Eis Training

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Technical support

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FDA & CE Registration Data File

Product Code: HCC Regulation Number: 882.5050 Manufacturer, Specification developer:

L.D Technology Biofeedback Class 2

Class 1 Active, non invasive medical device for

diagnostic and monitoring


93/42 CEE

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Clinical investigations

In progress:

IRB FDA approval: Harvard Medical School

McLean Hospital: New possibility for diagnosis of unipolar and bipolar depression

Gustave Roussy Institute (Oncology France)

Saint Louis Hospital (Andrology France)

Botkin hospital (meta analyses Moscou)

Marfino center( biochemical value and BIM Moscou)

Botkin Hospital (Follow up therapy Moscou )

Caudal Frederique ( ADHD children France)

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Indications and Intended Useof the EIS SYSTEM.

Estimation of the Body composition:

The applicable age range is 10 to 80 years old for sedentary subjects. For athletically active subjects, the applicable range is 16 to 60 years old.

By organs:Estimation of Physiological tissue and

blood parameters: pH, O2, pressure

Applicable age range is 5 to 80

In general:Estimation of Interstitial fluid biochemical values: pool of

ionograms, hormonal, neurotransmitters

Applicable age range is 5 to 80

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Clinical applicationsof the EIS SYSTEM.

The EIS System is a non-invasive bio-impedance analyzer used in estimating:

Neurologic disorders

Lifestyle evaluation

Pains visualization and evaluation

Early Treatment or lifestyle change Follow-up and visualization

Nutritional analysis

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• The interpretation of the EIS System requires medical knowledge in the areas of physiology, adequate references, the subject’s clinical context, and a list of variables which can modify the interpretation of results. The interpretation is the responsibility of the health care professional.

• The EIS System does not replace any existing medical examination

• This device is not intended to be used for therapy, or treatment of diseases.

• The result of the EIS BIM without any abnormal values does not mean that the subject is healthy; it means only that there are no detected physiological disorders at the tissue levels.

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Contraindications are situations making it impossible to take an accurate EIS measurement/scan, and/or to make a correct interpretation of the data gathered.

Dermatological lesions in contact with the electrodes or excessive perspiration

Presence of defibrillators, cardiac pacemakers, patients connected to electronic life support devices, or any implanted electronic device

People unable to be scanned while seated or standing

Metal pins or prostheses at the level of the extremities or the jointsPregnant women ([6 months-plus] the effects on the fetus, as well as accuracy of readings are


Absence of one or more limbs

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Undesirable Side Effects and Adverse Reactions

The EIS device delivers far less electrical energy than many other common biomedical devices.

Specifically, 84.5 milliJoules (mJ; or 0.0845 J) of electrical energy pass into the body, distributed across different anatomical regions, in the 110

seconds of active scanning during an EIS examination.

Expressed as electrical power (electrical power is defined as Watts [W])-- One Watt = 1 Joule/s) -- the EIS device operates at 0.00077 W.

The EIS System

To put this figure in perspective, compare the 0.00077 W to a standard incandescent light bulb using 60 W of electrical power. The light bulb draws nearly seventy eight thousand (78,000) times more energy than the EIS device.

No side effects or adverse reactions are known to date.

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Power supply 5V (power supply by USB port)

Type of Current Direct currentPower consumption 200mA Classification Class IIDegree of protection against electric shocks BF

Operating mode Continuous useTension on the electrodes, in operating mode 1,28 V

Speed transmission

12 Mbd Galvanic decoupling of the analogical part,

3 KV

Dimensions in mm

128 X 143 X 33 Weight kg


Component Technical specifications2 disposable forehead electrodes Ag/AgCl @ 15.75 cm2

2 reusable hand plates Polished stainless steel grade AISI 304 Size:272 cm2

2 reusable feet plates Polished stainless steel grade AISI 304 Size :330 cm2

3 audio-type cables to connect electrodes/ plates to the electronic controller box

long armored insulated cables. Color-coded for ease of use. Red one on the leftBlack one on the right

USB cable long standard USB cable connecting electronic controller box to PC.

