BONFOR-Symposium 201619. -Symposium 2016

Veranstalter: BONFOR-Forschungskommission der Medizinischen Fakultät Bonn • Sigmund-Freud-Str. 25 • Gebäude 23 • 53127 Bonn •Telefon: 0228/287–19142 • E-Mail: bonfor@uni-bonn.de

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Freitag, 16.12.2016 9:00 – 17:30 Uhr

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Einzelvorträge und PostersessionNachwuchswissenschaftler präsentieren das Ergebnis ihrer BONFOR-geförderten Projekte aus den verschiedenen Forschungslaboren der Medizinischen Fakultät

Die Teilnahme steht allen Interessierten offen.Eine Anmeldung ist nicht erforderlich.

Programm abrufbar unter: www.ukb.uni-bonn.de/bonfor

des internen Forschungsförderprogramms für Nachwuchswissenschaftler der Medizinischen Fakultät Bonn

Universitätsklinikum Bonn • Biomedizinisches Zentrum • Hörsaal 1

Programm 9:00 - 9:30 Uhr Begrüßung 9:30 – 12:45 Uhr Vorträge (Projektpräsentationen Förderinstr. 1, 6, 10 und 11)

Moderation: Prof. Volkmar Gieselmann / Prof. Markus Nöthen 9:30 Uhr F. C. Bode1, M. Fox1, S. Frede1, O. Boehm1, W. Barchet2, T. Zillinger2,

C.Putensen1, V. Hornung3, F. Steinhagen1 1Department of Anesthesiology and Critical Care Medicine, University of Bonn 2Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn 3Gene Center, University of Munich

Synthetic oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation

9:45 Uhr F. Steinhagen1, M. Fox1, S. Frede1, S. Klaschik1, O. Boehm1, D.

Klinman2, C. Putensen1, E. Latz3 and C. Bode1 1Department of Anesthesiology and Critical Care Medicine, University of Bonn 2Cancer and Inflammation Program, Center for Cancer Research, NCI, Frederick, MD, USA 3Institute of Innate Immunity, University Hospitals, University of Bonn The role of IRFs in the immunoregulation of human pDCs

10:00 Uhr B. Cabanillas, K. Brendes, N. Novak

Department of Dermatology and Allergy, University of Bonn Medical Center Characterization of IgE-mediated reactivity against herpes simplex virus-1

10:15 Uhr W. Peng1, W. Grobe1, G. Walgenbach-Brünagel2, S. Flicker6, C. Yu1,

M. Sylvester3, JP. Allam1, J. Oldenburg4, N. Garbi5, R. Valenta6, N. Novak1 1Department of Dermatology and Allergy, University of Bonn 2Institute of Clinical Chemistry and Pharmacology, University of Bonn 3Institute of Biochemistry and Molecular Biology, University of Bonn 4Institute of Experimental Hematology and Transfusion Medicine (IHT), University of Bonn 5Institute of Experimental Immunology (IEI), University of Bonn 6Department of Pathophysiology and Allergy Research, Medical University of Vienna Distinct function of Fc epsilon receptor II in human B cells and monocytes

10:30 Uhr A. Heine1, L.C. Norkus2, C. Flores2, M. Held2, P. Brossart1 and C. Kurts2

1Medical Clinic III for Oncology, Hematology and Rheumatology, University Hospital Bonn 2Institute of Experimental Immunology, University of Bonn Strategies to improve antigen-specific immune responses using chemokines

10:45 - 11:00 Uhr Kaffeepause

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11:00 Uhr S. Held, A. Heine, A. Kesper, K. Schönberg, A. Beckers, K. Riethausen, D. Wolf, P. Brossart Medizinische Klinik III, Universitätsklinikum Bonn IFNg modulates sensitivity of CML cells to TKI

11:15 Uhr Tobias A.W. Holderried1, Pia Sauerborn1, Hye-Jung Kim2, Harvey

Cantor2, Dominik Wolf1 and Peter Brossart1 1Department of Internal Medicine III, Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany 2Department of Cancer Immunology and Virology, Harvard Medical School, Boston, MA, USA CD8+ Treg in allogeneic stem-cell transplantation

11:30 Uhr C. Weisheit1, L. Eichhorn1, J. Kleiner1, H. Ehrentraut1, R. Meyer2, A.

