ELIMINATION OF CANCER CELLS BY RESISTIVE HEATING USING COMSOL MULTIPHYSICS

ABSTRACTThe elimination of cancer cells is done using

resistive heating method. Many methods are adopted for cancer

elimination. But this resistive heating method will be

more useful for eliminating the cancer cells. By using mems and COMSOL Multiphysics

techniques by resistive heating method, the cancer cells will be get eliminated.

CANCERCancer is the uncontrolled growth of

abnormal cells in the body. Cancerous cells are also called malignant

cells. Symptoms of cancer depend on the type and

location of the cancer

SurgeryChemotherapyImmunotherapyHormone therapyGene therapyRadiation – The method we use.

Radiation methodRadiation treatment, also known as

radiotherapy, destroys cancer by focusing high-energy rays on the cancer cells.

This causes damage to the molecules that make up the cancer cells and leads them to commit suicide.

Radiotherapy utilizes high-energy gamma-rays that are emitted from metals such as radium or high-energy x-rays which are created in a special machine.

Resistive heatingThe material heats up when an electric

current passes through it due to electric resistance.

The material’s electric resistance varies with the temperature, increasing as the material heats up .

TARGETING THE CANCER CELLSAn optimize clinically relevant parameters is

to maximize thermal energy deposition at the tumor site and minimize thermal diffusion.

The parameters include nanoparticle concentration, molecular bond ,energies external magnetic field strength and frequency.

COPPER INSULATIONCopper is selected as the heat material since

it has a good thermal response at relatively low voltages and a resistivity that exhibits a highly linear dependence on temperature.

This property also makes copper a suitable candidate for use in temperature sensors.

THERMAL INSULATIONFor the thermal boundary conditions, an air

stream at 300 K (27 °C) cools the plate except on the thermally insulated upper and lower edges.

In Joule heating, the temperature increases due to the resistive heating from the electric current.

HEAT TRANSFERResistivity at reference temperatureReference temperatureTemperature coefficientElectric potential

Initial condition of heat transfer

MATERIAL PROPERTIES FOR HEAT TRANSFERDensityHeat capacity at constant pressureIsotropic for thermal conductivityHeat source

Material properties are applied

Output of heat transfer

Boundary condition of heat transfer

Mesh generationThe models that have

been developed were first used to optimize the design of a small bench-top device for heating samples.

Part of the mesh from a simulation of the magnetic fields.

The cancer cells are targeted by the magnetic particles.

 

Mesh generation

Computing the solutionThe heat transfer in this model is a transient

process, so the model uses a time – dependent solver for transient analysis.

Resistive heating applied in the copper plate

Post processing and visualization

Resistive heating to target the cancer cellsArrows indicating the heat to target the

cancer cells.

Complete model – resistive heating

Final Output- various temperature

Final output- resistive heating

CONCLUSIONThe design that was developed optimizes the

temperature uniformity in a localized chamber within the chip as well as on the metal film’s surface, as desired.

Being able to provide uniform heating of the chamber and to utilize the element simultaneously as both a heater and a sensor was the intent.

The variations in the temperature determines the heat that is sufficient to destroy tumor.

Resistive heating according to the body condition it provides the heat from 300k to 370k to destroy the tumor cells .