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End-replication problem
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End-replication problem. Repetición telomérica : TTAGGG. Mecanismo de acción de la telomerasa. Extremo 3´ DNA telomérico. Actividad de telomerasa: Ensayo TRAP. Actividad de telomerasa: Ensayo TRAP. Límite de Hayflick. Determinación del largo del telómero. - PowerPoint PPT Presentation
Transcript of End-replication problem
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End-replication problem
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Repetición telomérica: TTAGGG
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Mecanismo de acción de la telomerasa
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Extremo 3´ DNA telomérico
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Actividad de telomerasa:
Ensayo TRAP
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Actividad de telomerasa:
Ensayo TRAP
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Límite de Hayflick
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Determinación del largo del telómero
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Reducción telómerica en sucesivas generaciones
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Estabilización del telómero por la telomerasa
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Cancer and telomerase
What price immortality?
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Blasco (2005) Nature Reviews Genetics 6, 611-622
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Extensión de la vida de células somáticas por expresión de
telomerasa
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¿Qué pasa con estos ratones?
• mRT -/-• p16INK4a -/- ; ARF -/-• mRT -/- ; p16INK4a -/- ; ARF -/-• p53 -/-• p53 -/- ; mRT -/-
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