Effects of AIN457, a Fully Human Antibody to Interleukin- 17A, on Psoriasis, Rheumatoid Arthritis,...
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Transcript of Effects of AIN457, a Fully Human Antibody to Interleukin- 17A, on Psoriasis, Rheumatoid Arthritis,...
![Page 1: Effects of AIN457, a Fully Human Antibody to Interleukin- 17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis by Wolfgang Hueber, Dhavalkumar D. Patel,](https://reader036.fdocuments.in/reader036/viewer/2022071807/56649e6a5503460f94b680b2/html5/thumbnails/1.jpg)
Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis
by Wolfgang Hueber, Dhavalkumar D. Patel, Thaddeus Dryja, Andrew M. Wright, Irina Koroleva, Gerard Bruin, Christian Antoni, Zoe Draelos, Michael H. Gold, ,
Patrick Durez, Paul P. Tak, Juan J. Gomez-Reino, , C. Stephen Foster, Rosa Y. Kim, C. Michael Samson, Naomi S. Falk, David S. Chu, David Callanan, Quan Dong
Nguyen, , Kristine Rose, Asifa Haider, and Franco Di Padova
Sci Transl MedVolume 2(52):52ra72-52ra72
October 6, 2010
Published by AAAS
![Page 2: Effects of AIN457, a Fully Human Antibody to Interleukin- 17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis by Wolfgang Hueber, Dhavalkumar D. Patel,](https://reader036.fdocuments.in/reader036/viewer/2022071807/56649e6a5503460f94b680b2/html5/thumbnails/2.jpg)
Fig. 1 Clinical response to AIN457 in patients with chronic plaque psoriasis.
Wolfgang Hueber et al., Sci Transl Med 2010;2:52ra72
Published by AAAS
![Page 3: Effects of AIN457, a Fully Human Antibody to Interleukin- 17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis by Wolfgang Hueber, Dhavalkumar D. Patel,](https://reader036.fdocuments.in/reader036/viewer/2022071807/56649e6a5503460f94b680b2/html5/thumbnails/3.jpg)
Fig. 2 Immunohistochemistry of skin biopsies: Representative immuno-costaining of CD3 and IL-17.
Wolfgang Hueber et al., Sci Transl Med 2010;2:52ra72
Published by AAAS
![Page 4: Effects of AIN457, a Fully Human Antibody to Interleukin- 17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis by Wolfgang Hueber, Dhavalkumar D. Patel,](https://reader036.fdocuments.in/reader036/viewer/2022071807/56649e6a5503460f94b680b2/html5/thumbnails/4.jpg)
Fig. 3 Gene expression changes in skin of patients with psoriasis treated with AIN457.
Wolfgang Hueber et al., Sci Transl Med 2010;2:52ra72
Published by AAAS
![Page 5: Effects of AIN457, a Fully Human Antibody to Interleukin- 17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis by Wolfgang Hueber, Dhavalkumar D. Patel,](https://reader036.fdocuments.in/reader036/viewer/2022071807/56649e6a5503460f94b680b2/html5/thumbnails/5.jpg)
Fig. 4 ACR20, DAS28, and CRP changes for a two-dose infusion regimen of AIN457 (10 mg/kg) versus placebo.
Wolfgang Hueber et al., Sci Transl Med 2010;2:52ra72
Published by AAAS
![Page 6: Effects of AIN457, a Fully Human Antibody to Interleukin- 17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis by Wolfgang Hueber, Dhavalkumar D. Patel,](https://reader036.fdocuments.in/reader036/viewer/2022071807/56649e6a5503460f94b680b2/html5/thumbnails/6.jpg)
Fig. 5 Vitreous haze (posterior segment uveitis) or anterior chamber cells (anterior uveitis) at week 8 versus week 0.
Wolfgang Hueber et al., Sci Transl Med 2010;2:52ra72
Published by AAAS