

Molecular BioHuman Populations

Statistics

Epidemiology

Molecular Biology Laboratory

Mol Biologists

Population DatabaseLaboratory

Prog/Data Mgrs.

EpidemiologyEpidemiologists

StatisticsBiostatisticians

InterviewersAbstractorsData Entry

Respiratory Research

Cancer

Neuro

Cardiovascular

Biostatistics & Research Epidemiologywww.henryford.com/body.cfm?id=39207

BRE Organizational BRE Organizational StructureStructure

Biostatisticians13

Epidemiologists16

Molecular Epid Research Lab6

Data Management & Programming10

Abstracting, Interviewing, RN/LPNs, MAs36

Data Entry2

Computer Facility4

Secretarial3

Grants Managers2

Project Support10

Administrative Manager1

Total Staff103

Benign Cohort1990 – 2006N=8,117*

PSA test +/- 1 year of benign specimen (N=7,122)

Prostate cancer diagnosis on or before 12/31/2010

CasesN=1,441

ControlsN=5,681

≥ 1 year between benign specimen and cancer

diagnosisN=1,136

≥ 1 year of follow-up after benign

biopsyN=4,431

Benign tissue available for study

N=931

Benign tissue available for study

N=3,633

Tumor tissue available for study

N=698

Aim 1 & Aim 2

Aim 3

Yes No

Case-Control Matching:

Age, race, and follow-up duration

800 case-control pairs

650 case-control pairs

A Nested Case-Control A Nested Case-Control Study using a Pathology-Study using a Pathology-

based Cohortbased Cohort

•At Henry Ford, epidemiologists lead and co-At Henry Ford, epidemiologists lead and co-lead research in step with the mission of the lead research in step with the mission of the health system. Biostatisticians are often co-health system. Biostatisticians are often co-investigators on epidemiologist-lead research, investigators on epidemiologist-lead research, but focus most on statistical issues across but focus most on statistical issues across multiple projects.multiple projects. • Epidemiologists tend to favor observational • Epidemiologists tend to favor observational studies, but often employ methodologies studies, but often employ methodologies developed by basic science researchers and developed by basic science researchers and team with clinical researchers doing team with clinical researchers doing intervention studies. intervention studies.

• Investigators who want to use • Investigators who want to use populationpopulation data to address a research question can data to address a research question can benefit from interactions with an benefit from interactions with an epidemiologist.epidemiologist.

SummarySummary