Dr. Peter Welters - ABIC 26th/Afternoon Parallel Sessions... · Dr. Peter Welters Phytowelt ......

GreenTechnologies GmbH

plantdustrial – linking plant and industrial biotechnology

Dr. Peter WeltersPhytowelt GreenTechnologies GmbH

ABIC2008, Cork, 26.08.08


Monococcum Mint protoplasts Seedless Tomatoes

Biological Conventional GM-Agriculture Agriculture Agriculture

Optimization of Plants


Life on Earth has evolved from a mélange ofchemicals via microbial organisms and

algae towards plants!

Why should chemistry be different?

Evolution


A B

Renewable Resources

GreenTechnologies GmbHSustainable Chemistry

2005: $ bio 77 2010: $ bio 125

McKinsey 2006

0

5

10

15

20

25

30

35

40

45

$ bio

BioFue

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Plant E

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Pharm

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BulkChe

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dients

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ls

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GMOs

Mol. Farm.

BioEnergy

Fermentation withMicrobial Cells

Fermentation improved byPlant Enzymes

Fermentation replacedby Plant Production

SustainableChemistry

BioChemicals

Technology Hype

GreenTechnologies GmbHphytomining

Screening with non endogenous, non biogenous substrates!


Isoprene

Hemiterpenes (1) – isopentenol, isoamyl alcoholMonoterpenes (2) – essential oils, mentholSesquiterpenes (3) – essential oils, artemisininDiterpenes (4 ) – phytol, vitamin A, crocetinSesterterpenes (5) – waxesTriterpenes (6 ) – celastrol, squalene, steroidsTetraterpenes (7 ) – carotenes, xantophyllsPolyterpenes (X ) – rubber, gutta

Enzymes

AA, purines /pyrimidines

Enzymes

Pyrrole/pyrrolidine A. – nicotine, cocainePyridine/piperidine A. – coniineTropane Alkaloids – atropineQuinoline Alkaloids – cinchonaIndole Alkaloids – rauwolfiaPurine Alkaloids – caffeineSteroidal Alkaloids – kurchiIsoquinoline A. – opium

Tannins – epigallocatechinLignin – p-hydroxyphenyl L, syringyl LFlavonoids – quercetin, kaempferol

(Poly)phenolics

Enzymes

Unique Plant Chemicals

GreenTechnologies GmbHProduction

Diosgenin(Steroidsaponin)

Sitosterin (Triterpen)

Stigmasterin(Triterpen)

CortisonProgesteron

Fusarium,Curvularia

phytochemistry & phytominingplant metabolites & enzymes forexiting products

GreenTechnologies GmbHExpression & analysis

GreenTechnologies GmbHSynergy

GreenTechnologies GmbHTerpene Biosynthesis

Bouvier et al., 2005


OPP

O O O

O OH OAc

O OH

Geranyldiphosphate

(-)-Limonene (-)-trans-Iso-piperitenol

(-)-Isopiperit-enone

(+)-cis-iso-pulegone

(+)-Pulegone (-)-Menthone (-)-Menthol

(+)-Mentofuran(+)-Neo-

menthol(-)-Menthyl-

acetat

OH

A

B

Storage


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Minze 18.23

1. Screening 2. Fusion 4. Evaluation3. Selection Application

phytodiversity


Regeneration ofHybrid Plants

Cell division, Callus andShoot Regeneration

Parameter Donor Material andProtoplast Isolation

Parameter Cell Fusion

Analysis

Somatic Hybridization

GreenTechnologies GmbHImproving Biodiversity

0

500000

1000000

1500000

2000000

2500000

3000000

3500000

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3 Fusion 2.1 Fusion 2.2 Fusion 2.4 Fusion 2.6 Fusion 2.7 32

Are

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GreenTechnologies GmbHMenthone

M. piperita

Biochemical complexity

plants build up

bacteria break down

Opportunities


IndustryAltana AGBayer MaterialScience AGBayer Technology Services GmbHCognis Deutschland GmbH & Co. KGEvonik Degussa GmbHHenkel KGaALANXESS AG