Hoeft1, S. Frede1, C. Kurts3 1Klinik für Anästhesie und operative Intensivmedizin, Universitätsklinikum Bonn 2Institut für Physiologie 2, Universität Bonn 3Institut für Experimentelle Immunologie, Universitätsklinikum Bonn A lack of Cx3cr1 dependent recruited macrophages reduces cardiac hypertrophy

11:45 Uhr F. Jansen1, X. Yang1, Tobias Stumpf1, David Przybilla1, Bernardo S.

Franklin2, Daniela Wenzel3, Bernd K Fleischmann3, Georg Nickenig1, Nikos Werner1 1Medizinische Klinik II, Universitätsklinikum Bonn 2Institut für Angeborene Immunität, Universitätsklinikum Bonn 3Institut für Physiologie, Universitätsklinikum Bonn Endothelial microparticles promote vascular endothelial cell repair via SPRED1 that is abrogated in glucose-damaged endothelial microparticles

12:00 Uhr G. Brügmann1, T. Schmidt1, J. Schmid-Burgk1, J. van den Boorn2, V.

Hornung1,3 1Institut für Molekulare Medizin, Universitätsklinikum Bonn 2Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn 3Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München CRISPR/Cas9 in a melanoma mouse model

12:15 Uhr D. Nettersheim1, S. Jostes1, M. Fabry1, F. Honecker2, V.

Schumacher3, J. Kirfel4, G. Kristiansen4 and H. Schorle1 1University Hospital Bonn, Institute of Pathology, Department of Developmental Pathology, Bonn 2Tumor- and Breast-Center, ZeTuP Silberturm, St. Gallen, Switzerland 3Harvard Medical School, Department of Pediatrics, Boston, MA, USA 4University Hospital Bonn, Institute of Pathology Romidepsin is a novel therapy option for cisplatin-resistant germ cell cancers

12:30 Uhr M.-D. Keyver-Paik1, A. Abramian1, T. Höller2, L. Otten1, C. Coch2, C.

Fuhrmann2, S. Hartz2, R. Fimmers2, W. Kuhn1 1Frauenklinik, Universitätsklinikum Bonn 2Studienzentrum, Universitätsklinikum Bonn ANTHEA- Adjuvant Neoadjuvant Therapy with HIPEC in advanced Epithelial ovarian cAncer: establishing a trial protocol for grant with Deutsche Krebshilfe e.V.

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12:45 - 13:30 Uhr Mittagspause 13:30 – 14:45 Uhr Vorträge (Projektpräsentationen Förderinstr. 1, 6, 10 und 11)

Moderation: Prof. Susanne Schoch McGovern / Prof. Heinz Beck 13:30 Uhr I. Hasan1,2, K. Solberg1, C. Madarlis1, S. Temizel1, L. Keilig1,2, F.

Heinemann3, C. Dirk1, H. Stark2, C. Bourauel1 1Endowed Chair of Oral Technology, Rheinische Friedrich-Wilhelms University, Bonn, Germany 2Department of Prosthetic Dentistry, Preclinical Education and Materials Science, Dental School, Rheinische Friedrich-Wilhelms University, Bonn, Germany 3Department of Prosthodontics, Gerodontology and Biomaterials, University of Greifswald, Germany Biomechanical aspects of mini dental implants

13:45 Uhr K.J. Czogalla1, A. Biswas1, K. Höning2, V. Hornung2,3, K. Liphardt1, M.

Watzka1, J. Oldenburg1 1Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn 2Institute of Molecular Medicine, University Hospital Bonn 3Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich A binding pocket in human VKORC1 is shared by vitamin K or warfarin

14:00 Uhr Doreen Braun und Ulrich Schweizer

Institut für Biochemie und Molekularbiologie, Universitätsklinikum Bonn Steroid hormones - Diffusion or transport?

14:15 Uhr D. Winter, C. Schoor, R. Sharma, A. Dheghani, V. Gieselmann Institut für Biochemie und Molekularbiologie, Universitätsklinikum Bonn Investigation of murine neural progenitor cell to NG2 cell differentiation by mass spectrometry based quantitative proteomics

14:30 Uhr A.-C. Schmöle1, R. Lundt1, G. Toporowski1, E. Beins1, J.N. Hansen2, A.

