Endocrine Control of Gastrointestinal Function Jack L. Leonard 2004.
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Transcript of Endocrine Control of Gastrointestinal Function Jack L. Leonard 2004.
Endocrine Control of Endocrine Control of Gastrointestinal FunctionGastrointestinal Function
Jack L. Leonard 2004Jack L. Leonard 2004
HormoneHormone ActionAction Release siteRelease site Secretion stimulusSecretion stimulus
GastrinGastrin Gastric acid secretion Gastric acid secretion
Growth of oxyntic gland Growth of oxyntic gland
mucosamucosa
AntrumAntrumduodenumduodenum
Peptides, AAPeptides, AA
DistentionDistention
Vagal activityVagal activity
CCKCCK Gall Bladder contraction Gall Bladder contraction
Pancreatic juice secretion Pancreatic juice secretion
enzymeenzyme
bicarbonatebicarbonate
Pancreatic exocirne growthPancreatic exocirne growth
DuodenumDuodenum
JejunumJejunum
Peptides, AAPeptides, AA
Fatty acids>8CFatty acids>8CAcidAcid
SecretinSecretin Pepsin secretion Pepsin secretion
Pancreatic juice secretion Pancreatic juice secretion
enzymesenzymes
bicarbonatebicarbonate
Pancreatic exocirne growthPancreatic exocirne growth
DuodenumDuodenum Acidfat
GIPGIP Insulin secretion Insulin secretion
Gastric acid secretionGastric acid secretionDuodenumDuodenum
JejunumJejunum
Glucose, AAGlucose, AA
Fatty acidsFatty acids
GI HormonesGI Hormones
PeptidePeptide ActionAction Release siteRelease site SecretionSecretion
stimulusstimulus
MotilinMotilin Gastric andGastric and
duodenal motilityduodenal motilityDuodenumDuodenum
JejunumJejunum
UnknownUnknown
Pancreatic Pancreatic polypeptidepolypeptide
Pancreatic juice secretion Pancreatic juice secretion
enzymeenzyme
bicarbonatebicarbonate
PancreasPancreas ProteinProteinFatFat
GlucoseGlucose
EnteroglucagonEnteroglucagon unknownunknown IleumIleum Glucose
Fat
Candidate HormonesCandidate Hormones
PeptidePeptide ActionAction Release siteRelease site
VIPVIP Relaxes sphinctersRelaxes sphincters
Relaxes gut circular muscleRelaxes gut circular muscle
Stimulates intestinal secretionStimulates intestinal secretion
Simulates pancreatic Simulates pancreatic secretionsecretion
DuodenumDuodenum
JejunumJejunum
Bombesin or GRPBombesin or GRP
EnkephalinsEnkephalins
Stimulates gastrin secretionStimulates gastrin secretion
Stimulates smooth muscle Stimulates smooth muscle contractioncontraction
Inhibits intestinal secretionInhibits intestinal secretion
Gastric mucosaGastric mucosa
Muscosa and Muscosa and smooth muscle smooth muscle of GI tractof GI tract
NeurocrinesNeurocrines
Fed meatFed meat
11 22 33 44
HoursHours
Vo
lum
e V
olu
me
(ml/
15
(ml/
15
min
)m
in)
55
1010
1515
2020
2525
5050
150150
100100
totaltotal
cephaliccephalic
gastricgastric
intestinalintestinaltotaltotal
cephaliccephalic
gastricgastric
intestinalintestinal
Volume SecretedVolume Secretedduring first 2 hrsduring first 2 hrs
The Three Phases of Acid SecretionThe Three Phases of Acid Secretion
BombesinBombesin
++AcetylcholineAcetylcholine
++
SomatostatinSomatostatin--
++
gastringastrin
G-cellG-cell SomatostatinSomatostatincellcell
OxynticOxynticcellcell
sight, smellsight, smelltaste, chewingtaste, chewing
swallowingswallowingconditioned reflexconditioned reflex
++Vagal nucleusVagal nucleus
--
HH++
Cephalic PhaseCephalic Phase
ProteinProteindigestiondigestion
PeptidesPeptidesAminoAminoacidsacids HH++acetylcholineacetylcholine
gastringastrinVago-Vago-vagalvagalreflexreflex
bombesinbombesin
locallocalreflexreflex acetylcholineacetylcholine
StomachStomachdistentiondistention
Gastric PhaseGastric Phase
Absorbed amino acidsAbsorbed amino acids
Intestinal PhaseIntestinal Phase
IntestinalIntestinalEndocrineEndocrine
CellCell
Entero-Entero-oxyntinoxyntin
ProteinProteinDigestionDigestionproductsproducts
HH++
IntestinalIntestinalG CellG Cell GastrinGastrin
Factors Regulating Acid SecretionFactors Regulating Acid Secretion
Factors Regulating Acid SecretionFactors Regulating Acid Secretion
Conditioned stimuliConditioned stimuliSmell, tasteSmell, tasteChewingChewingSwallowingSwallowinghypoglycemiahypoglycemia
Vagus nerveVagus nerve
G cellG cellGastrinGastrin
GastrinGastrin
Acinar cellsAcinar cells
HH220 &0 &
HCOHCO33--
EnzymesEnzymesDuct cellsDuct cells
AcHAcHAcHAcH
Factors Regulating Acid Secretion (cont)Factors Regulating Acid Secretion (cont)
Vagus nerveVagus nerve(vagovagal reflex)(vagovagal reflex)
Parietal cellParietal cell
FatFatProteinProtein
HH++
Peptides + Amino acidsPeptides + Amino acids
E cellsE cells
CCKCCK
CCKCCK
SecretinSecretin
HH220 &0 &
HCOHCO33--
SecretinSecretinAcHAcH
AcHAcH AcinarAcinarcellscells
DuctDuctcellscells
EnzymesEnzymes
FatFatS cellsS cells
H+H+
Pancreatic Enzyme SecretionPancreatic Enzyme Secretion
Pre-PrandialPre-PrandialPancreasPancreas
Monitor peptideMonitor peptide
ChymotrypsinChymotrypsin
TrypsinTrypsin
Small intestineSmall intestine
Post-PrandialPost-Prandial
Food ProteinFood Protein
CCKCCK
Gut – Insulin SecretionGut – Insulin SecretionNeural reflexesNeural reflexes
00
100100
00
100100
10% glucose10% glucose
10% glucose10% glucose
5 min5 min
00 44 88minmin11 2020 4040
100100
5050
00
minmin
Insu
lin
Insu
lin ((
U/m
lU
/ml
Insu
lin
Insu
lin ((
U/m
lU
/ml
2020
4040Oral doseOral dose Intestinal doseIntestinal dose