Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol:...
-
Upload
moses-stewman -
Category
Documents
-
view
219 -
download
2
Transcript of Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol:...
![Page 1: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/1.jpg)
“Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants”
Based on Protocol: “Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants” [NNR-02-111]
![Page 2: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/2.jpg)
Background
![Page 3: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/3.jpg)
What is influenza ?
• Influenza is a germ that can make people of any age sick.
• Commonly known as “the flu”
• Is a winter time illness
• Can cause fever, muscle aches, cough, and runny nose, and serious symptoms that require hospitalization
![Page 4: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/4.jpg)
Babies Everywhere Less than 6 Months Old are at High Risk for Influenza Hospitalization
1038
500
200100
0
200
400
600
800
1000
1200
<6 Months 6-12 Months 1-2 Years 2-4 Years
Age
Ho
spit
aliz
atio
n R
ate
per
10
0,00
0
Izurietta 2000; Neuzil 2000
![Page 5: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/5.jpg)
How do we prevent it?
** Vaccination is the best way to prevent influenza!!
![Page 6: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/6.jpg)
Problem: There is no vaccine for babies less than 6 months of age …
![Page 7: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/7.jpg)
Possible Solution?
…We wanted to see if giving the flu vaccine to pregnant women can protect their babies from the flu
![Page 8: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/8.jpg)
Study Conduct
![Page 9: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/9.jpg)
How was the maternal flu study conducted?
• Study conducted during the “flu season” (cold months of the year) between 2002-2005.
• Enrolled mother-infant pairs immediately after birth and followed infants for 6 months or to the end of “flu season”.
• Tested whether giving the flu vaccine to pregnant women can prevent their babies from getting the flu.
![Page 10: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/10.jpg)
Before Starting the Study We Needed to Get Approval…
• We got approval from Navajo and White Mountain Apache Tribes.
• We also asked mothers for permission to enroll them and their infants in the study.
![Page 11: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/11.jpg)
Who participated in the Study?•1162 infant and mother pairs.
•Service Units participating in the study were: Fort Defiance, Gallup, Chinle, Shiprock, Tuba City, Winslow and Whiteriver.
![Page 12: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/12.jpg)
How was the maternal flu study conducted?
• Blood was collected to test for antibodies (germ fighters) to the influenza virus.
![Page 13: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/13.jpg)
How was the maternal flu study conducted?
• Babies followed throughout the study to see if they went to the doctors for flu-like illness.
![Page 14: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/14.jpg)
How was the maternal flu study conducted?
• If a baby went to the doctors for flu-like illness, secretions from the baby’s nose were collected to test for influenza virus.
![Page 15: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/15.jpg)
How was the maternal flu study conducted?
• All information collected was entered into computer for analysis.
![Page 16: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/16.jpg)
Study Results
![Page 17: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/17.jpg)
1160 mother-infant
pairs
573 given the flu shot
31Lab-confirmed flu
cases
293 Flu-like Symptoms
76 Hospitalized for
flu like symptoms
587 not given the flu
shot
52Lab-confirmed flu
cases
312Flu-like Symptoms
117 Hospitalized for
flu like symptoms
Maternal influenza vaccination helps protect baby against influenza
![Page 18: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/18.jpg)
Conclusions
Influenza vaccination during pregnancy …
1.) Helps prevent babies less than 6 months from getting the flu
2.) Reduces chance of hospitalizations for babies with flu-like symptoms
![Page 19: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/19.jpg)
Acknowledgements
• Participants from the Navajo and White Mountain Apache tribes
• Community members who supported the project• Nurses and research program assistants • IRBs of the Navajo Nation, Phoenix Area IHS, and
Johns Hopkins School of Public Health• The Centers for Disease Control• Indian Health Service for their collaboration and
support
![Page 20: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.](https://reader036.fdocuments.in/reader036/viewer/2022062511/5516324255034694308b6099/html5/thumbnails/20.jpg)
Thank You!!