Advanced Paternal Age and Endocrine Disruptors: Two Causes ...
Endocrine Disruptors in Our Environment
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Transcript of Endocrine Disruptors in Our Environment
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Endocrine Disruptorsin
Our Environment
Linda TsengAugust 6th, 2009
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Outline
• Introduction• EDCs of interest• Results and Data• Current and future work
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Introduction
• Definition of EDC– A substance that has an effect in humans similar
to an effect produced by a naturally occurring estrogen, or such other endocrine effect
• Chemical that disrupts any part of the endocrine system
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Introduction
• Why are we interested in them– Harmful to humans & animals alike– Ubiquitously found– Bioaccumulative– Some are recalcitrant
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EDCs of Interest
• PFCs– Surfactants, surface protectors– Fire fighting foams, insecticides, etc.– No known natural degradation pathways
• Bisphenol A– Plasticizers, first used as an estrogen substitute– Polycarbonate plastics– ~15 days in river, ~4.5 hrs in air, ~30 days in soil
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EDCs of Interest
• (Galaxolide)– Fragrance– Shampoo, perfumes, body oils, lotions,
deodorants, soaps, shaving creams, conditioners, furniture polishes, laundry detergents, fabric softeners, etc.
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Results & Data—PFCs
• PFCs
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Results & Data—PFCs
• SC mostly has lower conc than CC• LCC < UCC
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Results & Data—PFCs
• Water conc < sediment conc• Similar conc found at 3 locations
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Results & Data—PFCs
• Higher conc upstream• Higher conc in sediment• Higher conc in CC• Potential sources
– Land use*– Time of day variations– GW recharge– Sediment types
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DEMFlow Direction
Check Sink of Flow Direction
Because there were sinks in the flow direction, the sinks must be filled using Fill on the DEM, and another flow direction was created from the new DEM
Flow Accumulation
Threshold flow accumulation to find river network
Stream Link Snap Pour Points of Watersheds
Identify Watersheds
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Results & Data—PFCs
• Why does CC have more PFCs?– Less developed land cover– GW recharge– Sediment types
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Results & Data—PFCs
• Extraction reproducibility
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Current Research & Future Plans
• BPA extraction from water & sediment– San Diego Creek
• Galaxolide extraction in water & biosolids– Partition of xenobiotics in WWTPs
• Future– Accumulation of xenobiotics in plants