Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.

96
Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons

TAGS:

Transcript of Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.

Page 1: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.

Epidemiology and Diagnosis

A Practical Guide to Therapy

Monotherapy

Combination Therapy

Add ons

Page 2: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 3: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 4: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.

Impaired GlucoseTolerance - IGT

Impaired FastingGlucose - IFG

Page 5: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 6: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 7: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 8: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 9: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 10: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 11: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 12: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 13: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 14: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 15: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 16: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 17: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 18: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 19: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 20: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 21: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 22: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 23: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 24: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 25: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 26: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 27: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 28: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 29: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 30: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 31: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 32: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 33: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 34: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 35: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 36: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 37: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 38: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 39: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 40: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 41: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 42: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 43: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 44: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 45: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 46: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 47: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 48: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 49: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 50: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 51: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 52: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 53: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 54: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 55: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 56: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 57: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 58: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 59: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 60: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 61: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 62: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 63: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 64: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 65: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 66: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 67: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 68: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 69: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 70: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 71: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 72: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 73: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 74: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 75: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 76: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 77: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 78: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 79: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 80: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 81: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 82: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 83: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 84: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 85: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 86: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 87: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 88: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 89: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 90: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 91: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.
Page 92: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.

Beta cell mechanism

Insulin secretion and Glucose regulation

Effects of hyper glycemia

Biphasic Insulin response

Insulin secretagogues

Glycaemic goals & Pregnancy

Diabetic retinopathy

Glitazones

Hyperglycemia

Page 93: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.

Etiologic classification of diabetes mellitus

Glucose tolerance categories

Diagnosis of Diabetes

Diagnosis of Diabetes II

Page 94: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.

Management Goals

Metabolic Targets

Deterioration in Median

Antihyperglycemic Agents

Antihyperglycemic Agents(Sites)

Antihyperglycemic Agents(Mechanism)

The -Glucosidase inhibitors

The -Glucosidase inhibitors(Effect)

Acarbose Effect on HbA1c

The Biguanides(Characteristics)

Metformin (Mechanism)

Page 95: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.

Metformin Effect(Glucose)

Metformin Effect(HbA1c)

Dose Response(Metformin)

Insulin Secretagogues

Repaglinide Effect(HbA1c)

Repaglinide after Sulfonylurea

Sulfonylurea Effect(Glucose)

Dose Response(Sulfonylurea)

Once vs Twice daily(Sulfonylurea)

Placebo subtracted dose

Selected insulin secretagogues

-Glucosidase Dosing

Hypoglycemic episodes

Sulfonylureas

Insulin Secretagogues

Initial treatment

Secondary Failures

Metformin

-Glucosidase Inhibitors

Page 96: Epidemiology and Diagnosis A Practical Guide to Therapy Monotherapy Combination Therapy Add ons.

Glycemic Improvements

Sulfonylurea+Metformin

Sulfonylurea+Acarbose

Combinations of Oral agents

Secondary Failure

Metformin+Repaglinide

Metformin+Acarbose

Glimepride+Insulin(FPG)

Glimepride+Insulin(HbA1c)

Oral Agents+Insulin

Sulfonyurea+Insulin

Insulin+Metformin(HbA1c)

Insulin+Metformin(Effect)


Ipilimumab Monotherapy Study

Ipilimumab Monotherapy Study

Bortezomib monotherapy for relapsed multiple myeloma

Bortezomib monotherapy for relapsed multiple myeloma

Consolidation and Maintenance Therapy for Multiple Myeloma ... · Novel Agent-Containing Consolidation Therapy Improves Depth of Response and Prolongs PFS • Bortezomib monotherapy

Consolidation and Maintenance Therapy for Multiple Myeloma ... · Novel Agent-Containing Consolidation Therapy Improves Depth of Response and Prolongs PFS • Bortezomib monotherapy

PD-1 Inhibitor Therapy S - ONS

PD-1 Inhibitor Therapy S - ONS

Dual Add-on Therapy in Type 2 Diabetes Poorly Controlled With Metformin Monotherapy: A Randomized Double-Blind Trial of Saxagliptin Plus Dapagliflozin.

