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Drugs containing carboxylic acid (2)
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Transcript of Drugs containing carboxylic acid (2)
Drugs containing
Carboxylic acid
INTRODUCTION
are organic acids characterized by the presence of at least one carboxyl group. The general formula of a carboxylic acid is R-COOH
General characters
Boiling point:Carboxylic acids tend to have higher boiling
points
Acidity:Carboxylic acids are typically weak acids
Odor :
Carboxylic acids often have strong odors,
especially the volatile derivatives. Most
common are acetic acid (vinegar) and butyric
acid (rancid butter) .
Solubility:Carboxylic acids
are polar .the Smaller carboxylic acids are soluble
with water, whereas higher carboxylic acids are less soluble
EXAMPLES FOR CARBOXYLIC ACIDS INCLUDED IN SOME DRUG:
1 .
Salicylic acid
.
2.
Fusidic acid
.
3 .
Citric acid
.
4 .
Ascorbic acid
.
5 .
Benzoic acid
.
6.
Lactic acid
.
7.
Tartaric acid
.
For Example
:1 -
Aspocid . ( shewable
tablets)
2 -
Rivo ( tablets)
3 -
Rivo ped ( supp) 4 -
aspocid buffer( eff)
5-
Aspegic( vial)
It is Acetyl salicylic acid which have many trade names in the Egyptian market
Aspirin
synthesis
Aspocid
Indications
Side effects
contraindications
Precautions
1- headache. ( the 1st drug in treatment of migraine) 2- pain( muscle, cramps ,skin irritation)3-prevention of heart
attacks and strokes . 4-for fever and pains associated with common cold 5-for joint pain of acute rheumatic fever
Indications
• Dyspepsia, heartburn, anorexia, nausea, occult blood loss, epigastric discomfort, massive GI bleeding, potentiation of peptic ulcer
GIT
• Bronchospasm, asthma-like symptoms, anaphylaxis, skin rashes, urticarial, rhinitis
Allergic
• Prolongation of bleeding time, thrombocytopenia, leukopenia, purpura, shortened erythrocyte survival time, decreased plasma iron levels.
Hematologic
Side
Effects:
Contraindications:
1-Hypersensitivity to salicylates 2-
Clients with asthma, hay fever3 -Severe anemia
4 -history of blood coagulation defects
, 5-in conjunction with anticoagulant
therapy 6-In pregnancy, especially the last
trimester as the drug may cause
problems in the newborn child or
complications during delivery.
Precautions
1-
Use with caution during
lactation
.
2-
gastric or peptic ulcers
,
3 -
in cardiac disease
.
4- in liver or kidney
disease.
Heel Forte ointment
Composition;
Salicylic acid 12 g
Urea 8 g
Dose:
A thin film of the ointment should
be applied twice daily to cover the
affected area completely
PROPERTIES :Salicylic acid has keratolytic property
which causes the cornified tissues to
swell, soften, macerate and
desquamate. Urea moisturizes and softens severely
dry, rough skin
SOINDICATIONS :
1-Removal of callus and corns
2-Smoothing of intensely rough
heels3-Helps in treatment of warts
contraindications
Hyper sensitivity to any of the
components of the ointment
Side effects
May cause dermatitis or
irritation
Precaution
Protect surrounding skin
and avoid application to
broken or inflamed skin.
Avoid contact with the eye.
Not to be used for diabetic patients and
those with poor blood circulation .
Scabinol soap
INGREDIANTS
benzyl benzoate
15%sulpher15%
USES:
For scabies and
pediculosis.
Dermacid soapINGREDIANTS benzoic a .1 % tartaric
a .7% salicylic
a .2%
•Acidic Soap. • Restores and maintains the
natural acidity of the skin.
• Used for mycotic skin
infections, prickly heat, sweat and diaper rashes,
acne, etc.
Salicylic acid soap
INGREDIANT
S : 2% salysilic acid.
USES :for infectious skin disease.
Examples for soaps containing carboxylic acids
Faw
ar F
ruit
PRESENTATION FORM :
Sachet
COMPOSITION :
Citric acid 16 gm
Flavor and color to 100
gm
Sodium bicarbonate 56 gm
Tartaric acid 26.7 gm
USES :
Antacids in the gastrointestinal
system.
Eva Spotless Cream
Components:
Special formula facial cream rich in lactic acid and lemon juice.
USES
the ideal solution to deal with black spots and other problems of teenage skin and not only.
Cream gently removes the top layer of dead cells and cleans pores, preventing problems.
The cream also lightens the skin and contributes to the disappearance of freckles.
What is fucidic acid??
fucidic acid is a
bacteriostatic antibiotic that is often used topically in
creams and eyedrops, but may also be given
systemically as tablets or injections. Fusidic acid is
often found in topical skin and eye preparations .
Drugs containing
fusidic acid:
Structure:
Fusi
derm
oin
tmen
t
Components:
Each 100 gm Fusiderm ointment containsSodium fusidate2 gm
USES:
Fusiderm is an antibiotic having a potent antimicrobial activity against many Gram-positive organisms such as, Streptococci,
Corynebacterium minutissimum and particularly Staphylococci, including the strains resistant to
penicillin or other antibiotics.
Fusiderm provides highly effective topical treatment in primary and secondary bacterial
infections of the skin and has a unique ability to penetrate intact skin
Bet
afuc
in c
ream
COMPOSITION:
Each gram contains :
Fucidic acid 20 mg
Betamethasone 1mg
PROPERTIES
: Betafucin cream combines the
potent topical antibacterial
action of fusidic acid with the
anti-inflammatory and
antipruritic effect of
betamethasone
VITACID C
Are e
ffervesc
ent
granule
s of s
ingle
vita
min
( asc
orbic
acid)
COMPOSIT
ION
:
1 -
sach
ets:
eac
h 4 g
m
sach
et con
tain
500
mg a
scor
bic a
cid
2 -1
gm e
fferve
scen
t
table
ts con
tain
1 g
m
asco
rbic a
cid
VITAMIN C PROPERTIES
:
1-
Vitamin C is an essential co-enzyme
for collagen formation
2-
tissue repair and synthesis of lipids
and proteins
.
3-
It acts both as a reducing agent and
as antioxidant
.
4-
It is necessary for many physiologic
functions
e.g. metabolism of iron, carbohydrate
and folic acid, resistance to infection,
cellular respiration and preservation of
blood vessel integrity
.
1-Prevention and
treatment of scurvy.
2-Symptomatic relief of
common cold and influenza
3-Pregnancy and lactation.
4-in certain diseases and
conditions such as:
hyperthyroidism, peptic
ulcer, chronic illness and
infections (whooping
cough, pneumonia, sinusitis and
rheumatic fever).
History of hyper sensitivity to
vitamin CIndication
s Contraindecations
REFERENCES:
1 -Organic chemistry (5th Edition),Paula Yurkanis Bruice.
2-2nd Edition Therapeutic drugs, Colin Dollergy,
Vol 1.3 -2nd Edition therapeutic drugs,
Colin Dollergy,vol2.
4-Drug Index ,Master on therapeutic Drugs,
Dr. Henein Wely & Dr. Usama Tharwat.5 -Mina El Bostany pharmacy .
BY:
1 -
Aya
Ahm
ed S
aber
2 -
Geh
an E
ssam
Mah
moo
d
3 -
Eman
Ala
a El
Sha
my
4-
Eman
Moh
amed
Mos
tafa
Facu
lty
of p
harm
acy
ASU
Phar
mac
eutica
l
Chem
istr
y de
part
men
t
1st Y
ear
Se
ctio
n 2