PC See requirement of the computer

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Computer specifications

Windows XP, ….

Apple Mac systems requirements of Windows

Processor type Intel Pentium 4, Pentium M INTEL Dual Core Processor or higher

RAM 512 Mo

Hard Disc or Higher

Graphics card Minimum memory 128KGaming cardDesktop:ATI Radeon X300, X600, X800 or higher  NVIDIA 6200, 6400, 6600 or higherIntel 945 or higherLaptop:ATI mobility Radeon X300, X600, X800 or higher  NVIDIA Ge Force Go 6200, 6400, 6600 or higherIntel 945 or higher

Screen Size Any

Screen Resolution 1280 X 800

Accessory Software Word or WordPad or Open Office

Accessory USB Ports 2.0

Accessory CD or DVD-ROM

Accessory Audio

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Touch screen

Hand plates

Feet plates

Patient’s chair


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The EIS System Uses the impedance technique

Bioelectrical Impedance Measurements (BIM)

1. Schoeller DA. Bioelectrical impedance analysis. What Does It Measure? Ann NY Acad Sci. 2000;904:159-162.2. Rigaud B, Morucci JP. Bioelectrical impedance techniques in medicine. Part III: Impedance imaging. First

section: general concepts and hardware. Crit Rev Biomed Eng. 1996;24:467-5973. Jain RK. Transport of molecules in the tumor interstitium: a review. Cancer Res. 1987;47:3039-51.4. Brodie D, Moscrip V, Hutcheon R. Body composition measurement: a review of hydrodensitometry,

anthropometry, and impedance methods. Nutrition. 1998;14:296-310.

A non-invasive technology where a diminutive electrical current is applied to the body via a surface electrode, and the electricity that passes through the body is detected at other surface electrodes placed elsewhere on the body.

A drop in voltage occurs as the current encounters A.C. impedance (D.C. resistance) inherent in the fluids and tissues through which it passes, as it courses through the body’s physiological compartments.(1)(3)

These compartments include the bloodstream, the intracellular space, the lymphatic system, the interstitial space, and others(3)(4); providing indirect data about the physical and chemical properties of the compartments.

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Total water60%

Extra cellular water 20%

Interstitial fluid16%

250KHz 50KHz D.C

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1. Sports & Health MedicineBody Mass Measuring Devices (ratio of lean mass to fat mass)

"The Biological Impedance Analyzer resistance readings were extremely stable. They exhibited virtually no change within the five measurements when the electrodes were kept in place. The accuracy of the measurement of resistance was checked using 250, 400, 500 and 750 ohm precision resistors. The measured resistance did not deviate from the expected values by more than ± 2%."

Segal, K.R., Gutin, B., Presta, E., Wang, J., Van Itallie, T.: Estimation of human body composition by electrical impedance methods: a comparative study. Journal of Applied Physiology, 58 (5): 1565-1571, 1985.

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APPLICATION OF IMPEDANCE IN MEDECINE 3.Medical Tomography (breast cancer screening)

The T-Scan™ 2000 is an electrical impedance scanning device that received approval for marketing from the U.S. Food and Drug Administration (FDA) in 1999, with the following labeled indication: "The T-Scan™ 2000 is intended for use as an adjunct to mammography in patients who have equivocal mammographic finding with ACR Bi-RADS™ categories 3 or 4…”

Electrical impedance studies are used as an adjunct to mammography to improve patient selection for biopsy in patients with equivocal indications. The T-Scan™ 2000 boasts the same accuracy percentage as mammograms.

