EBM E VIDENCE BASED MEDICINE R ESOURCES Lobna Al Juffali, Msc Spring 2010.
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Transcript of EBM E VIDENCE BASED MEDICINE R ESOURCES Lobna Al Juffali, Msc Spring 2010.
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EBMEVIDENCE BASED MEDICINE
RESOURCES
Lobna Al Juffali, Msc
Spring 2010
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A DRUG INFORMATION QUESTION
“ My 8 month baby has a severe earache for 2 days
Should I treat him with Antibiotics?”
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ON WHAT BASES SHOULD I ANSWER THE QUESTION?
1. On my current knowledge depending on my practice
2. By experts opinion 3. By the well structured studies that justifies
the use or non use of antibiotics
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COMMONSENCE I shook the tree, and a coconut fell on my
head. Hmm....maybe shaking the tree caused
the coconut to fall on my head! Better not shake trees without first watching for falling coconuts...
EBM
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I gave my patient who has had bronchitis for 4 or 5 days an antibiotic, and 3 days later she
felt better. Hmm...maybe giving the patient the
antibiotic caused her to feel better! I better give all of my patients with bronchitis an
antibiotic...
EBM
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ON WHAT BASES SHOULD I ANSWER THE QUESTION?
1. On my current knowledge depending on my practice
2. By experts opinion 3. By the well structured studies that justifies
the use or non use of antibiotics
EBM
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INTRODUCTIONIn the early 1990s, a group of clinicians and
epidemiologists at McMaster University in Ontario, Canada, officially lead by Dr. David Sackett which coined the term
"evidence-based medicine ”.
The concept faced mixed reviews: excitement from those in the academic and research worlds and suspicion from
those in the "real world," who found EBM impractical in a busy medical office.
EBM
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“Evidence-based medicine is the integration of best research evidence with clinical expertise and patient values”
DR. SACKETT DEFINES EBM AS:
EBM
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Patient Values
Research Evidence
Clinical Expertise
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WHY DO WE NEED EVIDENCE BASED MEDICINE?
Clinical examples that we practice without the best evidence which lead to harm for our patients.
Failure of common sense .
The wide variation in current clinical practice among practitioners.
The difficulty of managing medical information, when results conflict and thousands of articles are published every month .
The knowledge declines over time, and traditional CME doesn't work
EBM
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EBM
WHAT WERE THEY PRACTICING IN THE
PAST 50 YEARS?
EBM
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Opinion Based Medicine
EBM
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EBM VS TBMTBM
opinion based medicine own experience asking relatively few colleagues Guidelines, but they were
consensus-based. opinions not backed up by science." "BOGSATs,"
SO they fail to search for evidence which might cause them to reach a different conclusion or allow them to come to a more balanced decision
EBM Demands better evidence
external clinical evidence
Guidelines. systematic reviews meta-analyses
own experience Patients preference
evidence that matters
Focuses on outcomes that matter to the patient
EBM
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EBMHOW DO WE PRACTICE EVIDENCE BASED MEDICINE
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5 STEPS IN PRACTICING EBM
FormattingAn answerable question(well built clinical question)
tracking down the best evidence with which to answer that question
critically appraising that evidence for its validity ,impact and applicability
integrating the critical appraisal with our clinical expertise and with our patient’s
evaluating our effectiveness and efficiency in executing steps 1–4
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PICO
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TRACKING DOWN THE BEST EVIDENCE
To be useful, medical information should be relevant to everyday practice, correct (valid) and easy to obtain.
Usefulness equation
EBM
Relevance x Validity
Work
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VALIDITY The hard part of Information Mastery
The “Truth”-Probability statement that what we do does more good than harm.
