Dynamics of vaccine uptake in developing country markets

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CENTER FOR VACCINE INNOVATION AND ACCESS PATH/Gabe Bienczycki Dynamics of vaccine uptake in developing country markets: Achieving impact through successful partnership-a case study with JE vaccines Debbie Atherly PhD, Global Head Policy, Access, & IntroducOon October 26, 2016 DCVMN Annual General MeeOng Buenos Aires, ArgenOna

Transcript of Dynamics of vaccine uptake in developing country markets

Page 1: Dynamics of vaccine uptake in developing country markets

CENTER FOR VACC INE I NNOVAT ION AND ACCE S S

PATH/GabeBienczycki

Dynamicsofvaccineuptakeindevelopingcountrymarkets:Achievingimpactthroughsuccessfulpartnership-acasestudywithJEvaccinesDebbieAtherlyPhD,GlobalHeadPolicy,Access,&IntroducOonOctober26,2016

DCVMNAnnualGeneralMeeOngBuenosAires,ArgenOna

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Workinmorethan70countries.150millionpeoplereachedeachyearonaverage.PATHsnapshot

6billionvaccinevialmonitorsensuringthatvaccinesarepotentwhengiven

6.3millionpeoplereachedwithriceforOfiedwithcriOcalmicronutrients

6.2millionlivessavedwithPATH-pioneeredapproachestomalariacontrol

Weharnessour

entrepreneurialinsight,

scienOficandpublic

healthexperOse,and

passionforhealth

equity…

…tosavethelives

ofwomenandchildren.

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PATH’sCenterforVaccineInnovaOonandAccess(CVIA)CVIA’sprimaryobjecOveistoacceleratethedevelopmentandintroducOonoflifesavingvaccinesforopOmalpublichealthimpactintheworld’slowestresourcesebngs.Wefocusonvaccinesthatprotectwomenandchildrenfromtheleadingcausesofdiseaseanddeath.

DISEASEAREAS

RespiratoryInfecConsandMaternalImmunizaConpneumococcus•meningococcus•groupBstreptococcus•B.pertussis•influenzavirus•respiratorysyncyOalvirus

EntericandDiarrhealDiseasesrotavirus•enterotoxigenicEscherichiacoli•Shigellassp.•poliovirus

MalariaPlasmodiumfalciparum•Plasmodiumvivax

ZoonoCc,Emerging,andSexuallyTransmiLedInfecConshumanpapillomavirus•JapaneseencephaliOsvirus•denguevirus•yellowfevervirus•outbreaks

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RESEARCH/DESIGN DEVELOP/VALIDATE APPROVE/RECOMMEND INTRODUCE/OPTIMIZE SCALE-UP/APPLY

•  IdenOfypotenOalvaccineleadsandapproaches

•  ConductiniOalcandidateevaluaOons

•  AddresscountryneedsandprioriOesinproductdevelopment

•  Assessproofofconcept/efficacyinlow-resourcesebngs

•  Generateevidenceforregulatoryreviewandapproval

•  Supportqualitymanufacturingandadequatesupply

•  FacilitateWorldHeathOrganizaOonprequalificaOonandregulatoryapprovalatnaOonallevel

•  Enableevidence-baseddecisionmakingforpublicfinancingandglobalandnaOonalpolicies

•  Supportcountriesonplanning,preparaOon,andintroducOon

•  Capturelearningsfromearlyadopters

•  Ensuresustainablesupply

•  Facilitatewide-scaleuse•  Measureimpact

OurworkspanstheenOrevaccinedevelopmentanddeliveryspectrum

PATH/AaronJoelSantosPATH/MaghewDakinPATH/WillBoase

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JapaneseencephaliOsvaccineimpact:AchievingsuccessthroughcollaboraOon

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JapaneseencephaliOs(JE):AbriefintroducOon

•  JE:mosquito-borneflavivirus;closelyrelatedtodengueandWestNileviruses.

•  LeadingviralcauseofencephaliOsinAsia.

•  Nearly3billionpeopleliveinJE-endemicregions.

•  Childrenandruralpoorsufferthegreatestdiseaseburden.