Dual Add-on Therapy in Type 2 Diabetes Poorly Controlled With Metformin Monotherapy: A Randomized Double-Blind Trial of Saxagliptin Plus Dapagliflozin.

Daratumumab monotherapy for patients with relapsed or ...

Daratumumab monotherapy for patients with relapsed or ...

Antibiotic Monotherapy for Intraabdominal Infections IS BROAD SPECTRUM MONOTHERAPY ANTIBIOTIC TREATMENT ADEQUATE FOR INTRAABDOMINAL INFECTIONS ? Nicolas.

Antibiotic Monotherapy for Intraabdominal Infections IS BROAD SPECTRUM MONOTHERAPY ANTIBIOTIC TREATMENT ADEQUATE FOR INTRAABDOMINAL INFECTIONS ? Nicolas.

Androgen deprivation therapy: New concepts · LHRH agonist monotherapy 3. CAB with LHRH agonist & anti-androgen 4. Agonist/antagonist 5. 1/2/3/4/6 month depot 6. Anti-androgen monotherapy

Androgen deprivation therapy: New concepts · LHRH agonist monotherapy 3. CAB with LHRH agonist & anti-androgen 4. Agonist/antagonist 5. 1/2/3/4/6 month depot 6. Anti-androgen monotherapy

Monotherapy vs Polytherapy for Schizophrenia

Monotherapy vs Polytherapy for Schizophrenia

Virological failure to Protease inhibitors in Monotherapy ...

Virological failure to Protease inhibitors in Monotherapy ...

RhReport to the Investment Community Eli Lillyypy and ...files.shareholder.com/.../04_Carmine_BioMedicines.pdf · Adjunctive Therapy Trial Monotherapy Trials (2 studies)

RhReport to the Investment Community Eli Lillyypy and ...files.shareholder.com/.../04_Carmine_BioMedicines.pdf · Adjunctive Therapy Trial Monotherapy Trials (2 studies)

Monotherapy Versus Combination Therapy Done By: Ohoud AL-Juhani.

Monotherapy Versus Combination Therapy Done By: Ohoud AL-Juhani.

Original Article Comparison of the efficacy of tenofovir ...TDF monotherapy and TDF-based combination therapy are similarly effective and safe in adefovir-experienced CHB patients

Original Article Comparison of the efficacy of tenofovir ...TDF monotherapy and TDF-based combination therapy are similarly effective and safe in adefovir-experienced CHB patients

Effect of Bortezomib Regimens and Daratumumab Monotherapy ...

Effect of Bortezomib Regimens and Daratumumab Monotherapy ...

Antacid monotherapy is more effective in relieving ...

Antacid monotherapy is more effective in relieving ...

SPCRN News - Rainbow Surgery · l.wilkie@cpse.dundee.ac. uk ... London School of Hygiene and Tropical Medicine. ... (Monotherapy vs dual therapy for initial treatment to hypertension).

SPCRN News - Rainbow Surgery · [email protected]. uk ... London School of Hygiene and Tropical Medicine. ... (Monotherapy vs dual therapy for initial treatment to hypertension).

Acalabrutinib monotherapy in patients with chronic ...

Acalabrutinib monotherapy in patients with chronic ...

Learning Objectives Advocate Christ Medical Center (ACMC) · 2016-09-01 · – Compared patients on combination therapy of vancomycin + pip-tazo vs. monotherapy of either agent alone

Learning Objectives Advocate Christ Medical Center (ACMC) · 2016-09-01 · – Compared patients on combination therapy of vancomycin + pip-tazo vs. monotherapy of either agent alone

Systematic review on inhaled corticosteroid monotherapy ... · Continuous therapy with inhaled corticosteroids in COPD is controversially discussed. The aim of this systematic review

Systematic review on inhaled corticosteroid monotherapy ... · Continuous therapy with inhaled corticosteroids in COPD is controversially discussed. The aim of this systematic review

Empirical antibacterial treatment - Aminoglycosides · comparing beta-lactam monotherapy vs. beta-lactam-aminoglycoside combination therapy for high-risk febrile neutropenia included

Empirical antibacterial treatment - Aminoglycosides · comparing beta-lactam monotherapy vs. beta-lactam-aminoglycoside combination therapy for high-risk febrile neutropenia included