Efficacy and Potency of drug
-
Upload
muhammad-asad -
Category
Education
-
view
338 -
download
0
Transcript of Efficacy and Potency of drug
![Page 1: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/1.jpg)
Department of Pharmaceutical Department of Pharmaceutical sciencessciences
33rdrd Semester Semester
![Page 2: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/2.jpg)
Group membersGroup members
Mohammad AsadMohammad AsadHafiz JunaidHafiz JunaidAmir Sohail KhanAmir Sohail KhanSana MushtaqSana Mushtaq
![Page 3: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/3.jpg)
What is Pharmacodynamics Drug response curve EC50 Potency Efficacy Refrences
![Page 4: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/4.jpg)
Pharmacodynacmics describes the action of drug on body and influence of drug concentration on magnitude of response
Most of drugs exerts effect by ineracting with receptor
An agent that can bind to recepor and produces iological rsponse is called as agonist
![Page 5: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/5.jpg)
The interaction between drug and its receptor can be described by a curve called as drug response curve
on Vertical axix there is response of drug
On horizontal axix there is concentration of dose
![Page 6: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/6.jpg)
The magnitude of drug effect depends on drug concentration at receptor site and this availbilty and concentration of drug at receptor is determined by both dose of drug administered and by drug pharmacokinetics(ADME)
![Page 7: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/7.jpg)
When no drug is added then no effect is produced
![Page 8: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/8.jpg)
When some drug is added then we get response
![Page 9: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/9.jpg)
By adding more drug we get maximum response
![Page 10: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/10.jpg)
A time will reach on which adding more drug will not cause increase in response because we have reached to maximum effect
![Page 11: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/11.jpg)
EC50EC50Is concentration of drug needed to get half
of the maximum effect
![Page 12: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/12.jpg)
Two important properties of drug can be found by dose reponse curve
Efficacy Potency
PotencyPotency amount of drug necessary to
produce maximum effect is the potecncy of drug
![Page 13: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/13.jpg)
Candesartan and ibesartan are angiotensin receptor blocker
Candesartan is more potent then Ibesartan because the dose range for candesartan is 4 to 32 mg as compared to dose range of ibesartan whose dose range is 25 to 300 mg
![Page 14: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/14.jpg)
![Page 15: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/15.jpg)
Ability of a drug to elicit a response when it interacts with a receptorEfficacy is dependent on;
the number of drug-receptor complexes formedefficiency of the coupling of receptor activation to
cellular responses. Maximal efficacy of a drug assumes that all
receptors are occupied by the drug and if more drugs are added, no additive response will be observed.
Maximal response (efficacy) is more important than drug potency.
A drug with greater efficacy is more therapeutically beneficial than the one that is more potent.
![Page 16: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/16.jpg)
![Page 17: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/17.jpg)
![Page 18: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/18.jpg)
Lipincott pharmacology
Rang and dales pharmacology
![Page 19: Efficacy and Potency of drug](https://reader036.fdocuments.in/reader036/viewer/2022081515/58ef66341a28ab50358b460d/html5/thumbnails/19.jpg)