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Egg Donation Horizon Impact of Egg Banks · Source: Clinical experience with vitrified-warmed (V-W)...
Transcript of Egg Donation Horizon Impact of Egg Banks · Source: Clinical experience with vitrified-warmed (V-W)...
Egg Donation Horizon&
Impact of Egg Banks
Saghar KasiriDirector of European Operations
Cryos International1st November 2019
Overview
• Global donor egg market
• Fertility tourism and egg donation
• Fresh versus frozen donor eggs
• Impact of egg banks
Global Egg Donation Market
Global Egg Donation Market Projection
• The Global Egg Donation market was valued at US$ 2,172.6 Mn in 2018
• Estimated to grow at a CAGR of 7.5% over the forecast period (2018–2028) to reach US$ 4,474.0 Mn by 2028
• Europe region is the largest market with a revenue share of 50.1% in 2018
Source: Market report prepared for Cryos International by Future Market Insights - 2019
Global Egg Donation Market - 2018
Global Egg Donation Market Revenue Share by Cycle Type, 2018E Global Egg Donation Market Revenue Share by End User, 2018E
Source: Market report prepared for Cryos International by Future Market Insights - 2019
Reasons for Egg Donation Market Growth
• Increasing prevalence of infertility worldwide• Delayed motherhood • Social risk factors• Social acceptance of single parents – double donation• Countries legalizing same-sex marriages• Government & social support toward gamete donation & donor offspring • Patient awareness of pregnancy rates > 40 years• > 70% of women over 45 years use egg donation• Technological advancements in Egg Vitrification• Egg banks - cost less & greater range of choice
Fertility Tourism and Egg Donation
Fertility Tourism Drivers – Egg Donation
• Costs
• Lack of available donors in homeland
• Limited donor characteristic choices
• National regulations and limitations
➢ Banned donation
➢ Donor anonymity
➢ Egg recipient age limit
➢ Marital & social status
➢ Parental rights
• Egg donation success rates
• Better patient journey
Source: Photo curtesy of Egg Donation Friends website
Global Egg Donation Treatment – Success Rates“Spain and South Africa have the highest pregnancy success rates for egg donation”
Source: inviTRA, 2019 (Magazine specialized in assisted reproduction and pregnancy)
Egg Donation Abroad
Source: Egg Donation Friends website, updated Sept 2018
Fresh vs Frozen Donor Eggs
Fresh Egg Donation Process
Fresh vs Frozen Donor Eggs Egg Donation Advantages Disadvantages
Fresh
• High Number Eggs
• More Embryos
• High Number Cryopreserved?
• Low Cost Consecutive Cycle – Thaw
• Success Rate
• Time
• Synchronization
• Cancellation Risk
• Donor Liability
➢ Medication
➢ Empty Follicles
➢ OHSS
• Regulatory Compliance
• Initial Cost
Frozen
• Time
• Convenience
• No Synchronization
• No Cancellation Risk
• No Donor Liability
• Large Selection of Donors
• Success Rate
• Cost First Attempt
• 6-8 eggs
• Less Number Cryopreserved
• Technique
• Cost Consecutive Attempts
Impact of Egg Banks
Survival Clinical Pregnancy% With Surplus
Embryos
Ongoing and Live
Birth per Transfer
Cryos
International92% 75% 61% 62%
Source: Results compiled by Cryos International, 2018
Banking Statistics
Cryos, TWEB, FF, and DEB - cumulative clinical pregnancy rate of 54% and live birth rate of 44% (48.9%)
Live Birth Rates
Source: Clinical experience with vitrified-warmed (V-W) donor eggs versus fresh donor eggs at a busy IVF programMcCaffrey, C. et al., Fertility and Sterility , Volume 102 , Issue 3 , e314 2014
Live Birth & Miscarriage Rates
Source: There is no difference in clinical miscarriage rates between vitrified blastocysts developed from fresh donor oocytes vs. vitrified banked donor oocytesLamb, Julie D. et al., Fertility and Sterility , Volume 109 , Issue 3 , e34 , 2017
Fresh Donor Eggs
Source: SART National Data Summary Report 2017 Pooled Data
Frozen Donor Egg
Source: SART National Data Summary Report 2017 Pooled Data
Success rates using frozen donor eggs are dependent on several factors:
• The quality of the donor eggs
• The ability to perform effective freezing and thawing of the eggs
• The number of eggs thawed, and embryos produced
• The expertise and quality of the IVF program
• Embryo development & egg guarantee programme
Success Rate Factors
Impact of Egg Banks - B2B & B2C
• No need to recruit, screen or approve donors
• No donor payment
• No Regulatory concerns
• Syncing donor/recipient cycles are a thing of the past
• Ease lab pressure and workload
• Guaranteed blastocyst transfer
• Provide a greater selection to patients
• Immediately available
• Results are improving & treatment cycles are increasing
Making Your Life Simpler, One Task at a Time
Take Away
• Globally the egg donation market is growing
• Currently egg donor shortages remedied through fertility tourism – keep them home!
• Trends show increase in use of frozen donor eggs – vitrification technology advancement
• Egg banks experts in vitrification of eggs – matching success rates & less surplus eggs/embryos
Questions & Answer Session