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The EIS System’s specificityAdvanced Patented Technology

Bioelectric impedance measuring systems typically deliver to the body A.C. electricity at a wide range of imperceptible currents, frequencies, and voltages that are far below any level that could cause cellular or tissue damage.(1)(2)

Studies of A.C. bioelectric impedance measuring systems operating at 50 MHz or higher revealed that these high frequency A.C. electric currents flow non-selectively through both intracellular and extracellular spaces.(3)

However, unlike A.C. bioelectric impedance, the electric current produced by D.C. bioelectric resistance methods distinctively passes only through the interstitial fluid compartment.(4)

1. Gandhi OP. Electromagnetic fields: human safety issues. Annu Rev Biomed Eng. 2002;4:211-34.2. Valentinuzzi ME. Bioelectrical impedance techniques in medicine. Part I: Bioimpedance measurement. First

section: general concepts. Crit Rev Biomed Eng. 1996;24:223-55..3. Hanaki N, Ishikawa M, Nishioka M, Kashiwagi Y, Miki H, Miyake H, Tashiro S. Bioelectrical impedance analysis to

assess changes in body water compartments after digestive surgery. Hepatogastroenterology. 2006;53:723-9.4. Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg P, Elia M, Gomez JM, Heitmann BL, Kent-Smith L, Melchior JC,

Pirlich M, Scharfetter H, Schols AM, Pichard C; Composition of the ESPEN Working Group. Bioelectrical impedance analysis--part I: review of principles and methods. Clin Nutr. 2004;23:1226-43.

A.C. – D.C. paths through the body

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Total water60 % total

body water

Extracellular water 20% total body water

Interstitial fluid16% total body water

250KHz 50KHz

D.C.Since D.C. electricity only passes through the interstitial fluid and the interstitial fluid is not buffered, abnormalities in the chemical composition of the interstitial fluid can be detected with an adequately sensitive D.C. bioelectric impedance measuring systems/device – The EIS System.

Most physicians are forced to ignore the data of 16% of the body composition and function, as this data is stored in the interstitial fluids and is not available for analysis -- until now.

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2. Any substance passing between cells and the bloodstream must traverse the interstitial space. These substances include oxygen, carbon dioxide, glucose, as well as thousands of other compounds .

• (Gilanyi M, Ikrenyi C, Fekete J, Ikrenyi K, Kovach AGB. Ion concentrations in subcutaneous interstitial fluid: measured versus expected values. Am J Physiol 1988;255:F513-9)

• Niels Fogh-Andersen, Burton M. Altura, Bella T. Altura, and Ole Siggaard-Andersen; Composition of Interstitial Fluid CLIN. CHEM. 41/10, 1522-1525 (1995)

• Importance of the Cotrell equation for biosensors study.Journal of Applied Physiology 67(5): 1210-1519, 1998• Nyboer J, Bango S,Barnett A and Halsey RH: Radiocardiograms-the electrical impedance changes of the heart in relation to electrocardiograms and

heart sounds.J.Clin. Invest. , 19:963 ,1940

Image source: http://training.seer.cancer.gov/module_anatomy/unit7_3_cardvasc_blood2_physiology.html

No direct methods for No direct methods for sampling interstitial fluid are currently available. interstitial fluid are currently available.

The composition of interstitial fluid, which constitutes the environment of the cells and is regulated by body homeostasis, has previously been measured by the suction blister or liquid paraffin techniques, or by implantation of a perforated capsule or wick.

1. Interstitial fluid differs from whole blood by the absence of red blood cells, and it differs from blood plasma in that there are far fewer proteins (51). The absence of haemoglobin and poor level of proteins which are the main buffers of the blood system explains a more acid interstitial pH(7.33) and more importantly, the variations in interstitial fluid gases and blood gases .

The results varied, depending on the sampling technique and animal species investigated.(1)

3. The volume of the interstitial fluid is closely related to the containing sodium pool

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When the sodium concentration decreases in the interstitial fluid, the sodium moves inside the cell and affects the tissue(s) as follows:

1. Cellular volume increases

2. Mitochondrial activity decreases and ATP production decreases

3. Oxygen consumption decreases

4. Intracellular exit of K+, and H+ ions to the interstitial fluid causing an interstitial acidosis and an intracellular alkalosis. Note that The interstitial and intracellular acid base balance are according to cells activity due to the absence of haemoglobin and proteins (buffers)

