EPIC: Balloon AngioplastyEPIC: Balloon AngioplastyEPIC: Balloon AngioplastyEPIC: Balloon Angioplasty

12.8%11.4%

8.3%

1.4% (P=ns)

4.5% (P<0.004)

Placebo + heparin (ACT 300 sec)(n=696)

Abciximab 0.25mg/kg bolus + heparin (ACT 300 sec)(n=395)

Abciximab 0.25mg/kg bolus / 10 µg/kg infusion + heparin (ACT 300 sec)(n=708)

Primary Endpoint: Death, MI, UTVR at 30 daysPrimary Endpoint: Death, MI, UTVR at 30 days

%events

The EPIC investigators. N. Engl J Med. 1994; 330: 956-961.

EPIC ResultsEPIC ResultsEPIC ResultsEPIC Results

%events

%events

Placebo + heparin (ACT 300 sec)(n=696)

Placebo + heparin (ACT 300 sec)(n=696)

Abciximab + heparin (ACT 300 sec)(n=708)

Abciximab + heparin (ACT 300 sec)(n=708)

30 DayDeath/MI

3.5% (P=0.015)

30 DayDeath/MI

3.5% (P=0.015)

6 MonthDeath/MI

3.9% (P=0.019)

6 MonthDeath/MI

3.9% (P=0.019)

30 DayTVR

3.8% (P=0.003)

30 DayTVR

3.8% (P=0.003)

6 MonthTVR

5.8% (P=0.007)

6 MonthTVR

5.8% (P=0.007)

9.6%9.6%

6.1%6.1%

12.8%12.8%

8.9%8.9%7.8%7.8%

4.0%4.0%

22.3%22.3%

16.5%16.5%

1.4%1.4%

6.6%6.6%

MajorTIMI

Bleeding

MajorTIMI

Bleeding

The EPIC investigators. N. Engl J Med. 1994; 330: 956-961.