EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic...
Transcript of EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic...
![Page 1: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/1.jpg)
EFSA and RASFF
Ana Afonso
40 years of RASFF: “All you need is RASFF?” - smarter data = better analysis
13.12.2019. Brussels
![Page 2: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/2.jpg)
EFSA role - scientific and technical support to RASFF
Rapid Assessment of Contaminant Exposure tool (RACE)
RASFF Data for Rapid Outbreak and Risk assessment
Next….
Overview
![Page 3: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/3.jpg)
3
• Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food.
• The brand, batches of the products and positive analysis results were published in the association website, but no details on the analytical methodology used.
• A RASFF alert notification was issued by country Y. The level of risk was undecided.
![Page 4: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/4.jpg)
Develop a tool to harmonise risk evaluation
Propose methodology for a risk-based classification of RASFF notifications on contaminants
Based on science but practical to use
Application areas :
Industrial and environmental contaminants
Heavy metals
Mycotoxins and other biotoxins
Migration from food contact materials
Residues of pharmacologically active substances
Mandate to EFSA
4
![Page 5: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/5.jpg)
3 Work Packages (WP):
WP1 Toxicological parameters
WP2 Estimating exposure
WP3 IT tool
Consultation with RASFF network
5
![Page 6: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/6.jpg)
https://efsa.onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2019.EN-1625
Technical report
6
![Page 7: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/7.jpg)
A chemical contaminant of concern was detected in a food sample…..
Is the compound Genotoxic and Carcinogenic?
Is there an Acute reference dose available?
Is there a Chronic health-based guidance value available?
Is there a Reference Point available?
WP1 Toxicological parameters
7
![Page 8: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/8.jpg)
WP1 Toxicological parameters
![Page 9: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/9.jpg)
EFSA Comprehensive European Food Consumption Database
https://www.efsa.europa.eu/en/microstrategy/food-consumption-survey
WP2 Estimating exposure
9
![Page 10: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/10.jpg)
FoodEx2
Webinar: The FoodEx2 classification system
A common language
Developed and maintained by EFSA
Clearly defined groups
Parent-child structure
10
![Page 11: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/11.jpg)
WP3 IT tool
Overview
![Page 12: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/12.jpg)
Example: 127.63 µg/kg PAH4 in dried garlic
0. Is the compound genotoxic and carcinogenic?
Yes Yes
2G. Exposure assessment Is BMDL10 / exposure
> 10,000?
1G. Is there a RP (e.g. BMDL)
available?
EFSA, 2008: BMDL10 340 µg/kg bw/day
FoodEx2: IT tool: summary outcome*
![Page 13: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/13.jpg)
13
Analytical results
Use of the tool
OUTCOME
![Page 14: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/14.jpg)
Risk assessment vs Risk evaluation
No risk;
Low probability of adverse health effects;
Low concern for public health
No risk
Serious risk
Risk / Potential risk Not serious risk
Rate of exceedance;
Population categories exposed;
Severity of the effect;
Duration of exposure;
Characteristics of the food
14
![Page 15: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/15.jpg)
Published 15/5/19
RASFF network training 23/5/19
Crisis simulation exercise 28/8/19
Enquires and technical support
Next steps
229 registered users
93 of them run at least one analysis
452 analysis are now stored in the accounts of the users
RACE users’ stats
15
![Page 16: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/16.jpg)
50 cases of Listeria monocytogenes XXXX infections were reported from country A and B.
20 isolates from sliced ready-to-eat meat products, were found to be contaminated with strains matching the outbreak strain.
The exact points of contamination were not identified. Company A, is the only common manufacturing point of the contaminated products. Company A distributed products to several EU countries as well as to countries outside the EU.
Rapid outbreak assessment
16
![Page 17: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/17.jpg)
Notifications
Follow ups
Questions
Answers
Laboratory results
Trade documents
Distributions lists
Measures taken…..
RASFF
17
![Page 18: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/18.jpg)
iRASFF notification
Tracing identification,
LOTs, units, withdrawals from market, product
processing information
Document information, questions, answers
Analytical results, laboratory results,
methodology, serotyping results
(WGS data)
Tested product ID Product ID
Outbreak information
Data in RASFF
![Page 19: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/19.jpg)
iRASFF
Which establishment?
Which product?
DETAILS
Data in RASFF
![Page 20: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/20.jpg)
Information source
RASFF number (key) Follow-up number(key) Notifying country Type of notification Hazzard Dates
Company / FBO
Company name (key) Country (key) Register number / VAT… Position in the supply chain (key) Type of activities
Product
Product name (key) LOT number (key) BBD/UBD/Date of production (key) Storage information
Details - tracing
Back-/Forward-tracing (key) Company IN /Company OUT (key) Product Transportation Storage Dates of delivery
Details – Lab. results
Laboratory name (key) Samples product/environment (key) Stage of sampling Method (key) Results
WGS results
WGS methods (key) Matching with outbreak strain
Data model
![Page 21: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/21.jpg)
Tools to support Rapid assessments
21
structuring
• extracting information
reviewing
• combining information
consolidating
• clarifying inconsistencies
analysing
•reconstructing the food/feed supply chain
•identifying “hot spots” and hypothesis
summarizing
•reporting
![Page 22: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/22.jpg)
Data extraction tool
Inhouse system (Distiller software)
Data consolidation tool
Inhouse system (SAS software, FoodChain-Lab [DE-BfR])
Data analysis tool
FoodChain-Lab (EFSA-BfR partnership)
Data reporting tool
Summary of affected countries, food items, lots, contamination
Inhouse system (SAS software)
[Data collection tool]
Guided local data collection (EFSA-BfR partnership)
Tools to support rapid assessments
22
![Page 23: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/23.jpg)
Sharing of tools and structured information
23
![Page 24: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/24.jpg)
RASFF - AAC – What changes?
IMSOC – What changes?
Rapid Outbreak assessments and Food incidents coordinated response, what is needed?
Next…
![Page 25: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/25.jpg)
Improve data capture at the point of sampling and simplify reporting
Focus on data already collected by MS (interoperability)
Increase the quality of data reported (controlled terminologies and validation rules)
Engage with RASFF contact points and MS crisis coordinators
Next…
25
![Page 26: EFSA and RASFF · 3 •Consumer association X investigated the presence of potentially genotoxic processing contaminants in ready to eat food. •The brand, batches of the products](https://reader033.fdocuments.in/reader033/viewer/2022060320/5f0d01a17e708231d4383625/html5/thumbnails/26.jpg)
Stay connected Stay connected
www.efsa.europa.eu/en/engage/careers
www.efsa.europa.eu/en/rss
Subscribe to
Engage with careers
Follow us on Twitter @efsa_eu @plants_efsa @methods_efsa
www.efsa.europa.eu/en/news/newsletters
26