EBM
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RELEVANCE
Frequency Type of evidence presented Evidence that can change my practice
EBM
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RELEVANCE: TYPE OF EVIDENCE
POE: Patient-oriented evidence mortality, morbidity, quality of life
DOE: Disease-oriented evidence pathophysiology, pharmacology, etiology
EBM
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Comment Patient-Oriented Evidence
that Matters
Disease-Oriented Evidence
Example
The results of the POEM study are contrary to what the DOE study would suggest
Antiarrhythmic drug X increases mortality
Antiarrhythmic drug X decreases PVCs on ECGs
Antiarrhythmic therapy
The results of the POEM study are in concordance with DOEs
Antihypertensive drug treatment decreases mortality
Antihypertensive drug treatment lowers BP
Antihypertensive therapy
EBM
Type of Evidence
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WORK Basic law of human behavior: lowest amount
of work you can get away with
EBM
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Information source Relevance Validity Work Usefulness
Evidenced based textbook High High Low High
Standard textbook High Low Low Mod
Drug reference book ( PDR) High Mod Low High- Mod
Systematic review EB High High Low High
Practice Guidelines EB Mod High Low Mod-High
Practice guidelines consensus
Mod Mod Low Mod
Drug advertising Mod Low Low Low
Drug company representatives
High Low Low Low
Colleagues High Mod Low High- Mod
Internet in 10 years High High Low High
Internet now Low Low High Low
EBM
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IS ALL EVIDENCE CREATED EQUALLY ?
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HOW DO WE SEARCH
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LITERATURE RESOURCES
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FILTERED RESOURCES
appraise the quality of studies and often make recommendations for practice
Systematic ReviewsAuthors of a systematic review ask a specific
clinical question, perform a comprehensive literature search, eliminate the poorly done studies and attempt to make practice recommendations based on the well-done studies.
A meta-analysis is a systematic review that
combines all the results of all the studies into a single statistical analysis of results.
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EXAMPLES OF SYSTEMIC REVIEWS/ METAANYLSIS
The Cochrane Database of Systematic Reviews The Database of Abstracts of Reviews of Effects (DARE) Ovid MEDLINE: Enter your search query. Click on "More
Limits"; select “Systematic Reviews” under “Subject Subsets.”
PubMed: Click on “Clinical Queries” on the left side of the screen; select “Find Systematic Reviews” and enter your search query.
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FILTERED RESOURCES
Critically-Appraised Topicsevaluate and synthesize multiple research
studiesClinical evidenceNational Guideline Clearinghouse
Critically-Appraised Individual ArticlesAuthors of critically-appraised individual articles evaluate and summarize individual research studies.
The ACP Journal clubDaily POEMSEvidence updates
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FILTERED RESOURCES
“Evidence-Based…” Journal series (e.g., Evidence-Based Medicine, Evidence-Based Mental Health, Evidence-Based Nursing)
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UNFILTERED RESOURCES
Evidence is not always available via filtered resources. Searching the primary literature may be required. It is possible to use specific search strategies in MEDLINE and other databases to achieve the highest possible level of evidence
PubMed Ovid Medline
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BACKGROUND INFORMATION/EXPERT OPINION
Evidence in these resources may vary from expert opinion to high levels of evidence. UpToDate e-Medicine E-Books at Galter ACP Medicine
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5S APPROACH TO EVIDENCE BASED INFORMATION ACCESSS
ummari
es
synopses
Synthesis
Studi
es
Computerized decision support system (CDSS)
Evidence based-textbooks
Evidence based-journal abstracts
Cochrane reviews
Original published articles from journals
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SYSTEMS
Decision support tools. They integrate and concisely summarize all
relevant and important research evidence about a clinical problem and would automatically link, through an electronic medical record, a specific patient’s circumstances to the relevant information.
updated whenever important new research evidence becomes available.
would not tell decision-makers what to do. to ensure that the cumulative research evidence
concerning the patient’s problem is immediately at hand.
to maximize speed of use
Su
mmaries
synopses
Synthesis
Studies
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SUMMERIES
These are critically appraised topics Summaries that integrate best available
evidence to provide a full range of evidence concerning management options for a given health problem (eg, acute coronary syndromes [ACS]).
Su
mmaries
synopses
Synthesis
Studies
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Clinical Evidence PIER (Physicians' Information and Education Resources) DynaMed
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DYNAMED
is updated daily monitors the content of over 500 medical
journals and systematic evidence review databases
clinically-organized summaries for more than 3,000 topics,
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PIER (PHYSICIANS' INFORMATION AND EDUCATION RESOURCES)
Link: http://online.statref.com/UserLogin.aspx Is an American College of Physician product summarizes and evaluates current evidence
for patient care. It grades clinical recommendations based on
the strength of the evidence available.
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SYNOPSES
Critically appraised journal article/study •Concise short statements that summarized
the evidence for a particular clinical question •Available of multiple sources over the
internet •Some are downloadable to handheld
devicesExample of Synopses •ACP Journal Club •BMJ Updates •Bandolier •Essential Evidence Plus
Su
mmaries
synopses
Synthesis
Studies
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BMJ UPDATES
From BMJ Publishing Group and McMaster University's Health Information Research Unit.
