Endometriosis Talk
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Transcript of Endometriosis Talk
Endometriosis Surgery and Adhesion Prevention
Nicholas Leyland, BASc,MD,MHCM, FRCSC Chief of OB/GYN St Joseph’s Health Centre,Medical Director of Women’s, Children’s and Family Health Program.Associate Professor OB/GYN, University of Toronto.
Left Ureterolysis
*Trademark©ETHICON, INC. 2007
Interceed:
Years of proven efficacy in a wide variety of
procedures: Adhesiolysis
Myomectomy Ovarian Surgery Tubal Surgery Surgical Treatment for Endometriosis
Excellent safety profile Over 10 years of clinical experience
Surgical Approach: Objectives Is Surgery Even Necessary: Indications
What to do: Burn or Cut?
Special Situations: Endometriomas Deep Infiltrating Endometriosis
Adjunctive Surgical Techniques and Prevention of Adhesions
Is Surgery Even Necessary?
Risks – 0.2-3% overall complication rate
Requires additional expertise and training
Reimbursement limitations/OR resources limited
Excellent medical options exist for pain GnRH Agonists, Aromatase Inhibitors, Mirena IUS
Indication for Surgical Management of Endometriosis
Diagnosis
Acute, chronic pain
Significant impact on quality of life
Failure of medical therapy
Infertility investigation and treatment
Endometrioma
Secondary organ involvement (bowel,
bladder, ureter, nerve)
Surgery Pros and Cons
Diagnosis and Treatment
Prolonged therapeutic effect
Fecundity Improvement
(EndoCAN)
Risk of injury to organs
Greater adhesions Limited resources Limited expertise Negative
Laparoscopy
Advantages Disadvantages
Macroscopic appearance of endometriosis
black, red, vesicular POD obliteration Marked distorted anatomy
Endometriotic cysts
Adhesions Bowel endometriosis
Additional Limitations of Surgery
Missed lesions: false negative laparoscopy
Required Expertise –
Most grads not comfortable with advanced
and many basic endoscopic techniques
Ob/Gyn Endoscopy Survey, Raymond,Ternamian,Leyland JMIG 2004
SURGICAL OPTIONS:EXCISION OR ABLATION?
For Endometriosis
Surgical Options: Excision vs. Ablation Excision
Multiple energy modalities (Laser, Scissors, Harmonic)
Ablation Laser,
electrosurgery
Surgical Options: “to cut or not to cut”
Histologic diagnosis Greater depth of
treatment
Requires greater skill
Injury to adjacent organs
Faster Less skill required
Unable to determine full extent
Thermal damage risk
Excision Ablation
DOES SURGERY HELP?
Endometriosis Related Pain
Does Surgery Help Pain?
Sutton et al Fertil Steril 1994 (n=63) Laser ablation + LUNA improves pain at 6
months versus expectant management (63 vs. 23%)
At 73 months, 55% of follow up (n=38) pain free (JSLS 2001)
Abbot J et al. Fertil Steril 2004 (n=39) Lap excision improved pain at 6 months
compared with diagnostic laparoscopy (80% vs. 32 %)
Does Surgery Help Pain?
Cochrane Library: “Laparoscopic surgery reduces
pelvic pain caused by endometriosis”
Laparoscopic surgery for pelvic pain associated with endometriosis (Cochrane Review 2008)Jacobson TZ, Barlow DH, Garry R, Koninckx P
Ablation versus Excision
Limited evidence* Wright et al JMIG 2005 (n=24)
Mild disease, 6 month follow up ALL lesions treated Equally effective BUT did not include
Deeply infiltrating disease
Both likely effective to some degree for MILD disease but more involved disease requires wide excision for pain relief
*Consensus statement for the management of chronic pelvic pain and endometriosis: proceedings of an expert-panel consensus process
Chronic Pelvic Pain/Endometriosis Working Group, GAMBONE et al.
Additional Surgical Skills for Advanced Endometriosis Surgery Ureterolysis Appendectomy Suturing Bowel lesions Cystoscopy Rigid
Sigmoidscopy
Deeply infiltrating endometriosis
May be responsible for “failed surgical treatment”
Identification is difficult Deep Dyspaurenia Rectovaginal exam Rectal Ultrasound MRI
Deep Versus Superficial Endometriosis: What do you see?