Halle2 and A. Zimmer1 1Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany 2Center of Advanced European Studies and Research (Caesar), Max Planck research group “Neuroimmunology”, Bonn, Germany Cannabinoid receptor 2 deficiency alters neuronal loss and improves cognitives function in an Alzheimer’s disease mouse model

14:45 - 15:00 Uhr Kaffeepause 15:00 – 17:00 Uhr Postersession (Poster-Talks SciMed-Promotionstipendium) Stefan Bergner, F. Buket Basmanav, Aylar Tafazoli, Sabrina Wolf, Maria Wehner, Maria Teresa Romano, Regina C. Betz Institut für Humangenetik, Universitätsklinikum Bonn Identifying a new gene causing hypotrichosis simplex J. Klamt1,2, A. Hofmann1,2, A. C. Böhmer1,2, A. Hoebel1,2, L. Gölz3, J. Becker1,2, A. M. Zink2, M. Draaken1,2, A. Hemprich4, M. Scheer5, G. Schmidt6, M. Martini7, M. Knapp8, E. Mangold2, F. Degenhardt1,2, K. U. Ludwig1,2 1Department of Genomics, Life, and Brain Center, University of Bonn, Bonn, Germany 2Institute of Human Genetics, University of Bonn, Bonn, Germany 3Department of Orthodontics, University of Bonn, Bonn, Germany 4Department of Oral and Maxillo-Facial Surgery, University of Leipzig, Leipzig, Germany 5Department of Oral and Maxillo-Facial Surgery, University of Cologne, Cologne, Germany 6Department of Cleft Lip and Cleft Palate Surgery, Humboldt University of Berlin, Berlin, Germany 7Department of Oral and Maxillo-Facial-Plastic Surgery, University of Bonn, Bonn, Germany 8Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany Analysis of deletions in 7p14 in nonsyndromic cleft lip ± cleft palate

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Valerie Weitensteiner1, Julia Bungenberg2, Matthias Marks3, Damian J. Ralser1, Rong Zhang1,4, Alina Hilger1, Amit Sharma5, Ulrich Gembruch6, Waltraut Merz6, Albert Becker2, Bernhard Herrmann3, Michael Ludwig7, Heiko Reutter1,8 1Institute of Human Genetics, University of Bonn, Bonn, Germany 2Department of Neuropathology, University of Bonn, Bonn, Germany 3Department of Developmental Genetics, Max-Planck-Institute for Molecular Genetics, Berlin, Germany 4Department of Genomics - Life & Brain Center, Bonn, Germany 5Department of Neurology, University Clinic Bonn, Bonn, Germany 6Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, Germany 7Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany 8Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany Genetic and developmental biology implicate BAZ1A as a human malformation gene Große Greta1, Hilger Alina1, Ludwig Michael2, Reutter Heiko1,3, Woelfle Joachim4 1Institute of Human Genetics, University of Bonn

2Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn 3Department of Neonatology and Pediatric Intensive Care, University of Bonn, Germany

4Children’s Hospital, Pediatric Endocrinology Division, University of Bonn Whole exome sequencing in patients with severe primary IGF-1 deficiency A. Groetchen, S. Riesenberg, M. Hölzel Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn Role of the transcription factors MITF and c-Myc in malignant melanoma L. Rauschenbach1, A. Wieland1, A. Till1, R. Reinartz1, S. Kebir1,2, O. Brüstle1, M. Glas1,2,3, B. Scheffler1,4 1Institute of Reconstructive Neurobiology, University of Bonn Medical Center 2Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center 3Clinical Cooperation Unit Neurooncology, MediClin Robert Janker Clinic Bonn 4DKFZ-Division of Translational Oncology/Neurooncology, German Cancer Consortium (DKTK) & University Hospital Essen Repositioning of ritonavir for combinatorial chemoradiotherapy in glioblastoma N. Winterhoff, V. Böhnert, T. Zillinger, P. Müller, W. Barchet Institut für Klinische Chemie und Klinische Pharmakologie, Universitätsklinikum Bonn Tumor rejection and immunity to relapse via RNA-adjuvanted EOC cell vaccination A. Braun1, M. Mengoni1, T. Bald1,2, T. Tüting1,2 1Laboratory for Experimental Dermatology, Clinic for Dermatology, University Hospital Bonn 2Department for Dermatology, University Hospital Magdeburg Visualizing the dynamics of melanoma phenotypic plasticity due to inflammation M. Nastaly1, E. Bartók1,2, M. Gaidt1,3, G. Hartmann2, V. Hornung1,3 1Institute of Molecular Medicine, Universitätsklinikum Bonn 2Institute of Clinical Chemistry and Clinical Pharmacology, Universitätsklinikum Bonn 3Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München

