DRUG DELIVERY

Catheter Cortex

Fluid Physics and Transport Phenomena in the Human BrainFluid Physics and Transport Phenomena in the Human BrainLaboratory for Product and Process DesignLaboratory for Product and Process Design, Director A. A. LINNINGER

College of Engineering, University of Illinois, Chicago, IL, 60607, U.S.A.

Grant Support: NSF, Susman and Asher Foundation

Key Achievements

• 3D geometric reconstruction of patient-specific brain dimensions based on MRI data

• 3D patient-specific dynamic analysis of CSF flow in the human brain

Future Goals

• Optimal Drug Delivery to the Human Brain.

• Feedback control systems to better treat Hydrocephalus.

TECHNICAL APPROACH: MOVING GRID CODE

Novel Moving Grid Code+ FLUENT

MRImaging

ImageReconstruction

GridGeneration

SolversPost –

Processing

HYDROCEPHALUS

Live patient MRI Computer Simulation

• Data from Magnetic Resonance Imaging.

• Use of MRI reconstruction tools for generation of 3D patient specific brain geometry.

• Introduction of the geometry to Finite Volumes or Finite Elements advanced solvers.

• Post processing of the obtained results.

Problem Statement

• Prediction of large deformations of the brain parenchyma based on Fluid-Structure Interaction modeling.

• Coupling of the brain parenchyma, vascular and ventricular system in the human brain.

Motivation

• The therapeutic approach for hydrocephalus treatment is very brutal (shunting) and many revisions are needed.

• Ultimate goal: precise model of human brain dynamics to design treatments without in vivo test.

3-D model of the ventricular system and half of the subarachnoid space.

3-D model of the solid brain (white and gray matter).

Velocity magnitude (m/sec)

V a s c u l a r S y s t e m ( I )V a s c u l a r S y s t e m ( I )

P a r e n c h y m a ( I I )P a r e n c h y m a ( I I )

V e n t r i c u l a r S y s t e m ( I I I )V e n t r i c u l a r S y s t e m ( I I I )

V a s c u l a r S y s t e m ( I )V a s c u l a r S y s t e m ( I )

P a r e n c h y m a ( I I )P a r e n c h y m a ( I I )

V e n t r i c u l a r S y s t e m ( I I I )V e n t r i c u l a r S y s t e m ( I I I )