SolomonT,DungNM,KneenR,GainsboroughM,VaughnDW,KhanhVT.JapaneseencephaliOs.JNeurolNeurosurgPsychiatry.2000Apr;68(4):405-15.

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OurPartnershipwithChengduInsOtuteofBiologicalProducts(CDIBP)•  PartneredonpivotalclinicaltrialstoestablishvaccinesafetyandimmunogencityoutsideofChina

•  ProvidedtechnicalandfinancialsupporttopursueWHOprequalificaOonandmeetrigorousinternaOonalstandardsofquality,safety,andefficacy

•  Assistedinthedesignandfinancingofanewmanufacturingfacilitytoensurehigh-quality,adequate,stablevaccinesupply,whilescalingupproducOonforinternaOonalexport

•  ProvideconOnuedtechnicalandmanufacturingsupporttoadvancevaccineavailabilityandmaintaingoodmanufacturingpracOcestandards

•  Establishedalow,public-sectorvaccinepriceforJE-endemiccountriesthroughourcollaboraOveagreement

•  MonitorJEvaccinesupplytomeetcountrydemand

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HistoricMoment:JEVaccineWHOPrequalificaOon

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OtherKeyWins•  A180percentincreaseofCDIBP’sJEvaccineannualproducOon

capacityasresultofanewlyconstructed,GMP-compliantfacility

•  CDIBPcanproduce70milliondosesperyearonaverage,versusthe25milliondosesperyearproducedintheolder,recently-reOredfacility

•  WithinmonthsofWHOPQ,GaviopenedafundingwindowtosupportJEvaccinaConcatch-upcampaignsforchildrenlessthan15yearsofage

•  From2003–2017,anesCmated308millionchildrenoutsideofChinawillbevaccinatedbyCDIBP’svaccine

•  ThroughrecentnegoOaOonsofafairpublichealthpricethatreflectsactualvaccineproducOoncostatCDIBP,weincreasedthelikelihoodofvaccineuptakebyallcountrieswithahighJEburden,notjustGavicountries.ItalsoensuredsustainablevaccineproducOonunOl2033.CDIBP’sJEvaccineremainsoneofthemostcosteffecCvevaccinesonthemarket.

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KeyMilestonesinJEControlandPrevenOon

2006FirstWHOJEpositionpaperpublished,whichrecommendedreplacingolder,moreexpensivevaccineswithnewgenerationJEvaccines,giventheiradvantageoussafetyprofileandaffordability.

2012Newmanufacturingfacilitycomplete;dosecapacityraisedfrom25Mto70M.

2013WHO“Prequalification”statusobtainedforCD-JEV,whichmeansasafe,effectivevaccineismorewidelyaffordableandaccessible.

2015WHOJEpositionpaperupdated:StronglyendorsesintegratingvaccineintoallnationalimmunizationscheduleswhereJEisrecognizedasapublichealthpriority.

2006India

2007NepalThailand

2008DPRK

2002SouthKoreaSriLanka

2015LaosCambodia

2016Nepal

2017MyanmarVietnamIndonesiaPhilippines

2018Bangladesh

2014Gaviapplicationsopen,whichprovidesfinancingforCD-JEVintroductionforlowandlower-middleincomecountries.

CountryintroductionsofCD-JEV

1988China Vaccinedevelopmentandmanufacturing

PartneracCviCesCountryvaccineintroducCon/expansion

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China|1988

DPRK|2008

SouthKorea|2002Nepal|2007

JEvaccina=onexpanded2016

MyanmarExpectedintroduc=on2017

BangladeshExpectedintroduc=on2018India|2006

ConOnuestoexpand

SriLanka|2002

Thailand|2007

PhilippinesExpectedintroduc=on2017

IndonesiaExpectedintroduc=on2017

VietnamExpectedexpansion2017

Laos|2015

Cambodia|2016

Country-financedintroducOonofCD-JEVfollowedbyGavi-supportedexpansion

CountriesthathaveintroducedCD-JEV

AnOcipatedGavi-supportedJEvaccineintroducOonorprogramexpansion

Note:YearscorrespondtoyearthatCD-JEVwasincorporatedintochildhoodvaccinaOonprograms

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Thankyou!QuesOons?


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