POPs and COPs as putative inflammasome regulators L. Osang, A. Siebert, R. Kallies, C. Drosten, I. Eckerle Institut für Virologie, Universitätsklinikum Bonn Next-generation-sequencing: Viral pathogens in respiratory tract infections Anne Zillekens, Gun-Soo Hong, Mariola Lysson, Bianca Schneiker, Joerg C. Kalff, Sven Wehner Department of Surgery, University of Bonn Transcutaneous vagus nerve stimulation prevents postoperative ileus in mice D. Koch, F. Jansen, N. Werner Medizinische Klinik II, Labor für Molekulare Kardiologie, Universitätsklinikum Bonn Characterization of circulating MP-bound miRNAs in CHD patients

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T. Stumpf1, F. Jansen1, BS. Franklin2, D. Wenzel3, A. Flender1, T. Schmitz1, BK. Fleischmann3, G. Nickenig1, N. Werner1 1Medizinische Klinik II, Universitätsklinikum Bonn 2Institute of Innate Immunity, Universitätsklinikum Bonn 3Institut für Physiologie, Universität Bonn Intercellular transfer of miR-126-3p by EMPs limits neointima formation O. Hommerding1, M. Thier3, C. Cammann4, F. Schildberg5, U. Seifert4, O. Brüstle1, F. Edenhofer2 1Institut für Rekonstruktive Neurobiologie, Universitätsklinikum Bonn

2Institut für Molekularbiologie, Universität Innsbruck

3Deutsches Krebsforschungszentrum, Heidelberg

4Institut für Molekulare und Klinische Immunologie, Universitätsklinikum Magdeburg

5Departement of Microbiology and Immunobiology, Harvard Medical School Interferon-γ promotes generation of induced pluripotent stem cells S. Marx1, J. Doerr1, J. Mertens2, B. Giebel3, O. Brüstle1, P. Koch1 1Institut für Rekonstruktive Neurobiologie, Universitätsklinikum Bonn 2Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, USA 3Institut für Transfusionsmedizin, Universitätsklinikum Essen Polarized LAMP+-vesicle distribution during asymmetric stem cell division R. Kaczmarczyk1, D. Tejera1, B. Simon2, M. Kummer1, MT. Heneka1 1Institut für Klinische Neurowissenschaften, Universitätsklinikum Bonn 2ElectroCore Medical, LLC Microglia modulation through external vagus nerve stimulation M. Funken, T. Bruegmann, P. Sasse Institute of Physiology I, University of Bonn, Germany Electrical interaction of fibroblasts and cardiomyocytes proved by optogenetics Julia Bungenberg1, Alexander Grote3, Rainer Surges2, Katharina Pernhorst1, Andrea Hofmann4, Per Hoffmann4, Susanne Schoch1,§, Christoph Helmstaedter2,§, Albert J. Becker1,§ 1Institut für Neuropathologie, Universitätsklinikum Bonn 2Klinik für Epileptologie, Universitätsklinikum Bonn 3Klinik für Neurochirurgie, Universitätsklinikum Bonn 4Institut für Humangenetik, Universitätsklinikum Bonn Memory performance in TLE: Future prognostic biomarkers Kunz L1,2, Schröder TN3, Lee H1, Montag C4, Lachmann B4, Sariyska R4, Reuter M5,6, Stirnberg R1, Stöcker T1, Messing-Floeter PC1,2, Fell J2, Doeller CF3, Axmacher N1,2,7 1German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany 2Department of Epileptology, University of Bonn, Bonn, Germany 3Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands 4Department of Psychology, Ulm University, Ulm, Germany 5Department of Psychology, University of Bonn, Bonn, Germany 6Center for Economics and Neuroscience, University of Bonn, Bonn, Germany 7Department of Neuropsychology, Institute of Cognitive Neuroscience, Ruhr-University Bochum, Bochum, Germany Reduced grid representations in adults at genetic risk for Alzheimer’s disease C. Petschow1, L. Scheef1, S. Paus2, N. Zimmermann2, H. H. Schild3, T. Klockgether2, H. Boecker1 1Functional Neuroimaging Group, Department of Radiology, University of Bonn, Germany 2Department of Neurology, University of Bonn, Germany 3Department of Radiology, University of Bonn, Germany Central pain processing in early-stage Parkinson’s disease 17:00 - 17:15 Uhr Kaffeepause 17:15 Uhr Schlusswort und Verleihung der Forschungspreise