Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)
description
Transcript of Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)
![Page 1: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/1.jpg)
Enhancing Training and Mentorship Opportunities for Young and Early
Investigators (YECIs)
Jonathan Fuchs, MD, MPHDirector of Vaccines and Training, San Francisco Dept. of Public Health
Assistant Clinical Professor of Medicine, UCSFPrincipal Investigator, The OCTAVE Project
Co-chair, HVTN Training and Education Committee
IAS, Rome19 July 2011
![Page 2: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/2.jpg)
Nature Medicine, 2010, 16: pp.981-989
![Page 3: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/3.jpg)
The Need for Training and Mentorship Opportunities
“Strategies are needed to strengthen and clarify career paths for early-career investigators through mentorship, training and leadership opportunities…”
“More comprehensive multidisciplinary training opportunities could be provided, such as expanding the popular satellite workshops that are focused on a variety of scientific and career development topics and that are held in conjunction with major scientific conferences. The goal of these training sessions would be to provide more comprehensive educational experiences without increasing the overall length of postdoctoral training.”
Enterprise WG 5 YECI Report, Nature Precedings 07 Sep 2010
![Page 4: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/4.jpg)
Outline• Global HIV Vaccine Enterprise Initiatives
– OCTAVE Project (Online Collaborative Training for AIDS Vaccine Evaluation) Capacity Building Workshop Series
– HIVe– Mentoring
• HIV Vaccine Trials Network (HVTN) Training and Mentoring Programs– NHP ESI Scholars– SHAPe– RAMP
![Page 5: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/5.jpg)
OCTAVE Project
• Online Collaborative Training for AIDS Vaccine Evaluation• OAR pilot project, funded in 2004
– Led by the Health Sciences and eTraining Foundation (HSeT), the HVTN, and NIH
– Contributors from many other lead partners (e.g., IAVI, VRC, USMHRP)
• Vision: Collaboratively create high quality training materials and approaches focused on global audiences of YECIs, clinical trial staff, and laboratorians
![Page 6: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/6.jpg)
• Philosophy– Acknowledges the power of interactive, graphic-rich
content to convey complex concepts, particularly in immunology/vaccinology
– Interactive workshops that blend online and face-to-face training
– Collaborative leadership in planning and implementation
![Page 7: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/7.jpg)
The OCTAVE Training Model
Orientation Kickoff Webinar
Preparatory Online Learning
Interactive, Face-to-face workshop
Longitudinal Works in Progress Webinars/ Social
Networking
![Page 8: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/8.jpg)
Organizational Portals draw content from resource websites
![Page 9: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/9.jpg)
OCTAVE Portal for the Enterprise: enterprise.bio-med.ch
![Page 10: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/10.jpg)
![Page 11: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/11.jpg)
![Page 12: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/12.jpg)
2010-2011 Workshops• Vienna, July 2010 – Good Participatory Practices Guidelines
• Lead Partners: AVAC (Lori Miller) and UNAIDS.• 73 applicants, 33 selected• Case studies for GPP Guidelines in preparation
• Seattle, December 2010 –Correlates of vaccine protection • Workshop leads: Galit Alter, Penny Moore, Guido Ferrari, Clive Gray• 94 applicants; 12 selected• Manuscript on Correlates of Vaccine Protection in preparation
• Sao Paulo, March 2011 – Statistical Methods in Vaccine Trials • Lead partners: Brazilian Ministry of Health, SCHARP, Emmes Corporation• 63 Applicants; 29 selected
![Page 13: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/13.jpg)
2010-2011 Workshops (continued)
• New York, June 2011 -Adjuvant design • Lead Partners: Novartis, Ragon Institute, NYU, IAVI• 82 applicants; 27 selected
• Bangkok, September 2011 –Statistical Methods in Vaccine Trials• Lead Partner: SCHARP, Emmes Corporation, Mahidol Univ.• 84 applicants; 29 selected
• Africa, December 2011 – Grant writing with strong mentoring component
• UCSF/ MUHAS/ HVTN/ HEARD• Call for applications: August 2011
![Page 14: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/14.jpg)
OCTAVE Blended Learning Workshops
• From Concept to Clinic– HVTN 2006
• Train the Trainers– Seattle, AIDS Vaccine 2007
• Mucosal Immunity– CapeTown, AIDS Vaccine 2008
• Standardized Measurement of Neutralizing Antibodies
– Paris, AIDS Vaccine 2009
• RV144: Correlates of Immune Protection – Kampala, AAVP 2009
• NHP Challenge Models– HVTN/CHAVI ESI Scholars, Durham,
CHAVI Retreat 2010
OCTAVE -specific workshops– 270 trainees, 21 countries
Other workshops, self-directed learning– Over 1500 trainees
![Page 15: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/15.jpg)
Enterprise Advisory Committee
• Informs our strategy to ensure workshops complement existing capacity building efforts for YECIs organized by institutions globally
• Identifies highest priority training needs• Provides input on upcoming workshops• Evaluation strategies• Focuses on sustainability of capacity building efforts
![Page 16: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/16.jpg)
v