5. An interstitial Chlorine retention and a corresponding retention of intracellular bicarbonate

6. CO2 increases interstitially resulting in an increase in the elimination of CO2 via blood circulation by the lungs

7. Interstitial fluid volume decreases, the oncotic pressure is more high that the hydrostatic pressure

8. Blood microcirculation: vasodilatation and blood viscosity decreases

Cells activity and ionic equilibrium

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H+ H+ H+ H+H+



Carbonic Anhydrase







Vasodilation and reduce the flow and viscosity


Volume reduced

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When the sodium concentration increases in the interstitial fluid, the sodium moves outside of the cell and affects the tissue(s) as follows:

1. Cellular volume decreases

2. Mitochondria activity increase and ATP production increases

3. Oxygen consumption increases

4. Interstitial K+ and H+ ions move into the cell causing an interstitial alkalosis and an intracellular acidosis

5. Interstitial Chlorine moves to intracellular space, and a corresponding intracellular decrease of bicarbonate

6. Interstitial CO2 decreases and a corresponding decrease in the elimination of CO2 via blood circulation by the lungs

7. Interstitial fluid volume increases, the hydrostatic pressure is more high that the oncotic pressure

8. Blood microcirculation, vasoconstriction and blood viscosity increases

Cells activity and ionic equilibrium

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H+ H+ H+ H+H+



Carbonic Anhydrase







Vasoconstriction and increased blood flow and viscosity

Volume increased

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Effect of intercapillary distance on relation between oxygen delivery and consumption when delivery is reduced by hypoxia (a fall in Pao2), reduced flow (stagnant), and anaemia (fall in

haemoglobin concentration)BMJ. 1998 November 14; 317(7169): 1370–1373. Copyright © 1998, British Medical Journal

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Oxygen haemoglobin dissociation curve. The curves hifts to the right with increased temperature,acidosis,and2,3 diphosphoglycerate concentrations

BMJ. 1998 November 14; 317(7169): 1370–1373. Copyright © 1998, British Medical Journal

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Corresponding Values ofbody compartments

Biochemical constants

Venous blood

Arterial blood

Capillary blood

Intracellular fluid

Interstitial fluid

Na+ mEq/l 130 137 135 10 130

K+ mEq/l 3.2 3.5 4 140 3.17

Ca++ mEq/l 2.5 2.2 2.3 0.0001 1.55

Mg mEq/l 0.64 0.62 0.60 58 0.50

Cl- mEq/l 104 101 103 4 106

HCO2 mEq/l 22 24 23 10 24

P mEq/l 2.5 2.3 2 75 0.70

SO4 mEq/l 0.8 0.6 0.5 2 0

Glycemia mg/dl 1 1 1.01 0.20 0.90

Cholesterol mg/dl 0.65 0.630 0.676 0.2 0.188

pO2 mmHg

80 90 89 20 87.2

pCO2 mmHg 46 40 42 50 46

pH 7.35 7.4 7.38 7.0 7.33

Proteins gm/dl 72 74 73.7 68 20.6

Reference Studies: Niels Fogh-Andersen, Burton M. Altura, Bella T. Altura, and Ole Siggaard-Andersen CLIN. CHEM. 41/10, 1522-1525 (1995)

Gilanyi M, Ikrenyi C, Fekete J, Ikrenyi K, Kovach AGB. Ion concentrations in subcutaneous interstitial fluid: measured versus expected values. Am J Physiol 1988; 255:F513-9

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Modeling and localization of the organs

Mathematical principles:Direct methodsInverse problems

Electro Interstitial ScanElectro Interstitial ScanE.I.SE.I.S

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Foreword on modeling

• The E.I.S device allows a modeling of the human body.

• What is modeling? • Modeling is not the same imagery

conventionally used in medicine. The approach is more like that of a physicist. We reduce the diversity and complexity of the bodily functions by an appropriate choice of assumptions and measurements.

• We choose for EIS modeling the following parameter: the conductivity of interstitial fluid

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Modeling design

Modeling is a mathematical reconstruction using:• Direct problem: direct measurements analysis• Inverse problem:The mathematical algorithms of the

“inverse problems” based upon the following principle:

Each phenomenon is governed by equations with parameters, like the initial conditions or various coefficients; when some of these parameters are unknown, we are within the framework of inverse problems, and we can find the unknown parameters using the results of experimental measurements to solve the problem.

