Compton Based Polarized Positron Sources for e + /e - Linear Colliders
E. Zakazakii Sources
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7/24/2019 E. Zakazakii Sources
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Enterobacter sakazakii
General description
Enterobacter sakazakiiis a motile, gram-negative, non-spore-forming, rod-shaped
bacterium, that has been found in infant formulas as a contaminant.Enterobacterspeciesare biochemically similar to Klebsiella, but unlike Klebsiella,Enterobacteris ornithine
positive.E. sakazakiihas been found to be more resistant to osmotic and dry stress than
other members of the Enterobacteriaceae family.
Human health effects
Enterobacter sakazakii has been associated with sporadic cases or small outbreaks of
sepsis, meningitis, cerebritis and necrotizing enterocolitis. Most of the infections are seen
in low-birth weight infants (i.e., less than 2,000 g) or infants born premature (i.e., lessthan 37 weeks of gestation). Mortality has been reported to be as high as 50% but has
decreased to less than 20% in recent years.
Source and occurrence
The reservoir forE. sakazakiiis unknown. Various environmental samples (surface water,
soil, mud, bird faeces) have tested negative. It has been identified in the guts of certain
flies. The organism has been frequently identified in factories that produce milk powderand other food substances and in households. Commercially produced non-sterile
powdered infant formula has often been implicated as the source of the bacteria during
outbreaks. In a study of 141 powdered infant formulas 20 were found to be culture-positive forE. sakazakii even though the formulas complied with Codex microbial
requirements for coliforms (
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Breeuwer P et al. (2003). Desiccation and heat tolerance ofEnterobacter sakazakii.Journal of Applied Microbiology, Vol. 95:967-973.
Kandhai CM, et al. (2004). Occurrence ofEnterobacter sakazakiiin food production
environments and households. (Research letters) The Lancet, Vol. 363: 39-40.Hamilton JV, Lehane MJ, and Braig HR (2003). Isolation ofEnterobacter sakazakiifrom
Midgut of Stomoxys calcitrans(letter to the editor),Emerging Infectious Diseases,
Vol. 9(10):1355-1356).WHO/FAO (2004).Enterobacter sakazakii and other microorganisms in powdered infant
formula, Meeting Report,(Microbiological Risk Assessment Series, 6), World Health
Organization, Food and Agriculture Organization of the United Nations, Geneva.