AcademiaForschungszentrum Jülich GmbHFraunhofer IMEFraunhofer UMSICHTFraunhofer WKIISAS – Institute for Analytical SciencesUniversität BielefeldUniversität DortmundHeinrich Heine-Universität DüsseldorfUniversität Münster

Investors & FoundersProf. Dr. Detlev RiesnerSirius VentureDr. Martin Wilhelm, focus ehfNRW.BANK

InfrastructureBioanalytik Münster e.V.Bioindustry e.V.Bio-OWL e.V.PROvendis GmbHVCI NRW

CLIB2021: Industry, SME, AcademiaInvestors & Infrastructure

SMEArtes Biotechnology GmbHAqura GmbHBayGenetics GmbHbitop AGBioreact GmbHBIOTECmarin GmbHButalco GmbHCilian AGCognis Oleochemicalsc-LEcta GmbHDASGIP AGDirevo Biotech AGDohms Ingredients GmbHevocatal GmbHHöFer bioreact GmbHInsilico Biotechnology AGKaye Scholerm2p-labs GmbHMöller Group GmbH & Co KGNanotecMARIN GmbHNova Institut GmbHPATEV GmbH & Co. KGPharmedArtis GmbHPhytowelt GreenTechnologies GmbHProtagen AGRhein Biotech GmbHTaros Chemicals GmbH & Co. KGWEE-Solve GmbH


AcademiaForschungszentrum Jülich GmbHFraunhofer IMEFraunhofer UMSICHTFraunhofer WKIISAS – Institute for Analytical SciencesUniversität BielefeldUniversität DortmundHeinrich Heine-Universität DüsseldorfUniversität Münster

Investors & FoundersProf. Dr. Detlev RiesnerSirius VentureDr. Martin Wilhelm, focus ehfNRW.BANK

InfrastructureBioanalytik Münster e.V.Bioindustry e.V.Bio-OWL e.V.PROvendis GmbHVCI NRW

SMEArtes Biotechnology GmbHAqura GmbHBayGenetics GmbHbitop AGBioreact GmbHBIOTECmarin GmbHButalco GmbHCilian AGCognis Oleochemicalsc-LEcta GmbHDASGIP AGDirevo Biotech AGDohms Ingredients GmbHevocatal GmbHHöFer bioreact GmbHInsilico Biotechnology AGKaye Scholerm2p-labs GmbHMöller Group GmbH & Co KGNanotecMARIN GmbHNova Institut GmbHPATEV GmbH & Co. KGPharmedArtis GmbHPhytowelt GreenTechnologies GmbHProtagen AGRhein Biotech GmbHTaros Chemicals GmbH & Co. KGWEE-Solve GmbH


CLIB2021: Industry, SME, AcademiaInvestors & Infrastructure

IndustryAltana AGBayer MaterialScience AGBayer Technology Services GmbHCognis Deutschland GmbH & Co. KGEvonik Degussa GmbHHenkel KGaALANXESS AG

Sugar

Starch

Glucosesyrup

Sugar caneSugar beet

CornSeed

Value

R&D

Biomass

Amylase

Feedstock

Microbialintermediates

Pulpingenzymes

Plant, animal,microbial biomass

CLIB2021: Partnering with Ag-Biotechall over the Value-Chain

Enantiomericallypure drug

Polymers

PolylaminesSuccinic acid

Amines

Amino Acid

AdhesivesAdhesivePeptides

Enzyme

Ethanol

Superabsorber

Plastics

Consumer product

Intermediate

ButadieneAcetaldehyde

Acrolein

Chemical productsPyridines

Feedstock-Supplier

Agro-Industry

Chemical Industry

Consumer Industries

Shortens Time to Market


Thank You for Your Attention!

Further Information:

www.phytowelt.comwww.clib2021.com

[email protected]

Dr. Peter Welters - ABIC 26th/Afternoon Parallel Sessions... · Dr. Peter Welters Phytowelt ......

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