Drug Order for prostatic cancr

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    VIII. DRUG STUDY

    A c a s e s t u d y o n P r o s t a t i c C a n c e r w i t h B o n e M e t a s t a s i s ( T h o r a x ) Page 1

    DRUG ORDER(generic

    name, brandname,

    classification,frequency,

    route,)

    MECHANISM OFACTION

    INDICATION CONTRAINDIATION ADVERSE EFFECTS NURSING RESPONSIBIL

    Generic name:

    Albuterol

    Brand name:Comvibent

    Classification:Bronchodilators

    Dosage:1 neb

    Route:Inhalation

    Frequency:

    q 4

    Binds to beta2-

    adrenergicreceptors inairway smoothmuscle, leading toactivation ofadenylcyclase andincreased levels ofcyclic.

    Treatment for

    bronchospasms

    Contraindicated to

    hypersensitivity ofalbuterol

    CNS: nervousness,

    restlessness

    CV: chest pain,palpitations,

    GI: nausea andvomiting.

    1. Chest tapping after inh

    2. Do not exceed recodosage.

    3. Administer prinhalation drugs formsecond half of because the airways

    wider lead to distribution is more ex

    4. Use minimal doses foperiods drug toleraoccur if prolonged use

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    VIII. DRUG STUDY

    A c a s e s t u d y o n P r o s t a t i c C a n c e r w i t h B o n e M e t a s t a s i s ( T h o r a x ) Page 2

    DRUG ORDER(generic

    name, brandname,

    classification,frequency,

    route,)

    MECHANISM OFACTION

    INDICATION CONTRAINDIATION ADVERSE EFFECTS NURSING RESPONSIBIL

    Generic name:

    Esomeprazolemagnesium

    Brand name:Nexium

    Classification:Proton pump

    inhibitor

    Route:IVTT

    Dosage:40mg

    Frequency:Q12

    Blocks theformation step ofacid production.

    GERD- treatmentof heartburn andother relatedsymptoms.

    Contraindicated withallergy to nexium.

    CNS: headache,dizziness

    GI: diarrhea,abdominal pain,nausea, and vomiting.

    Respiratory:URI symptoms

    1. Obtain baseline of livetest and monitored pdosage therapy.

    2. Maintain supportive as appropriate for uproblem

    3. Provide additional measure to alleviate d

    from GI effects and he

    4. Arrange regular medicvisits when taking this

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    VIII. DRUG STUDY

    A c a s e s t u d y o n P r o s t a t i c C a n c e r w i t h B o n e M e t a s t a s i s ( T h o r a x ) Page 3

    DRUG ORDER(generic

    name, brandname,

    classification,frequency,

    route,)

    MECHANISM OFACTION

    INDICATION CONTRAINDIATION ADVERSE EFFECTS NURSING RESPONSIBIL

    Generic name:

    Paracetamol

    Brand name:Naprex

    Classification:

    Analgesia

    Route:IVTT

    Dosage:300mg

    Frequency:Q 4

    Reduces fever byacting directly onthe hypothalamusheat regulatingcenter tocausevasodilationand sweatingwhich helpsdissipate heat..

    Analgesic-antipyretic inpatient withbleeding diathesesand upper GIdisorder

    Contrainicated withallergy to naprex

    CV: myocardialdamage

    CNS: headache

    GI: hepatic toxicityand failure.

    1. Do not excerecommended dosage

    2. Avoid using preparations acetaminophen.

    3. Give drug with food ifoccurs.

    4. Discontinue if hyperoccurs

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    VIII. DRUG STUDY

    A c a s e s t u d y o n P r o s t a t i c C a n c e r w i t h B o n e M e t a s t a s i s ( T h o r a x ) Page 4

    DRUG ORDER(generic

    name, brandname,

    classification,frequency,

    route,)

    MECHANISM OFACTION

    INDICATION CONTRAINDIATION ADVERSE EFFECTS NURSING RESPONSIBIL

    Generic name:

    Dopamine

    hydrochloride

    Brand name:intropin

    Classification:symphatomimetics

    Route:IV

    Dosage:14cc/hr

    Frequency:Q1

    Stimulatesdopaminrgic and

    alpha and betareceptors of thesympatheticnervous system.

