ED4 - Diabetes

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    APM Diabetes Session

    Rhonda Fruhling, MS, ARNP, CDE

    Judy Sigler, BSN, CDE(updated 8/11)

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    Correlation: A1c and Estimated

    Average glucoseA1c (%) eAG

    Estimated Average Glucose (mg/dl)

    6 126

    7 154

    8 183

    9 212

    10 240

    11 269

    12 298

    American Diabetes Association, 2011

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    Goals for Outpatient Blood GlucoseControl

    Pre-meal blood glucose levels

    70-130 mg/dl

    Post-prandial

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    Key Concepts in Setting

    Glycemic Goals Individualize

    Certain populations need special considerations

    Less intensive goals may be indicated in personswith severe or frequent hypoglycemia

    More stringent goals may be appropriate (a

    normal A1c, < 6 %) Postprandial glucose may be targeted if A1c

    goals not met

    American Diabetes Association, 2007

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    Continuous Glucose Monitoring

    (CGM) Measures interstitial glucose

    Require calibration with SMBG (treatment

    decisions should be based on SMBG notCGM readings).

    BG meter readings and sensor readings

    will rarely match exactly. Focus on trends

    Focus on direction and speed of thesensor glucose change.

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    Insulin Therapy Principles

    Basal insulin

    Controls glucose production by the liver

    Bolus insulin

    Food insulin

    Use and store carbohydrates eaten

    Correction (supplemental) insulin Treat an acute elevation in blood glucose

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    Glucose & insulin concentration

    Basal

    Bolus

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    Insulin Preparations

    Rapid-acting Insulin Analogs Lispro (Humalog), Aspart (Novolog), Glulisine (Apidra)

    Short-acting Insulin Regular

    Intermediate-acting Insulin NPH

    Long-acting Insulin Analog Detemir (Levemir), Glargine (Lantus)

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    Insulin Action Patterns

    InsulinPreparation

    Onset ofAction

    PeakAction

    EffectiveDuration

    Rapid-acting

    Analogs

    5-15

    minutes

    30-90

    minutes

    3-5 hours

    Short-acting 30-60minutes

    2-3 hours 5-8 hours

    Intermediate-

    acting

    2-4 hours 4-10 hours 10-16 hours

    Long-acting

    (glargine)

    2-4 hours Peakless 20-24 hours

    Long-acting

    (detemir)

    2-4 hours(dose-related)

    6-14 hours(relatively flat)

    16-20 hours(dose-related)

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    Pre-Mixed Insulins

    Humalog Mix 50/50 50 % lispro protamine and 50 % lispro

    Humulin 70/30 (human) 70 % NPH and 30 % Regular

    Humalog Mix 75/25 (analog) 75 % lispro protamine and 25 % lispro

    NovoLog Mix 70/30 (analog) 70 % aspart protamine suspension and 30 % aspart

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    NPH and Fast-Acting Insulin

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    Syringes 1 cc (holds 100 units)

    1/2 cc (holds 50 units)

    1/3 cc (holds 30 units)

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    Insulin PensAdvantages

    Convenient

    Accurate

    Often used by person on multi-dose regime

    Disadvantage

    Usually more expensive (exception is a personon a small dose insulin)

    Injection force

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    Insulin Storage Keep current vial in refrigerator or at room

    temperature (once opened, it is good for

    28 days). Keep extra vials in the refrigerator

    Avoid temperatures extremes (86

    degrees) Not in direct sunlight

    Never let freeze

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    Insulin Resistance

    Among Patients Lack of confidence/self-efficacy

    Concern regarding the ability to handle insulin

    therapy Fears and Concerns

    Insulin will restrict lifestyle

    Hypoglycemia

    Diabetes has become more severe

    Fear of pain, fear of giving injections

    Kruger, D. (2007). Tying It All Together: Matching Insulin Regimens to

    Individual Patient Needs. The Diabetes Educator, 33(Suppl. 4) 91-95.

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    Insulin Resistance

    Among Patients Personal failure

    The need for insulin is a result of not taking care of

    his or her diabetes This sense of failure may be exacerbated by providers

    who threaten patients with insulin

    Perceived lack of benefit

    Do not consider insulin efficacious

    Kruger, D. (2007). Tying It All Together: Matching Insulin Regimens toIndividual Patient Needs. The Diabetes Educator, 33(Suppl. 4) 91-95.

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    Insulin Resistance

    Among Healthcare Providers Denial, avoidance, procrastination, wishful

    thinking

    Fear of alienating the patient Insulin therapy is time-consuming

    Fear of hypoglycemia

    Peragallo-Dittko,V. (2007). Removing Barriers to Insulin Therapy. TheDiabetes Educator, 33(Suppl.3) 60-65.

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    Diabetes Education

    Inpatient survival skills teaching

    Contact by EPIC consult Int Med Diabetes

    Nurse or contact by pager 7215 Outpatient (consult on EPIC)

    Group Diabetes Self-Management Classes

    Individual Diabetes Education appointment