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Twenty-two (22) volumes of interstitial fluid are sampled during the EIS.

Measurement in direct problem.

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Venn Diagram

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How The EIS System’s Advanced Patented Technology Operates

Patients’ Reference Values












1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22



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Atherosclerosis Hypertension associated with renal calculi

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How The EIS System’s Advanced Patented Technology Operates


Cerebral circulatory disorders Behavioral disorders

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How The EIS System’s Advanced Patented Technology Operates


Ulcers Hepatitis

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Chromatology andParameters

Electro Interstitial ScanElectro Interstitial ScanE.I.SE.I.S

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Osseous density reduce

Chronic inflammation

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ATP Edema


Neuronal excitability



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Electro Interstitial ScanElectro Interstitial ScanE.I.SE.I.S

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D. C in V I in A



1 2 3

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Electro Interstitial ScanElectro Interstitial ScanE.I.SE.I.S

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How The EIS System’s Advanced Patented Technology Operates

In just three (3) consecutive steps, The EIS System generates 3 diverse pulse sequences, for different durations.










1 A.C. 1 sec. 221. Body composition

2. Improve signal-to-noise ratio

2 D.C. 1 sec. 221. Interstitial conductivity measurement

2. Determine maximum conductivity value and modeling

3 D.C. 3 sec. 221. Interstitial biochemical analysis

2. Determine minimum conductivity value

Body compositionSignal-to-signal ratio

A.C. 50KHz

Interstitial fluidMaximum conductivity


Interstitial fluidMinimum conductivity


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Tissue parameters and microcirculation

Electro Interstitial ScanElectro Interstitial ScanE.I.SE.I.S

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Statistical risk analysis

Electro Interstitial ScanElectro Interstitial ScanE.I.SE.I.S

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Statistical Functional RisksStatistical Functional Risks

Respiratory functional risk

Cardiovascular functional risk

Renal & Urogenital functional risk

Endocrine functional riskDigestive functional risk

Neurological functional riskImmune functional risk

Neuromuscular functional risk

Metabolic general functional risk

Statistical functional Risk Analysis

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Interstitial biochemical values

Electro Interstitial ScanElectro Interstitial ScanE.I.SE.I.S

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Interstitial fluid Ionograms

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Anti-Aging Medicine Oxidative stress and Entropy

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Acid base balance:Davenport Diagram

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2 34












86 Cardiovascular risk

Respiratory riskType II Diabetes

5 Cardiovascular and

Respiratory risk

4 Hypertension



3 Cardiovascular risk Digestive


2 HypertensionNephropathy


9 Neuromuscular or

articular or osseous disorders

7 - 8 Respiratory risk

1 -22 Digestive and osseous


10 Neuromuscular

and osseous risk muscular



11 -12 · Chronic asthenia · Depressive states, . Migraines·Digestive disorders

13 Cancer

Chronic hepatitis

14 Renal disorders


15 Hepatic


Respiratory disordersDrugs side effects

18-19 Respiratory risk20

Hepatic disorders

21 Hepatic and

pancreatic disorders

16 Cardiac

insufficiency and Drug or food side


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BODY COMPOSITIONThe calculation of the body composition is made according to the Bioelectrical Impedance Analysis (BIA) .The BIA is segmentary analysis and uses a range of frequencies between 5Hz and 200 KHz.

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LIFESTYLE AND NUTRITION AND MICRO NUTRITION• The recommended or not recommended

foods are temporary (4- 6 weeks), and will be revised at the next examination:

• The recommendations are compiled by a statistical analysis program which considers the acid-base balance, the main functional risk, the brain analysis ,the BMI and the body composition. Only the EIS can incorporate all parameters to correctly analyse the best nutrition for each person

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Nutritional and micro nutrional program Analysis


Acid base balance

Body composition Risk

Brain analysis

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Application in your clinical Practice

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Aide à la consultation Assistance at the consultation

The patient is not always capable of objectively describing his or her symptoms. Often they exaggerate

or under-estimate symptoms or choose not to speak of them because they are taboo or

so old that they are part of the daily routine. In addition, certain diseases in development or

established present no symptoms.The EIS system which allows the visualization of parameters

of tissues and blood helps guide the consultation and eventually helps to better understand the patient’s psychological factors and, through a statistical analysis

of the risk involved, to prescribe certain targeted supplementary examinations.