Ovarian Endometriomas
Ovarian Endometriomas
Laparoscopic ovarian cystectomyconfirm the diagnosis histologicallyreduces risk of recurrence over
fulgurationreduce the risk of infection at IVFImproves access to follicles and
possibly improve ovarian responseMay impair ovarian reserve
Endometriomas
Tissue specimen Decrease
recurrence
Post op adhesions Risk of decreasing
number of follicles (Ragni et al AmJOG 2004)
Simpler technique ? Preserve
greater ovarian tissue
Risk of Recurrence
Excision Fulguration
Endometriomas
Excision versus Fulguration Recurrence of pain (19 mos vs. 9.5 mos)
Berretta et al Fertil Steril 1998
Recurrence of symtoms at 2 years(15.8% vs. 56.7%)
Re-operation rate (5.8% vs. 22.9%) Alborzi et al. Fertil Steril 2004
Overall: EXCISION OF CYST preferable for PAIN
Ablation versus Excision of Cysts
Cochrane Review 2008:
Authors' Conclusions:There is good evidence that excisional surgery for endometriomata provides for a more favourable outcome than drainage and ablation with regard to the recurrence of the endometrioma, recurrence of pain symptoms, and in women who were previously subfertile, subsequent spontaneous pregnancy rates
Caveat: ART
Excisional surgery versus ablative surgery for ovarian endometriomata
R J Hart, et al The Cochrane Library 2008
ADJUNCTIVE SURGICAL TECHNIQUES
Additional Surgical Options
1.-Adhesion Prevention 2.- Presacral
Neurectomy Significant benefit in select cases but duration unknown (Zullo, Am J Obstet Gynecol, 2003)
3.- Appendectomy Up to 20% diseased in
endometriosis/pain patients
Appendectomy: “The Hockey Stick” Sign
Adhesions:
Despite even the best surgical techniques, post-surgical adhesions form in the majority of patients undergoing gynecologic pelvic surgery
Adhesions following some gynecologic surgery are a major cause of post-operative pelvic pain, infertility, bowel obstruction and the need for repeat surgery.
Adhesion barriers are a method of enhancing good surgical technique in reducing post-surgical adhesions
Post-surgical Adhesions—A common & costly outcome
Despite even the best surgical techniques, post-surgical adhesions form in the majority of patients undergoing gynecologic pelvic surgery
Adhesions following some gynecologic surgery are a major cause of post-operative pelvic pain, infertility, bowel obstruction and the need for repeat surgery6
It is impossible to predict who will develop adhesions or where they will occur
In addition to the emotional cost to the patient, post-surgical adhesions cost the U.S. healthcare system $1.6 billion annually7
Adhesion barriers are a proven method of enhancing good surgical technique in reducing post-surgical adhesions
Interceed:
Years of proven efficacy in a wide variety of
procedures: Adhesiolysis
Myomectomy Ovarian Surgery Tubal Surgery Surgical Treatment for Endometriosis
Excellent safety profile Over 10 years of clinical experience
TAKE HOME MESSAGES
Take Home Messages:
Ideal practice: diagnose and remove endometriosis surgically at same time
Laparoscopic excision and ablation of endometriosis provides pain relief
Pain can be reduced by removing the entire lesions in severe and deeply infiltrating disease
Role for adjunctive procedures is evidence beased
Adhesion barriers have a role
Take Home Messages
Consider Adjunctive Surgical Procedures:
Presacral Neurectomy
Appendectomy
Adhesiolysis and Adhesion Prevention
Approach to Managing Endometriosis:
Available expertise Accurate diagnosis Surgical skills
Anatomy knowledge Dissection skills Knowledge of energy Suturing skills
Specialized team Multi-disciplinary
approach Nurse educator Family physician Bowel surgeon Urologist Pain Specialists
Surgical Approach: Objectives Is Surgery Even Necessary: Indications
What to do: Burn or Cut?
Special Situations: Endometriomas Deep Infiltrating Endometriosis
Adjunctive Surgical Techniques
THANK YOU!