Quality articles from over 110 clinical journals are selected by research staff, then rated for clinical relevance and interest by an international group of physicians.
Includes a searchable database of the best evidence from the medical literature and an email alerting system
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ACP JOURNAL CLUB
published by the American College of Physicians-
American Society of Internal Medicine. The editors of this journal screen the top
100+ clinical journals and identify studies that are methodologically sound and clinically relevant.
An enhanced abstract, with conclusions clearly stated, and a commentary are provided for each selected article
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SYNTHESIS
If more detail is needed or no synopsis is at hand, then databases of systematic reviews (syntheses) are available,
Examples Cochrane Library Ovid’s EBMR service.
Su
mmaries
synopses
Synthesis
Studies
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COCHRANE DATABASE OF SYSTEMATIC REVIEWS (COCHRANE REVIEWS)
'Gold Standard' for high-quality systematic reviews
Full-text included in Cochrane Library Cochrane Reviews includes complete reviews
and protocols (reviews that are still in progress). Cochrane Reviews abstracts are in PubMed
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COCHRANE DATABASE OF SYSTEMATIC REVIEWS (COCHRANE REVIEWS) DATABASES
Cochrane Database of Systematic Reviews (Cochrane Reviews)
Database of Abstracts of Reviews of Effects (Other Reviews)
Central Register of Controlled Trials (Clinical Trials)
Cochrane Methodology Register (Methods Studies)
Health Technology Assessment Database (Technology
Assessments)
NHS Economic Evaluation Database (Economic Evaluations)
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EBM
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DATABASE OF ABSTRACTS OF REVIEWS OF EFFECTS (OTHER REVIEWS - DARE)
prepared by the National Health Service Centre for Reviews and Dissemination, University of York, England.
Complements the Cochrane Reviews by offering a selection of quality assessed reviews in those subjects where there is currently no Cochrane review.
Brief critical appraisals of previously published reviews of the effects of health care.
Structured abstracts, not full-text DARE not indexed in PubMed, but original
research articles may be Also available at no charge on the web from
University of York | www.crd.york.ac.uk/crdweb/
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PUBMED MEDLINE - SYSTEMATIC REVIEWS
part of PubMed's Clinical Queries Identifies systematic reviews and other
similar types of studies found in biomedical journals included in PubMed database.
No evaluation of comparative quality of different reviews on a topic.
Abstracts supplied by authors/journals. No separate evaluation of quality of research. Identify systematic reviews in the biomedical
area - gathers together much larger collection than other evidence-based practice resources.
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STUDIES
original studies It takes time to summarize new evidence,
and systems, synopses and syntheses necessarily follow the publication of original studies, usually by at least 6-12 months.
Su
mmaries
synopses
Synthesis
Studies
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EXAMPLE OF STUDIES There are also at least two levels of evidence-based databases to search
directly: specialized and general. If the topic falls within the areas of internal medicine, primary care,
nursing or mental health, then ACP Journal Club (www.acpjc.org, formerly Best Evidence) Evidence Based Medicine (http://ebm.bmjjournals.com/), Evidence Based Nursing (http://ebn.bmjjournals.com/) Evidence Based Mental Health (http://ebmh.bmjjournals.com/)
If the search is for a treatment, the Cochrane Library includes the Cochrane Central Register of
Controlled Trials also available as part of EBMR on Ovid, where it is integrated with ACP
Journal Club and DARE. For original articles and reviews MEDLINE itself is freely available and
the Clinical Queries screen If you still have no luck and the topic is, say, a new treatment (that one
of your patients has asked about but you don’t yet know about …), then you can try Google (http://www.google. com
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EXPERT OPINION
Evidence in these resources may vary from expert opinion to high-level evidence but
updates are generally less frequent and level-
of-evidence grading systems are lacking. –UpToDate –eMedicine –Harrison's Online
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UP TO DATE
Provide comprehensive reviews on primary care,
internal medicine, and pediatric topics. Content is enhanced by –many graphics links –Lexi-Comp's drug reference –PubMed abstracts. Evidence gaps are filled by expert opinion.
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EBMEXAMPLE OF EBM SEARCH ENGINES
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