    Action is dose-related; largedoses causemainly alphastimulation.

    To correcthypotension thus,

    improving tissueperfusion

    Contraindicated inpatients with

    uncorrectedtachyarrythmias,pheochromocytoma,or ventricularfibrillation.

    CNS: headacheCV: ectopic beats,

    tachycardia, angina,palpitations,hypotension,GI: nausea, vomitingGU: elevated urinarycatecholamine levels.Metabolic: azotemia,hyperglycemiaRespiratory: dyspnea,asthmatic episodes.Skin: necrosis andtissue sloughing withextravasation,piloerectionOther: anaphylactioc

    reactions.

    1. Use cautiously in patocclusive vascular dise

    injuries, diabetic endartarterial embolism.

    2. During infusion, frequentECG, blood pressure,output, central venous pulmonary artery wedge pulse rate, urine output, and temperature of limbs

    3. Check urine output oftenflow decreases hypotension, notify because dosage may nreduced

    4. After drug is discontinueclosely for sudden dec

    blood pressure. Taperslowly to evaluate stabilitpressure

    5. Instruct client that report of discomfort at the insert

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    VIII. DRUG STUDY

    A c a s e s t u d y o n P r o s t a t i c C a n c e r w i t h B o n e M e t a s t a s i s ( T h o r a x ) Page 5

    DRUG ORDER(generic

    name, brandname,

    classification,frequency,

    route,)

    MECHANISM OFACTION

    INDICATION CONTRAINDIATION ADVERSE EFFECTS NURSING RESPONSIBIL

    Generic name:Zolendronicacid

    Brand name:Zometa

    Classification:

    Calciumregulator

    Route:

    Via vial

    Dosage:200ml

    Frequency:OD

    Action leads todecrease in the

    release of calciumfrom bone and adecrease in serumcalcium.

    Treatment formyelomas and

    documented bonemetastases fromsolid tumors inconjunction withstandardantineoplastictherapy.

    Contraindicated with

    allergy to zometa

    CV: hypotension

    GI: nausea andvomiting

    Respi.: dyspnea

    Make sure that patient is welbefore use; vigorous saline

    to establish a urine output2L/day is suggested.

    Monitor urinary output anpatient for hydration status c

    Ensure that drug infuses arethan 15min.

    Provide small meal if Goccurs

    Assess for nutritional consultand vomiting persist.

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    VIII. DRUG STUDY

    A c a s e s t u d y o n P r o s t a t i c C a n c e r w i t h B o n e M e t a s t a s i s ( T h o r a x ) Page 6

    DRUG ORDER(generic

    name, brandname,

    classification,frequency,

    route,)

    MECHANISM OFACTION

    INDICATION CONTRAINDIATION ADVERSE EFFECTS NURSING RESPONSIBIL

    Generic name:

    calcium

    gluconate

    Brand name:Cal-lac

    Classification:Elecrolytereplacementagent

    Route:Via vial

    Frequency:OD

    Dosage:

    10% solution

    Increase serumlevel through

    direct effects onbone.Decreaseosteoclastic byreduces mineralrelease andcollagenbreakdown inbones.

    Hypocalcemicemergency

    Hypersensitivity to

    drug

    CNS: headache

    GI: nausea andvomiting

    1. Instruct patient to conand dairy product

    therapy

    2. Refer patient to diehelp in meal planpreparation.

    3. Review all other signilife threatening reaction and interactio

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    VIII. DRUG STUDY

    A c a s e s t u d y o n P r o s t a t i c C a n c e r w i t h B o n e M e t a s t a s i s ( T h o r a x ) Page 7

    DRUG ORDER(generic

    name, brandname,

    classification,frequency,

    route,)

    MECHANISM OFACTION

    INDICATION CONTRAINDIATION ADVERSE EFFECTS NURSING RESPONSIBIL

    Generic name:

    cefuroxime

    Brand name:Zegen

    Classification:

    anti infective

    Dosage:750mg

    Route:PO

    Frequency:Q8

    .Interferes withbacterial cell wall

    synthesis anddivision by bindingto all cell wallcausing cell to die.