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Aid to therapeutic decision making

• the calculations performed by the computer are 1000 times quicker than the human brain (the computer can perform 50,000 operations each second). Nowadays practitioners who practice functional medicine are in the same position as were accountants before the adding machine. The adding machine has not done away with the accountant; it simply allows the accountant to perform his profession differently. The EIS, with its measured parameters and analytic software, can represent the same advance and change the means of exercising the medical profession into one more rational with higher mastery.

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Therapeutic follow-up• Through visualization of a tissue’s parameters , the EIS

is positioned as the first step to visualization for all treatments. Actually, whether the treatment is allopathic or functional (alternative) or nutritional or micro nutritional, the results are quickly seen firstly at the level of cellular activity of the targeted organ and therefore at the tissue level, much later at the blood level and even later at the structural level (imagery).

• In addition, this therapeutic follow-up is non-invasive and very low cost. There are no good or bad treatments. There is only a treatment adapted for each person. With a therapeutic follow-up you can, as quickly as possible, visualize if a treatment is correct for the patient... whether it is effective, adapted and if there are side effects. This aspect is important for the practitioner who can at all times control and master the treatment (efficacy, side effects, dosage) and equally for the patient who can visualize their good prescription and the control of his or her treatment.

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Biofeedback therapy for certain dysfunctions and stress• The biofeedback therapy proposed by EIS

permits regulating certain parameters of tissues and blood and from this, to rebalance certain dysfunctions such as digestive problems, stress, insomnia or chronic fatigue, etc.

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Improves patient compliance with their treatment• The ability to visualize by EIS modeling of organic

problems in connection with certain symptoms reassures the patient. In effect, some pains or symptoms which have no explanation at the level of conventional exams can leave the patient feeling hopeless and/or helpless, since practitioners may propose no treatment, or treatments that are often difficult to understand (functional or alternative medicine).

• By visualizing an improvement of values by EIS modeling, the patient can better accept the treatment.

• Likewise, a patient who presents with a pathology and for whom the practitioner prescribes an allopathic treatment of long duration needs reassurance of its efficacy, its correct dosage and eventually that it does not cause side effects that are more dangerous than the illness for which he or she is being treated.

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Positioning of EIS device as a supplementary examination in neurology

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Positioning of EIS device as a supplementary examination in cardiology

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ONCOLOGY• The tests carried out at the Botkin hospital in 2003 made

it possible to determine an important specificity (80%) for cancer. However, this specificity was calculated around only one parameter: the pH of interstitial fluid (metabolic acidosis). This specific parameter has also been confirmed by several respected publications (62) (63).

• However, the sensitivity scoring is very low and therefore the EIS scan, as a screening, can not be considered to be a validation and marker for cancer. However, the EIS scan has validity as a therapeutic follow up (i.e. as in cancer treatment with chemotherapy) to determine the effectiveness of treatment, and to find associated side effects caused by the treatment. This has been confirmed by the pre study made in Gustave Roussy Institute (France 2002).

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Therapeutic follow up

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Effect of oxygenation (20 minutes).

You can see the effect on the digestive system (vasodilatation)

and in the brain (neuronal excitability increased).


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Effect of anti-biological therapy (treatment for Escherichia coli after 1 week)

You can see the vasodilatation of organs and reduction of infection.

Effect of antidepressant (IRSS after 45 days)

The neuronal excitability became normal.


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Follow up of thyroid treatment 1

TSH 9 before treatment dose 80µg

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Follow up of thyroid treatment 2

dose 120µg dose 100µg

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Hormonal assessment and follow-up over the course of one 1 year.The doses prescribed can be adjusted until satisfactory stabilization is reached.

