Endocrine 1- Path Pics Pituitary infarction The architecture of the pituitary is retained with the anterior lobe at the top of the picture. The whole gland is necrotic and an area of haemorrhage can be seen Histology of pituitary infarction with a surviving rim of pituitary on the outer surface of the gland in one corner (arrows) A large adenoma (arrows) has filled and expanded the pituitary fossa in a woman aged 54 A large adenoma (arrows) of the pituitary compressing the optic chiasma Pan hypo pituitarism. From top to bottom: pituitary fossa with a recurrent pituitary gland adenoma filling and expanding the pituitary fossa, gross atrophy of thyroid, adrenal cortex and testis A man aged 71,presented with decreased libido, shaving only every third day, cold sensitivity, tiredness, headaches and bitemporal hemianopia. Craniopharyngioma (arrows) causing internal hydrocephalus Girl aged 10 years. She presented with the signs of raised intracranial pressure, headache and vomiting. Histology of craniopharyngioma showing nests of squamous cells merging into columnar cells surrounding cystic spaces. Bisected adrenals. Extensive necrosis and granulomatous inflammation due to Cryptococcus neoformans infection. This is one cause of Addisons disease. Tuberculosis also causes destruction of the adrenal medulla. Extensive haemorrhage into both adrenals in a male aged 10 months with meningococcal septicaemia Adrena l cortical atrophy in a woman aged 57 with aplastic anaemia who was given large doses of prednisone (40-90mg/day) during the last 4 months of life. Note how thin the cortex (blue arrows) is compared with the medulla (red arrows) Adrenal cortical hyperplasia Nodular adrenal cortical hyperplasia: an incidental autopsy finding in a woman aged 54 who died of suppurative pyelonephritis. Adrenal cortical adenoma Carcinoma of the adrenal cortex in a male aged 11 months who presented with virilization. Operative surgical specimen. (The hole in the cut surface of the specimen is an artefact.) Carcinomas of the adrenal cortex are generally much larger than adrenal adenomas. Haemorrhage and necrosis are also characteristic of carcinomas and not adenomas Phaeochromocytoma of the adrenal. Note its location in the medulla see the residual cortex at the edge of it (blue arrows). The redbrown colour is characteristic and quite different to the yellow of adrenal cortical hyperplasia and neoplasm The cells are similar to those of the normal adrenal medulla but are arranged in broad trabeculae or islands. Bilateral adrenal secondaries from a primary lung cancer