Endocrine Bone Legends - Columbia
Transcript of Endocrine Bone Legends - Columbia
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Disorders of Bone Mass
OsteoporosisDefinitionLoss of bone mass associated with deterioration of bone architecture and increasedsusceptibility to fracture
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Epidemiology
75 million in US, Europe and Japan300,000 new hip fractures/ year500,000 vertebral fractures/ year1 of every 4 postmenopausal women
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Osteoporosis Risks Factors
Genetic• Race • Familial
prevalenceAge/ Sex
Endocrine• Menopause • Ovarian/
testicular dysfunction
Osteoporosis Risks Factors
Nutritional• Low calcium • High alcohol• High caffeine/
sodium• High anim. protein
Lifestyle• Low physical
activity• Cigarette
smoking
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• Postmenopausal• Age-related• Idiopathic
OsteoporosisPrimary
• Endocrine disorders• Gastro-intestinal diseases• Chronic Inflammatory diseases• Malignant neoplasms• Connective tissue disorders• Drug-induced
OsteoporosisSecondary
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Endocrine• Ovarian/ testicular dysfunction
early menopause• Cushing syndrome• Hyperthyroidism• Hyperparathyroidism (severe)
OsteoporosisRisk Factors
Fracture sites• Spine• Hips• Distal radius (Colle’s fracture)• Proximal humerus
OsteoporosisClinical
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Unsuitable for early detectionIndicate advanced disease
RadiologyRoutine Xrays
• “Fish-mouth” deformity• Thin cortices• Diffuse osteopenia• Old or current fractures
RadiologyRoutine Xrays
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Diseases of Mineralization
RicketsOsteomalacia
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RicketsPathogenesis
Defective mineralization/ turnover
• Bone matrix• Growth cartilage
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• Cranio-tabes/ frontal bossing• Widely opened fontanels• Rachitic rosary• Harrison groove/pigeon breast• Swelling of wrists and ankles• Genu valgum/ varum
RicketsClinical
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Long bonesDeformitiesFractures
Growth platesBlurred/WidenedEpiphyses cup-
shaped
RicketsRadiology
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Defective mineralization/ turnover
• Bone matrix
OsteomalaciaPathogenesis
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• Bone pain• Fractures• Proximal myopathy• Muscle weakness• Waddling gait
OsteomalaciaClinical
Bowing of long bones (genu varum)
Pseudo-fractures “Looser’s lines”
Fractures (Milkman)
OsteomalaciaRadiology
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Rickets/ OsteomalaciaHistopathology/ Morphometry
↑ ↑↓↑
↓↓
• Osteoid surface/thickness • Mineral apposition rate• Mineralization lag time/
osteoid maturation• Tetracycline double labels• Bone formation rate/
activation frequency
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Renal OsteodystrophyDefinition
A spectrum of skeletal abnormalities resulting from renal failure
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Renal OsteodystrophySubtypes
• Secondary hyperparathyroidism• Mixed bone disease• Low bone turnover
Pure osteomalaciaAplastic/ adynamic bone disease
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CLASS OF 2008
Thank you!