    Severe infectioninclude bone

    infection

    Hypersensitivity todrugs.

    CNS: seizures

    GI: nausea andvomiting

    Hematologic disorder:hemolytic anemia.

    1. Monitor neurologicparticularly sign of i

    seizures.

    2. Monitor kidney afunction.

    3. Advise the patient CNC changes.

    4. Advise patient to imreport rash or tendencies.

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    VIII. DRUG STUDY

    A c a s e s t u d y o n P r o s t a t i c C a n c e r w i t h B o n e M e t a s t a s i s ( T h o r a x ) Page 8

    DRUG ORDER(generic

    name, brandname,

    classification,frequency,

    route,)

    MECHANISM OFACTION

    INDICATION CONTRAINDIATION ADVERSE EFFECTS NURSING RESPONSIBIL

    Generic name:

    Bicalutamide

    Brand name:Casodex

    Classification:

    Antiandrogen

    Dosage:50mg

    Route:Po

    Frequency:OD

    Antagonizes theeffects of

    androgen andcellular level bybinding toandrogen receptoron target bone

    Treatment ofadvanced

    prostaticcarcinoma incombination withLH-RH analogue

    Contraindicated withallergy to

    bicalutamide and itscomponent.

    Hot flushes, breattenderness, nausea

    and vomiting, dry skin, jaundice, anorexia,dry mouth.

    1. Monitor liver function t

    2. Administer LH_RH an

    3. Tell the patient that anrelated to hair loss shoreport immediately.

    4. As appropriate, reviewsignificant and life threadverse reaction andintervention especiallyto the drugs and test

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    VIII. DRUG STUDY

    A c a s e s t u d y o n P r o s t a t i c C a n c e r w i t h B o n e M e t a s t a s i s ( T h o r a x ) Page 9

    DRUG ORDER(generic

    name, brandname,

    classification,frequency,

    route,)

    MECHANISM OFACTION

    INDICATION CONTRAINDIATION ADVERSE EFFECTS NURSING RESPONSIBIL

    Generic name:

    Sulperazone

    Brand name:Cefobid

    Classification:

    antibiotic

    Route:oral

    Dosage:250mg

    Frequency:Q12

    Bactericidal:inhibits synthesis

    of bacterial cellwall causing celldeath.

    Treatment for intraabdominal

    infection

    Contraindicated withallergy to

    sulperazone

    CNS: headache

    GI: nausea andvomiting

    GU: nephrotoxicity

    1. Report if some advermay worsens

    2. Discontinue druhypersensitivity occur

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    VIII. DRUG STUDY

    A c a s e s t u d y o n P r o s t a t i c C a n c e r w i t h B o n e M e t a s t a s i s ( T h o r a x ) Page 10

    DRUG ORDER(generic

    name, brandname,

    classification,frequency,

    route,)

    MECHANISM OFACTION

    INDICATION CONTRAINDIATION ADVERSE EFFECTS NURSING RESPONSIBIL

    Generic name:

    Tranexemic

    acid

    Brand name:Hemostan

    Classification:Antihemorrhagic

    Route: IVTT

    Dosage:500g

    Frequency:ev

    ery 6 hours

    Forms a reversible

    complex thatdisplaces

    plasminogen from

    fibrin resulting in

    inhibition of

    fibrinolysis; it also

    inhibits the

    proteolytic activity

    of plasmin

    Treatment forbleeding (lower

    gastrointestinalbleeding).

    Contraindicated withhypersensitivity to

    hemostan and itscomponent

    GI: nausea andvomiting, anorexia

    also.

    CNS: headache mayoccur

    1. Report if some advermay worsens

    2. Discontinue drug if

    hypersensitivity occur

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    VIII. DRUG STUDY

    A c a s e s t u d y o n P r o s t a t i c C a n c e r w i t h B o n e M e t a s t a s i s ( T h o r a x ) Page 11