The YECI Committee• Galit Alter, The Ragon Institute, Massachusetts General Hospital, USA• Jintanat Ananworanich (Co-chair), AFRIMS) Thailand• Michele Andrasik, Fred Hutchinson Cancer Research Center, USA• Dan Barouch, Beth Israel Deaconess Medical Center, USA• Tim Cardozo, NY Langone Medical Center, NYU School of Medicine, USA• Bhavna Chohan, University of Nairobi, Kenya• Hayley Crawford, University of Oxford, UK• Jacques Fellay (Co-chair), Federal Institute of Technology (EPFL), Switzerland• Nicole Frahm, HVTN, Fred Hutchinson Cancer Research Center, USA• Jonathan Fuchs, San Francisco Dept of Public Health, USA• William Kilembe, Zambia-Emory HIV Research Project (ZEHRP), Zambia• Al Leslie, University of Oxford, UK• Penny Moore, National Institute for Communicable Diseases, South Africa• Morgane Rolland, US Military HIV Research Program (MHRP), USA• Rogier Sanders, University of Amsterdam and Weill Medical College, The
Netherlands/USA• Andrew Scheibe, University of Cape Town, South Africa• Misaki Wayengera, Makerere University, Uganda
![Page 17: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/17.jpg)
v
Activities in Support of the Scientific Strategic Plan and Young and Early-career Investigators
The HIV Vaccine electronic (e) resource, or “HIVe,” is a global electronic clearinghouse of information for the HIV vaccine research community.
HIVe includes:
• Easy-to-navigate links to jobs, grants, scholarships and training opportunities
• The latest HIV vaccine research news, researcher profiles and other resources
• Prominent guest speakers weighing in on the most pressing issues in the field
• Open fora, where visitors can post their opinions, participate in debates and discussions, exchange information and pose questions to colleagues.
www.vaccineenterprise.org/hive
![Page 18: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/18.jpg)
![Page 19: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/19.jpg)
v
Planned activities of the YECI Committee
Mentorship: this initiative aims to raise awareness, highlight the importance and build mentoring skills of YECIs. It will consist of different components including:• Development of a mentoring award• Article series on mentoring• OCTAVE workshop on mentoring and increasing number of training workshops to
accommodate demand
Open Access: aims to accelerate the access to research results by increasing access to HIV articles by:• Creating a central preprint server for HIV vaccine articles• Lobbing for data sharing and open science
Visibility: increase oral presentation by YECIs at conference by• Contacting conference organizers and lobbying for increasing the number of YECIs
invited to give oral presentations and included in organizing committees
Funding: increase funding opportunities for YECIs by• Developing a research report justifying increase in funding for YECIs
![Page 20: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/20.jpg)
Outline• Global HIV Vaccine Enterprise Initiatives
– OCTAVE Project (Online Collaborative Training for AIDS Vaccine Evaluation) Capacity Building Workshop Series
– HIVe– Mentoring
• HIV Vaccine Trials Network (HVTN) Training and Mentoring Programs– NHP ESI Scholars– SHAPe– RAMP
![Page 21: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/21.jpg)
HVTN/CHAVI NHP Early Stage Investigator Scholar Award
Funding Pilot Studies to Advance Non-Human Primate Models in Support of HIV Vaccines Clinical Research
![Page 22: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/22.jpg)
HVTN/CHAVI NHP ESI Program Goals
• To bridge the gap between NHP and clinical vaccine science
• Attract promising new investigators• Invest in new ideas posed by early stage
investigators in collaboration with both Clinical and NHP scientist mentors
• Sponsored by NIAID; HVTN and CHAVI• 3 rounds have been funded
![Page 23: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/23.jpg)
2009 Scholars – Cohort 1
Keith Reeves
David Kaufman
Sallie Permar
Shelby O’Connor
Lili Yang
New England Primate Research
Center
Beth Israel Deaconess
Medical Center
Children's Hospital Boston
University of Wisconsin
California Institute of Technology
![Page 24: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/24.jpg)
2010 Scholars – Cohort 2
Ann-Sophie Dugast
James Kobie
Katherine Bar
Mohammed Asmal
Boston General Hospital
University of Rochester
University of Alabama
Birmingham
Beth Israel Deaconess Medical Center
![Page 25: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/25.jpg)
2011 Scholars – Cohort 3
Keith Reeves
Wendy Yeh
Carolina Herrera
Afam Okoye
New England Primate Research
Center
Beth Israel Deaconess
Medical Center
St. George's, University of
London
Oregon Health and Science University
Shaunna Shen
Lu-Ann Pozzi
Duke University
New England Primate Research
Center
![Page 26: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/26.jpg)
SHAPe Program• Need to identify new physician scientists in
South Africa to lead HIV vaccine clinical trial and discovery efforts
• 25% of medical graduates specialize. Majority stay in hospital general track or go into general practice.– Research career paths are less well defined and
awareness of and access to research opportunities is limited
• Development of a PhD program to bolster HIV vaccine expertise in South Africa
• Co-sponsored by NIH, Fogarty International Center and the HVTN
![Page 27: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/27.jpg)
SHAPe aims to:• Recruit young South African doctors (<11 yrs
from completing medical school)• Offers a salaried research position at HVTUs
in South Africa • Provides an environment conducive to Ph.D.