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Effect of chemotherapy (after 1 week). You can see in Davenport Diagram before the treatment (metabolic acidosis) and after the treatment (metabolic alkalosis)

Effect of hypotensor and anti-aggregate drugs (after one month).

In Davenport Diagram before the treatment (metabolic alkalosis) and after treatment (metabolic acidosis) results are obvious.


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Effect of auriculopuncture on the catecholamine after 10 minutes (Right ear: Cosmonaut, O’, SPM points)



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Effect of Homeopathy after 20 minutes: Nux Vomica 6X


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Effect of Homeopathy after 20 minutes: Nux Vomica 6X


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Biofeedback Effect EIS for reduce the stress (9 minutes)


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Effect of one egg by day in the diet for a strict vegetarian (result after 6 weeks)


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Time necessary for follow-up as a function of treatment:• Auricular acupuncture, somatic acupuncture, homeopathy,

biofeedback: 5 minutes

• Chiropractic: immediately following the appointment

• Plant therapy, micro nutrition, oligo elements, nutrition: 6 weeks

• Allopathic treatments:

Antibiotics: 3 days

Hypotensive therapies: 3 weeks

Antiagregants: 3 weeks

Anticoagulant: 24 hours

Diuretics: 3 weeks

Antidepressants: SSRI: 45 days

Surgery: 24 hours

Chemotherapy: 1 week

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Help in Interpretation

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• 1. The results obtained by the EIS system should not be used imperatively to confirm nor deny laboratory tests, the results of imagery devices, or an electrical activity recording device. Each medical examination or evaluation has its own specificities and results on the same organ can be different according to the technique used . EIS scanning brings new elements of a complementary nature such as physiologic tissue and blood parameters as well as the biochemical values of the interstitial fluid.

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2. Biochemical values, EIS and Laboratory tests: further comments

• There are differences in concentration of the biochemical values for each compartment.

• All the values of interstitial fluid are different from the laboratory tests

For 2 reasons:The interstitial fluid is static no circulatory

The biochemical interstitial values are the pool of a substance and not the concentration

• The pH values are different, (i.e. than arterial blood) because interstitial fluid does not have the main blood buffering elements (such as Haemoglobin and proteins). The acid base balance of interstitial fluid is regulated by the cells’ activity and the electrolytic balance between the extra and intracellular medium.

• The clinical investigations at Botkin Hospital (Moscow 2006) show that the results of TSH from EIS system have similar evolution to the TSH results of venous blood.

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3. The EIS modelling is a representation of the organs as well as the physiopathology of interstitial fluid which traverses them. The physiopathology of interstitial fluid will be a direct reflection of the cellular activity of these organs. EIS does not give information about the physical structure of organs.

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4. The risk analysis and the possibility of disorders are statistical and come from algorithms made from clinical investigations included in external statistical program . These possibilities are not diagnostic

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5. The interpretation of an EIS scan must not be based only upon a comparison between the result(s) and the reference values provided by the scan. Interpretation also requires a definition of physiological limits. On the other hand, physiological limits of decision fluctuate according to the objectives:– Established diagnosis – Follow-up of the patient– Diseases considered– Possible therapies – Prevalence

Just like laboratory tests, the interpretation of the EIS requires that the user has medical knowledge of adequate references and a list of variables which can modify the results

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6. The EIS device provides a lot of results, but for the interpretation of cases, you do not need all the data. The EIS device is a modeling of the human body and perhaps my point will be better understood if we make a comparison with another type of modeling, the GPS (Global Positioning Service).

GPS is a modeling allowing one to find the specific directions about how to get to a specific destination. To use a GPS, you must first input both the departure address and the destination address. For the EIS system, the interpretation requires the same information: the departure address is the clinical context (check up, known pathology, symptoms, any treatment in progress, antecedents etc.), the destination address is the goal you wish to achieve for the client and what parameters you need to check in relation to the departure address (clinical context)

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5 of the strongest points about the EIS System, as well its non-invasive nature, are:


2. Visualization of the Pains

3. Nutritional analysis

1. New diagnoses approach in neurological or psychological disorders

4. Biochemical pool estimation

5. Early follow up and visualization of life style and all therapies