Ebola virus ppt

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1TOPIC EBOLA VIRUSPRESENTED BY DR. AMIR SOHAIL KHATTAK B.SC VISION SCIENCES(PICO) BANNU MEDICAL COLLEGE , BANNUCONTENTSINTRODUCTIONCLASSIFICATIONLIFE CYCLEEPIDEMIOLOGICAL DISTRIBUTIONMAJOR OUTBREAKSSIGNS AND SYMPTOMSLABORTARY INVESTIGATIONPREVENTIVE MEASURESPOSSIBLE TREATMENT

INTRODUCTIONFirst identification 1976, Sudan, D.R Congo(Zaire) Order Mononegavirales, Enveloped,non-segmented, negative strand RNA viruses. approx. 19 kb in length (1 kb = 1000 RNA bases per nucleotides) or 60-80 nm in diameter. spikes due to glycoprotein on outside membrane

Family Filoviridae Ebolavirus(1976) Marburgvirus(1967) Cuevavirus (2002)SPECIES Zaire ebolavirus: 1976, D.R of Congo. Sudan ebolavirus: 1976, Sudan. Bundibugyo ebolavirus: 2007, Uganda. Ta Forest ebolavirus 1994, Ivory Coast Reston ebolavirus: 1989, Philippines.

LIFE CYCLE OF EBOLA VIRUS

EPIDEMIOLOGICAL DISTRIBUTION

SIGNS AND SYMPTOMSIncubation period 8-10 days Sudden onset of Fever >38.60C Flu-like symptoms: chills, sore throat Nausea, vomiting , abdominal pain, diarrhea chest pain, shortness of breath and cough Headache, confusion and coma Rash occurs around day 5 Hypotension, peripheral edema Bleeding manifestations develop in >50% (internal/external) hemorrhage, uncontrolled bleeding and massive GI blood lossuvietis Multi-organ dysfunction : kidneys and LiverThrombocytopenia and leukopenia Elevated transaminases ,Reduced albumin

OUTBREAKS

LABORTARY INVESTIGATIONNational medical labortary conducts PCR testing for 2 Ebola virus targets: Polymerase gene Nucleoprotein gene PREVENTIVE MEASURESImproving living conditionsAvoid contacts with suspected personsTesting before exporting and importing of goodsAvoid needle stick injury.Tests before blood transfussionPost-exposure prophylaxis and vaccines prenatal care, vaccination gloves usage during surgery proper sterilization and disposal of all equipmentisolating infected individuals

TREATMENTNo specific treatmentAntiviral drugsTerose perfumeGene therapy-Small interfering RNAs+ Adenosine analogue, inhibits viral RNA polymerase functionSarepta Binds to viral RNA and stops replication

PREVENTION IS BETTER THAN CURE

ANY DOUBT OR QUESTION