studies Research project Mentorship teams/ guidance Training (e.g., short-term placements to learn new
techniques, professional development, eLearning)
Opportunities for course work
![Page 28: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/28.jpg)
SHAPe Scholars (July 2011)
• Dr. Shaun Barnabas: Research interests: Impact of genital tract inflammation and cellular activation on mucosal vaccine-induced antibody responses following HIV vaccination
• Dr. Katherine Young: Research interests: Factors within the South African population contributing to differences in immune activation (particularly co-morbid infectious diseases and risk behaviours)
![Page 29: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/29.jpg)
![Page 30: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/30.jpg)
• Carstarphen, Kathy Jo, MAUniversity of Alabama School of MedicineHVTN Site: University of Alabama and LimaMentors: Paul Goepfert and Jorge SanchezProject Title: "Public Perceptions of HIV Prevention Strategies”
• Chiosi, JohnMount Sinai School of MedicineHVTN Site: Cape Town Mentors: Linda-Gail Bekker and Magda SobieszczykProject Title: "Assessing the impact of an HIV education campaign in a peri-urban community of Cape Town, South Africa."
• Garnett, Chris, MPHUniversity of Kentucky School of MedicineHVTN Site: Lima Mentors: Javier Lama and Greg WilsonProject Title: "HIV Vaccine Acceptability Among Groups at High Risk for HIV Infection in Lima, Peru”
2011 RAMP Scholars – 1 of 2
www.hvtn.org/ramp
![Page 31: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/31.jpg)
• Gonzalez, DanielCommonwealth Medical CollegeHVTN Site: FenwayMentors: Ken Mayer and Michele Peak-AndrasikProject Title: "Evaluating the effectiveness of HIV clinical trials recruitment strategies in subpopulations of MSM and MTF transgender individuals“
• Jones, Kathryn Lorraine, Ph.DDuke Medical SchoolHVTN Site: Duke Central Lab Mentors: Julie McElrath and Barton HaynesProject Title: "Characterization of the Memory B Cell and Plasma Cell Repertoires with Functional Analysis of the Antibodies Generated in Response to a HIV Envelope DNA Prime and rAd5 Vector Boost Vaccination Regimen.“
• Lopez Angel, Cesar, JoelStanford School of MedicineHVTN Site: San Francisco Department of Public HealthMentor: Jonathan FuchsProject Title: "Facilitators and Barriers to Participating in HIV Vaccine Trials."
2011 RAMP Scholars – 2 of 2
www.hvtn.org/ramp
![Page 32: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/32.jpg)
Other Research focused Training and Mentorship programs targeting YECIs
• ACTG Minority Scholars Program• HPTN Scholar Program• IAVI Fellowship Program• Europrise PhD program
![Page 33: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/33.jpg)
Summary
• Multiple approaches will be needed to expand training and mentoring opportunities for global audiences of YECIs
• Several groups are developing YECI-focused programs – Relying on distance learning +/- face-to-face
learning• Training Centers of Excellence capable of deploying
multimodal training should be explored
![Page 34: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/34.jpg)
Acknowledgements
• San Francisco Dept. of Public Health– Emily Schaeffer, OCTAVE Series Coordinator
• HSeT– Jean Pierre Krahenbuhl– Mark Breitler– Alain Meystre– Nathalie Debard– Michelle Rossier
• Global HIV Vaccine Enterprise – Amapola Manrique– Jennifer Brunet– Yegor Grigoriev– Alan Bernstein
• Conference Solutions– Kate Porter– Jaclyn Skrivseth
• HVTN – Larry Corey– Jim Kublin– Danna Flood– Blythe Adamson– Alex Berger– Steve Wakefield
– Paul Johnson (Harvard)– Linda Gail Bekker (Desmond Tutu)– Gavin Churchyard
• NIH Office of AIDS Research– Bonnie Mathieson– Jack Whitescarver
![Page 35: Enhancing Training and Mentorship Opportunities for Young and Early Investigators (YECIs)](https://reader035.fdocuments.in/reader035/viewer/2022062218/56816176550346895dd10288/html5/thumbnails/35.jpg)
Discussion questions
• What are high priority, unmet training needs?• What other approaches are being taken to support
training and mentorship that can be developed further?