ephiósIn-Sight to fight Blindness

Source : http://www.who.int/blindness/estimates2011.pdf

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Global causes of Blindness in 2010RE: Refractive ErrorsAMD: Age related Macular DegenerationCO : Corneal OpacitiesDR: Diabetic Retinopathy

Vision Examination?

• ERG and VEP are both electrophysiology tests and can be compared to ECG.

• ERG (ElectroRetinoGraphy) is an eye test that evaluates the function of the retinal cells of the eye.

The ERG test helps diagnose retinal diseases and also diseases in the body that secondary affect the eye (diseases like diabetic retinopathy).

• VEP (Visual Evoked Potentials) are used to detect and evaluate dysfunction of the optic pathway including the visual cortex, like inflammation of the optic nerve or diseases like Multiple Sclerosis.

∗ ephiós ERG and VEP is handheld. Use anywhere at anytime enhancing the access to this diagnostic modality to the masses as a screener.

∗ Comprehensive Vision Examination with a high degree of sensitivity and specificity for detection of ROP.

∗ 5-10 times cheaper than the existing stationary ERG & VEP system∗ Conforms to the ISCEV Standard Protocol∗ Safe for patients. Runs on a battery.∗ Is “tele-diagnosis” enabled for remote specialist reading. ERG and VEP data

gives higher sensitivity in telediagnosis – Compact data transmission than fundus image and much lower intra/inter-operator variability.

Unique Positioning

Key Customer Feedback

The easy portability and performance of the product has enabled me to conduct a VEP & ERG examination in the Operating Room – Dr. Parveen Sen, Sankara Neteralaya, Chennai, India

I have been able to use the ephios Handheld ERG & VEP in the most rural parts of Gujarat and diagnose pediatric patients in the pre speech age- The device is operated by a technician in a remotely located health camp and recorded data relayed to me by e-mail for reading and interpretation. Has been working very well for my kind of work Dr. Jitendra Jethani, Dr. T.V. Patel Eye Institute, Vadodara, India

The ephios handheld ERG was subjected to a performance comparison with the standard ERG equipment we have been using and compared very well. Its handheld format and price will definitely go a long way in making this sophisticated diagnostic procedure more accessible and affordable to the people – Dr. Vikas Kaitan, Sankara Netralaya, Chennai, India

Epidemiology of Vision Related DiseasesIndication Prevalence

in India Sub Continent (/1000)

Prevalence in ROW(/1000)

Current Diagnostic Screening

ERG/VEP role as Diagnostic /Screener

Retinitis Pigmentosa 1 0.25 Not Available

Yes

Diabetic Mellitus & Retinopathy 0.63 (2006) 24.2 (2011) NA Yes

Macula Degeneration 90 - NA YesRetinopathy of Prematurity (ROP)India: 22.5 birth/1000/yearROW: 19.95 birth/1000/year

2 0.95 NA Yes

Toxicity Alcohol InducedIndia: 16.7%- 58% of population (50%- Illicit Liquor)

206 No Available Data

NA Yes

Childhood Blindness 0.80 0.30 NA YesGlaucoma 58.3 - NA Yes

Epidemiology of Vision Related Diseases

Indication Prevalence in India Sub Continent (/1000)

Prevalence in ROW(/1000)

Current Diagnostic Screening

ERG/VEP role as Diagnostic /Screener

fetal alcohol syndrome (FAS)alcohol-related neurodevelopmental disorder (ARND) per 1000 life birth

No Available Data (NAD)

0.2 – 1.5 Not Available (NA)

Yes

Optic neuropathy NAD 1.15 NA Yes

Albinism NAD 0.50 NA Yes

Progressive Cone Dystropies NAD 0.30 NA Yes

Achromatopsia NAD NA Yes

Metallic Intraocular Foreign bodies NAD NA Yes

Disassociative Visual Disorder NAD NA Yes

∗ In cases where ophthalmoscopic observation is precluded due to the presence of opacities in the media.

∗ When subjective tests are unreliable due to the age of the patient.

∗ In prognosis in cases of vascular disorders.∗ In early diagnosis of hereditary or congenital diseases.∗ In prevention of disease, as in toxic retinopathies.∗ In providing information in some of the conditions

where there are no physical signs of eye disease.

ERG/VEP Tests are indicated

∗ To reach to the population & help early detection of retinal diseases, optical nerve disorders & retinopathy from ocular diseases.

∗ High cost of tests & limited health infrastructure which is concentrated in urban population.

∗ >70% of most effected population lives in rural/semi urban areas, can’t be reached with expensive stationary ERG & VEP systems.

∗ Prelim screening of rural population.

“The etiology and pathology of blindness has always been reported with a verysignificant number of cases that are reported as of unknown origin. Handheld Visual

Electrophysiology equipments can help finding some answers.”

Need for handheld ERG/VEP System

∗ Björn-Åke Skjöld Master of degree of fine arts, Stockholm. Skjöld Design AB, Design is an International Red Dot Design Award winning design

company. Working in Medical Devices, Traffic safety for children, ergonomics for last 25+ years.

Designed ephiós handheld ERG/VEP Unit.

∗ Linköping University ephiós is working with Department of Biomedical Engineeringin the area of electronics design, programming, imaging, wireless & optical methods on new modalities.

And Regulations for Medical Devices and hospitals, CE.

∗ NTH New tools for Health, organization with contacts for verify Member and test of new methods and products.

∗ Clinical Research ephiós is in discussion for partnership with leading clinical research organization for data collection & its management.

Co operationCo operation

Contact:Aditya Prakash

ephios Medicare (P) Limited, New Delhi, India ephiós ab, Norrköping, Sweden

Website www.ephios.com | e-mail: aditya.prakash@ephios.com; aditya@srsglobalsoft.comAddress Visit C/o Swedish Trade Council - Exportradet, Embassy of Sweden, Nyaya Marg, Chanakayapuri, New

Delhi- 110 021Mobile India +91 98110 61885 | fax +91 11 46 06 7110

“Thank you for you Patience”